Development Level

Tbio 57 | 11,651
Tchem 15 | 1,388
Tdark 4 | 6,593
Tclin 3 | 612

IMPC Phenotype

preweaning lethality, complete... 10 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 6 | 278
decreased body weight 4 | 161
decreased total body fat amoun... 4 | 207
increased circulating alkaline... 4 | 122
abnormal behavior 3 | 298
decreased circulating choleste... 3 | 93
increased or absent threshold ... 3 | 101
abnormal embryo size 2 | 220
abnormal kidney morphology 2 | 65
abnormal seminal vesicle morph... 2 | 114
abnormal testis morphology 2 | 43
decreased circulating alanine ... 2 | 47
decreased circulating glucose ... 2 | 126
embryonic growth retardation 2 | 106
hyperactivity 2 | 148
hypoactivity 2 | 132
increased heart weight 2 | 62
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
small testis 2 | 58
thrombocytosis 2 | 27
abnormal bone mineralization 1 | 38
abnormal cranium morphology 1 | 36
abnormal eye anterior chamber ... 1 | 9
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal glucose homeostasis 1 | 4
abnormal hair texture 1 | 4
abnormal heart morphology 1 | 162
abnormal incisor morphology 1 | 4
abnormal maxilla morphology 1 | 17
abnormal pupil morphology 1 | 2
abnormal tail morphology 1 | 25
absent startle reflex 1 | 24
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating creatini... 1 | 39
decreased circulating glycerol... 1 | 16
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased heart rate variabili... 1 | 7
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
limb grasping 1 | 41
male infertility 1 | 123
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small adrenal glands 1 | 16
small lymph nodes 1 | 1
syndactyly 1 | 23
thrombocytopenia 1 | 56

Disease

Carcinoma 57 | 11,493
ovarian cancer 50 | 8,520
osteosarcoma 40 | 7,950
psoriasis 38 | 6,694
glioblastoma 37 | 5,792
medulloblastoma, large-cell 37 | 6,241
atypical teratoid / rhabdoid tumor 33 | 5,112
ependymoma 33 | 4,679
Cancer 25 | 2,499
lung cancer 25 | 4,740
astrocytic glioma 23 | 2,597
diabetes mellitus 22 | 1,728
group 3 medulloblastoma 22 | 4,104
oligodendroglioma 21 | 2,850
Breast cancer 20 | 3,578
invasive ductal carcinoma 20 | 2,951
adult high grade glioma 19 | 3,801
primitive neuroectodermal tumor 18 | 3,035
Kidney cancer 17 | 2,613
Pick disease 17 | 1,894
subependymal giant cell astrocytoma 17 | 2,287
Astrocytoma, Pilocytic 16 | 3,081
Obesity 15 | 678
Schizophrenia 15 | 1,160
ductal carcinoma in situ 15 | 1,745
lung adenocarcinoma 15 | 2,716
pituitary cancer 15 | 1,972
group 4 medulloblastoma 14 | 1,855
non-small cell lung cancer 14 | 2,890
pancreatic cancer 14 | 2,398
Hyperinsulinism 13 | 133
malignant mesothelioma 13 | 3,232
Hyperglycemia 12 | 137
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
Alzheimer's disease 11 | 658
Rheumatoid arthritis 11 | 1,191
breast carcinoma 11 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
juvenile dermatomyositis 11 | 1,187
Autosomal recessive predisposition 10 | 1,442
colon cancer 10 | 1,478
lung carcinoma 10 | 2,843
pediatric high grade glioma 10 | 1,064
Liver Cirrhosis, Experimental 9 | 769
acute quadriplegic myopathy 9 | 1,158
adrenocortical carcinoma 9 | 1,428
cystic fibrosis 9 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Epilepsy 8 | 792
Insulin Resistance 8 | 72
Intellectual disability 8 | 1,016
Polycystic ovary syndrome 8 | 360
Carcinoma, Hepatocellular 7 | 228
Diabetes Mellitus, Non-Insulin-Dependent 7 | 145
Multiple myeloma 7 | 1,332
Seizures 7 | 596
astrocytoma 7 | 1,146
dermatomyositis 7 | 966
pancreatic carcinoma 7 | 562
primary pancreatic ductal adenocarcinoma 7 | 1,109
spina bifida 7 | 1,074
ulcerative colitis 7 | 1,819
Atopic dermatitis 6 | 952
Bipolar Disorder 6 | 666
Diabetes Mellitus, Type 2 6 | 142
Fatty liver disease 6 | 103
Fetal Growth Retardation 6 | 189
Infant, Small for Gestational Age 6 | 176
Intrauterine retardation 6 | 176
Liver carcinoma 6 | 240
Prostatic Neoplasms 6 | 495
Short stature 6 | 531
active Crohn's disease 6 | 922
medulloblastoma 6 | 720
tuberculosis 6 | 2,010
Alzheimer Disease 5 | 83
Anemia 5 | 365
Blepharoptosis 5 | 231
Broad flat nasal bridge 5 | 236
Cataract 5 | 297
Cognitive delay 5 | 608
Delayed bone age 5 | 136
Diabetes Mellitus, Experimental 5 | 108
Diabetes Mellitus, Noninsulin-Dependent 5 | 31
Failure to gain weight 5 | 365
Frontal bossing 5 | 157
Global developmental delay 5 | 608
Hypertension 5 | 396
Kidney disease 5 | 430
Lipodystrophy 5 | 40
Mental and motor retardation 5 | 608
Nasal bridge wide 5 | 236
Orbital separation excessive 5 | 244
Osteopetrosis 5 | 43
Parkinson's disease 5 | 392
Pediatric failure to thrive 5 | 365
Precancerous Conditions 5 | 80
active ulcerative colitis 5 | 764
Glaucoma 4 | 239

