Development Level

Tbio 107 | 11,445
Tchem 34 | 1,598
Tclin 14 | 613
Tdark 9 | 6,588

Collection

Kinase: IDG Consortium (Target... 3 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 16 | 979
preweaning lethality, incomple... 5 | 499
abnormal embryo size 4 | 220
increased startle reflex 4 | 112
decreased body weight 3 | 161
embryonic lethality prior to t... 3 | 278
abnormal behavior 2 | 298
abnormal eye morphology 2 | 68
abnormal lens morphology 2 | 81
abnormal neural tube closure 2 | 46
cataract 2 | 92
decreased circulating total pr... 2 | 49
decreased lean body mass 2 | 135
embryonic growth retardation 2 | 106
improved glucose tolerance 2 | 79
increased heart weight 2 | 62
increased mean corpuscular hem... 2 | 96
limb grasping 2 | 41
pallor 2 | 34
prenatal lethality 2 | 28
abnormal allantois morphology 1 | 8
abnormal body wall morphology 1 | 9
abnormal coat-hair pigmentatio... 1 | 64
abnormal facial morphology 1 | 17
abnormal gait 1 | 69
abnormal heart morphology 1 | 162
abnormal humerus morphology 1 | 11
abnormal incisor color 1 | 3
abnormal limb bud morphology 1 | 17
abnormal limb morphology 1 | 13
abnormal neural tube morpholog... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal tail morphology 1 | 25
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
cleft palate 1 | 8
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating phosphat... 1 | 27
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
exencephaly 1 | 2
female infertility 1 | 60
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating glycerol... 1 | 9
increased fasted circulating g... 1 | 76
increased heart left ventricle... 1 | 4
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
lordosis 1 | 1
pale yolk sac 1 | 25
short tibia 1 | 97
small testis 1 | 58
thick ventricular wall 1 | 7
vertebral fusion 1 | 23
vertebral transformation 1 | 12

Disease

Carcinoma 121 | 11,493
ovarian cancer 101 | 8,520
osteosarcoma 87 | 7,950
medulloblastoma, large-cell 72 | 6,241
glioblastoma 70 | 5,792
ependymoma 69 | 4,679
lung cancer 69 | 4,740
psoriasis 65 | 6,694
Cancer 63 | 2,499
atypical teratoid / rhabdoid tumor 61 | 5,112
Breast cancer 57 | 3,578
malignant mesothelioma 49 | 3,232
adult high grade glioma 46 | 3,801
invasive ductal carcinoma 45 | 2,951
Kidney cancer 44 | 2,613
lung carcinoma 41 | 2,843
oligodendroglioma 41 | 2,850
primitive neuroectodermal tumor 41 | 3,035
group 3 medulloblastoma 40 | 4,104
non-small cell lung cancer 39 | 2,890
pancreatic cancer 39 | 2,398
Astrocytoma, Pilocytic 38 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 38 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,955
lung adenocarcinoma 37 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 36 | 2,989
interstitial cystitis 35 | 2,312
astrocytic glioma 34 | 2,597
diabetes mellitus 28 | 1,728
ductal carcinoma in situ 28 | 1,745
subependymal giant cell astrocytoma 27 | 2,287
ulcerative colitis 27 | 1,819
Autosomal recessive predisposition 26 | 1,442
Pick disease 26 | 1,894
breast carcinoma 26 | 1,638
cystic fibrosis 26 | 1,696
pituitary cancer 26 | 1,972
Heart disease 23 | 306
Intellectual disability 23 | 1,016
Schizophrenia 23 | 1,160
Short stature 23 | 531
astrocytoma 23 | 1,146
nasopharyngeal carcinoma 23 | 1,058
colon cancer 22 | 1,478
Hypertension 21 | 396
Hypertensive disease 21 | 292
Melanoma 21 | 711
Epilepsy 19 | 792
Seizures 19 | 596
gastric carcinoma 19 | 807
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
Dull intelligence 18 | 645
Low intelligence 18 | 645
Mental Retardation 18 | 645
Mental deficiency 18 | 645
Poor school performance 18 | 645
Liver cancer 17 | 604
Orbital separation excessive 17 | 244
group 4 medulloblastoma 17 | 1,855
juvenile dermatomyositis 17 | 1,187
spina bifida 17 | 1,074
Acquired scoliosis 16 | 281
Cognitive delay 16 | 608
Cryptorchidism 16 | 296
Curvature of spine 16 | 282
Global developmental delay 16 | 608
Hypoplastic mandible condyle 16 | 275
Liver Cirrhosis, Experimental 16 | 769
Mandibular hypoplasia 16 | 275
Mental and motor retardation 16 | 608
Micrognathism 16 | 275
Obesity 16 | 678
Ventricular Septal Defects 16 | 119
Cleft Palate 15 | 271
Congenital heart disease 15 | 93
Patent ductus arteriosus 15 | 90
Prostatic Neoplasms 15 | 495
acute quadriplegic myopathy 15 | 1,158
medulloblastoma 15 | 720
primary pancreatic ductal adenocarcinoma 15 | 1,109
Coronary artery disease 14 | 268
Depressive disorder 14 | 409
Muscle hypotonia 14 | 571
Rheumatoid arthritis 14 | 1,191
Skin cancer 14 | 469
adrenocortical carcinoma 14 | 1,428
dermatomyositis 14 | 966
Atopic dermatitis 13 | 952
Autistic Disorder 13 | 364
Bipolar Disorder 13 | 666
Craniofacial Abnormalities 13 | 151
Glaucoma 13 | 239
Lung Neoplasms 13 | 232
Small head 13 | 374
pediatric high grade glioma 13 | 1,064
tuberculosis 13 | 2,010
Cataract 12 | 297
Kidney disease 12 | 430
Major Depressive Disorder 12 | 301
Multiple myeloma 12 | 1,332

Tissue

Male tissues 163 | 17,142
Endocrine System 162 | 18,159
Female tissues 162 | 17,400
Digestive Tract 161 | 17,369
Skin and soft tissues 161 | 17,230
Liver and Pancreas 160 | 16,750
Nervous System 159 | 16,725
Urinary Tract 159 | 16,678
Blood and immune system 156 | 16,909
Respiratory system 156 | 16,393
Cardiovascular System 151 | 15,192

Target Family

Non-IDG 76 | 12,091
Transcription Factor 32 | 1,400
Enzyme 23 | 4,145
Kinase 18 | 634
Epigenetic 4 | 242
GPCR 4 | 408
Ion Channel 4 | 344
Nuclear Receptor 3 | 48

GO Process

heart development 164 | 164
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Methyl-CpG-binding domain protein 3 MBD3 Tbio Transcription Factor -0.85800 7.92 309
Histone deacetylase 9 HDAC9 Tclin Epigenetic -2.27309 185.2 431
Guanine nucleotide-binding protein subunit alpha-11 GNA11 Tbio Non-IDG -2.80484 555.1 184
Putative segment polarity protein dishevelled homolog DVL1P1 DVL1P1 Tdark Non-IDG -2.11561 188.4 0
Plakophilin-2 PKP2 Tbio Non-IDG -2.10355 135.3 243
Forkhead box protein C2 FOXC2 Tbio Transcription Factor -2.23435 187.0 419
Intraflagellar transport protein 25 homolog HSPB11 Tbio Non-IDG -1.40552 26.1 61
Nuclear factor of activated T-cells, cytoplasmic 4 NFATC4 Tbio Transcription Factor -1.93766 88.3 358
Homeobox protein Nkx-3.1 NKX3-1 Tbio Transcription Factor -2.13442 140.5 524