Development Level

Tbio 41 | 11,445
Tchem 5 | 1,598
Tclin 3 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal embryo size 3 | 220
increased lean body mass 3 | 172
increased total body fat amoun... 3 | 134
decreased body weight 2 | 161
decreased circulating glucose ... 2 | 126
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased circulating calcium ... 2 | 34
increased circulating total pr... 2 | 28
increased heart weight 2 | 62
pallor 2 | 34
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal hindbrain development 1 | 16
abnormal limb bud morphology 1 | 17
abnormal locomotor behavior 1 | 24
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal placenta development 1 | 1
abnormal placenta morphology 1 | 5
abnormal placenta size 1 | 20
abnormal response to tactile s... 1 | 17
abnormal skin coloration 1 | 25
abnormal startle reflex 1 | 15
abnormal vibrissa morphology 1 | 25
decreased IgM level 1 | 1
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating chloride... 1 | 30
decreased circulating fructosa... 1 | 30
decreased circulating glycerol... 1 | 16
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased fasted circulating g... 1 | 65
decreased large unstained cell... 1 | 11
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lymphocyte cell numb... 1 | 32
limb grasping 1 | 41
prenatal lethality 1 | 28
short tibia 1 | 97
small kidney 1 | 16
small superior vagus ganglion 1 | 74

Disease

Carcinoma 26 | 11,493
psoriasis 23 | 6,694
ovarian cancer 22 | 8,520
lung cancer 17 | 4,740
Autosomal recessive predisposition 16 | 1,442
Obesity 16 | 678
osteosarcoma 15 | 7,950
glioblastoma 13 | 5,792
invasive ductal carcinoma 12 | 2,951
subependymal giant cell astrocytoma 11 | 2,287
diabetes mellitus 10 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
medulloblastoma, large-cell 10 | 6,241
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Multiple myeloma 9 | 1,332
Muscle hypotonia 9 | 571
astrocytic glioma 9 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
malignant mesothelioma 9 | 3,232
Kidney cancer 8 | 2,613
atypical teratoid / rhabdoid tumor 8 | 5,112
breast carcinoma 8 | 1,638
ependymoma 8 | 4,679
group 3 medulloblastoma 8 | 4,104
Breast cancer 7 | 3,578
Epilepsy 7 | 792
Liver Cirrhosis, Experimental 7 | 769
Seizures 7 | 596
astrocytoma 7 | 1,146
colon cancer 7 | 1,478
ductal carcinoma in situ 7 | 1,745
lung adenocarcinoma 7 | 2,716
oligodendroglioma 7 | 2,850
Astrocytoma, Pilocytic 6 | 3,081
Bipolar Disorder 6 | 666
Cancer 6 | 2,499
Glycogen storage disease 6 | 39
Neuropathy 6 | 261
Schizophrenia 6 | 1,160
adult high grade glioma 6 | 3,801
Cognitive delay 5 | 608
Failure to gain weight 5 | 365
Global developmental delay 5 | 608
Heart failure 5 | 162
Hepatomegaly 5 | 285
Hypoglycemia 5 | 152
Mental and motor retardation 5 | 608
Pediatric failure to thrive 5 | 365
Pick disease 5 | 1,894
acute quadriplegic myopathy 5 | 1,158
lung carcinoma 5 | 2,843
Cardiomyopathies 4 | 110
Diabetes Mellitus, Non-Insulin-Dependent 4 | 145
Diabetes Mellitus, Type 2 4 | 142
Hyperglycemia 4 | 137
Hypertension 4 | 396
Hypertensive disease 4 | 292
Infantile onset 4 | 238
Liver Dysfunction 4 | 99
Melanoma 4 | 711
Motor delay 4 | 147
Muscle Weakness 4 | 170
Neurogenic Muscular Atrophy 4 | 139
Neurogenic muscle atrophy, especially in the lower limbs 4 | 139
No development of motor milestones 4 | 147
Short stature 4 | 531
Skeletal muscle atrophy 4 | 139
Weight decreased 4 | 103
dermatomyositis 4 | 966
fibroadenoma 4 | 559
muscle degeneration 4 | 139
non-small cell lung cancer 4 | 2,890
pituitary cancer 4 | 1,972
Acidosis, Lactic 3 | 97
Anemia 3 | 365
Carcinoma, Hepatocellular 3 | 228
Cerebrovascular disease 3 | 238
Cushing's syndrome 3 | 48
Depressive disorder 3 | 409
Hepatic enzyme increased 3 | 81
Impaired exercise tolerance 3 | 42
Kidney disease 3 | 430
Lactic acidemia 3 | 95
Liver Cirrhosis 3 | 181
Liver carcinoma 3 | 240
Liver enzymes abnormal 3 | 81
Liver function tests abnormal finding 3 | 81
Major Depressive Disorder 3 | 301
Mental Depression 3 | 333
Mood Disorders 3 | 184
Myopathy 3 | 185
Neurodegenerative disease 3 | 414
Strabismus 3 | 270
Transaminases increased 3 | 81
Type 2 diabetes mellitus 3 | 272
adrenocortical carcinoma 3 | 1,428
aldosterone-producing adenoma 3 | 665
cystic fibrosis 3 | 1,696
tuberculosis 3 | 2,010

Tissue

Endocrine System 51 | 18,159
Digestive Tract 50 | 17,369
Liver and Pancreas 50 | 16,750
Skin and soft tissues 50 | 17,230
Urinary Tract 50 | 16,678
Blood and immune system 49 | 16,909
Female tissues 48 | 17,400
Nervous System 47 | 16,725
Male tissues 46 | 17,142
Cardiovascular System 45 | 15,192
Respiratory system 45 | 16,393

Target Family

Enzyme 28 | 4,145
Non-IDG 9 | 12,091
GPCR 5 | 408
Kinase 4 | 634
Transcription Factor 3 | 1,400
Nuclear Receptor 1 | 48
Transporter 1 | 473

GO Process

generation of precursor metabo... 51 | 51
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein phosphatase inhibitor 2 PPP1R2 Tbio Enzyme -1.20523 26.2 259
Aconitate hydratase, mitochondrial ACO2 Tbio Enzyme -2.21106 157.2 307
Phosphorylase b kinase regulatory subunit alpha, liver isoform PHKA2 Tbio Kinase -2.21111 153.2 59
Xylulose kinase XYLB Tbio Kinase -1.97293 93.1 74
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform PHKA1 Tbio Kinase -1.17814 14.3 71
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.07841 114.8 103
Cytochrome c oxidase subunit 7A1, mitochondrial COX7A1 Tbio Enzyme -1.32763 20.5 70
Beta-3 adrenergic receptor ADRB3 Tclin GPCR -2.73090 568.4 254
Neurosecretory protein VGF VGF Tbio Non-IDG -2.12346 150.7 212
CCAAT/enhancer-binding protein alpha CEBPA Tbio Transcription Factor -2.94393 846.3 518