Tissue

Blood and immune system 77 | 16,909
Digestive Tract 77 | 17,369
Endocrine System 77 | 18,159
Female tissues 77 | 17,400
Male tissues 77 | 17,142
Nervous System 77 | 16,725
Skin and soft tissues 77 | 17,230
Urinary Tract 76 | 16,678
Liver and Pancreas 75 | 16,750
Respiratory system 75 | 16,393
Cardiovascular System 74 | 15,192

Target Family

Enzyme 34 | 4,145
Non-IDG 28 | 12,091
Kinase 10 | 634
Transcription Factor 4 | 1,400
Epigenetic 1 | 242
TF/Epigenetic 1 | 38
Transporter 1 | 473

GO Process

insulin receptor signaling pat... 79 | 79
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V-type proton ATPase subunit B, kidney isoform ATP6V1B1 Tchem Enzyme -1.71459 43.7 251
DCC-interacting protein 13-alpha APPL1 Tbio Non-IDG -2.75344 511.0 230
V-type proton ATPase subunit D ATP6V1D Tbio Enzyme -1.48812 30.2 69
V-type proton ATPase 116 kDa subunit a isoform 2 ATP6V0A2 Tbio Enzyme -2.46402 298.9 76
Insulin receptor substrate 2 IRS2 Tbio Non-IDG -2.64133 414.7 227
V-type proton ATPase 16 kDa proteolipid subunit ATP6V0C Tbio Enzyme -1.87899 78.9 72
V-type proton ATPase 116 kDa subunit a isoform 1 ATP6V0A1 Tbio Enzyme -1.40105 25.1 63
V-type proton ATPase subunit d 2 ATP6V0D2 Tbio Enzyme -1.17065 12.0 74
Tyrosine-protein phosphatase non-receptor type 2 PTPN2 Tchem Enzyme -2.53451 297.2 192
V-type proton ATPase 116 kDa subunit a isoform 3 TCIRG1 Tbio Enzyme -1.92345 93.5 63