Development Level

Tbio 58 | 11,178
Tchem 24 | 1,885
Tclin 15 | 612
Tdark 1 | 6,569

Collection

GPCR: IDG Consortium (Targets) 2 | 126
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 9 | 979
abnormal behavior 6 | 298
abnormal gait 4 | 69
decreased prepulse inhibition 4 | 82
decreased vertical activity 4 | 208
increased circulating choleste... 4 | 66
limb grasping 4 | 41
abnormal bone structure 3 | 187
abnormal locomotor behavior 3 | 24
decreased bone mineral content 3 | 151
decreased bone mineral density 3 | 126
decreased circulating glucose ... 3 | 126
decreased startle reflex 3 | 75
embryonic lethality prior to t... 3 | 278
hyperactivity 3 | 148
impaired glucose tolerance 3 | 75
increased circulating HDL chol... 3 | 80
increased circulating alanine ... 3 | 13
increased total body fat amoun... 3 | 134
preweaning lethality, incomple... 3 | 499
short tibia 3 | 97
abnormal sleep behavior 2 | 70
decreased circulating alkaline... 2 | 46
decreased circulating chloride... 2 | 30
decreased fasted circulating g... 2 | 65
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
enlarged heart 2 | 210
impaired righting response 2 | 26
improved glucose tolerance 2 | 79
increased circulating aspartat... 2 | 15
increased circulating bilirubi... 2 | 16
increased circulating phosphat... 2 | 26
increased circulating serum al... 2 | 22
increased circulating triglyce... 2 | 42
increased fasted circulating g... 2 | 76
increased hemoglobin content 2 | 45
increased mean corpuscular vol... 2 | 92
increased mean platelet volume 2 | 45
increased monocyte cell number 2 | 63
increased startle reflex 2 | 112
tremors 2 | 39
abnormal coat appearance 1 | 31
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal heart morphology 1 | 162
abnormal lip morphology 1 | 2
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
decreased circulating HDL chol... 1 | 68
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased mean platelet volume 1 | 25
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic lethality prior to o... 1 | 239
enlarged spleen 1 | 41
hydrometra 1 | 53
hypoactivity 1 | 132
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased lactate dehydrogenas... 1 | 3
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased prepulse inhibition 1 | 32
increased red blood cell distr... 1 | 34
increased total retina thickne... 1 | 4
prenatal lethality prior to he... 1 | 87
shortened RR interval 1 | 17
small adrenal glands 1 | 16
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
small thymus 1 | 16
trunk curl 1 | 16

