Development Level

Tbio 16 | 11,445

IMPC Phenotype

abnormal eye morphology 1 | 68
abnormal snout morphology 1 | 23
abnormal tail movements 1 | 12
curly tail 1 | 1
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased blood urea nitrogen ... 1 | 48
kinked tail 1 | 2
mammalian phenotype 1 | 17
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 13 | 11,493
osteosarcoma 9 | 7,950
psoriasis 8 | 6,694
lung carcinoma 7 | 2,843
ovarian cancer 7 | 8,520
Astrocytoma, Pilocytic 5 | 3,081
ependymoma 5 | 4,679
glioblastoma 5 | 5,792
malignant mesothelioma 5 | 3,232
Autosomal recessive predisposition 4 | 1,442
Exostosis 4 | 15
Intellectual disability 4 | 1,016
adult high grade glioma 4 | 3,801
atypical teratoid / rhabdoid tumor 4 | 5,112
medulloblastoma, large-cell 4 | 6,241
Brachycephaly 3 | 88
Broad cranium shape 3 | 88
Hyperopia 3 | 70
Kidney cancer 3 | 2,613
Radioulnar synostosis 3 | 35
Short stature 3 | 531
Wide skull shape 3 | 88
astrocytic glioma 3 | 2,597
cystic fibrosis 3 | 1,696
group 3 medulloblastoma 3 | 4,104
group 4 medulloblastoma 3 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung cancer 3 | 4,740
oligodendroglioma 3 | 2,850
pituitary cancer 3 | 1,972
subependymal giant cell astrocytoma 3 | 2,287
Abnormality of the humerus 2 | 6
Abnormality of the metaphyses 2 | 48
Abnormality of the tibia 2 | 9
Acquired scoliosis 2 | 281
Amblyopia 2 | 38
Anteverted nostril 2 | 191
Aseptic Necrosis of Bone 2 | 8
Aseptic necrosis 2 | 8
Bone infarction 2 | 8
Bone necrosis 2 | 9
Bone pain 2 | 42
Breast cancer 2 | 3,578
Bushy eyebrows 2 | 49
Cervical myelopathy 2 | 6
Chondrosarcoma 2 | 21
Cognitive delay 2 | 608
Congenital clubfoot 2 | 109
Cranial nerve palsies 2 | 11
Craniofacial Abnormalities 2 | 151
Curvature of spine 2 | 282
Dental abnormalities 2 | 60
Downward slant of palpebral fissure 2 | 158
Dull intelligence 2 | 645
Eastern equine encephalitis 2 | 16
Ehlers-Danlos syndrome 2 | 43
Failure to gain weight 2 | 365
Foramen Ovale, Patent 2 | 10
Frontal bossing 2 | 157
Global developmental delay 2 | 608
Hereditary multiple exostoses 2 | 3
Hip joint varus deformity - observation 2 | 24
Hydrocephalus 2 | 152
Juvenile astrocytoma 2 | 3
Knee joint valgus deformity 2 | 56
Low intelligence 2 | 645
Madelung Deformity 2 | 5
Maffucci syndrome 2 | 6
Mast cell neoplasm 2 | 8
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Micromelia 2 | 58
Muscle Weakness 2 | 170
Muscle hypotonia 2 | 571
Ollier disease 2 | 18
Orbital separation excessive 2 | 244
Pediatric failure to thrive 2 | 365
Pelvic exostoses 2 | 3
Peripheral nerve compression 2 | 2
Poor school performance 2 | 645
Poor speech 2 | 37
Problems speaking 2 | 37
Prominent ear 2 | 56
Protruding ears 2 | 56
Pseudoxanthoma elasticum 2 | 18
Rib exostoses 2 | 2
Scapular exostoses 2 | 2
Short metacarpal 2 | 43
Short ulnae 2 | 24
Tooth Abnormalities 2 | 69
ULNAR HYPOPLASIA 2 | 24
astrocytoma 2 | 1,146
gastric carcinoma 2 | 807
hepatocellular carcinoma 2 | 547
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
invasive ductal carcinoma 2 | 2,951
pancreatic cancer 2 | 2,398
tuberculosis 2 | 2,010

Tissue

Blood and immune system 16 | 16,909
Digestive Tract 16 | 17,369
Endocrine System 16 | 18,159
Female tissues 16 | 17,400
Liver and Pancreas 16 | 16,750
Male tissues 16 | 17,142
Nervous System 16 | 16,725
Urinary Tract 16 | 16,678
Skin and soft tissues 15 | 17,230
Cardiovascular System 14 | 15,192
Respiratory system 14 | 16,393

Target Family

Enzyme 15 | 4,145
Non-IDG 1 | 12,091

GO Process

heparan sulfate proteoglycan b... 16 | 16
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dermatan-sulfate epimerase DSE Tbio Enzyme -2.57112 360.0 44
Xylosyltransferase 1 XYLT1 Tbio Enzyme -2.10436 129.4 88
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 NDST3 Tbio Enzyme -0.66930 5.78 111
Exostosin-like 3 EXTL3 Tbio Enzyme -2.69110 483.9 208
D-glucuronyl C5-epimerase GLCE Tbio Enzyme -1.19848 19.9 34
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 NDST1 Tbio Enzyme -1.91878 84.7 146
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 NDST2 Tbio Enzyme -1.23427 17.2 74
Exostosin-like 2 EXTL2 Tbio Enzyme -1.08858 13.8 124
Xylosyltransferase 2 XYLT2 Tbio Enzyme -2.61071 412.3 78
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 NDST4 Tbio Enzyme -0.92585 7.84 90