Development Level

Tbio 12 | 11,445

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal embryo size 1 | 220
abnormal skin morphology 1 | 50
abnormal tooth morphology 1 | 24
decreased circulating sodium l... 1 | 22
embryonic lethality prior to t... 1 | 278
prenatal lethality prior to he... 1 | 87

Disease

Autosomal recessive predisposition 11 | 1,442
Carcinoma 11 | 11,493
Epidermolysis bullosa 11 | 21
Atrophic scar 10 | 18
Dystrophia unguium 10 | 53
non-small cell lung cancer 10 | 2,890
Breast cancer 9 | 3,578
Milium Cyst 9 | 16
Nail dysplasia 9 | 52
Dental Enamel Hypoplasia 8 | 43
Prenatal onset 8 | 139
breast carcinoma 8 | 1,638
lung cancer 8 | 4,740
malignant mesothelioma 8 | 3,232
pancreatic cancer 8 | 2,398
ANONYCHIA 7 | 20
Abnormal blistering of the skin 7 | 54
Anemia 7 | 365
Aplasia Cutis Congenita 7 | 14
Blister of skin 7 | 54
Congenital scar 7 | 13
Defective enamel matrix 7 | 35
Dental caries 7 | 164
Dysplasia of tooth enamel 7 | 35
Hemoglobin low 7 | 124
Kidney cancer 7 | 2,613
Oral mucosal blistering 7 | 10
Rotting teeth 7 | 73
Skin bulla 7 | 54
Thin dental enamel 7 | 35
esophageal adenocarcinoma 7 | 737
osteosarcoma 7 | 7,950
Abnormal pigmentation 6 | 25
Cancer 6 | 2,499
Death in early childhood 6 | 82
Death in infancy 6 | 82
Fragile nails 6 | 16
Junctional split 6 | 6
Plantar hyperkeratosis 6 | 7
Scarring alopecia of scalp 6 | 13
ependymoma 6 | 4,679
glioblastoma 6 | 5,792
lung carcinoma 6 | 2,843
Adult junctional epidermolysis bullosa (disorder) 5 | 5
Dehydration 5 | 40
Epidermolysis Bullosa, Junctional, Non-Herlitz Type 5 | 5
Failure to gain weight 5 | 365
Flexion contracture of proximal interphalangeal joint 5 | 75
Hypodontia 5 | 81
Junctional epidermolysis bullosa 5 | 7
Palmar hyperhidrosis 5 | 5
Pediatric failure to thrive 5 | 365
Skin Erosion 5 | 12
Sparse body hair 5 | 32
interstitial cystitis 5 | 2,312
lung adenocarcinoma 5 | 2,716
ovarian cancer 5 | 8,520
psoriasis 5 | 6,694
Bullous pemphigoid 4 | 18
Epidermolysis Bullosa, Junctional 4 | 4
Epidermolysis bullosa simplex 4 | 9
Feeding difficulties 4 | 127
Recurrent skin infections 4 | 21
ductal carcinoma in situ 4 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
invasive ductal carcinoma 4 | 2,951
medulloblastoma, large-cell 4 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Age related macular degeneration 1 3 | 4
Arthrogryposis 3 | 54
Axillary pterygia 3 | 6
Barrett's esophagus 3 | 182
Dyspnea 3 | 76
Ecchymosis 3 | 66
Esophageal Stenosis 3 | 15
Esophageal atresia 3 | 43
Growth delay 3 | 114
Growth failure 3 | 114
Growth retardation 3 | 115
Hoarseness 3 | 31
Hydronephrosis 3 | 89
Hyperhidrosis disorder 3 | 81
Increased sweating 3 | 81
Increased tendency to bruise 3 | 66
Laryngismus 3 | 3
Laryngostenosis 3 | 10
Onychogryposis 3 | 13
Palmoplantar keratosis 3 | 74
Paronychia Inflammation 3 | 9
Polyhydramnios 3 | 108
Poor growth 3 | 114
Pyloric Stenosis 3 | 47
RENAL ADYSPLASIA 3 | 25
Renal dysplasia 3 | 28
Sweating 3 | 81
Urethral Stricture 3 | 18
Very poor growth 3 | 114
cystic fibrosis 3 | 1,696
nasopharyngeal carcinoma 3 | 1,058

Tissue

Blood and immune system 12 | 16,909
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678
Liver and Pancreas 11 | 16,750
Cardiovascular System 10 | 15,192

Target Family

Non-IDG 12 | 12,091

GO Process

hemidesmosome assembly 12 | 12
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Collagen alpha-1(XVII) chain COL17A1 Tbio Non-IDG -2.75473 576.3 123
CD151 antigen CD151 Tbio Non-IDG -2.40013 244.5 420
Laminin subunit gamma-1 LAMC1 Tbio Non-IDG -1.79184 56.7 318
Keratin, type I cytoskeletal 14 KRT14 Tbio Non-IDG -2.90790 721.6 780
Keratin, type II cytoskeletal 5 KRT5 Tbio Non-IDG -2.87489 691.1 885
Dystonin DST Tbio Non-IDG -2.73231 506.0 127
Plectin PLEC Tbio Non-IDG -2.50749 337.2 130
Integrin beta-4 ITGB4 Tbio Non-IDG -2.26591 177.4 704
Laminin subunit gamma-2 LAMC2 Tbio Non-IDG -2.09168 112.5 175
Laminin subunit beta-3 LAMB3 Tbio Non-IDG -2.07156 116.4 170