Development Level

Tbio 3 | 11,651

IMPC Phenotype

preweaning lethality, complete... 2 | 979
decreased circulating alkaline... 1 | 46
decreased erythrocyte cell num... 1 | 62
increased basophil cell number 1 | 7
increased mean corpuscular hem... 1 | 96

Disease

Agenesis of corpus callosum 3 | 83
Aggressive behavior 3 | 75
Aggressive reaction 3 | 75
Autosomal recessive predisposition 3 | 1,442
Death in early childhood 3 | 82
Death in infancy 3 | 82
Dull intelligence 3 | 645
Encephalopathies 3 | 43
Epilepsy 3 | 792
Glycine encephalopathy 3 | 29
Glycinuria 3 | 10
HYPERGLYCINURIA (disorder) 3 | 12
Hiccup 3 | 3
Hyperactive behavior 3 | 91
Hyperglycinemia 3 | 6
Hyperglycinemia, Nonketotic 3 | 3
Hyperreflexia 3 | 209
Impulsive Behavior 3 | 9
Intellectual disability 3 | 1,016
Irritation - emotion 3 | 68
Lethargy 3 | 77
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Muscle hypotonia 3 | 571
Myoclonus 3 | 74
Nonketotic Hyperglycinemia 3 | 4
Physical aggression 3 | 76
Poor school performance 3 | 645
Recurrent singultus 3 | 3
Restlessness 3 | 14
Seizures 3 | 596
Breast cancer 2 | 3,578
alcohol-related neurodevelopmental disorder 2 | 13
pancreatic cancer 2 | 2,398
Astrocytoma, Pilocytic 1 | 3,081
Carcinoma 1 | 11,493
Crohn's disease 1 | 321
Desquamative interstitial pneumonia 1 | 4
Familial lipoprotein lipase deficiency 1 | 3
adrenocortical carcinoma 1 | 1,428
atypical teratoid/rhabdoid tumor 1 | 357
glioblastoma 1 | 5,792
group 3 medulloblastoma 1 | 4,104
interstitial cystitis 1 | 2,312
lung cancer 1 | 4,740
non-small cell lung cancer 1 | 2,890
oligodendroglioma 1 | 2,850
osteosarcoma 1 | 7,950
ovarian cancer 1 | 8,520
pancreatic carcinoma 1 | 562
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,962
pediatric high grade glioma 1 | 1,064
pituitary cancer 1 | 1,972
primary Sjogren syndrome 1 | 735
primary pancreatic ductal adenocarcinoma 1 | 1,109
psoriasis 1 | 6,694
ulcerative colitis 1 | 1,819

Tissue

Blood and immune system 3 | 16,909
Digestive Tract 3 | 17,369
Endocrine System 3 | 18,159
Female tissues 3 | 17,400
Liver and Pancreas 3 | 16,750
Male tissues 3 | 17,142
Nervous System 3 | 16,725
Respiratory system 3 | 16,393
Skin and soft tissues 3 | 17,230
Urinary Tract 3 | 16,678
Cardiovascular System 2 | 15,192

Target Family

Enzyme 2 | 4,145
Non-IDG 1 | 12,091

GO Process

glycine catabolic process 3 | 3
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glycine cleavage system H protein, mitochondrial GCSH Tbio Non-IDG -1.60484 37.2 148
Glycine dehydrogenase (decarboxylating), mitochondrial GLDC Tbio Enzyme -1.79392 65.7 131
Aminomethyltransferase, mitochondrial AMT Tbio Enzyme -2.19912 157.9 94