Development Level

Tbio 49 | 10,625
Tchem 19 | 1,890
Tdark 6 | 7,003
Tclin 3 | 602

IMPC Term

embryonic lethality prior to o... 6 | 148
embryonic lethality prior to t... 6 | 187
preweaning lethality, complete... 5 | 633
decreased body weight 4 | 174
decreased circulating choleste... 3 | 85
decreased total body fat amoun... 3 | 186
hypoactivity 3 | 89
increased circulating alkaline... 3 | 119
abnormal behavior 2 | 226
abnormal seminal vesicle morph... 2 | 47
decreased body length 2 | 108
decreased grip strength 2 | 123
decreased lean body mass 2 | 195
decreased mean corpuscular vol... 2 | 50
increased mean corpuscular hem... 2 | 93
increased or absent threshold ... 2 | 128
thrombocytosis 2 | 23
abnormal bone mineralization 1 | 55
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal eye anterior chamber ... 1 | 3
abnormal eye size 1 | 11
abnormal forebrain development 1 | 18
abnormal glucose homeostasis 1 | 5
abnormal hair texture 1 | 4
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal incisor morphology 1 | 3
abnormal kidney morphology 1 | 30
abnormal maxilla morphology 1 | 16
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal retina morphology 1 | 100
abnormal spinal cord morpholog... 1 | 8
abnormal testis morphology 1 | 30
absent heartbeat 1 | 6
absent startle reflex 1 | 15
cardiovascular system phenotyp... 1 | 35
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating aspartat... 1 | 27
decreased circulating creatini... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating glycerol... 1 | 19
decreased circulating insulin ... 1 | 75
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased erythrocyte cell num... 1 | 43
decreased hemoglobin content 1 | 53
decreased leukocyte cell numbe... 1 | 54
decreased lumbar vertebrae num... 1 | 62
decreased lymphocyte cell numb... 1 | 9
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased mean platelet volume 1 | 12
decreased prepulse inhibition 1 | 52
decreased startle reflex 1 | 48
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
hyperactivity 1 | 108
impaired pupillary reflex 1 | 14
increased circulating LDL chol... 1 | 15
increased circulating alanine ... 1 | 11
increased circulating amylase ... 1 | 13
increased circulating aspartat... 1 | 17
increased circulating choleste... 1 | 53
increased circulating iron lev... 1 | 25
increased circulating potassiu... 1 | 31
increased fasted circulating g... 1 | 68
increased heart rate 1 | 17
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased neutrophil cell numb... 1 | 15
increased sacral vertebrae num... 1 | 62
limb grasping 1 | 35
mydriasis 1 | 9
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82
small adrenal glands 1 | 15
small lymph nodes 1 | 1
small testis 1 | 37

