Targets

Target Filters...

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Name	Gene	Development Level	Target Family	Log Novelty	Pubmed Score	Antibody Count
Mitogen-activated protein kinase kinase kinase kinase 5	MAP4K5	Tchem	Kinase	-1.76072	56.9	0
Serine/threonine-protein kinase 32C	STK32C	Tbio	Kinase	-1.61718	40.1	85
Serine/threonine-protein kinase WNK2	WNK2	Tbio	Kinase	-0.93507	8.93	92
Glutamate receptor-interacting protein 1	GRIP1	Tbio	Non-IDG	-2.16287	147.6	149
Death-associated protein kinase 2	DAPK2	Tchem	Kinase	-1.35800	27.0	383
Retinal guanylyl cyclase 1	GUCY2D	Tbio	Kinase	-2.18888	178.4	196
Mitogen-activated protein kinase kinase kinase 3	MAP3K3	Tchem	Kinase	-1.70303	53.0	162
Sequestosome-1	SQSTM1	Tbio	Non-IDG	-2.71345	536.6	655
Testis-specific serine/threonine-protein kinase 2	TSSK2	Tbio	Kinase	-1.03021	11.5	47
Rap guanine nucleotide exchange factor 2	RAPGEF2	Tbio	Non-IDG	-1.34433	25.0	58

	Tbio	185 \| 10,625
	Tchem	110 \| 1,890
	Tdark	40 \| 7,003
	Tclin	20 \| 602

	decreased total body fat amoun...	8 \| 186
	preweaning lethality, complete...	8 \| 633
	abnormal behavior	7 \| 226
	decreased body weight	6 \| 174
	increased lean body mass	5 \| 107
	decreased bone mineral density	4 \| 126
	decreased circulating HDL chol...	4 \| 77
	decreased circulating glucose ...	4 \| 121
	decreased circulating triglyce...	4 \| 83
	improved glucose tolerance	4 \| 56
	increased circulating alkaline...	4 \| 119
	preweaning lethality, incomple...	4 \| 260
	decreased body length	3 \| 108
	decreased circulating LDL chol...	3 \| 37
	decreased circulating alanine ...	3 \| 53
	decreased circulating choleste...	3 \| 85
	decreased circulating insulin ...	3 \| 75
	decreased grip strength	3 \| 123
	decreased lean body mass	3 \| 195
	increased body length	3 \| 20
	increased bone mineral content	3 \| 92
	increased mean corpuscular hem...	3 \| 93
	increased mean corpuscular vol...	3 \| 91
	male infertility	3 \| 62
	abnormal QRS complex	2 \| 25
	abnormal bone structure	2 \| 131
	abnormal coat appearance	2 \| 25
	abnormal testis morphology	2 \| 30
	abnormal vertebrae morphology	2 \| 14
	abnormal vibrissa morphology	2 \| 17
	decreased T cell number	2 \| 31
	decreased bone mineral content	2 \| 157
	decreased circulating free fat...	2 \| 39
	decreased circulating magnesiu...	2 \| 11
