Development Level

Tbio 233 | 11,445
Tchem 95 | 1,598
Tclin 42 | 613
Tdark 3 | 6,588

Collection

GPCR: IDG Consortium (Targets) 4 | 126
Kinase: IDG Consortium (Target... 3 | 125
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, incomple... 11 | 499
decreased vertical activity 8 | 208
decreased circulating insulin ... 6 | 76
abnormal bone structure 5 | 187
decreased lymphocyte cell numb... 5 | 83
improved glucose tolerance 5 | 79
increased neutrophil cell numb... 5 | 46
decreased circulating creatini... 4 | 39
decreased mean corpuscular vol... 4 | 79
hypoactivity 4 | 132
increased bone mineral content 4 | 108
abnormal behavior 3 | 298
abnormal gait 3 | 69
abnormal seminal vesicle morph... 3 | 114
cataract 3 | 92
decreased blood urea nitrogen ... 3 | 51
decreased circulating alanine ... 3 | 47
enlarged heart 3 | 210
increased circulating alkaline... 3 | 122
increased eosinophil cell numb... 3 | 11
increased leukocyte cell numbe... 3 | 47
increased mean corpuscular vol... 3 | 92
increased monocyte cell number 3 | 63
increased startle reflex 3 | 112
male infertility 3 | 123
tremors 3 | 39
abnormal colon morphology 2 | 3
abnormal eye anterior chamber ... 2 | 9
abnormal heart morphology 2 | 162
abnormal kidney morphology 2 | 65
abnormal spleen morphology 2 | 55
decreased T cell number 2 | 15
decreased circulating alkaline... 2 | 46
decreased circulating amylase ... 2 | 28
decreased circulating glucose ... 2 | 126
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased grip strength 2 | 116
decreased heart left ventricle... 2 | 28
decreased heart weight 2 | 27
decreased large unstained cell... 2 | 11
decreased leukocyte cell numbe... 2 | 73
decreased monocyte cell number 2 | 8
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating alanine ... 2 | 13
increased circulating aspartat... 2 | 15
increased circulating calcium ... 2 | 34
increased circulating glucose ... 2 | 24
increased circulating iron lev... 2 | 30
increased circulating sodium l... 2 | 71
increased circulating total pr... 2 | 28
increased large unstained cell... 2 | 5
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular hem... 2 | 96
increased spleen weight 2 | 10
limb grasping 2 | 41
preweaning lethality, complete... 2 | 979
small superior vagus ganglion 2 | 74
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal lens morphology 1 | 81
abnormal liver morphology 1 | 17
abnormal locomotor activation 1 | 16
abnormal lung morphology 1 | 26
abnormal optic disc morphology 1 | 10
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
absent vibrissae 1 | 12
decreased circulating iron lev... 1 | 32
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
enlarged uterus 1 | 11
hydrometra 1 | 53
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased circulating choleste... 1 | 66
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
long tibia 1 | 25
persistence of hyaloid vascula... 1 | 33
stereotypic behavior 1 | 3
trunk curl 1 | 16