Disease

ovarian cancer 48 | 8,484
osteosarcoma 40 | 7,933
psoriasis 37 | 6,685
glioblastoma 35 | 5,572
medulloblastoma, large-cell 35 | 6,234
atypical teratoid / rhabdoid tumor 28 | 4,369
ependymoma 24 | 2,514
Cancer 23 | 2,346
lung cancer 21 | 4,466
diabetes mellitus 20 | 1,663
invasive ductal carcinoma 20 | 2,950
oligodendroglioma 19 | 2,849
Breast cancer 18 | 3,094
Pick disease 16 | 1,893
astrocytic glioma 16 | 2,241
pediatric high grade glioma 16 | 2,712
primitive neuroectodermal tumor 16 | 3,031
subependymal giant cell astrocytoma 16 | 2,287
ductal carcinoma in situ 15 | 1,745
pituitary cancer 15 | 1,972
lung adenocarcinoma 14 | 2,713
non-small cell lung cancer 14 | 2,798
pilocytic astrocytoma 14 | 3,086
Obesity 13 | 616
malignant mesothelioma 13 | 3,162
pancreatic cancer 13 | 2,300
Carcinoma 12 | 2,147
group 4 medulloblastoma 12 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
Alzheimer's disease 11 | 644
Hyperinsulinism 11 | 63
adult high grade glioma 11 | 2,148
astrocytoma 11 | 1,493
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,289
juvenile dermatomyositis 11 | 1,189
Hyperglycemia 10 | 120
Rheumatoid Arthritis 10 | 1,160
breast carcinoma 10 | 1,614
lung carcinoma 10 | 2,844
medulloblastoma 10 | 1,524
sonic hedgehog group medulloblastoma 10 | 1,482
acute quadriplegic myopathy 9 | 1,157
colon cancer 9 | 1,475
group 3 medulloblastoma 9 | 2,254
ulcerative colitis 9 | 2,087
Metabolic syndrome X 8 | 155
cystic fibrosis 8 | 1,665
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
primary pancreatic ductal adenocarcinoma 8 | 1,271
Multiple myeloma 7 | 1,327
Polycystic Ovary Syndrome 7 | 332
Schizophrenia 7 | 501
adrenocortical carcinoma 7 | 1,427
dermatomyositis 7 | 933
pancreatic carcinoma 7 | 567
posterior fossa group A ependymoma 7 | 1,511
spina bifida 7 | 1,064
Atopic dermatitis 6 | 944
Diabetes Mellitus, Non-Insulin-Dependent 6 | 157
Fatty liver disease 6 | 84
active Crohn's disease 6 | 918
Insulin Resistance 5 | 48
Kidney disease 5 | 396
Liver carcinoma 5 | 217
Osteopetrosis 5 | 40
Parkinson Disease 5 | 102
Parkinson's disease 5 | 364
Prostatic Neoplasms 5 | 471
tuberculosis 5 | 1,557
tuberculosis and treatment for 6 months 5 | 686
Atherosclerosis 4 | 275
Diabetes Mellitus, Experimental 4 | 106
Hypertension 4 | 287
Lewy Body Disease 4 | 19
Liver disease 4 | 219
Myopathy 4 | 128
Osteoporosis 4 | 257
Waldenstrons macroglobulinemia 4 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 499
chronic rhinosinusitis 4 | 512
fibroadenoma 4 | 557
interstitial cystitis 4 | 2,299
progressive supranuclear palsy 4 | 674
Acromegaly 3 | 40
Adenoma 3 | 165
Autistic Disorder 3 | 320
Coronary artery disease 3 | 240
Cutis laxa 3 | 28
Endometriosis 3 | 535
Gaucher disease type 1 3 | 171
Heart disease 3 | 279
Hyperandrogenism 3 | 32
Infertility 3 | 163
Lipid metabolism disorder 3 | 102
active ulcerative colitis 3 | 477
atypical teratoid/rhabdoid tumor 3 | 1,095
esophageal adenocarcinoma 3 | 737
hepatocellular carcinoma 3 | 532
nasopharyngeal carcinoma 3 | 1,056

Tissue

Nervous System 77 | 18,561
Blood and immune system 76 | 17,995
Digestive Tract 76 | 18,473
Female tissues 75 | 18,647
Liver and Pancreas 75 | 18,136
Male tissues 75 | 17,969
Cardiovascular System 74 | 17,958
Endocrine System 74 | 18,512
Skin and soft tissues 74 | 18,115
Urinary Tract 74 | 18,444
Respiratory system 72 | 17,484

Target Family

Enzyme 34 | 4,146
Non-IDG 26 | 11,971
Kinase 10 | 634
Transcription Factor 4 | 1,400
Epigenetic 1 | 242
TF/Epigenetic 1 | 38
Transporter 1 | 473

GO Process

insulin receptor signaling pat... 77 | 77
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
V-type proton ATPase catalytic subunit A ATP6V1A Tbio Enzyme -1.80191 64.7 120
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
Insulin-degrading enzyme IDE Tchem Enzyme -2.54789 384.2 283
V-type proton ATPase 116 kDa subunit a isoform 1 ATP6V0A1 Tbio Enzyme -1.36455 23.7 59
Syntaxin-binding protein 4 STXBP4 Tbio Non-IDG -0.73535 7.61 58
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -2.99303 933.5 424
V-type proton ATPase subunit e 2 ATP6V0E2 Tdark Enzyme 0.18 0.40 19
Glycogen synthase kinase-3 alpha GSK3A Tclin Kinase -1.81647 52.3 722
V-type proton ATPase subunit E 1 ATP6V1E1 Tbio Enzyme -0.98803 10.3 111