Development Level

Tbio 28 | 11,445
Tdark 4 | 6,588
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to o... 5 | 239
abnormal embryo size 3 | 220
abnormal embryo turning 2 | 31
decreased grip strength 2 | 116
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal snout morphology 1 | 23
abnormal vitreous body morphol... 1 | 10
aorta dilation 1 | 3
cataract 1 | 92
corneal opacity 1 | 32
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating insulin ... 1 | 76
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased prepulse inhibition 1 | 82
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
improved glucose tolerance 1 | 79
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating total pr... 1 | 28
increased grip strength 1 | 41
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
thin ventricular wall 1 | 24
vertebral transformation 1 | 12

Disease

osteosarcoma 22 | 7,950
ovarian cancer 18 | 8,520
group 3 medulloblastoma 14 | 4,104
Carcinoma 12 | 11,493
lung cancer 10 | 4,740
medulloblastoma, large-cell 9 | 6,241
psoriasis 9 | 6,694
glioblastoma 7 | 5,792
Multiple myeloma 6 | 1,332
astrocytic glioma 6 | 2,597
atypical teratoid / rhabdoid tumor 6 | 5,112
oligodendroglioma 6 | 2,850
Autosomal recessive predisposition 5 | 1,442
Waldenstrons macroglobulinemia 5 | 765
acute myeloid leukemia 5 | 783
ependymoma 5 | 4,679
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
malignant mesothelioma 5 | 3,232
pancreatic cancer 5 | 2,398
primitive neuroectodermal tumor 5 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,291
Breast cancer 3 | 3,578
Cognitive delay 3 | 608
Failure to gain weight 3 | 365
Global developmental delay 3 | 608
Mental and motor retardation 3 | 608
Pediatric failure to thrive 3 | 365
Rheumatoid arthritis 3 | 1,191
acute quadriplegic myopathy 3 | 1,158
diabetes mellitus 3 | 1,728
invasive ductal carcinoma 3 | 2,951
lung adenocarcinoma 3 | 2,716
Afro-textured hair 2 | 13
Biopsy shows villous atrophy 2 | 16
Brachydactyly 2 | 156
Brittle hair 2 | 25
Bulging forehead 2 | 66
Cerebral atrophy 2 | 178
Clastothrix 2 | 4
Diarrhea 2 | 253
Duodenal villous atrophy 2 | 16
Feeding difficulties 2 | 127
Fetal Growth Retardation 2 | 189
Fractured hair 2 | 25
Fragile hair 2 | 25
Hepatomegaly 2 | 285
Infant, Small for Gestational Age 2 | 176
Intellectual disability 2 | 1,016
Intrauterine retardation 2 | 176
Kidney cancer 2 | 2,613
Kinky hair texture 2 | 13
Liver Cirrhosis 2 | 181
Low Birth Weights 2 | 69
Low set ears 2 | 181
Microstomia 2 | 78
Nappy hair texture 2 | 13
Neurodegenerative disease 2 | 414
Orbital separation excessive 2 | 244
Polycystic ovary syndrome 2 | 360
Polyhydramnios 2 | 108
Pontocerebellar Hypoplasia Type 1 2 | 5
Pontocerebellar hypoplasia 2 | 36
Prenatal onset 2 | 139
Prominent forehead 2 | 66
Reduced tensile strength of hair 2 | 25
Small for gestational age (disorder) 2 | 69
Small intestine biopsy shows villous atrophy 2 | 16
Sparse hair 2 | 59
Spinal muscular atrophy 2 | 34
Thin, sparse hair 2 | 59
Trichohepatoenteric Syndrome 2 | 2
Trichohepatoenteric syndrome 1 2 | 2
Variable degree of villous atrophy 2 | 16
Villous atrophy 2 | 16
Villous atrophy of intestine 2 | 16
Wide nose 2 | 35
Wooly hair 2 | 17
X-linked cerebral adrenoleukodystrophy 2 | 116
aldosterone-producing adenoma 2 | 665
astrocytoma 2 | 1,146
atypical teratoid/rhabdoid tumor 2 | 357
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
dermatomyositis 2 | 966
non-small cell lung cancer 2 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pediatric high grade glioma 2 | 1,064
primary pancreatic ductal adenocarcinoma 2 | 1,109
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 2,010
Candidiasis 1 | 55
Cataract 7 1 | 32
Degenerative brain disorder 1 | 100
Downward slant of palpebral fissure 1 | 158
Muscle Weakness 1 | 170
Respiratory Failure 1 | 104
Supratentorial atrophy 1 | 94
sarcoidosis 1 | 370

Tissue

Blood and immune system 33 | 16,909
Cardiovascular System 33 | 15,192
Digestive Tract 33 | 17,369
Endocrine System 33 | 18,159
Female tissues 33 | 17,400
Liver and Pancreas 33 | 16,750
Male tissues 33 | 17,142
Nervous System 33 | 16,725
Respiratory system 33 | 16,393
Skin and soft tissues 33 | 17,230
Urinary Tract 33 | 16,678

Target Family

Non-IDG 21 | 12,091
Enzyme 12 | 4,145

GO Process

exonucleolytic nuclear-transcr... 33 | 33
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
CCR4-NOT transcription complex subunit 8 CNOT8 Tbio Non-IDG -2.83783 687.5 209
m7GpppX diphosphatase DCPS Tbio Enzyme -2.57336 366.1 161
HBS1-like protein HBS1L Tbio Non-IDG -2.55785 357.2 263
Tetratricopeptide repeat protein 37 TTC37 Tbio Non-IDG -2.28365 188.3 15
Enhancer of mRNA-decapping protein 4 EDC4 Tbio Non-IDG -2.26552 178.5 97
U6 snRNA-associated Sm-like protein LSm4 LSM4 Tbio Non-IDG -2.13782 132.0 149
Exosome complex component CSL4 EXOSC1 Tbio Non-IDG -2.07438 110.2 129
U6 snRNA-associated Sm-like protein LSm1 LSM1 Tbio Non-IDG -2.01162 106.0 191
m7GpppN-mRNA hydrolase DCP2 Tbio Enzyme -1.94580 87.7 161
Exosome complex component RRP41 EXOSC4 Tbio Enzyme -1.96200 85.3 113