	decreased circulating serum al...	2 \| 79
	decreased leukocyte cell numbe...	2 \| 54
	embryonic lethality prior to t...	2 \| 187
	enlarged spleen	2 \| 26
	hyperactivity	2 \| 108
	hypoactivity	2 \| 89
	impaired glucose tolerance	2 \| 52
	increased circulating LDL chol...	2 \| 15
	increased grip strength	2 \| 83
	increased heart weight	2 \| 37
	increased hematocrit	2 \| 36
	increased mature B cell number	2 \| 12
	increased or absent threshold ...	2 \| 128
	prenatal lethality prior to he...	2 \| 64
	small testis	2 \| 37
	abnormal behavioral response t...	1 \| 52
	abnormal eye size	1 \| 11
	abnormal eyelid morphology	1 \| 6
	abnormal gait	1 \| 51
	abnormal limb bud morphology	1 \| 15
	abnormal respiratory quotient	1 \| 9
	abnormal retina morphology	1 \| 100
	abnormal retinal blood vessel ...	1 \| 18
	abnormal spleen morphology	1 \| 36
	abnormal tooth morphology	1 \| 24
	abnormal vocalization	1 \| 21
	decreased CD8-positive, alpha-...	1 \| 26
	decreased IgE level	1 \| 3
	decreased IgG1 level	1 \| 4
	decreased basophil cell number	1 \| 11
	decreased caudal vertebrae num...	1 \| 49
	decreased circulating chloride...	1 \| 32
	decreased circulating creatini...	1 \| 31
	decreased circulating iron lev...	1 \| 25
	decreased fasted circulating g...	1 \| 49
	decreased gamma-delta T cell n...	1 \| 18
	decreased heart rate	1 \| 10
	decreased heart weight	1 \| 44
	decreased hemoglobin content	1 \| 53
	decreased mean corpuscular hem...	1 \| 34
	decreased neutrophil cell numb...	1 \| 37
	decreased red blood cell distr...	1 \| 11
	decreased rib number	1 \| 59
	decreased total retina thickne...	1 \| 20
	decreased vertical activity	1 \| 22
	female infertility	1 \| 34
	hemorrhage	1 \| 12
	hydrops fetalis	1 \| 22
	impaired righting response	1 \| 19
	increased bone mineral density	1 \| 52
	increased circulating bilirubi...	1 \| 16
	increased circulating calcium ...	1 \| 32
	increased circulating choleste...	1 \| 53
	increased circulating sodium l...	1 \| 71
	increased circulating total pr...	1 \| 20
	increased eosinophil cell numb...	1 \| 9
	increased gamma-delta T cell n...	1 \| 16
	increased hemoglobin content	1 \| 45
	increased respiratory quotient	1 \| 12
	increased rib number	1 \| 41
	oligodactyly	1 \| 14
	polycystic kidney	1 \| 9
	short tibia	1 \| 82
	straub tail	1 \| 26
	thrombocytosis	1 \| 23
	tremors	1 \| 34

