Development Level

Tbio 93 | 10,625
Tclin 36 | 602
Tchem 27 | 1,890
Tdark 18 | 7,003

Collection

Eligible Ion Channel Proteins 26 | 117

IMPC Term

preweaning lethality, complete... 11 | 633
embryonic lethality prior to t... 7 | 187
embryonic lethality prior to o... 5 | 148
abnormal behavior 4 | 226
decreased prepulse inhibition 4 | 52
abnormal retina morphology 3 | 100
hypoactivity 3 | 89
increased blood urea nitrogen ... 3 | 44
preweaning lethality, incomple... 3 | 260
abnormal seminal vesicle morph... 2 | 47
abnormal vibrissa morphology 2 | 17
absent vibrissae 2 | 14
cardiovascular system phenotyp... 2 | 35
decreased bone mineral density 2 | 126
decreased eosinophil cell numb... 2 | 41
decreased erythrocyte cell num... 2 | 43
decreased hemoglobin content 2 | 53
decreased lean body mass 2 | 195
decreased mean corpuscular vol... 2 | 50
decreased rib number 2 | 59
decreased total body fat amoun... 2 | 186
increased circulating alkaline... 2 | 119
increased circulating creatini... 2 | 29
increased circulating sodium l... 2 | 71
increased circulating total pr... 2 | 20
short tibia 2 | 82
abnormal clavicle morphology 1 | 5
abnormal coat/hair pigmentatio... 1 | 54
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal eye size 1 | 11
abnormal heart morphology 1 | 51
abnormal iris transilluminatio... 1 | 1
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal pelvic girdle bone mo... 1 | 11
abnormal retinal pigmentation 1 | 61
abnormal sensory capabilities/... 1 | 3
abnormal testis morphology 1 | 30
abnormal vocalization 1 | 21
absent startle reflex 1 | 15
cataract 1 | 26
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating amylase ... 1 | 24
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart rate variabili... 1 | 11
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased mean platelet volume 1 | 12
decreased memory-marker CD4-po... 1 | 4
decreased startle reflex 1 | 48
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
hydrops fetalis 1 | 22
hyperactivity 1 | 108
impaired glucose tolerance 1 | 52
increased body length 1 | 20
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased caudal vertebrae num... 1 | 8
increased circulating amylase ... 1 | 13
increased circulating aspartat... 1 | 17
increased circulating calcium ... 1 | 32
increased circulating creatine... 1 | 2
increased circulating serum al... 1 | 25
increased erythrocyte cell num... 1 | 26
increased grip strength 1 | 83
increased hemoglobin content 1 | 45
increased mature B cell number 1 | 12
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased or absent threshold ... 1 | 128
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
male infertility 1 | 62
small adrenal glands 1 | 15
small lymph nodes 1 | 1
small testis 1 | 37
thrombocytosis 1 | 23
trunk curl 1 | 15

