Development Level
Tbio | 185 | 10,625 | |
Tchem | 110 | 1,890 | |
Tdark | 40 | 7,003 | |
Tclin | 20 | 602 |
Collection
Eligible Kinase Proteins | 25 | 134 |
IMPC Term
decreased total body fat amoun... | 8 | 186 | |
preweaning lethality, complete... | 8 | 633 | |
abnormal behavior | 7 | 226 | |
decreased body weight | 6 | 174 | |
increased lean body mass | 5 | 107 | |
decreased bone mineral density | 4 | 126 | |
decreased circulating HDL chol... | 4 | 77 | |
decreased circulating glucose ... | 4 | 121 | |
decreased circulating triglyce... | 4 | 83 | |
improved glucose tolerance | 4 | 56 | |
increased circulating alkaline... | 4 | 119 | |
preweaning lethality, incomple... | 4 | 260 | |
decreased body length | 3 | 108 | |
decreased circulating LDL chol... | 3 | 37 | |
decreased circulating alanine ... | 3 | 53 | |
decreased circulating choleste... | 3 | 85 | |
decreased circulating insulin ... | 3 | 75 | |
decreased grip strength | 3 | 123 | |
decreased lean body mass | 3 | 195 | |
increased body length | 3 | 20 | |
increased bone mineral content | 3 | 92 | |
increased mean corpuscular hem... | 3 | 93 | |
increased mean corpuscular vol... | 3 | 91 | |
male infertility | 3 | 62 | |
abnormal QRS complex | 2 | 25 | |
abnormal bone structure | 2 | 131 | |
abnormal coat appearance | 2 | 25 | |
abnormal testis morphology | 2 | 30 | |
abnormal vertebrae morphology | 2 | 14 | |
abnormal vibrissa morphology | 2 | 17 | |
decreased T cell number | 2 | 31 | |
decreased bone mineral content | 2 | 157 | |
decreased circulating free fat... | 2 | 39 | |
decreased circulating magnesiu... | 2 | 11 | |
decreased circulating serum al... | 2 | 79 | |
decreased leukocyte cell numbe... | 2 | 54 | |
embryonic lethality prior to t... | 2 | 187 | |
enlarged spleen | 2 | 26 | |
hyperactivity | 2 | 108 | |
hypoactivity | 2 | 89 | |
impaired glucose tolerance | 2 | 52 | |
increased circulating LDL chol... | 2 | 15 | |
increased grip strength | 2 | 83 | |
increased heart weight | 2 | 37 | |
increased hematocrit | 2 | 36 | |
increased mature B cell number | 2 | 12 | |
increased or absent threshold ... | 2 | 128 | |
prenatal lethality prior to he... | 2 | 64 | |
small testis | 2 | 37 | |
abnormal behavioral response t... | 1 | 52 | |
abnormal eye size | 1 | 11 | |
abnormal eyelid morphology | 1 | 6 | |
abnormal gait | 1 | 51 | |
abnormal limb bud morphology | 1 | 15 | |
abnormal respiratory quotient | 1 | 9 | |
abnormal retina morphology | 1 | 100 | |
abnormal retinal blood vessel ... | 1 | 18 | |
abnormal spleen morphology | 1 | 36 | |
abnormal tooth morphology | 1 | 24 | |
abnormal vocalization | 1 | 21 | |
decreased CD8-positive, alpha-... | 1 | 26 | |
decreased IgE level | 1 | 3 | |
decreased IgG1 level | 1 | 4 | |
decreased basophil cell number | 1 | 11 | |
decreased caudal vertebrae num... | 1 | 49 | |
decreased circulating chloride... | 1 | 32 | |
decreased circulating creatini... | 1 | 31 | |
decreased circulating iron lev... | 1 | 25 | |
decreased fasted circulating g... | 1 | 49 | |
decreased gamma-delta T cell n... | 1 | 18 | |
decreased heart rate | 1 | 10 | |
decreased heart weight | 1 | 44 | |
decreased hemoglobin content | 1 | 53 | |
decreased mean corpuscular hem... | 1 | 34 | |
decreased neutrophil cell numb... | 1 | 37 | |
decreased red blood cell distr... | 1 | 11 | |
decreased rib number | 1 | 59 | |
decreased total retina thickne... | 1 | 20 | |
decreased vertical activity | 1 | 22 | |
female infertility | 1 | 34 | |
hemorrhage | 1 | 12 | |
hydrops fetalis | 1 | 22 | |
impaired righting response | 1 | 19 | |
increased bone mineral density | 1 | 52 | |
increased circulating bilirubi... | 1 | 16 | |
increased circulating calcium ... | 1 | 32 | |
increased circulating choleste... | 1 | 53 | |
increased circulating sodium l... | 1 | 71 | |
increased circulating total pr... | 1 | 20 | |
increased eosinophil cell numb... | 1 | 9 | |
increased gamma-delta T cell n... | 1 | 16 | |
increased hemoglobin content | 1 | 45 | |
increased respiratory quotient | 1 | 12 | |
increased rib number | 1 | 41 | |
oligodactyly | 1 | 14 | |
polycystic kidney | 1 | 9 | |
short tibia | 1 | 82 | |
straub tail | 1 | 26 | |
thrombocytosis | 1 | 23 | |
tremors | 1 | 34 |
Disease
Tissue
Nervous System | 348 | 18,561 | |
Digestive Tract | 347 | 18,473 | |
Female tissues | 347 | 18,647 | |
Liver and Pancreas | 346 | 18,136 | |
Urinary Tract | 346 | 18,444 | |
Blood and immune system | 345 | 17,995 | |
Cardiovascular System | 345 | 17,958 | |
Endocrine System | 345 | 18,512 | |