Disease

Carcinoma 69 | 11,192
psoriasis 45 | 6,514
diabetes mellitus 43 | 1,683
osteosarcoma 37 | 7,766
ovarian cancer 37 | 8,297
glioblastoma 35 | 5,635
Obesity 32 | 655
medulloblastoma, large-cell 32 | 6,086
Cancer 30 | 2,388
atypical teratoid / rhabdoid tumor 30 | 4,971
lung cancer 30 | 4,607
invasive ductal carcinoma 28 | 2,867
Breast cancer 27 | 3,469
adult high grade glioma 26 | 3,701
breast carcinoma 25 | 1,589
Hyperglycemia 24 | 134
ductal carcinoma in situ 24 | 1,686
ependymoma 23 | 4,559
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,204
malignant mesothelioma 22 | 3,135
Autosomal recessive predisposition 19 | 1,407
Diabetes Mellitus, Non-Insulin-Dependent 19 | 140
pituitary cancer 19 | 1,915
Astrocytoma, Pilocytic 18 | 3,006
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,902
Diabetes Mellitus, Type 2 17 | 136
Kidney cancer 17 | 2,548
group 3 medulloblastoma 17 | 4,002
lung adenocarcinoma 17 | 2,627
lung carcinoma 17 | 2,755
non-small cell lung cancer 17 | 2,799
pancreatic cancer 17 | 2,322
Fatty liver disease 16 | 102
Hyperinsulinism 16 | 128
Hypertension 16 | 372
Hypoglycemia 16 | 146
Seizures 16 | 584
interstitial cystitis 16 | 2,237
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,872
oligodendroglioma 16 | 2,768
Bipolar Disorder 15 | 646
Diabetes Mellitus, Experimental 15 | 101
Epilepsy 14 | 775
Hypertensive disease 14 | 278
Polycystic ovary syndrome 14 | 348
Prostatic Neoplasms 14 | 472
Schizophrenia 14 | 1,136
astrocytic glioma 14 | 2,530
fibroadenoma 14 | 538
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,911
Depressive disorder 13 | 401
Diabetes Mellitus, Noninsulin-Dependent 13 | 31
Liver Cirrhosis, Experimental 13 | 733
Mental Depression 13 | 325
Type 2 diabetes mellitus 13 | 268
group 4 medulloblastoma 13 | 1,806
ulcerative colitis 13 | 1,765
Alzheimer's disease 12 | 640
Intellectual disability 12 | 998
Lipid metabolism disorder 12 | 111
Liver carcinoma 12 | 229
Osteoporosis 12 | 348
non primary Sjogren syndrome sicca 12 | 861
primitive neuroectodermal tumor 12 | 2,957
Atopic dermatitis 11 | 915
Carcinoma, Hepatocellular 11 | 217
Cardiomegaly 11 | 114
Insulin Resistance 11 | 70
Short stature 11 | 514
adrenocortical carcinoma 11 | 1,385
juvenile dermatomyositis 11 | 1,147
Acquired metabolic disease 10 | 329
Adenoma 10 | 159
Asthma 10 | 370
Cognitive delay 10 | 596
Dull intelligence 10 | 634
Global developmental delay 10 | 596
Heart disease 10 | 288
Heart failure 10 | 157
Kidney disease 10 | 411
Low intelligence 10 | 634
Mental Retardation 10 | 634
Mental and motor retardation 10 | 596
Mental deficiency 10 | 634
Multiple myeloma 10 | 1,296
Poor school performance 10 | 634
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 492
Blepharoptosis 9 | 229
Breast Neoplasms 9 | 423
Cerebrovascular disease 9 | 223
Coronary artery disease 9 | 253
Hepatomegaly 9 | 280
Mammary Neoplasms 9 | 403
Multiple Sclerosis 9 | 527
Parkinson's disease 9 | 378
acute quadriplegic myopathy 9 | 1,133
aldosterone-producing adenoma 9 | 646
primary pancreatic ductal adenocarcinoma 9 | 1,071
subependymal giant cell astrocytoma 9 | 2,230
tuberculosis 9 | 1,963

Tissue

Endocrine System 96 | 18,159
Digestive Tract 95 | 17,369
Liver and Pancreas 93 | 16,750
Skin and soft tissues 91 | 17,230
Urinary Tract 91 | 16,678
Female tissues 90 | 17,400
Male tissues 88 | 17,142
Blood and immune system 87 | 16,909
Nervous System 87 | 16,725
Respiratory system 83 | 16,393
Cardiovascular System 81 | 15,192

Target Family

Non-IDG 33 | 12,091
Enzyme 17 | 4,145
Transcription Factor 15 | 1,400
Kinase 11 | 634
GPCR 10 | 408
Transporter 4 | 473
Ion Channel 3 | 344
Nuclear Receptor 3 | 48
Epigenetic 2 | 242

GO Process

glucose homeostasis 98 | 98
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Insulin receptor INSR Tclin Kinase -2.50045 306.8 1417
Cytochrome b5 reductase 4 CYB5R4 Tbio Enzyme -1.15554 17.5 107
Acyl-coenzyme A synthetase ACSM2A, mitochondrial ACSM2A Tbio Enzyme -2.11752 121.7 60
Hepatocyte nuclear factor 3-alpha FOXA1 Tbio Transcription Factor -2.41829 249.1 744
Glucose-6-phosphate isomerase GPI Tbio Enzyme -2.87105 706.1 447
Glycogen phosphorylase, liver form PYGL Tchem Enzyme -2.00371 98.2 170
Hepatocyte nuclear factor 1-alpha HNF1A Tbio Transcription Factor -2.87439 680.9 0
Glucose-6-phosphatase 2 G6PC2 Tbio Enzyme -1.88404 87.7 44
Alpha-2A adrenergic receptor ADRA2A Tclin GPCR -2.42160 261.4 232
Mitochondrial sodium/calcium exchanger protein SLC8B1 Tbio Transporter -1.53269 33.9 58