Disease

medulloblastoma, large-cell 75 | 6,234
psoriasis 72 | 6,685
ovarian cancer 67 | 8,484
glioblastoma 64 | 5,572
osteosarcoma 58 | 7,933
atypical teratoid / rhabdoid tumor 50 | 4,369
primitive neuroectodermal tumor 47 | 3,031
oligodendroglioma 43 | 2,849
Carcinoma 40 | 2,147
lung carcinoma 37 | 2,844
ependymoma 36 | 2,514
Pick disease 35 | 1,893
lung cancer 34 | 4,466
pilocytic astrocytoma 33 | 3,086
subependymal giant cell astrocytoma 32 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 31 | 3,289
pituitary cancer 30 | 1,972
Breast cancer 29 | 3,094
astrocytic glioma 29 | 2,241
pediatric high grade glioma 29 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,956
adult high grade glioma 26 | 2,148
intraductal papillary-mucinous carcinoma (IPMC) 26 | 2,988
astrocytoma 25 | 1,493
lung adenocarcinoma 23 | 2,713
medulloblastoma 23 | 1,524
invasive ductal carcinoma 22 | 2,950
Epilepsy 21 | 346
cystic fibrosis 20 | 1,665
malignant mesothelioma 20 | 3,162
interstitial cystitis 19 | 2,299
pancreatic cancer 19 | 2,300
ulcerative colitis 19 | 2,087
non-small cell lung cancer 18 | 2,798
sonic hedgehog group medulloblastoma 18 | 1,482
ductal carcinoma in situ 17 | 1,745
group 3 medulloblastoma 16 | 2,254
Autistic Disorder 15 | 320
General anesthesia 15 | 53
atypical teratoid/rhabdoid tumor 15 | 1,095
group 4 medulloblastoma 15 | 1,875
colon cancer 14 | 1,475
Irritable bowel syndrome 13 | 59
adrenocortical carcinoma 13 | 1,427
posterior fossa group A ependymoma 13 | 1,511
Anxiety 12 | 24
Hypertension 12 | 287
Insomnia 12 | 20
Tonic-clonic epilepsy 12 | 47
active Crohn's disease 12 | 918
primary pancreatic ductal adenocarcinoma 12 | 1,271
Cancer 11 | 2,346
Hypertensive disease 11 | 193
Kidney disease 11 | 396
Multiple myeloma 11 | 1,327
Osteopetrosis 11 | 40
Panic disorder 11 | 55
Sedation as Adjunct to Anesthesia 11 | 15
progressive supranuclear palsy 11 | 674
tuberculosis 11 | 1,557
Alcohol dependence 10 | 107
Congestive heart failure 10 | 30
Spasticity 10 | 26
Status Epilepticus 10 | 85
acute quadriplegic myopathy 10 | 1,157
dermatomyositis 10 | 933
diabetes mellitus 10 | 1,663
nasopharyngeal carcinoma 10 | 1,056
non primary Sjogren syndrome sicca 10 | 840
Atrial Fibrillation 9 | 110
Chronic heart failure 9 | 46
Generalized anxiety disorder 9 | 29
Parkinson's disease 9 | 364
Peptic ulcer 9 | 22
breast carcinoma 9 | 1,614
chronic rhinosinusitis 9 | 512
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
posterior fossa group B ependymoma 9 | 1,530
Alcohol withdrawal delirium 8 | 9
Alcohol withdrawal syndrome 8 | 9
Benzodiazepine Induced Sedation 8 | 8
Benzodiazepine Maintained Anesthesia 8 | 8
Benzodiazepine Toxicity 8 | 8
Chemotherapy-induced nausea and vomiting 8 | 18
Gastroesophageal reflux disease 8 | 37
Induce Anterograde Amnesia 8 | 9
Local anesthesia 8 | 40
Poisoning by digitalis glycoside 8 | 8
Preoperative Anxiety 8 | 9
Rheumatoid Arthritis 8 | 1,160
Sedation 8 | 11
Sedation in Intubated Patients 8 | 8
Tetanus 8 | 66
aldosterone-producing adenoma 8 | 664
Heart disease 7 | 279
Schizophrenia 7 | 501
acute myeloid leukemia 7 | 780
esophageal adenocarcinoma 7 | 737
juvenile dermatomyositis 7 | 1,189
spina bifida 7 | 1,064

Tissue

Digestive Tract 171 | 18,473
Female tissues 171 | 18,647
Nervous System 171 | 18,561
Urinary Tract 171 | 18,444
Endocrine System 170 | 18,512
Skin and soft tissues 170 | 18,115
Liver and Pancreas 169 | 18,136
Cardiovascular System 167 | 17,958
Blood and immune system 166 | 17,995
Male tissues 166 | 17,969
Respiratory system 166 | 17,484

Target Family

Ion Channel 71 | 341
Transporter 36 | 473
Enzyme 31 | 4,146
Non-IDG 31 | 11,971
Kinase 4 | 634
Transcription Factor 1 | 1,400

GO Process

ion transmembrane transport 174 | 174
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 Tchem Ion Channel -1.68717 47.7 33
V-type proton ATPase catalytic subunit A ATP6V1A Tbio Enzyme -1.80191 64.7 120
Gamma-aminobutyric acid receptor subunit rho-1 GABRR1 Tchem Ion Channel -1.70715 50.4 134
H(+)/Cl(-) exchange transporter 7 CLCN7 Tbio Ion Channel -1.91579 94.4 137
H(+)/Cl(-) exchange transporter 4 CLCN4 Tbio Ion Channel -1.48227 31.6 116
H(+)/Cl(-) exchange transporter 5 CLCN5 Tbio Ion Channel -2.29453 217.9 141
Amiloride-sensitive sodium channel subunit beta SCNN1B Tclin Ion Channel -1.69464 46.7 245
Potassium-transporting ATPase subunit beta ATP4B Tclin Transporter -0.76953 6.01 159
Amiloride-sensitive sodium channel subunit delta SCNN1D Tbio Ion Channel -0.97159 8.72 179
Glycine receptor subunit beta GLRB Tclin Ion Channel -1.15613 15.9 85