Development Level

Tbio 27 | 11,178
Tchem 4 | 1,885
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal heart morphology 1 | 162
abnormal retina morphology 1 | 71
abnormal retinal inner nuclear... 1 | 8
abnormal seminal vesicle morph... 1 | 114
decreased KLRG1+ CD4 alpha bet... 1 | 5
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
increased anti-nuclear antigen... 1 | 19
increased circulating potassiu... 1 | 29
increased mean corpuscular hem... 1 | 36

Disease

ovarian cancer 22 | 8,297
Carcinoma 16 | 11,192
Cockayne syndrome 16 | 59
Cancer 15 | 2,388
osteosarcoma 15 | 7,766
Xeroderma pigmentosum 13 | 42
lung cancer 12 | 4,607
Photosensitive trichothiodystrophy 10 | 30
medulloblastoma, large-cell 9 | 6,086
psoriasis 9 | 6,514
Hypogonadism 8 | 169
Melanoma 8 | 689
Autosomal recessive predisposition 7 | 1,407
Cataract 7 | 290
Cryptorchidism 7 | 287
Electroencephalogram abnormal 7 | 100
Lens Opacities 7 | 227
Photosensitivity of skin 7 | 51
Sensorineural Hearing Loss (disorder) 7 | 281
ependymoma 7 | 4,559
glioblastoma 7 | 5,635
Arthralgia 6 | 85
Atrophic condition of skin 6 | 24
Basal cell carcinoma 6 | 54
Breast cancer 6 | 3,469
Conjunctival telangiectasis 6 | 14
Dental abnormalities 6 | 57
Developmental regression 6 | 94
Dry skin 6 | 74
Erythema 6 | 57
Failure to gain weight 6 | 359
Fatigue 6 | 176
Fever 6 | 136
Flushing 6 | 59
Freckles 6 | 33
Hyperkeratosis 6 | 50
Hyperpigmented macules 6 | 41
Impaired cognition 6 | 95
Intellectual disability 6 | 998
Keratitis 6 | 60
Loss of developmental milestones 6 | 94
Mental deterioration in childhood 6 | 94
Mental impairment 6 | 95
Neurodevelopmental regression 6 | 94
Optic Atrophy 6 | 239
Papilloma 6 | 44
Pediatric failure to thrive 6 | 359
Poikiloderma 6 | 14
Progressive mental retardation 6 | 37
Psychomotor regression 6 | 94
Psychomotor regression beginning in infancy 6 | 94
Psychomotor regression in infants 6 | 94
Psychomotor regression, progressive 6 | 94
Strabismus 6 | 265
Telangiectasia of the skin 6 | 38
Thin skin 6 | 44
Tooth Abnormalities 6 | 66
Xerosis 6 | 74
atypical teratoid / rhabdoid tumor 6 | 4,971
hypopigmented skin patch 6 | 59
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,204
Basal cell nevi 5 | 23
Defective DNA repair after ultraviolet radiation damage 5 | 7
Dull intelligence 5 | 634
Low intelligence 5 | 634
Mental Retardation 5 | 634
Mental deficiency 5 | 634
Multiple myeloma 5 | 1,296
Poor school performance 5 | 634
Short stature 5 | 514
Small head 5 | 366
Squamous cell carcinoma of skin 5 | 10
Waldenstrons macroglobulinemia 5 | 742
Xeroderma pigmentosum group B 5 | 20
Xeroderma pigmentosum group D 5 | 32
group 3 medulloblastoma 5 | 4,002
Cachexia 4 | 50
Cerebellar Ataxia 4 | 302
Conjunctivitis 4 | 51
Conjunctivitis, recurrent 4 | 35
Ectropion 4 | 36
Entropion 4 | 22
Epilepsy 4 | 775
Hypoplastic mandible condyle 4 | 273
Mandibular hypoplasia 4 | 273
Micrognathism 4 | 273
Muscle Spasticity 4 | 192
Photodysphoria 4 | 117
Photophobia 4 | 117
Pick disease 4 | 1,856
Seizures 4 | 584
Spider Veins 4 | 17
Telangiectasis 4 | 35
Xeroderma pigmentosum group G 4 | 16
acute myeloid leukemia 4 | 760
astrocytic glioma 4 | 2,530
malignant mesothelioma 4 | 3,135
pituitary cancer 4 | 1,915
Prostatic Neoplasms 3 | 472
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,902

Tissue

Blood and immune system 32 | 16,909
Cardiovascular System 32 | 15,192
Digestive Tract 32 | 17,369
Endocrine System 32 | 18,159
Female tissues 32 | 17,400
Liver and Pancreas 32 | 16,750
Male tissues 32 | 17,142
Nervous System 32 | 16,725
Respiratory system 32 | 16,393
Skin and soft tissues 32 | 17,230
Urinary Tract 32 | 16,678

Target Family

Non-IDG 24 | 12,091
Enzyme 8 | 4,145

GO Process

global genome nucleotide-excis... 32 | 32
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA damage-binding protein 1 DDB1 Tchem Non-IDG -2.34719 202.5 353
TFIIH basal transcription factor complex helicase XPD subunit ERCC2 Tbio Enzyme -2.58326 365.8 191
Ubiquitin carboxyl-terminal hydrolase 45 USP45 Tbio Enzyme -1.29557 18.7 115
General transcription factor IIH subunit 2 GTF2H2 Tbio Non-IDG -1.32757 20.2 148
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
Ubiquitin-conjugating enzyme E2 N UBE2N Tchem Non-IDG -2.08846 107.8 268
General transcription factor IIH subunit 1 GTF2H1 Tbio Non-IDG -1.65323 46.0 231