	osteosarcoma	186 \| 7,933
	ovarian cancer	182 \| 8,492
	medulloblastoma, large-cell	160 \| 6,234
	psoriasis	143 \| 6,685
	glioblastoma	136 \| 5,572
	atypical teratoid / rhabdoid tumor	107 \| 4,369
	lung cancer	105 \| 4,473
	lung carcinoma	90 \| 2,844
	pilocytic astrocytoma	86 \| 3,086
	malignant mesothelioma	82 \| 3,163
	primitive neuroectodermal tumor	78 \| 3,031
	Carcinoma	77 \| 2,147
	interstitial cystitis	76 \| 2,299
	oligodendroglioma	75 \| 2,849
	Cancer	73 \| 2,346
	ependymoma	73 \| 2,514
	subependymal giant cell astrocytoma	73 \| 2,287
	intraductal papillary-mucinous carcinoma (IPMC)	72 \| 2,988
	pediatric high grade glioma	72 \| 2,712
	intraductal papillary-mucinous adenoma (IPMA)	70 \| 2,956
	non-small cell lung cancer	69 \| 2,798
	lung adenocarcinoma	68 \| 2,714
	Breast cancer	67 \| 3,099
	intraductal papillary-mucinous neoplasm (IPMN)	67 \| 3,289
	invasive ductal carcinoma	67 \| 2,950
	adult high grade glioma	64 \| 2,148
	ulcerative colitis	59 \| 2,087
	astrocytic glioma	56 \| 2,241
	group 4 medulloblastoma	55 \| 1,875
	pancreatic cancer	52 \| 2,300
	pituitary cancer	51 \| 1,972
	Pick disease	50 \| 1,893
	astrocytoma	46 \| 1,493
	group 3 medulloblastoma	43 \| 2,254
	cystic fibrosis	42 \| 1,670
	tuberculosis	39 \| 1,563
	medulloblastoma	38 \| 1,524
	Rheumatoid Arthritis	37 \| 1,171
	pancreatic ductal adenocarcinoma liver metastasis	37 \| 1,795
	posterior fossa group A ependymoma	37 \| 1,511
	spina bifida	37 \| 1,064
	ductal carcinoma in situ	36 \| 1,745
	sonic hedgehog group medulloblastoma	36 \| 1,482
	breast carcinoma	32 \| 1,614
	cutaneous lupus erythematosus	32 \| 1,056
	diabetes mellitus	32 \| 1,663
	adrenocortical carcinoma	31 \| 1,427
	colon cancer	31 \| 1,475
	posterior fossa group B ependymoma	26 \| 1,530
	primary pancreatic ductal adenocarcinoma	26 \| 1,271
	primary Sjogren syndrome	25 \| 789
	acute quadriplegic myopathy	24 \| 1,157
	juvenile dermatomyositis	24 \| 1,189
	nasopharyngeal carcinoma	24 \| 1,056
	Parkinson's disease	23 \| 364
	atypical teratoid/rhabdoid tumor	23 \| 1,095
	Schizophrenia	22 \| 503
	Alzheimer's disease	21 \| 644
	gastric carcinoma	21 \| 832
	Atopic dermatitis	20 \| 944
	aldosterone-producing adenoma	20 \| 664
	IGA Glomerulonephritis	19 \| 454
	active Crohn's disease	19 \| 918
	autosomal dominant Emery-Dreifuss muscular dystrophy	18 \| 499
	dermatomyositis	18 \| 967
	progressive supranuclear palsy	18 \| 674
	Renal Cell Carcinoma	17 \| 199
	esophageal adenocarcinoma	17 \| 737
	Chronic Myelocytic Leukemia Accelerated Phase	16 \| 59
	Down syndrome	16 \| 548
	Kidney disease	16 \| 397
	Multiple myeloma	16 \| 1,328
	Asthma	15 \| 349
	Blastic phase chronic myeloid leukemia	15 \| 58
	Waldenstrons macroglobulinemia	15 \| 765
	non primary Sjogren syndrome sicca	15 \| 840
	Hypertension	14 \| 293
	Osteoporosis	14 \| 259
	acute myeloid leukemia	14 \| 785
	Amyotrophic Lateral Sclerosis	13 \| 432
	Arthritis	13 \| 248
	Crohn's disease	13 \| 304
	Duchenne muscular dystrophy	13 \| 602
	mucosa-associated lymphoid tissue lymphoma	13 \| 480
	sarcoidosis	13 \| 368
	Obesity	12 \| 616
	Vascular disease	12 \| 281
	chronic lymphosyte leukemia	12 \| 232
	tuberculosis and treatment for 6 months	12 \| 686
	Endometriosis	11 \| 535
	Mammary Neoplasms	11 \| 410
	chronic lymphocytic leukemia	11 \| 244
	fibroadenoma	11 \| 557
	Bipolar Disorder	10 \| 266
	Colorectal Neoplasms	10 \| 217
	Heart disease	10 \| 279
	chronic rhinosinusitis	10 \| 512
	hepatocellular carcinoma	10 \| 550
	non-small cell lung carcinoma	10 \| 413
	tuberculosis and treatment for 3 months	10 \| 327

