Development Level

Tbio 185 | 10,625
Tchem 110 | 1,890
Tdark 40 | 7,003
Tclin 20 | 602

Collection

Eligible Kinase Proteins 25 | 134

IMPC Term

decreased total body fat amoun... 8 | 186
preweaning lethality, complete... 8 | 633
abnormal behavior 7 | 226
decreased body weight 6 | 174
increased lean body mass 5 | 107
decreased bone mineral density 4 | 126
decreased circulating HDL chol... 4 | 77
decreased circulating glucose ... 4 | 121
decreased circulating triglyce... 4 | 83
improved glucose tolerance 4 | 56
increased circulating alkaline... 4 | 119
preweaning lethality, incomple... 4 | 260
decreased body length 3 | 108
decreased circulating LDL chol... 3 | 37
decreased circulating alanine ... 3 | 53
decreased circulating choleste... 3 | 85
decreased circulating insulin ... 3 | 75
decreased grip strength 3 | 123
decreased lean body mass 3 | 195
increased body length 3 | 20
increased bone mineral content 3 | 92
increased mean corpuscular hem... 3 | 93
increased mean corpuscular vol... 3 | 91
male infertility 3 | 62
abnormal QRS complex 2 | 25
abnormal bone structure 2 | 131
abnormal coat appearance 2 | 25
abnormal testis morphology 2 | 30
abnormal vertebrae morphology 2 | 14
abnormal vibrissa morphology 2 | 17
decreased T cell number 2 | 31
decreased bone mineral content 2 | 157
decreased circulating free fat... 2 | 39
decreased circulating magnesiu... 2 | 11
decreased circulating serum al... 2 | 79
decreased leukocyte cell numbe... 2 | 54
embryonic lethality prior to t... 2 | 187
enlarged spleen 2 | 26
hyperactivity 2 | 108
hypoactivity 2 | 89
impaired glucose tolerance 2 | 52
increased circulating LDL chol... 2 | 15
increased grip strength 2 | 83
increased heart weight 2 | 37
increased hematocrit 2 | 36
increased mature B cell number 2 | 12
increased or absent threshold ... 2 | 128
prenatal lethality prior to he... 2 | 64
small testis 2 | 37
abnormal behavioral response t... 1 | 52
abnormal eye size 1 | 11
abnormal eyelid morphology 1 | 6
abnormal gait 1 | 51
abnormal limb bud morphology 1 | 15
abnormal respiratory quotient 1 | 9
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal spleen morphology 1 | 36
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
decreased CD8-positive, alpha-... 1 | 26
decreased IgE level 1 | 3
decreased IgG1 level 1 | 4
decreased basophil cell number 1 | 11
decreased caudal vertebrae num... 1 | 49
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating iron lev... 1 | 25
decreased fasted circulating g... 1 | 49
decreased gamma-delta T cell n... 1 | 18
decreased heart rate 1 | 10
decreased heart weight 1 | 44
decreased hemoglobin content 1 | 53
decreased mean corpuscular hem... 1 | 34
decreased neutrophil cell numb... 1 | 37
decreased red blood cell distr... 1 | 11
decreased rib number 1 | 59
decreased total retina thickne... 1 | 20
decreased vertical activity 1 | 22
female infertility 1 | 34
hemorrhage 1 | 12
hydrops fetalis 1 | 22
impaired righting response 1 | 19
increased bone mineral density 1 | 52
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 20
increased eosinophil cell numb... 1 | 9
increased gamma-delta T cell n... 1 | 16
increased hemoglobin content 1 | 45
increased respiratory quotient 1 | 12
increased rib number 1 | 41
oligodactyly 1 | 14
polycystic kidney 1 | 9
short tibia 1 | 82
straub tail 1 | 26
thrombocytosis 1 | 23
tremors 1 | 34

