Development Level

Tbio 157 | 10,625
Tdark 34 | 7,003
Tchem 10 | 1,890
Tclin 4 | 602

Collection

Kinase: IDG Consortium (Targets) 2 | 125

IMPC Phenotype

preweaning lethality, complete... 8 | 633
decreased total body fat amoun... 6 | 186
increased circulating alkaline... 6 | 119
decreased circulating HDL chol... 5 | 77
decreased circulating choleste... 5 | 85
decreased body weight 4 | 174
decreased circulating glucose ... 4 | 121
decreased circulating serum al... 4 | 79
decreased circulating triglyce... 4 | 83
decreased grip strength 4 | 123
decreased lean body mass 4 | 195
embryonic lethality prior to t... 4 | 187
increased mean corpuscular hem... 4 | 93
increased or absent threshold ... 4 | 128
preweaning lethality, incomple... 4 | 260
abnormal behavior 3 | 226
abnormal bone structure 3 | 131
decreased circulating LDL chol... 3 | 37
decreased circulating free fat... 3 | 39
decreased circulating insulin ... 3 | 75
embryonic lethality prior to o... 3 | 148
increased hematocrit 3 | 36
increased sacral vertebrae num... 3 | 62
abnormal bone mineralization 2 | 55
abnormal embryo size 2 | 112
abnormal lens morphology 2 | 73
abnormal sleep behavior 2 | 63
absent pinna reflex 2 | 21
cardiovascular system phenotyp... 2 | 35
decreased Ly6C low monocyte nu... 2 | 23
decreased bone mineral content 2 | 157
decreased circulating alanine ... 2 | 53
decreased circulating alkaline... 2 | 41
decreased circulating fructosa... 2 | 31
decreased hemoglobin content 2 | 53
decreased leukocyte cell numbe... 2 | 54
decreased lumbar vertebrae num... 2 | 62
decreased monocyte cell number 2 | 28
embryonic growth retardation 2 | 28
enlarged heart 2 | 111
hyperactivity 2 | 108
increased blood urea nitrogen ... 2 | 44
increased bone mineral content 2 | 92
increased circulating chloride... 2 | 43
increased circulating free fat... 2 | 17
increased circulating sodium l... 2 | 71
increased lean body mass 2 | 107
limb grasping 2 | 35
straub tail 2 | 26
abnormal behavioral response t... 1 | 52
abnormal gait 1 | 51
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal respiratory quotient 1 | 9
abnormal retinal inner nuclear... 1 | 5
abnormal retinal pigmentation 1 | 61
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
abnormal vertebrae morphology 1 | 14
decreased Ly6C high monocyte n... 1 | 18
decreased alpha-beta T cell nu... 1 | 12
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating chloride... 1 | 32
decreased circulating glycerol... 1 | 19
decreased circulating potassiu... 1 | 17
decreased circulating sodium l... 1 | 18
decreased gamma-delta T cell n... 1 | 18
decreased heart weight 1 | 44
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
decreased total retina thickne... 1 | 20
decreased vertical activity 1 | 22
enlarged spleen 1 | 26
female infertility 1 | 34
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
impaired righting response 1 | 19
increased NK T cell number 1 | 11
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased cardiac muscle contr... 1 | 5
increased circulating HDL chol... 1 | 63
increased circulating aspartat... 1 | 17
increased circulating choleste... 1 | 53
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 91
increased rib number 1 | 41
persistence of hyaloid vascula... 1 | 22
prolonged PR interval 1 | 4
small testis 1 | 37
stereotypic behavior 1 | 3
thrombocytosis 1 | 23
tremors 1 | 34
trunk curl 1 | 15