Male tissues | 345 | 17,969 | |
Skin and soft tissues | 340 | 18,115 | |
Respiratory system | 333 | 17,484 |
Target Family
Non-IDG | 154 | 11,969 | |
Kinase | 128 | 634 | |
Enzyme | 59 | 4,146 | |
Transcription Factor | 8 | 1,400 | |
GPCR | 6 | 408 |
GO Process
intracellular signal transduct... | 355 | 355 | |
transcription, DNA-templated | 1,779 | 1,779 | |
regulation of transcription, D... | 1,170 | 1,170 | |
signal transduction | 969 | 969 | |
positive regulation of transcr... | 845 | 845 | |
G-protein coupled receptor sig... | 666 | 666 | |
negative regulation of transcr... | 620 | 620 | |
apoptotic process | 506 | 506 | |
positive regulation of transcr... | 504 | 504 | |
negative regulation of transcr... | 483 | 483 | |
multicellular organism develop... | 456 | 456 | |
positive regulation of cell pr... | 451 | 451 | |
cell differentiation | 442 | 442 | |
negative regulation of apoptot... | 440 | 440 | |
innate immune response | 410 | 410 | |
cell adhesion | 409 | 409 | |
immune response | 398 | 398 | |
negative regulation of cell pr... | 379 | 379 | |
inflammatory response | 371 | 371 | |
viral process | 368 | 368 | |
spermatogenesis | 365 | 365 | |
cell proliferation | 358 | 358 | |
protein transport | 356 | 356 | |
cell division | 330 | 330 | |
regulation of transcription fr... | 324 | 324 | |
protein phosphorylation | 320 | 320 | |
response to drug | 297 | 297 | |
positive regulation of apoptot... | 292 | 292 | |
nervous system development | 275 | 275 | |
transcription from RNA polymer... | 272 | 272 | |
cell surface receptor signalin... | 267 | 267 | |
protein ubiquitination | 260 | 260 | |
transport | 257 | 257 | |
cell-cell signaling | 249 | 249 | |
regulation of immune response | 247 | 247 | |
positive regulation of gene ex... | 242 | 242 | |
mitotic nuclear division | 241 | 241 | |
MAPK cascade | 238 | 238 | |
chemical synaptic transmission | 238 | 238 | |
mRNA splicing, via spliceosome | 219 | 219 | |
angiogenesis | 218 | 218 | |
small GTPase mediated signal t... | 215 | 215 | |
translation | 215 | 215 | |
rRNA processing | 209 | 209 | |
intracellular protein transpor... | 205 | 205 | |
cellular response to DNA damag... | 201 | 201 | |
cell cycle | 200 | 200 | |
proteasome-mediated ubiquitin-... | 200 | 200 | |
proteolysis | 199 | 199 | |
visual perception | 198 | 198 | |
DNA repair | 196 | 196 | |
extracellular matrix organizat... | 193 | 193 | |
regulation of apoptotic proces... | 190 | 190 | |
brain development | 183 | 183 | |
positive regulation of cell mi... | 181 | 181 | |
protein polyubiquitination | 181 | 181 | |
in utero embryonic development | 178 | 178 | |
Fc-epsilon receptor signaling ... | 176 | 176 | |
Wnt signaling pathway | 175 | 175 | |
ion transmembrane transport | 174 | 174 | |
protein homooligomerization | 173 | 173 | |
heart development | 170 | 170 | |
positive regulation of ERK1 an... | 170 | 170 | |
blood coagulation | 169 | 169 | |
cell migration | 168 | 168 | |
regulation of cell proliferati... | 167 | 167 | |
protein autophosphorylation | 166 | 166 | |
response to hypoxia | 164 | 164 | |
mRNA processing | 162 | 162 | |
negative regulation of canonic... | 162 | 162 | |
protein folding | 162 | 162 | |
T cell receptor signaling path... | 161 | 161 | |
response to lipopolysaccharide | 161 | 161 | |
defense response to virus | 160 | 160 | |
RNA splicing | 158 | 158 | |
aging | 158 | 158 | |
positive regulation of I-kappa... | 158 | 158 | |
axon guidance | 157 | 157 | |
homophilic cell adhesion via p... | 155 | 155 | |
sensory perception of smell | 155 | 155 | |
ER to Golgi vesicle-mediated t... | 151 | 151 | |
interferon-gamma-mediated sign... | 150 | 150 | |
protein ubiquitination involve... | 150 | 150 | |
transcription initiation from ... | 150 | 150 | |
ubiquitin-dependent protein ca... | 149 | 149 | |
DNA replication | 144 | 144 | |
adaptive immune response | 139 | 139 | |
cell cycle arrest | 139 | 139 | |
receptor-mediated endocytosis | 139 | 139 | |
skeletal system development | 136 | 136 | |
regulation of cell shape | 135 | 135 | |
regulation of small GTPase med... | 134 | 134 | |
G2/M transition of mitotic cel... | 133 | 133 | |
oxidation-reduction process | 133 | 133 | |
positive regulation of cytosol... | 133 | 133 | |
protein stabilization | 133 | 133 | |
sensory perception of sound | 132 | 132 | |
positive regulation of NF-kapp... | 131 | 131 | |
antigen processing and present... | 130 | 130 | |
type I interferon signaling pa... | 130 | 130 |
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