Disease

osteosarcoma 186 | 7,933
ovarian cancer 182 | 8,484
medulloblastoma, large-cell 160 | 6,234
psoriasis 143 | 6,685
glioblastoma 136 | 5,572
atypical teratoid / rhabdoid tumor 107 | 4,369
lung cancer 105 | 4,466
lung carcinoma 90 | 2,844
pilocytic astrocytoma 86 | 3,086
malignant mesothelioma 82 | 3,162
primitive neuroectodermal tumor 78 | 3,031
Carcinoma 77 | 2,147
interstitial cystitis 76 | 2,299
oligodendroglioma 75 | 2,849
Cancer 73 | 2,346
ependymoma 73 | 2,514
subependymal giant cell astrocytoma 73 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 72 | 2,988
pediatric high grade glioma 72 | 2,712
intraductal papillary-mucinous adenoma (IPMA) 70 | 2,956
non-small cell lung cancer 69 | 2,798
lung adenocarcinoma 68 | 2,713
Breast cancer 67 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 67 | 3,289
invasive ductal carcinoma 67 | 2,950
adult high grade glioma 64 | 2,148
ulcerative colitis 59 | 2,087
astrocytic glioma 56 | 2,241
group 4 medulloblastoma 55 | 1,875
pancreatic cancer 52 | 2,300
pituitary cancer 51 | 1,972
Pick disease 50 | 1,893
astrocytoma 46 | 1,493
group 3 medulloblastoma 43 | 2,254
cystic fibrosis 41 | 1,665
tuberculosis 39 | 1,557
medulloblastoma 38 | 1,524
Rheumatoid Arthritis 37 | 1,160
pancreatic ductal adenocarcinoma liver metastasis 37 | 1,795
posterior fossa group A ependymoma 37 | 1,511
spina bifida 37 | 1,064
ductal carcinoma in situ 36 | 1,745
sonic hedgehog group medulloblastoma 36 | 1,482
breast carcinoma 32 | 1,614
cutaneous lupus erythematosus 32 | 1,056
diabetes mellitus 32 | 1,663
adrenocortical carcinoma 31 | 1,427
colon cancer 31 | 1,475
posterior fossa group B ependymoma 26 | 1,530
primary pancreatic ductal adenocarcinoma 26 | 1,271
primary Sjogren syndrome 25 | 789
acute quadriplegic myopathy 24 | 1,157
juvenile dermatomyositis 24 | 1,189
nasopharyngeal carcinoma 24 | 1,056
Parkinson's disease 23 | 364
atypical teratoid/rhabdoid tumor 23 | 1,095
Schizophrenia 22 | 501
Alzheimer's disease 21 | 644
gastric carcinoma 21 | 832
Atopic dermatitis 20 | 944
aldosterone-producing adenoma 20 | 664
IGA Glomerulonephritis 19 | 454
active Crohn's disease 19 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 18 | 499
dermatomyositis 18 | 933
progressive supranuclear palsy 18 | 674
Renal Cell Carcinoma 17 | 199
esophageal adenocarcinoma 17 | 737
Chronic Myelocytic Leukemia Accelerated Phase 16 | 59
Down syndrome 16 | 548
Kidney disease 16 | 396
Multiple myeloma 16 | 1,327
Asthma 15 | 349
Blastic phase chronic myeloid leukemia 15 | 58
Waldenstrons macroglobulinemia 15 | 765
non primary Sjogren syndrome sicca 15 | 840
Hypertension 14 | 287
Osteoporosis 14 | 257
acute myeloid leukemia 14 | 780
Amyotrophic Lateral Sclerosis 13 | 431
Arthritis 13 | 248
Crohn's disease 13 | 304
Duchenne muscular dystrophy 13 | 602
mucosa-associated lymphoid tissue lymphoma 13 | 480
sarcoidosis 13 | 358
Obesity 12 | 616
Vascular disease 12 | 281
chronic lymphosyte leukemia 12 | 232
tuberculosis and treatment for 6 months 12 | 686
Chronic Lymphocytic Leukemia 11 | 242
Endometriosis 11 | 535
Mammary Neoplasms 11 | 410
fibroadenoma 11 | 557
Bipolar Disorder 10 | 266
Colorectal Neoplasms 10 | 217
Heart disease 10 | 279
chronic rhinosinusitis 10 | 512
hepatocellular carcinoma 10 | 532
non-small cell lung carcinoma 10 | 413
tuberculosis and treatment for 3 months 10 | 327

Tissue

Nervous System 348 | 18,561
Digestive Tract 347 | 18,473
Female tissues 347 | 18,647
Liver and Pancreas 346 | 18,136
Urinary Tract 346 | 18,444
Blood and immune system 345 | 17,995
Cardiovascular System 345 | 17,958
Endocrine System 345 | 18,512
Male tissues 345 | 17,969
Skin and soft tissues 340 | 18,115
Respiratory system 333 | 17,484

Target Family

Non-IDG 154 | 11,971
Kinase 128 | 634
Enzyme 59 | 4,146
Transcription Factor 8 | 1,400
GPCR 6 | 406

GO Process

intracellular signal transduct... 355 | 355
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Transmembrane protease serine 6 TMPRSS6 Tchem Enzyme -1.99222 118.1 102
SH2B adapter protein 3 SH2B3 Tbio Non-IDG -2.46631 317.6 137
Putative GRINL1B complex locus protein 2 GCOM2 Tdark Non-IDG -1.14190 15.0 0
Inactive phospholipase C-like protein 2 PLCL2 Tbio Enzyme -0.27372 2.11 81
Serine/threonine-protein kinase N3 PKN3 Tchem Kinase -1.11681 14.4 104
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 PLCD1 Tchem Enzyme -2.16125 137.5 96
Serine/threonine-protein kinase DCLK1 DCLK1 Tchem Kinase -1.97724 113.9 288
Mitogen-activated protein kinase kinase kinase MLT MAP3K20 Tchem Kinase -1.14470 13.6 205
Retinitis pigmentosa 1-like 1 protein RP1L1 Tbio Non-IDG -1.19453 19.3 0