Development Level

Tbio 327 | 11,651
Tchem 59 | 1,388
Tdark 59 | 6,593
Tclin 24 | 612

Collection

GPCR: IDG Consortium (Complete... 1 | 25
Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 12 | 979
preweaning lethality, incomple... 10 | 499
abnormal behavior 6 | 298
embryonic lethality prior to t... 6 | 278
decreased bone mineral content 5 | 151
abnormal bone structure 4 | 187
abnormal embryo size 4 | 220
decreased lymphocyte cell numb... 4 | 83
decreased mean corpuscular vol... 4 | 79
embryonic lethality prior to o... 4 | 239
abnormal gait 3 | 69
decreased blood urea nitrogen ... 3 | 51
decreased bone mineral density 3 | 126
decreased circulating HDL chol... 3 | 68
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased total body fat amoun... 3 | 207
embryonic growth retardation 3 | 106
hypoactivity 3 | 132
increased blood urea nitrogen ... 3 | 48
increased mean corpuscular vol... 3 | 92
increased neutrophil cell numb... 3 | 46
small superior vagus ganglion 3 | 74
abnormal neural tube closure 2 | 46
abnormal seminal vesicle morph... 2 | 114
abnormal skin morphology 2 | 50
decreased circulating amylase ... 2 | 28
decreased circulating magnesiu... 2 | 13
decreased circulating phosphat... 2 | 27
decreased eosinophil cell numb... 2 | 24
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular hem... 2 | 31
enlarged heart 2 | 210
enlarged spleen 2 | 41
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased eosinophil cell numb... 2 | 11
increased heart weight 2 | 62
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular hem... 2 | 96
increased spleen weight 2 | 10
increased startle reflex 2 | 112
thrombocytopenia 2 | 56
tremors 2 | 39
abnormal cornea morphology 1 | 31
abnormal hair growth 1 | 10
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 25
absent vibrissae 1 | 12
cataract 1 | 92
decreased T cell number 1 | 15
decreased circulating bilirubi... 1 | 19
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
enlarged lymph nodes 1 | 37
enlarged urinary bladder 1 | 8
enlarged uterus 1 | 11
hydrometra 1 | 53
impaired righting response 1 | 26
increased aggression 1 | 4
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lactate dehydrogenas... 1 | 3
increased large unstained cell... 1 | 5
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
persistence of hyaloid vascula... 1 | 33
premature death 1 | 5
scaly skin 1 | 4
small testis 1 | 58
stereotypic behavior 1 | 3
trunk curl 1 | 16

