Development Level

Tbio 11 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

decreased heart left ventricle... 2 | 28
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal forebrain development 1 | 20
abnormal heart looping 1 | 5
abnormal heart morphology 1 | 162
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pharyngeal arch morph... 1 | 8
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
female infertility 1 | 60
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
male infertility 1 | 123
preweaning lethality, complete... 1 | 979
thin ventricular wall 1 | 24

Disease

Carcinoma 8 | 11,493
ovarian cancer 8 | 8,520
atypical teratoid / rhabdoid tumor 7 | 5,112
osteosarcoma 7 | 7,950
glioblastoma 6 | 5,792
medulloblastoma, large-cell 6 | 6,241
Cancer 5 | 2,499
ependymoma 5 | 4,679
lung cancer 5 | 4,740
psoriasis 5 | 6,694
adult high grade glioma 4 | 3,801
Astrocytoma, Pilocytic 3 | 3,081
Cryptorchidism 3 | 296
Kidney cancer 3 | 2,613
Multiple myeloma 3 | 1,332
Muscle hypotonia 3 | 571
Short stature 3 | 531
astrocytic glioma 3 | 2,597
group 3 medulloblastoma 3 | 4,104
group 4 medulloblastoma 3 | 1,855
oligodendroglioma 3 | 2,850
subependymal giant cell astrocytoma 3 | 2,287
Acquired metabolic disease 2 | 336
Aggressive behavior 2 | 75
Aggressive reaction 2 | 75
Autosomal recessive predisposition 2 | 1,442
Big calvaria 2 | 147
Bilateral fifth finger clinodactyly 2 | 110
Blepharophimosis 2 | 70
Breast cancer 2 | 3,578
Cachexia 2 | 50
Cataract 2 | 297
Cockayne syndrome 2 | 60
Curvature of little finger 2 | 110
Dental abnormalities 2 | 60
Dull intelligence 2 | 645
Epilepsy 2 | 792
Hypogonadism 2 | 173
Inadequate arch length for tooth size 2 | 45
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of skull 2 | 147
Intellectual disability 2 | 1,016
Lens Opacities 2 | 231
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental deficiency 2 | 645
Penile hypospadias 2 | 106
Physical aggression 2 | 76
Pick disease 2 | 1,894
Poor school performance 2 | 645
Rheumatoid arthritis 2 | 1,191
Schizophrenia 2 | 1,160
Seizures 2 | 596
Sensorineural Hearing Loss (disorder) 2 | 284
Sloping shoulders 2 | 21
Strabismus 2 | 270
Tooth Abnormalities 2 | 69
Tooth Crowding 2 | 45
Tooth mass arch size discrepancy 2 | 45
Tooth size discrepancy 2 | 45
Xeroderma pigmentosum 2 | 43
invasive ductal carcinoma 2 | 2,951
malignant mesothelioma 2 | 3,232
pediatric high grade glioma 2 | 1,064
primary pancreatic ductal adenocarcinoma 2 | 1,109
primitive neuroectodermal tumor 2 | 3,035
spina bifida 2 | 1,074
tuberculosis 2 | 2,010
Abnormal hair pattern 1 | 1
Abnormality of earlobe 1 | 5
Angle class 2 malocclusion 1 | 57
Angle class 3 malocclusion 1 | 57
Ataxia telangiectasia 1 | 34
Bowen-Conradi syndrome 1 | 16
Bushy eyebrows 1 | 49
Coloboma of optic disc 1 | 9
Conjunctivitis 1 | 53
Conjunctivitis, recurrent 1 | 37
Conjunctivochalasis 1 | 6
Full lower lip 1 | 64
Fundus coloboma 1 | 18
Gynecomastia 1 | 64
Joint laxity 1 | 54
Linear atrophy 1 | 15
MENTAL RETARDATION, X-LINKED, SYNDROMIC, CABEZAS TYPE 1 | 1
MENTAL RETARDATION, X-LINKED, WITH SHORT STATURE, HYPOGONADISM, AND ABNORMAL GAIT 1 | 1
Mild Mental Retardation 1 | 70
Mulibrey nanism 1 | 13
Neuronal ceroid lipofuscinosis 1 1 | 15
Obesity, Abdominal 1 | 24
Overfolded helix 1 | 24
Relative macrocephaly 1 | 12
Sandal gap 1 | 24
Scheuermann's disease 1 | 11
Short hands 1 | 50
Small hand 1 | 36
Spider Veins 1 | 17
Syndromic X-linked mental retardation, Cabezas type 1 | 1
Xeroderma pigmentosum group E 1 | 3

Tissue

Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678

Target Family

Non-IDG 6 | 12,091
Enzyme 5 | 4,145
Epigenetic 1 | 242

GO Process

histone H2A monoubiquitination 12 | 12
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Polycomb group RING finger protein 1 PCGF1 Tbio Non-IDG -0.99091 11.4 101
E3 ubiquitin-protein ligase TRIM37 TRIM37 Tbio Enzyme -3.25892 1754.8 177
Lysine-specific demethylase 2B KDM2B Tchem Epigenetic -1.56328 41.7 248
BCL-6 corepressor BCOR Tbio Non-IDG -2.04681 115.7 157
DNA damage-binding protein 1 DDB1 Tbio Non-IDG -2.34719 202.5 353
Cullin-4B CUL4B Tbio Non-IDG -1.68710 54.9 251
S-phase kinase-associated protein 1 SKP1 Tbio Enzyme -2.57150 310.1 381
E3 ubiquitin-protein ligase RNF168 RNF168 Tbio Enzyme -1.53836 33.4 166
E3 ubiquitin-protein ligase RING1 RING1 Tbio Enzyme -2.28368 171.8 475
E3 ubiquitin-protein ligase RING2 RNF2 Tbio Enzyme -2.04525 115.7 332