Development Level

Tbio 3 | 11,651
Tchem 1 | 1,388
Tclin 1 | 612

IMPC Phenotype

decreased IgM level 1 | 1
decreased body weight 1 | 161
decreased circulating choleste... 1 | 93
increased circulating amylase ... 1 | 25
increased circulating choleste... 1 | 66
long tibia 1 | 25

Disease

Carcinoma 5 | 11,493
ovarian cancer 5 | 8,520
Kidney cancer 3 | 2,613
Multiple myeloma 3 | 1,332
atypical teratoid / rhabdoid tumor 3 | 5,112
psoriasis 3 | 6,694
Abnormality of the metaphyses 2 | 48
Acquired scoliosis 2 | 281
Acute Promyelocytic Leukemia 2 | 40
Autosomal recessive predisposition 2 | 1,442
Biliary tract cancer 2 | 19
Bone cancer 2 | 16
Bone pain 2 | 42
Breast cancer 2 | 3,578
Cancer 2 | 2,499
Carcinoma, Hepatocellular 2 | 228
Cholangiocarcinoma 2 | 35
Chondroma 2 | 15
Chondrosarcoma 2 | 21
Curvature of spine 2 | 282
D-2-hydroxyglutaric aciduria 2 | 9
DOID:2627 2 | 94
Enchondromatosis 2 | 5
Epilepsy 2 | 792
Exostoses 2 | 11
Glioma Susceptibility 1 2 | 5
Hemangioma 2 | 69
Hemangiomatosis 2 | 2
Immune system cancer 2 | 140
Interval angle-closure glaucoma 2 | 2
Joint stiffness 2 | 84
Leukemia, Myelocytic, Acute 2 | 120
Leukemia, Myeloid, Acute 2 | 105
Leukemia, Promyelocytic, Acute 2 | 36
Liver carcinoma 2 | 240
Low Vision 2 | 174
Lymphoid leukemia 2 | 160
Lytic lesion 2 | 32
Maffucci syndrome 2 | 6
Micromelia 2 | 58
Multiple, subcutaneous nodules 2 | 53
Muscle hypotonia 2 | 571
Myelofibrosis 2 | 14
Neoplasm Recurrence, Local 2 | 37
Nystagmus 2 | 317
Ollier disease 2 | 18
Optic Atrophy 2 | 242
Papilloma 2 | 44
Polycythemia vera 2 | 27
Seizures 2 | 596
Short stature 2 | 531
Subcutaneous nodule 2 | 53
Tropical spastic paraparesis 2 | 15
Venous Thrombosis 2 | 47
Visceral angiomatosis 2 | 13
Visual Impairment 2 | 174
Waldenstrons macroglobulinemia 2 | 765
glioblastoma 2 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung adenocarcinoma 2 | 2,716
non primary Sjogren syndrome sicca 2 | 891
oligodendroglioma 2 | 2,850
osteosarcoma 2 | 7,950
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
tuberculosis 2 | 2,010
Abnormality of retinal pigmentation 1 | 111
Abnormality of the retinal vasculature 1 | 59
Athetosis 1 | 16
Atypical scarring of skin 1 | 62
Cardiomegaly 1 | 116
Cardiomyopathies 1 | 110
Color Blindness, Red-Green 1 | 4
Conductive hearing loss 1 | 123
Congenital anomaly of testis 1 | 52
Craniofacial Abnormalities 1 | 151
Degenerative polyarthritis 1 | 115
Disease Models, Animal 1 | 155
ENSP00000256078 1 | 30
Glioma 1 | 74
Global developmental delay, severe 1 | 47
Growth Disorders 1 | 35
Hydronephrosis 1 | 89
Hyperinsulinism 1 | 133
Keratoconus 1 | 113
Night blindness, progressive 1 | 51
Ophthalmoplegia 1 | 106
Osteoarthritis 1 | 184
Osteoporosis 1 | 363
Pallor of optic disc 1 | 39
Photodysphoria 1 | 121
Photophobia 1 | 121
Red/green color vision defect 1 | 3
Respiratory Failure 1 | 104
Retinal pigment epithelial abnormality 1 | 111
Sensorineural Hearing Loss (disorder) 1 | 284
Severe psychomotor retardation 1 | 47
Thalassemia 1 | 53
Visual field constriction 1 | 36
Zellweger syndrome 1 | 37

Tissue

Blood and immune system 5 | 16,909
Cardiovascular System 5 | 15,192
Digestive Tract 5 | 17,369
Endocrine System 5 | 18,159
Female tissues 5 | 17,400
Liver and Pancreas 5 | 16,750
Male tissues 5 | 17,142
Nervous System 5 | 16,725
Respiratory system 5 | 16,393
Skin and soft tissues 5 | 17,230
Urinary Tract 5 | 16,678

Target Family

Enzyme 5 | 4,145

GO Process

isocitrate metabolic process 5 | 5
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B Tbio Enzyme -1.11334 11.9 177
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G Tbio Enzyme -0.19406 0.67 196
Isocitrate dehydrogenase [NADP], mitochondrial IDH2 Tclin Enzyme -2.94039 813.3 296
Aconitate hydratase, mitochondrial ACO2 Tbio Enzyme -2.21106 157.2 307
Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 Tchem Enzyme -3.19944 1567.0 498