Disease

Carcinoma 239 | 11,493
osteosarcoma 210 | 7,950
ovarian cancer 193 | 8,520
psoriasis 192 | 6,694
lung cancer 150 | 4,740
glioblastoma 141 | 5,792
Cancer 128 | 2,499
medulloblastoma, large-cell 125 | 6,241
lung carcinoma 118 | 2,843
interstitial cystitis 108 | 2,312
tuberculosis 102 | 2,010
intraductal papillary-mucinous neoplasm (IPMN) 96 | 3,291
adult high grade glioma 91 | 3,801
non-small cell lung cancer 86 | 2,890
ulcerative colitis 85 | 1,819
lung adenocarcinoma 84 | 2,716
Astrocytoma, Pilocytic 81 | 3,081
pancreatic cancer 81 | 2,398
ependymoma 80 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 78 | 2,955
malignant mesothelioma 78 | 3,232
cutaneous lupus erythematosus 76 | 1,057
intraductal papillary-mucinous carcinoma (IPMC) 75 | 2,989
atypical teratoid / rhabdoid tumor 73 | 5,112
invasive ductal carcinoma 73 | 2,951
subependymal giant cell astrocytoma 73 | 2,287
Breast cancer 72 | 3,578
group 3 medulloblastoma 58 | 4,104
Kidney cancer 57 | 2,613
cystic fibrosis 54 | 1,696
diabetes mellitus 53 | 1,728
juvenile dermatomyositis 52 | 1,187
Rheumatoid arthritis 51 | 1,191
group 4 medulloblastoma 50 | 1,855
primary Sjogren syndrome 50 | 735
Schizophrenia 48 | 1,160
dermatomyositis 47 | 966
oligodendroglioma 45 | 2,850
astrocytoma 43 | 1,146
Autosomal recessive predisposition 42 | 1,442
Multiple myeloma 41 | 1,332
pancreatic ductal adenocarcinoma liver metastasis 40 | 1,962
pituitary cancer 40 | 1,972
mucosa-associated lymphoid tissue lymphoma 39 | 484
adrenocortical carcinoma 38 | 1,428
astrocytic glioma 38 | 2,597
active Crohn's disease 37 | 922
Atopic dermatitis 35 | 952
Liver Cirrhosis, Experimental 35 | 769
ductal carcinoma in situ 35 | 1,745
Multiple Sclerosis 34 | 540
esophageal adenocarcinoma 33 | 737
primitive neuroectodermal tumor 33 | 3,035
Systemic lupus erythematosus 32 | 194
breast carcinoma 32 | 1,638
colon cancer 31 | 1,478
Arthritis 28 | 290
Melanoma 28 | 711
Waldenstrons macroglobulinemia 28 | 765
acute quadriplegic myopathy 27 | 1,158
pancreatic carcinoma 27 | 562
active ulcerative colitis 26 | 764
nasopharyngeal carcinoma 26 | 1,058
Asthma 25 | 385
spina bifida 25 | 1,074
Influenza 24 | 142
Kidney disease 24 | 430
Pick disease 24 | 1,894
periodontitis 24 | 293
primary pancreatic ductal adenocarcinoma 24 | 1,109
Prostatic Neoplasms 22 | 495
acute myeloid leukemia 22 | 783
gastric carcinoma 21 | 807
head and neck cancer and chronic obstructive pulmonary disease 21 | 239
chronic lymphosyte leukemia 20 | 204
Alzheimer's disease 19 | 658
Bipolar Disorder 19 | 666
Duchenne muscular dystrophy 19 | 601
Immunologic Deficiency Syndromes 19 | 113
hepatocellular carcinoma 19 | 547
Anemia 18 | 365
Blastic phase chronic myeloid leukemia 18 | 58
Chronic Lymphocytic Leukemia 18 | 262
Chronic Myelocytic Leukemia Accelerated Phase 18 | 59
Diarrhea 18 | 253
Down syndrome 18 | 499
Hypersensitivity reaction type II disease 18 | 253
aldosterone-producing adenoma 18 | 665
pediatric high grade glioma 18 | 1,064
Atherosclerosis 17 | 291
Chemical and Drug Induced Liver Injury 17 | 195
Fatigue 17 | 182
Inflammatory bowel disease 17 | 151
Vascular disease 17 | 319
gastric cancer 17 | 459
non primary Sjogren syndrome sicca 17 | 891
Arthritis, Rheumatoid 16 | 174
Hypertension 16 | 396
Inflammation 16 | 120
Splenomegaly 16 | 190

Tissue

Digestive Tract 374 | 17,369
Endocrine System 373 | 18,159
Male tissues 372 | 17,142
Blood and immune system 367 | 16,909
Skin and soft tissues 367 | 17,230
Female tissues 365 | 17,400
Urinary Tract 356 | 16,678
Liver and Pancreas 355 | 16,750
Respiratory system 349 | 16,393
Nervous System 337 | 16,725
Cardiovascular System 323 | 15,192

Target Family

Non-IDG 325 | 12,091
Enzyme 67 | 4,145
Kinase 53 | 634
Transcription Factor 13 | 1,400
GPCR 4 | 408
Epigenetic 2 | 242
Ion Channel 2 | 344
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38

GO Process

innate immune response 469 | 469
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pyrin domain-containing protein 1 PYDC1 Tbio Non-IDG -2.88567 750.0 115
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19
Tyrosine-protein kinase ZAP-70 ZAP70 Tchem Kinase -2.91589 798.2 1515
C4b-binding protein alpha chain C4BPA Tbio Non-IDG -2.43425 244.7 172
Trem-like transcript 4 protein TREML4 Tbio Non-IDG -0.49474 3.87 36
Macrophage receptor MARCO MARCO Tbio Non-IDG -2.37206 210.3 189
Peptidoglycan recognition protein 4 PGLYRP4 Tbio Non-IDG -0.77368 3.75 126
Cysteine-rich secretory protein 3 CRISP3 Tbio Non-IDG -1.58618 43.2 129
C-type lectin domain family 6 member A CLEC6A Tbio Non-IDG -1.54098 33.3 328
CMRF35-like molecule 7 CD300LB Tbio Non-IDG -0.85242 10.4 74