Development Level

Tbio 53 | 11,178
Tchem 19 | 1,885
Tdark 4 | 6,569
Tclin 3 | 612

IMPC Phenotype

preweaning lethality, complete... 10 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 6 | 278
decreased body weight 4 | 161
decreased total body fat amoun... 4 | 207
increased circulating alkaline... 4 | 122
abnormal behavior 3 | 298
decreased circulating choleste... 3 | 93
increased or absent threshold ... 3 | 101
abnormal embryo size 2 | 220
abnormal kidney morphology 2 | 65
abnormal seminal vesicle morph... 2 | 114
abnormal testis morphology 2 | 43
decreased circulating alanine ... 2 | 47
decreased circulating glucose ... 2 | 126
embryonic growth retardation 2 | 106
hyperactivity 2 | 148
hypoactivity 2 | 132
increased heart weight 2 | 62
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
small testis 2 | 58
thrombocytosis 2 | 27
abnormal bone mineralization 1 | 38
abnormal cranium morphology 1 | 36
abnormal eye anterior chamber ... 1 | 9
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal glucose homeostasis 1 | 4
abnormal hair texture 1 | 4
abnormal heart morphology 1 | 162
abnormal incisor morphology 1 | 4
abnormal maxilla morphology 1 | 17
abnormal pupil morphology 1 | 2
abnormal tail morphology 1 | 25
absent startle reflex 1 | 24
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating creatini... 1 | 39
decreased circulating glycerol... 1 | 16
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased heart rate variabili... 1 | 7
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
limb grasping 1 | 41
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small adrenal glands 1 | 16
small lymph nodes 1 | 1
syndactyly 1 | 23
thrombocytopenia 1 | 56

Disease

Carcinoma 55 | 11,192
ovarian cancer 49 | 8,297
osteosarcoma 40 | 7,766
psoriasis 38 | 6,514
medulloblastoma, large-cell 37 | 6,086
glioblastoma 36 | 5,635
atypical teratoid / rhabdoid tumor 33 | 4,971
ependymoma 33 | 4,559
Cancer 24 | 2,388
lung cancer 24 | 4,607
astrocytic glioma 23 | 2,530
group 3 medulloblastoma 22 | 4,002
oligodendroglioma 21 | 2,768
Breast cancer 20 | 3,469
diabetes mellitus 20 | 1,683
adult high grade glioma 19 | 3,701
invasive ductal carcinoma 19 | 2,867
primitive neuroectodermal tumor 18 | 2,957
Pick disease 17 | 1,856
subependymal giant cell astrocytoma 17 | 2,230
Astrocytoma, Pilocytic 16 | 3,006
Kidney cancer 16 | 2,548
Schizophrenia 15 | 1,136
Obesity 14 | 655
ductal carcinoma in situ 14 | 1,686
lung adenocarcinoma 14 | 2,627
pituitary cancer 14 | 1,915
group 4 medulloblastoma 13 | 1,806
malignant mesothelioma 13 | 3,135
non-small cell lung cancer 13 | 2,799
pancreatic cancer 13 | 2,322
Hyperinsulinism 12 | 128
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,872
Alzheimer's disease 11 | 640
Hyperglycemia 11 | 134
Rheumatoid arthritis 11 | 1,156
breast carcinoma 11 | 1,589
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,902
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,204
juvenile dermatomyositis 11 | 1,147
Autosomal recessive predisposition 10 | 1,407
colon cancer 10 | 1,428
lung carcinoma 10 | 2,755
acute quadriplegic myopathy 9 | 1,133
adrenocortical carcinoma 9 | 1,385
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,911
pediatric high grade glioma 9 | 1,035
Epilepsy 8 | 775
Insulin Resistance 8 | 70
Intellectual disability 8 | 998
Liver Cirrhosis, Experimental 8 | 733
Carcinoma, Hepatocellular 7 | 217
Diabetes Mellitus, Non-Insulin-Dependent 7 | 140
Multiple myeloma 7 | 1,296
Polycystic ovary syndrome 7 | 348
Seizures 7 | 584
astrocytoma 7 | 1,113
cystic fibrosis 7 | 1,629
dermatomyositis 7 | 941
pancreatic carcinoma 7 | 555
primary pancreatic ductal adenocarcinoma 7 | 1,071
spina bifida 7 | 1,053
ulcerative colitis 7 | 1,765
Atopic dermatitis 6 | 915
Bipolar Disorder 6 | 646
Fatty liver disease 6 | 102
Fetal Growth Retardation 6 | 186
Infant, Small for Gestational Age 6 | 174
Intrauterine retardation 6 | 174
Liver carcinoma 6 | 229
Prostatic Neoplasms 6 | 472
Short stature 6 | 514
active Crohn's disease 6 | 882
medulloblastoma 6 | 702
tuberculosis 6 | 1,963
Alzheimer Disease 5 | 80
Anemia 5 | 353
Blepharoptosis 5 | 229
Broad flat nasal bridge 5 | 232
Cataract 5 | 290
Cognitive delay 5 | 596
Delayed bone age 5 | 132
Diabetes Mellitus, Experimental 5 | 101
Diabetes Mellitus, Noninsulin-Dependent 5 | 31
Diabetes Mellitus, Type 2 5 | 136
Failure to gain weight 5 | 359
Frontal bossing 5 | 154
Global developmental delay 5 | 596
Lipodystrophy 5 | 37
Mental and motor retardation 5 | 596
Nasal bridge wide 5 | 232
Orbital separation excessive 5 | 240
Osteopetrosis 5 | 42
Parkinson's disease 5 | 378
Pediatric failure to thrive 5 | 359
active ulcerative colitis 5 | 736
Glaucoma 4 | 232
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 492
chronic rhinosinusitis 4 | 505
fibroadenoma 4 | 538

Tissue

Blood and immune system 77 | 16,909
Digestive Tract 77 | 17,369
Endocrine System 77 | 18,159
Female tissues 77 | 17,400
Male tissues 77 | 17,142
Nervous System 77 | 16,725
Skin and soft tissues 77 | 17,230
Urinary Tract 76 | 16,678
Liver and Pancreas 75 | 16,750
Respiratory system 75 | 16,393
Cardiovascular System 74 | 15,192

Target Family

Enzyme 34 | 4,145
Non-IDG 28 | 12,091
Kinase 10 | 634
Transcription Factor 4 | 1,400
Epigenetic 1 | 242
TF/Epigenetic 1 | 38
Transporter 1 | 473

GO Process

insulin receptor signaling pat... 79 | 79
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Insulin receptor INSR Tclin Kinase -2.50045 306.8 1417
Phosphatidylinositol-glycan-specific phospholipase D GPLD1 Tbio Enzyme -2.08209 126.8 222
Rho-related GTP-binding protein RhoQ RHOQ Tbio Enzyme -1.48059 28.3 111
V-type proton ATPase subunit F ATP6V1F Tbio Enzyme -0.91914 8.76 118
V-type proton ATPase subunit S1 ATP6AP1 Tchem Enzyme -1.94689 91.3 166
V-type proton ATPase 21 kDa proteolipid subunit ATP6V0B Tbio Enzyme -0.96261 10.7 81
V-type proton ATPase subunit G 2 ATP6V1G2 Tbio Enzyme -0.88393 7.05 52
Growth factor receptor-bound protein 10 GRB10 Tbio Non-IDG -1.98746 111.0 315
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 BAIAP2L2 Tdark Non-IDG 0.40 0.15 107
Eukaryotic translation initiation factor 4E-binding protein 2 EIF4EBP2 Tbio Non-IDG -1.55776 33.4 189