Development Level

Tchem 4 | 1,598
Tbio 3 | 11,445

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal behavior 1 | 298
decreased grip strength 1 | 116
hypoactivity 1 | 132
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19

Disease

Carcinoma 6 | 11,493
lung cancer 4 | 4,740
osteosarcoma 4 | 7,950
Cancer 3 | 2,499
Kidney cancer 3 | 2,613
glioblastoma 3 | 5,792
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
medulloblastoma, large-cell 3 | 6,241
ovarian cancer 3 | 8,520
Breast cancer 2 | 3,578
Colonic Neoplasms 2 | 142
Intellectual disability 2 | 1,016
atypical teratoid / rhabdoid tumor 2 | 5,112
ependymoma 2 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
juvenile dermatomyositis 2 | 1,187
malignant mesothelioma 2 | 3,232
non-small cell lung cancer 2 | 2,890
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
primary pancreatic ductal adenocarcinoma 2 | 1,109
primitive neuroectodermal tumor 2 | 3,035
psoriasis 2 | 6,694
spina bifida 2 | 1,074
tuberculosis 2 | 2,010
Aggressive behavior 1 | 75
Aggressive reaction 1 | 75
Alzheimer's disease 1 | 658
Autism spectrum disorder 1 | 101
Autistic Disorder 1 | 364
Azoospermia 1 | 110
Babinski Reflex 1 | 100
Big calvaria 1 | 147
Brachydactyly 1 | 156
Carcinoma, Non-Small-Cell Lung 1 | 107
Carcinoma, Renal Cell 1 | 124
Class III malocclusion 1 | 78
Congenital clubfoot 1 | 109
Decreased projection of maxilla 1 | 66
Deficiency of upper jaw bones 1 | 66
Delayed speech and language development 1 | 112
Disease Progression 1 | 136
Enophthalmos 1 | 75
Epilepsy 1 | 792
High, narrow palate 1 | 32
Hyperopia 1 | 70
Hyperplasia 1 | 27
Hyperreflexia 1 | 209
Hypertrophy of lower jaw 1 | 78
Hypoplasia of the maxilla 1 | 66
Hypoplastic feet 1 | 66
Hypotrophic maxilla 1 | 66
Increased head circumference 1 | 147
Increased size of cranium 1 | 147
Increased size of mandible 1 | 78
Increased size of skull 1 | 147
Language Delay 1 | 112
Large auricle 1 | 87
Large dysplastic ears 1 | 87
Large intestine cancer 1 | 126
Large pinnae 1 | 87
Large prominent ears 1 | 87
Large protruding ears 1 | 87
Large, floppy ears 1 | 87
Lower limb atrophy 1 | 8
Lower limb muscle hypotrophy 1 | 8
Macrotia 1 | 87
Mandibular hyperplasia 1 | 78
Maxillary retrognathia 1 | 66
Muscle Spasticity 1 | 195
Muscle atrophy, lower limb, distal 1 | 8
Myopia 1 | 176
Neoplasm Invasiveness 1 | 161
Pectus excavatum 1 | 100
Physical aggression 1 | 76
Renal Cell Carcinoma 1 | 214
Retrusion of upper jaw bones 1 | 66
Seizures 1 | 596
Severe mental retardation (I.Q. 20-34) 1 | 99
Smooth philtrum 1 | 43
Speech Delay 1 | 112
Speech impairment 1 | 112
Sunken eyes 1 | 63
Systemic lupus erythematosus 1 | 194
Thin upper lip vermilion 1 | 67
Upward slant of palpebral fissure 1 | 75
Waldenstrons macroglobulinemia 1 | 765
X- linked recessive 1 | 110
acute quadriplegic myopathy 1 | 1,158
adrenocortical carcinoma 1 | 1,428
astrocytoma 1 | 1,146
atypical teratoid/rhabdoid tumor 1 | 357
cystic fibrosis 1 | 1,696
hepatocellular carcinoma 1 | 547
hereditary spastic paraplegia 1 | 318
mandibular excess (physical finding) 1 | 78
non-small cell lung carcinoma 1 | 317
pediatric high grade glioma 1 | 1,064

Tissue

Blood and immune system 7 | 16,909
Cardiovascular System 7 | 15,192
Digestive Tract 7 | 17,369
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Male tissues 7 | 17,142
Nervous System 7 | 16,725
Respiratory system 7 | 16,393
Skin and soft tissues 7 | 17,230
Urinary Tract 7 | 16,678

Target Family

TF/Epigenetic 4 | 38
Epigenetic 3 | 242

GO Process

histone H3-K4 demethylation 7 | 7
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lysine-specific demethylase 5C KDM5C Tchem TF/Epigenetic -1.94004 86.4 135
Lysine-specific histone demethylase 1B KDM1B Tbio Epigenetic -1.45110 27.6 106
Lysine-specific demethylase 5D KDM5D Tbio TF/Epigenetic -2.38009 240.2 32
Ribosomal oxygenase 1 RIOX1 Tbio Epigenetic 0.00000 67
Lysine-specific demethylase 5B KDM5B Tchem TF/Epigenetic -2.20655 168.1 252
Lysine-specific demethylase 5A KDM5A Tchem TF/Epigenetic -1.79331 64.4 149
Lysine-specific histone demethylase 1A KDM1A Tchem Epigenetic -2.68692 516.3 473