Development Level

Tbio 4 | 10,625
Tchem 1 | 1,890

IMPC Term

abnormal coping response 1 | 12
decreased IgM level 1 | 1
decreased body weight 1 | 174
decreased lean body mass 1 | 195
increased circulating choleste... 1 | 53

Disease

ovarian cancer 5 | 8,484
Multiple myeloma 3 | 1,327
psoriasis 3 | 6,685
Breast cancer 2 | 3,094
Cancer 2 | 2,346
Carcinoma 2 | 2,147
Cholangiocarcinoma 2 | 32
Chondroma 2 | 12
D-2-hydroxyglutaric aciduria 2 | 9
DOID:2627 2 | 14
Enchondromatosis 2 | 4
Hemangioma 2 | 35
Immune system cancer 2 | 38
Interval angle-closure glaucoma 2 | 2
Liver carcinoma 2 | 217
Maffucci syndrome 2 | 7
Myelofibrosis 2 | 11
Ollier disease 2 | 15
Papilloma 2 | 27
Tropical spastic paraparesis 2 | 17
Waldenstrons macroglobulinemia 2 | 765
atypical teratoid/rhabdoid tumor 2 | 1,095
glioblastoma 2 | 5,572
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,289
lung adenocarcinoma 2 | 2,713
non primary Sjogren syndrome sicca 2 | 840
oligodendroglioma 2 | 2,849
osteosarcoma 2 | 7,933
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,795
pediatric high grade glioma 2 | 2,712
tuberculosis 2 | 1,557
2-hydroxyglutaric aciduria 1 | 5
Anaplastic Oligoastrocytoma 1 | 1
Anaplastic Oligodendroglioma 1 | 2
Anaplastic astrocytoma 1 | 1
Angioimmunoblastic Lymphadenopathy 1 | 4
Biliary tract cancer 1 | 8
Bone cancer 1 | 9
Chondrosarcoma 1 | 24
Combined D-2- and L-2-hydroxyglutaric aciduria 1 | 4
D-2-HYDROXYGLUTARIC ACIDURIA 2 1 | 1
Degenerative polyarthritis 1 | 93
Disease Progression 1 | 125
Dysembryoplastic neuroepithelial tumor 1 | 10
Fibrillary astrocytoma 1 | 2
GLIOMA SUSCEPTIBILITY 1 1 | 3
Ganglioglioma 1 | 16
Gemistocytic astrocytoma 1 | 1
Giant Cell Glioblastoma 1 | 12
Glioma 1 | 65
INFANTILE CEREBELLAR-RETINAL DEGENERATION 1 | 3
Inguinal hernia 1 | 13
METAPHYSEAL ENCHONDROMATOSIS WITH D-2-HYDROXYGLUTARIC ACIDURIA 1 | 1
Mixed Oligodendroglioma-Astrocytoma 1 | 1
Neurodegenerative disease 1 | 383
Osteoporosis 1 | 257
Peripheral T-cell lymphoma 1 | 24
Polycythemia Vera 1 | 24
Precursor Cell Lymphoblastic Leukemia Lymphoma 1 | 42
Protoplasmic astrocytoma 1 | 1
Respiratory failure 1 | 30
Retinitis Pigmentosa 46 1 | 1
Retinitis pigmentosa 1 | 153
Sideroblastic anemia with spinocerebellar ataxia 1 | 6
Spinal cord disease 1 | 22
Stomach Neoplasms 1 | 282
Zellweger Syndrome 1 | 38
astrocytoma 1 | 1,493
atypical teratoid / rhabdoid tumor 1 | 4,369
breast carcinoma 1 | 1,614
ductal carcinoma in situ 1 | 1,745
gastric carcinoma 1 | 832
gliosarcoma 1 | 19
group 3 medulloblastoma 1 | 2,254
hepatocellular carcinoma 1 | 532
interstitial cystitis 1 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,988
invasive ductal carcinoma 1 | 2,950
lung cancer 1 | 4,466
malignant mesothelioma 1 | 3,162
medulloblastoma, large-cell 1 | 6,234
nasopharyngeal carcinoma 1 | 1,056
non-small cell lung cancer 1 | 2,798
pancreatic cancer 1 | 2,300
pancreatic carcinoma 1 | 567
pilocytic astrocytoma 1 | 3,086
pituitary cancer 1 | 1,972
posterior fossa group A ependymoma 1 | 1,511
primitive neuroectodermal tumor 1 | 3,031

Tissue

Blood and immune system 5 | 17,995
Cardiovascular System 5 | 17,958
Digestive Tract 5 | 18,473
Endocrine System 5 | 18,512
Female tissues 5 | 18,647
Liver and Pancreas 5 | 18,136
Male tissues 5 | 17,969
Nervous System 5 | 18,561
Respiratory system 5 | 17,484
Skin and soft tissues 5 | 18,115
Urinary Tract 5 | 18,444

Target Family

Enzyme 5 | 4,146

GO Process

isocitrate metabolic process 5 | 5
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B Tbio Enzyme -1.13428 13.6 146
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G Tbio Enzyme -0.19018 0.67 161
Aconitate hydratase, mitochondrial ACO2 Tbio Enzyme -2.17104 145.2 256
Isocitrate dehydrogenase [NADP], mitochondrial IDH2 Tbio Enzyme -2.83742 700.9 270
Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 Tchem Enzyme -3.09706 1358.1 384