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Development Level

Tbio 194 | 11,445
Tchem 127 | 1,598
Tdark 35 | 6,588
Tclin 20 | 613

Collection

Kinase: IDG Consortium (Target... 38 | 125
RFA-RM-18-021 38 | 328
Kinase: IDG Consortium (Comple... 10 | 37
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 14 | 979
preweaning lethality, incomple... 12 | 499
decreased total body fat amoun... 8 | 207
abnormal behavior 7 | 298
decreased vertical activity 6 | 208
increased lean body mass 6 | 172
abnormal gait 4 | 69
decreased body weight 4 | 161
embryonic lethality prior to t... 4 | 278
hyperactivity 4 | 148
improved glucose tolerance 4 | 79
increased bone mineral content 4 | 108
increased bone mineral density 4 | 72
abnormal bone structure 3 | 187
abnormal testis morphology 3 | 43
decreased circulating LDL chol... 3 | 38
decreased circulating alanine ... 3 | 47
decreased circulating glucose ... 3 | 126
decreased circulating insulin ... 3 | 76
decreased grip strength 3 | 116
decreased mean corpuscular hem... 3 | 50
decreased mean platelet volume 3 | 25
increased body length 3 | 32
increased circulating alkaline... 3 | 122
increased hematocrit 3 | 46
increased startle reflex 3 | 112
prenatal lethality 3 | 28
small testis 3 | 58
abnormal embryo size 2 | 220
abnormal femur morphology 2 | 14
abnormal locomotor behavior 2 | 24
abnormal pelvic girdle bone mo... 2 | 12
abnormal skin morphology 2 | 50
abnormal tooth morphology 2 | 24
abnormal vertebrae morphology 2 | 18
decreased basophil cell number 2 | 16
decreased body length 2 | 101
decreased circulating choleste... 2 | 93
decreased circulating iron lev... 2 | 32
decreased circulating magnesiu... 2 | 13
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased eosinophil cell numb... 2 | 24
decreased fasted circulating g... 2 | 65
decreased lean body mass 2 | 135
decreased lymphocyte cell numb... 2 | 83
decreased prepulse inhibition 2 | 82
enlarged heart 2 | 210
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased circulating LDL chol... 2 | 13
increased circulating calcium ... 2 | 34
increased circulating choleste... 2 | 66
increased circulating sodium l... 2 | 71
increased heart weight 2 | 62
increased hemoglobin content 2 | 45
increased monocyte cell number 2 | 63
increased or absent threshold ... 2 | 101
male infertility 2 | 123
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal optic disc morphology 1 | 10
abnormal pericardium morpholog... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal sensory capabilities-... 1 | 8
abnormal snout morphology 1 | 23
abnormal vocalization 1 | 21
cataract 1 | 92
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased food intake 1 | 13
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
dilated heart left ventricle 1 | 11
edema 1 | 59
enlarged spleen 1 | 41
hemorrhage 1 | 23
hydrometra 1 | 53
impaired righting response 1 | 26
increased circulating HDL chol... 1 | 80
increased circulating aspartat... 1 | 15
increased circulating phosphat... 1 | 26
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased red blood cell distr... 1 | 34
long tibia 1 | 25
polycystic kidney 1 | 15
shortened RR interval 1 | 17
small superior vagus ganglion 1 | 74
small thymus 1 | 16
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 292 | 11,493
osteosarcoma 197 | 7,950
ovarian cancer 185 | 8,520
medulloblastoma, large-cell 170 | 6,241
psoriasis 153 | 6,694
glioblastoma 148 | 5,792
ependymoma 135 | 4,679
atypical teratoid / rhabdoid tumor 133 | 5,112
adult high grade glioma 125 | 3,801
lung cancer 121 | 4,740
lung carcinoma 96 | 2,843
Astrocytoma, Pilocytic 95 | 3,081
group 3 medulloblastoma 95 | 4,104
primitive neuroectodermal tumor 93 | 3,035
Kidney cancer 92 | 2,613
malignant mesothelioma 91 | 3,232
Breast cancer 81 | 3,578
oligodendroglioma 78 | 2,850
Cancer 77 | 2,499
subependymal giant cell astrocytoma 75 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 74 | 2,989
interstitial cystitis 73 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 72 | 2,955
non-small cell lung cancer 72 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 70 | 3,291
invasive ductal carcinoma 70 | 2,951
astrocytic glioma 68 | 2,597
lung adenocarcinoma 68 | 2,716
group 4 medulloblastoma 60 | 1,855
ulcerative colitis 60 | 1,819
pancreatic cancer 55 | 2,398
Pick disease 54 | 1,894
tuberculosis 53 | 2,010
pituitary cancer 51 | 1,972
cystic fibrosis 46 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 44 | 1,962
Schizophrenia 39 | 1,160
ductal carcinoma in situ 39 | 1,745
Rheumatoid arthritis 37 | 1,191
astrocytoma 37 | 1,146
spina bifida 36 | 1,074
diabetes mellitus 35 | 1,728
breast carcinoma 34 | 1,638
colon cancer 33 | 1,478
cutaneous lupus erythematosus 33 | 1,057
adrenocortical carcinoma 31 | 1,428
nasopharyngeal carcinoma 28 | 1,058
Autosomal recessive predisposition 26 | 1,442
Bipolar Disorder 25 | 666
Intellectual disability 25 | 1,016
acute quadriplegic myopathy 25 | 1,158
primary Sjogren syndrome 25 | 735
Parkinson's disease 24 | 392
Renal Cell Carcinoma 24 | 214
juvenile dermatomyositis 23 | 1,187
Melanoma 22 | 711
Atopic dermatitis 21 | 952
Liver Cirrhosis, Experimental 21 | 769
dermatomyositis 21 | 966
medulloblastoma 21 | 720
Liver cancer 20 | 604
active Crohn's disease 20 | 922
aldosterone-producing adenoma 20 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 20 | 510
primary pancreatic ductal adenocarcinoma 20 | 1,109
gastric carcinoma 19 | 807
pediatric high grade glioma 19 | 1,064
progressive supranuclear palsy 19 | 676
Dull intelligence 18 | 645
Low intelligence 18 | 645
Mental Retardation 18 | 645
Mental deficiency 18 | 645
Obesity 18 | 678
Poor school performance 18 | 645
Skin cancer 18 | 469
Alzheimer's disease 17 | 658
Chronic Myelocytic Leukemia Accelerated Phase 17 | 59
Depressive disorder 17 | 409
Multiple myeloma 17 | 1,332
esophageal adenocarcinoma 17 | 737
Amyotrophic lateral sclerosis 16 | 451
Blastic phase chronic myeloid leukemia 16 | 58
Down syndrome 16 | 499
Epilepsy 16 | 792
Hypertension 16 | 396
Kidney disease 16 | 430
Osteoporosis 16 | 363
active ulcerative colitis 16 | 764
Arthritis 15 | 290
Asthma 15 | 385
Duchenne muscular dystrophy 15 | 601
Hypertensive disease 15 | 292
Mental Depression 15 | 333
Seizures 15 | 596
Waldenstrons macroglobulinemia 15 | 765
acute myeloid leukemia 15 | 783
non primary Sjogren syndrome sicca 15 | 891
sarcoidosis 14 | 370
Crohn's disease 13 | 321
mucosa-associated lymphoid tissue lymphoma 13 | 484