	Nervous System	348 \| 18,561
	Digestive Tract	347 \| 18,473
	Female tissues	347 \| 18,647
	Liver and Pancreas	346 \| 18,136
	Urinary Tract	346 \| 18,444
	Blood and immune system	345 \| 17,995
	Cardiovascular System	345 \| 17,958
	Endocrine System	345 \| 18,512
	Male tissues	345 \| 17,969
	Skin and soft tissues	340 \| 18,115
	Respiratory system	333 \| 17,484

	Non-IDG	154 \| 11,969
	Kinase	128 \| 634
	Enzyme	59 \| 4,146
	Transcription Factor	8 \| 1,400
	GPCR	6 \| 408

Development Level

Collection

IMPC Term

Disease

Tissue

Target Family

GO Process

Drug Target Ontology

Target Development Level

Target Family

PANTHER Protein Ontology

Ligand

GTEx Tissue

HPA RNA Tissue

HPA Protein Tissue

HPM Tissue

JAX/MGI Phenotype

OMIM Phenotype

GWAS Trait

GO Component

UniProt Keywords

Grant Funding IC

Grant Activity

Data Source

	intracellular signal transduct...	355 \| 355
	transcription, DNA-templated	1,779 \| 1,779
	regulation of transcription, D...	1,170 \| 1,170
	signal transduction	969 \| 969
	positive regulation of transcr...	845 \| 845
	G-protein coupled receptor sig...	666 \| 666
	negative regulation of transcr...	620 \| 620
	apoptotic process	506 \| 506
	positive regulation of transcr...	504 \| 504
	negative regulation of transcr...	483 \| 483
	multicellular organism develop...	456 \| 456
	positive regulation of cell pr...	451 \| 451
	cell differentiation	442 \| 442
	negative regulation of apoptot...	440 \| 440
	innate immune response	410 \| 410
	cell adhesion	409 \| 409
	immune response	398 \| 398
	negative regulation of cell pr...	379 \| 379
	inflammatory response	371 \| 371
	viral process	368 \| 368
	spermatogenesis	365 \| 365
	cell proliferation	358 \| 358
	protein transport	356 \| 356
	cell division	330 \| 330
	regulation of transcription fr...	324 \| 324
	protein phosphorylation	320 \| 320
	response to drug	297 \| 297
	positive regulation of apoptot...	292 \| 292
	nervous system development	275 \| 275
	transcription from RNA polymer...	272 \| 272
	cell surface receptor signalin...	267 \| 267
	protein ubiquitination	260 \| 260
	transport	257 \| 257
	cell-cell signaling	249 \| 249
	regulation of immune response	247 \| 247
	positive regulation of gene ex...	242 \| 242
	mitotic nuclear division	241 \| 241
	MAPK cascade	238 \| 238
	chemical synaptic transmission	238 \| 238
	mRNA splicing, via spliceosome	219 \| 219
	angiogenesis	218 \| 218
	small GTPase mediated signal t...	215 \| 215
	translation	215 \| 215
	rRNA processing	209 \| 209
	intracellular protein transpor...	205 \| 205
	cellular response to DNA damag...	201 \| 201
	cell cycle	200 \| 200
	proteasome-mediated ubiquitin-...	200 \| 200
	proteolysis	199 \| 199
	visual perception	198 \| 198
	DNA repair	196 \| 196
	extracellular matrix organizat...	193 \| 193
	regulation of apoptotic proces...	190 \| 190
	brain development	183 \| 183
	positive regulation of cell mi...	181 \| 181
	protein polyubiquitination	181 \| 181
	in utero embryonic development	178 \| 178
	Fc-epsilon receptor signaling ...	176 \| 176
	Wnt signaling pathway	175 \| 175
	ion transmembrane transport	174 \| 174
	protein homooligomerization	173 \| 173
	heart development	170 \| 170
	positive regulation of ERK1 an...	170 \| 170
	blood coagulation	169 \| 169
	cell migration	168 \| 168
	regulation of cell proliferati...	167 \| 167
	protein autophosphorylation	166 \| 166
	response to hypoxia	164 \| 164
	mRNA processing	162 \| 162
	negative regulation of canonic...	162 \| 162
	protein folding	162 \| 162
	T cell receptor signaling path...	161 \| 161
	response to lipopolysaccharide	161 \| 161
	defense response to virus	160 \| 160
	RNA splicing	158 \| 158
	aging	158 \| 158
	positive regulation of I-kappa...	158 \| 158
	axon guidance	157 \| 157
	homophilic cell adhesion via p...	155 \| 155
	sensory perception of smell	155 \| 155
	ER to Golgi vesicle-mediated t...	151 \| 151
	interferon-gamma-mediated sign...	150 \| 150
	protein ubiquitination involve...	150 \| 150
	transcription initiation from ...	150 \| 150
	ubiquitin-dependent protein ca...	149 \| 149
	DNA replication	144 \| 144
	adaptive immune response	139 \| 139
	cell cycle arrest	139 \| 139
	receptor-mediated endocytosis	139 \| 139
	skeletal system development	136 \| 136
	regulation of cell shape	135 \| 135
	regulation of small GTPase med...	134 \| 134
	G2/M transition of mitotic cel...	133 \| 133
	oxidation-reduction process	133 \| 133
	positive regulation of cytosol...	133 \| 133
	protein stabilization	133 \| 133
	sensory perception of sound	132 \| 132
	positive regulation of NF-kapp...	131 \| 131
	antigen processing and present...	130 \| 130
	type I interferon signaling pa...	130 \| 130