Development Level

Tbio 86 | 11,445
Tchem 25 | 1,598
Tclin 21 | 613
Tdark 16 | 6,588

Collection

Ion Channel: IDG Consortium (T... 9 | 99

IMPC Phenotype

preweaning lethality, complete... 15 | 979
embryonic lethality prior to t... 8 | 278
abnormal behavior 6 | 298
embryonic lethality prior to o... 6 | 239
decreased prepulse inhibition 4 | 82
preweaning lethality, incomple... 4 | 499
abnormal seminal vesicle morph... 3 | 114
decreased hemoglobin content 3 | 68
decreased lymphocyte cell numb... 3 | 83
hypoactivity 3 | 132
increased monocyte cell number 3 | 63
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
abnormal kidney morphology 2 | 65
abnormal retina morphology 2 | 71
abnormal vibrissa morphology 2 | 25
cardiovascular system phenotyp... 2 | 36
decreased body weight 2 | 161
decreased circulating alkaline... 2 | 46
decreased erythrocyte cell num... 2 | 62
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
decreased mean platelet volume 2 | 25
decreased red blood cell distr... 2 | 41
decreased vertical activity 2 | 208
edema 2 | 59
enlarged heart 2 | 210
hyperactivity 2 | 148
impaired glucose tolerance 2 | 75
increased blood urea nitrogen ... 2 | 48
increased circulating alkaline... 2 | 122
increased mean platelet volume 2 | 45
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
abnormal clavicle morphology 1 | 6
abnormal coat-hair pigmentatio... 1 | 64
abnormal epididymis morphology 1 | 42
abnormal eye size 1 | 7
abnormal iris transilluminatio... 1 | 2
abnormal lens morphology 1 | 81
abnormal pancreas morphology 1 | 13
abnormal pelvic girdle bone mo... 1 | 12
abnormal sensory capabilities-... 1 | 8
abnormal vocalization 1 | 21
absent startle reflex 1 | 24
absent vibrissae 1 | 12
brachydactyly 1 | 19
cataract 1 | 92
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating chloride... 1 | 30
decreased circulating creatini... 1 | 39
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
decreased heart weight 1 | 27
decreased neutrophil cell numb... 1 | 42
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged lymph nodes 1 | 37
enlarged pancreas 1 | 2
hydrometra 1 | 53
increased basophil cell number 1 | 7
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating creatine... 1 | 5
increased circulating creatini... 1 | 38
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased heart rate variabili... 1 | 7
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 36
increased neutrophil cell numb... 1 | 46
increased respiratory quotient 1 | 2
increased spleen weight 1 | 10
increased total retina thickne... 1 | 4
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
small adrenal glands 1 | 16
small lymph nodes 1 | 1
small superior vagus ganglion 1 | 74
syndactyly 1 | 23
thrombocytosis 1 | 27