Tissue

Endocrine System 368 | 18,159
Skin and soft tissues 360 | 17,230
Female tissues 356 | 17,400
Digestive Tract 355 | 17,369
Male tissues 353 | 17,142
Liver and Pancreas 349 | 16,750
Nervous System 349 | 16,725
Urinary Tract 346 | 16,678
Respiratory system 345 | 16,393
Blood and immune system 343 | 16,909
Cardiovascular System 333 | 15,192

Target Family

Kinase 156 | 634
Non-IDG 149 | 12,091
Enzyme 58 | 4,145
Transcription Factor 7 | 1,400
GPCR 6 | 408

GO Process

intracellular signal transduct... 376 | 376
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 PLCB2 Tbio Enzyme -2.14048 137.8 104
Linker for activation of T-cells family member 1 LAT Tbio Non-IDG -2.16291 169.4 667
Cytosolic phospholipase A2 gamma PLA2G4C Tchem Enzyme -1.27690 20.9 63
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 MAGI3 Tbio Enzyme -1.20980 18.0 42
Regulator of G-protein signaling 14 RGS14 Tbio Non-IDG -1.61170 43.9 233
Rho guanine nucleotide exchange factor 5 ARHGEF5 Tbio Non-IDG -0.48804 5.75 249
Tyrosine-protein kinase Blk BLK Tchem Kinase -1.88753 81.6 418
Beta-chimaerin CHN2 Tbio Non-IDG -1.78873 58.0 149
Ras GTPase-activating protein 4B RASA4B Tdark Enzyme 0.00000 0
Serine/threonine-protein kinase WNK3 WNK3 Tchem Kinase -1.14290 17.3 193