Disease

ovarian cancer 114 | 8,491
osteosarcoma 113 | 7,933
medulloblastoma, large-cell 72 | 6,234
psoriasis 71 | 6,685
glioblastoma 67 | 5,572
atypical teratoid / rhabdoid tumor 56 | 4,369
lung cancer 44 | 4,473
invasive ductal carcinoma 40 | 2,950
Breast cancer 39 | 3,098
intraductal papillary-mucinous neoplasm (IPMN) 38 | 3,289
oligodendroglioma 38 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,956
ependymoma 36 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 35 | 2,988
malignant mesothelioma 35 | 3,163
pilocytic astrocytoma 34 | 3,086
Pick disease 33 | 1,893
subependymal giant cell astrocytoma 32 | 2,287
astrocytic glioma 30 | 2,241
lung carcinoma 30 | 2,844
pancreatic cancer 30 | 2,300
pediatric high grade glioma 30 | 2,712
lung adenocarcinoma 29 | 2,714
non-small cell lung cancer 27 | 2,798
tuberculosis 26 | 1,563
primitive neuroectodermal tumor 25 | 3,031
interstitial cystitis 24 | 2,299
medulloblastoma 23 | 1,524
astrocytoma 22 | 1,493
group 4 medulloblastoma 22 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,795
primary pancreatic ductal adenocarcinoma 22 | 1,271
Multiple myeloma 21 | 1,327
Carcinoma 20 | 2,147
adult high grade glioma 20 | 2,148
diabetes mellitus 20 | 1,663
pituitary cancer 20 | 1,972
ductal carcinoma in situ 19 | 1,745
sonic hedgehog group medulloblastoma 19 | 1,482
posterior fossa group B ependymoma 18 | 1,530
acute quadriplegic myopathy 17 | 1,157
group 3 medulloblastoma 16 | 2,254
posterior fossa group A ependymoma 16 | 1,511
adrenocortical carcinoma 15 | 1,427
breast carcinoma 14 | 1,614
colon cancer 14 | 1,475
dermatomyositis 14 | 966
spina bifida 14 | 1,064
cystic fibrosis 13 | 1,670
ulcerative colitis 13 | 2,087
Alzheimer's disease 12 | 644
Rheumatoid Arthritis 12 | 1,170
active Crohn's disease 12 | 918
pancreatic carcinoma 12 | 567
atypical teratoid/rhabdoid tumor 11 | 1,095
juvenile dermatomyositis 11 | 1,189
tuberculosis and treatment for 6 months 11 | 686
Cancer 10 | 2,346
active ulcerative colitis 10 | 477
Intellectual disability 9 | 573
gastric carcinoma 9 | 832
mucosa-associated lymphoid tissue lymphoma 9 | 480
progressive supranuclear palsy 9 | 674
Duchenne muscular dystrophy 8 | 602
nasopharyngeal carcinoma 8 | 1,056
Down syndrome 7 | 548
IGA Glomerulonephritis 7 | 454
Prostatic Neoplasms 7 | 471
Waldenstrons macroglobulinemia 7 | 764
acute myeloid leukemia 7 | 785
non primary Sjogren syndrome sicca 7 | 840
Hermansky-Pudlak syndrome 6 | 43
Menkes disease 6 | 20
Neurodegenerative disease 6 | 383
Schizophrenia 6 | 503
Type 2 diabetes mellitus 6 | 192
esophageal adenocarcinoma 6 | 737
fibroadenoma 6 | 557
glioblastoma multiforme 6 | 347
hereditary spastic paraplegia 6 | 313
primary Sjogren syndrome 6 | 788
tuberculosis and treatment for 3 months 6 | 327
ARC syndrome 5 | 14
Amyotrophic Lateral Sclerosis 5 | 432
Gaucher disease type 1 5 | 171
Leber congenital amaurosis 5 | 72
Parkinson's disease 5 | 364
Polycystic Ovary Syndrome 5 | 334
Tetanus 5 | 66
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
Cerebral palsy 4 | 28
Chylomicron retention disease 4 | 11
Congenital dyserythropoietic anemia 4 | 17
Melanoma 4 | 261
Microcephaly 4 | 149
Retinitis pigmentosa 4 | 156
aldosterone-producing adenoma 4 | 664
gastric cancer 4 | 436
head and neck cancer and chronic obstructive pulmonary disease 4 | 237
hepatocellular carcinoma 4 | 550

Tissue

Male tissues 204 | 17,968
Blood and immune system 201 | 17,994
Cardiovascular System 201 | 17,957
Digestive Tract 201 | 18,472
Endocrine System 201 | 18,511
Female tissues 201 | 18,646
Liver and Pancreas 201 | 18,135
Nervous System 201 | 18,560
Urinary Tract 200 | 18,443
Respiratory system 199 | 17,483
Skin and soft tissues 199 | 18,114

Target Family

Non-IDG 184 | 11,969
Enzyme 14 | 4,146
Kinase 3 | 634
Epigenetic 2 | 242
Ion Channel 2 | 341

GO Process

intracellular protein transpor... 205 | 205
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 367 | 367
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
chemical synaptic transmission 238 | 238
MAPK cascade 237 | 237
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 199 | 199
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 180 | 180
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 175 | 175
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
protein folding 162 | 162
negative regulation of canonic... 161 | 161
response to lipopolysaccharide 161 | 161
T cell receptor signaling path... 160 | 160
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2-M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
type I interferon signaling pa... 130 | 130
endocytosis 129 | 129

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Small G protein signaling modulator 2 SGSM2 Tbio Non-IDG -0.28255 1.93 58
Alpha-soluble NSF attachment protein NAPA Tbio Non-IDG -1.91708 86.7 133
Regulating synaptic membrane exocytosis protein 2 RIMS2 Tbio Non-IDG -1.59472 39.9 142
TBC1 domain family member 2A TBC1D2 Tbio Non-IDG -1.21514 16.2 70
SEC23-interacting protein SEC23IP Tbio Non-IDG -0.85332 6.51 123
Cyclin-dependent-like kinase 5 CDK5 Tchem Kinase -3.04076 1184.8 589
Synergin gamma SYNRG Tdark Non-IDG -1.66612 46.4 22
Exportin-T XPOT Tbio Non-IDG -1.47684 28.8 76
AP-1 complex subunit mu-1 AP1M1 Tbio Non-IDG -1.18893 12.9 104
[Protein ADP-ribosylarginine] hydrolase-like protein 1 ADPRHL1 Tdark Enzyme 0.37 0.83 31