Disease

Carcinoma 102 | 11,493
ovarian cancer 63 | 8,520
psoriasis 63 | 6,694
medulloblastoma, large-cell 62 | 6,241
glioblastoma 56 | 5,792
osteosarcoma 55 | 7,950
atypical teratoid / rhabdoid tumor 52 | 5,112
ependymoma 42 | 4,679
adult high grade glioma 37 | 3,801
group 3 medulloblastoma 37 | 4,104
primitive neuroectodermal tumor 37 | 3,035
Kidney cancer 34 | 2,613
oligodendroglioma 34 | 2,850
Breast cancer 33 | 3,578
astrocytic glioma 33 | 2,597
lung cancer 32 | 4,740
lung carcinoma 30 | 2,843
Pick disease 29 | 1,894
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,291
Autosomal recessive predisposition 26 | 1,442
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,955
subependymal giant cell astrocytoma 26 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,989
pituitary cancer 25 | 1,972
Astrocytoma, Pilocytic 23 | 3,081
lung adenocarcinoma 23 | 2,716
invasive ductal carcinoma 22 | 2,951
pancreatic cancer 22 | 2,398
cystic fibrosis 21 | 1,696
malignant mesothelioma 21 | 3,232
Epilepsy 18 | 792
interstitial cystitis 18 | 2,312
non-small cell lung cancer 18 | 2,890
Hypertension 16 | 396
ductal carcinoma in situ 16 | 1,745
group 4 medulloblastoma 16 | 1,855
Failure to gain weight 15 | 365
Pediatric failure to thrive 15 | 365
Intellectual disability 14 | 1,016
colon cancer 14 | 1,478
ulcerative colitis 14 | 1,819
Seizures 13 | 596
tuberculosis 13 | 2,010
Dull intelligence 12 | 645
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Osteopetrosis 12 | 43
Poor school performance 12 | 645
adrenocortical carcinoma 12 | 1,428
Atrial Fibrillation 11 | 124
Congestive heart failure 11 | 113
Hyperaldosteronism 11 | 35
Hypertensive disease 11 | 292
Multiple myeloma 11 | 1,332
active Crohn's disease 11 | 922
astrocytoma 11 | 1,146
nasopharyngeal carcinoma 11 | 1,058
primary pancreatic ductal adenocarcinoma 11 | 1,109
Cancer 10 | 2,499
Kidney disease 10 | 430
Liver cancer 10 | 604
acute quadriplegic myopathy 10 | 1,158
chronic rhinosinusitis 10 | 512
dermatomyositis 10 | 966
diabetes mellitus 10 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
progressive supranuclear palsy 10 | 676
Anemia 9 | 365
Chronic heart failure 9 | 46
Edema 9 | 81
Short stature 9 | 531
active ulcerative colitis 9 | 764
breast carcinoma 9 | 1,638
Diarrhea 8 | 253
Feeding difficulties in infancy 8 | 175
Hypokalemia 8 | 52
Melanoma 8 | 711
Poisoning by digitalis glycoside 8 | 8
Skin cancer 8 | 469
non primary Sjogren syndrome sicca 8 | 891
pediatric high grade glioma 8 | 1,064
Constipation 7 | 181
Endometrial cancer 7 | 311
Heart disease 7 | 306
Liver Cirrhosis, Experimental 7 | 769
Muscle Weakness 7 | 170
Muscle hypotonia 7 | 571
Neurodegenerative disease 7 | 414
Parkinson's disease 7 | 392
Polyhydramnios 7 | 108
Recurrent respiratory infections 7 | 141
Rheumatoid arthritis 7 | 1,191
Schizophrenia 7 | 1,160
Sensorineural hearing loss 7 | 106
acute myeloid leukemia 7 | 783
aldosterone-producing adenoma 7 | 665
esophageal adenocarcinoma 7 | 737
juvenile dermatomyositis 7 | 1,187
spina bifida 7 | 1,074

Tissue

Endocrine System 144 | 18,159
Digestive Tract 141 | 17,369
Male tissues 141 | 17,142
Female tissues 140 | 17,400
Urinary Tract 140 | 16,678
Nervous System 139 | 16,725
Skin and soft tissues 139 | 17,230
Liver and Pancreas 136 | 16,750
Blood and immune system 135 | 16,909
Respiratory system 127 | 16,393
Cardiovascular System 116 | 15,192

Target Family

Ion Channel 48 | 344
Transporter 36 | 473
Enzyme 31 | 4,145
Non-IDG 28 | 12,091
Kinase 4 | 634
Transcription Factor 1 | 1,400

GO Process

ion transmembrane transport 148 | 148
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Calcium homeostasis modulator protein 3 CALHM3 Tdark Ion Channel -0.10646 0.35 86
Sodium/potassium-transporting ATPase subunit alpha-4 ATP1A4 Tclin Transporter -1.73566 51.3 5
Acid-sensing ion channel 5 ASIC5 Tbio Ion Channel -0.41218 3.22 86
Calcium-activated chloride channel regulator family member 3 CLCA3P Tdark Ion Channel 0.00000 0
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 ATP2A2 Tbio Transporter -2.87498 737.3 295
Solute carrier family 12 member 1 SLC12A1 Tclin Transporter -2.37125 226.3 178
Anoctamin-8 ANO8 Tbio Non-IDG -0.24444 1.60 13
Aquaporin-6 AQP6 Tbio Non-IDG -1.52088 32.7 57
Anoctamin-10 ANO10 Tbio Non-IDG -1.22069 14.6 54
FXYD domain-containing ion transport regulator 3 FXYD3 Tbio Ion Channel -1.78093 58.4 76