Disease

Carcinoma 209 | 11,493
psoriasis 204 | 6,694
osteosarcoma 166 | 7,950
ovarian cancer 164 | 8,520
Cancer 162 | 2,499
glioblastoma 157 | 5,792
lung cancer 154 | 4,740
tuberculosis 138 | 2,010
lung carcinoma 134 | 2,843
interstitial cystitis 130 | 2,312
medulloblastoma, large-cell 119 | 6,241
ulcerative colitis 112 | 1,819
malignant mesothelioma 105 | 3,232
Astrocytoma, Pilocytic 100 | 3,081
non-small cell lung cancer 98 | 2,890
adult high grade glioma 94 | 3,801
invasive ductal carcinoma 93 | 2,951
cutaneous lupus erythematosus 87 | 1,057
lung adenocarcinoma 87 | 2,716
ependymoma 84 | 4,679
atypical teratoid / rhabdoid tumor 83 | 5,112
diabetes mellitus 82 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 81 | 2,955
pancreatic cancer 81 | 2,398
Breast cancer 78 | 3,578
cystic fibrosis 78 | 1,696
subependymal giant cell astrocytoma 75 | 2,287
Rheumatoid arthritis 74 | 1,191
Asthma 73 | 385
intraductal papillary-mucinous carcinoma (IPMC) 73 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 72 | 3,291
Arthritis 67 | 290
Hypersensitivity reaction type II disease 60 | 253
group 3 medulloblastoma 55 | 4,104
Multiple Sclerosis 54 | 540
Schizophrenia 52 | 1,160
pituitary cancer 52 | 1,972
Kidney disease 51 | 430
Inflammatory bowel disease 50 | 151
Liver Cirrhosis, Experimental 50 | 769
colon cancer 48 | 1,478
Atherosclerosis 47 | 291
breast carcinoma 46 | 1,638
Kidney cancer 45 | 2,613
mucosa-associated lymphoid tissue lymphoma 45 | 484
pancreatic ductal adenocarcinoma liver metastasis 45 | 1,962
Pneumonia 44 | 174
ductal carcinoma in situ 44 | 1,745
Dermatitis 43 | 157
Hypertension 42 | 396
gastric carcinoma 42 | 807
primitive neuroectodermal tumor 42 | 3,035
Lung disease 41 | 142
Inflammation 40 | 120
periodontitis 39 | 293
adrenocortical carcinoma 38 | 1,428
primary Sjogren syndrome 38 | 735
Atopic dermatitis 36 | 952
Allergic hypersensitivity disease 35 | 126
Depressive disorder 35 | 409
Hypersensitivity 35 | 63
active Crohn's disease 35 | 922
group 4 medulloblastoma 35 | 1,855
Obesity 34 | 678
juvenile dermatomyositis 34 | 1,187
Coronary artery disease 33 | 268
Influenza 33 | 142
Vascular disease 33 | 319
esophageal adenocarcinoma 33 | 737
head and neck cancer and chronic obstructive pulmonary disease 33 | 239
nasopharyngeal carcinoma 33 | 1,058
oligodendroglioma 33 | 2,850
sarcoidosis 33 | 370
Cerebrovascular disease 32 | 238
astrocytoma 32 | 1,146
Arthritis, Rheumatoid 31 | 174
Autosomal recessive predisposition 31 | 1,442
Bipolar Disorder 30 | 666
Hypertensive disease 30 | 292
Malaria 30 | 160
astrocytic glioma 30 | 2,597
hepatocellular carcinoma 30 | 547
Human immunodeficiency virus infectious disease 29 | 138
Liver disease 29 | 237
Breast Neoplasms 28 | 445
Heart disease 28 | 306
Mammary Neoplasms 28 | 425
Fever 27 | 138
Multiple myeloma 27 | 1,332
pediatric high grade glioma 27 | 1,064
Pick disease 26 | 1,894
Prostatic Neoplasms 26 | 495
active ulcerative colitis 26 | 764
pancreatic carcinoma 26 | 562
primary pancreatic ductal adenocarcinoma 26 | 1,109
Alzheimer's disease 25 | 658
Mental Depression 25 | 333
Crohn's disease 24 | 321
Diarrhea 24 | 253
acute myeloid leukemia 24 | 783

Tissue

Blood and immune system 361 | 16,909
Digestive Tract 361 | 17,369
Endocrine System 359 | 18,159
Female tissues 358 | 17,400
Skin and soft tissues 358 | 17,230
Liver and Pancreas 354 | 16,750
Urinary Tract 351 | 16,678
Respiratory system 348 | 16,393
Male tissues 346 | 17,142
Nervous System 335 | 16,725
Cardiovascular System 315 | 15,192

Target Family

Non-IDG 219 | 12,091
Enzyme 50 | 4,145
GPCR 46 | 408
Kinase 31 | 634
Transcription Factor 18 | 1,400
Epigenetic 3 | 242
Ion Channel 3 | 344
Transporter 2 | 473
Nuclear Receptor 1 | 48

GO Process

inflammatory response 373 | 373
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Poly [ADP-ribose] polymerase 4 PARP4 Tchem Enzyme -1.45503 26.0 123
Tumor necrosis factor receptor superfamily member 11A TNFRSF11A Tbio Non-IDG -3.26478 1689.0 464
TIR domain-containing adapter molecule 2 TICAM2 Tbio Non-IDG -1.18212 14.6 258
Histone deacetylase 9 HDAC9 Tclin Epigenetic -2.27309 185.2 431
Stabilin-1 STAB1 Tbio Non-IDG -1.61013 45.4 107
Junctional adhesion molecule A F11R Tbio Non-IDG -2.56739 380.0 394
Zinc finger protein 580 ZNF580 Tbio Transcription Factor -1.04597 11.4 74
C-C motif chemokine 3-like 1 CCL3L1 Tbio Non-IDG -1.80717 51.3 142
Pentraxin-related protein PTX3 PTX3 Tbio Non-IDG -0.80888 8.68 307
NACHT, LRR and PYD domains-containing protein 2 NLRP2 Tbio Non-IDG -1.82146 68.5 245