Development Level

Tbio 6 | 10,625
Tchem 4 | 1,890
Tclin 1 | 602

IMPC Term

abnormal behavior 1 | 226
abnormal behavioral response t... 1 | 52
abnormal lens morphology 1 | 73
abnormal motor coordination/ b... 1 | 4
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal sleep behavior 1 | 63
decreased circulating glucose ... 1 | 121
decreased exploration in new e... 1 | 9
hyperactivity 1 | 108
impaired righting response 1 | 19
increased circulating alkaline... 1 | 119
increased circulating potassiu... 1 | 31
increased circulating total pr... 1 | 20

Disease

malignant mesothelioma 5 | 3,163
psoriasis 5 | 6,685
ovarian cancer 4 | 8,492
Congenital adrenal hyperplasia 3 | 74
Infertility 3 | 163
Polycystic Ovary Syndrome 3 | 335
Prostatic Neoplasms 3 | 471
cystic fibrosis 3 | 1,670
medulloblastoma, large-cell 3 | 6,234
Anovulation 2 | 20
Breast cancer 2 | 3,099
Endometriosis 2 | 535
Hyperandrogenism 2 | 32
Hypogonadism 2 | 70
Luteoma 2 | 4
Multiple myeloma 2 | 1,328
Pseudohermaphroditism 2 | 16
Testicular Leydig cell tumor 2 | 2
atypical teratoid / rhabdoid tumor 2 | 4,369
glioblastoma 2 | 5,572
lung adenocarcinoma 2 | 2,714
non-small cell lung cancer 2 | 2,798
osteosarcoma 2 | 7,933
Acne vulgaris 1 | 16
Adenocarcinoma 1 | 115
Adrenal carcinoma 1 | 4
Adrenal hyperplasia 1 1 | 1
Adrenal rest tumor 1 | 5
Age related macular degeneration 1 | 84
Alzheimer's disease 1 | 644
Amenorrhea 1 | 60
Antley-Bixler syndrome 1 | 15
Aromatase excess syndrome 1 | 2
Autistic Disorder 1 | 320
Barrett's esophagus 1 | 185
Bone Resorption 1 | 7
Carcinoma of female breast 1 | 20
Chemotherapy-induced nausea and vomiting 1 | 18
Cholesterol Ester Storage Disease 1 | 6
Congenital adrenal insufficiency 1 | 7
Contraception 1 | 15
Cushing's syndrome 1 | 47
Duchenne muscular dystrophy 1 | 602
Endometrial Neoplasms 1 | 50
Endometrial cancer 1 | 32
Esophageal Neoplasms 1 | 67
Fatty Liver 1 | 48
Female infertility 1 | 28
Fibrosis 1 | 40
Gestational Diabetes 1 | 17
Gynecomastia 1 | 13
Hormone receptor positive malignant neoplasm of breast 1 | 10
Hypopituitarism 1 | 36
Hypospadias 1 | 65
Klinefelter's syndrome 1 | 59
Leydig cell tumor 1 | 9
Lipoid congenital adrenal hyperplasia 1 | 2
Male infertility 1 | 170
Mammary Neoplasms 1 | 410
Myopia 1 | 99
Neuroblastoma 1 | 78
Osteoporosis 1 | 259
Ovarian Diseases 1 | 2
Ovarian dysfunction 1 | 19
Peripheral Neuropathy 1 | 303
Polycystic kidney disease 1 | 54
Premature ovarian failure 1 | 64
Prevention of Post-Operative Nausea and Vomiting 1 | 14
Prevention of Radiation-Induced Nausea and Vomiting 1 | 7
Primary pigmented nodular adrenocortical disease 1 | 13
Prostate cancer 1 | 172
Refractive error 1 | 43
Secondary malignant neoplasm of female breast 1 | 3
Spontaneous abortion 1 | 108
Waldenstrons macroglobulinemia 1 | 765
active Crohn's disease 1 | 918
acute myeloid leukemia 1 | 785
adrenocortical adenoma 1 | 134
adrenocortical carcinoma 1 | 1,427
adult high grade glioma 1 | 2,148
atypical teratoid/rhabdoid tumor 1 | 1,095
breast carcinoma 1 | 1,614
dermatomyositis 1 | 967
ependymoma 1 | 2,514
esophageal adenocarcinoma 1 | 737
estrogen-receptor positive breast cancer 1 | 7
fibroadenoma 1 | 557
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,988
medulloblastoma 1 | 1,524
nasopharyngeal carcinoma 1 | 1,056
oligodendroglioma 1 | 2,849
pancreatic cancer 1 | 2,300
pediatric high grade glioma 1 | 2,712
pilocytic astrocytoma 1 | 3,086
primary pancreatic ductal adenocarcinoma 1 | 1,271
sonic hedgehog group medulloblastoma 1 | 1,482
subependymal giant cell astrocytoma 1 | 2,287
substance-related disorder 1 | 105
tuberculosis 1 | 1,563

Tissue

Cardiovascular System 11 | 17,958
Digestive Tract 11 | 18,473
Endocrine System 11 | 18,512
Female tissues 11 | 18,647
Liver and Pancreas 11 | 18,136
Male tissues 11 | 17,969
Nervous System 11 | 18,561
Skin and soft tissues 11 | 18,115
Urinary Tract 11 | 18,444
Blood and immune system 10 | 17,995
Respiratory system 10 | 17,484

Target Family

Enzyme 10 | 4,146
Non-IDG 1 | 11,969

GO Process

estrogen biosynthetic process 11 | 11
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Estradiol 17-beta-dehydrogenase 1 HSD17B1 Tchem Enzyme -2.33011 205.7 174
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 HSD3B1 Tchem Enzyme -2.58913 345.2 223
Steroidogenic acute regulatory protein, mitochondrial STAR Tbio Non-IDG -2.82212 708.8 168
Aldo-keto reductase family 1 member B15 AKR1B15 Tbio Enzyme -0.24304 2.10 4
Very-long-chain 3-oxoacyl-CoA reductase HSD17B12 Tbio Enzyme -1.52833 31.9 103
Estradiol 17-beta-dehydrogenase 11 HSD17B11 Tbio Enzyme -0.96979 10.8 116
Retinol dehydrogenase 8 RDH8 Tbio Enzyme -1.03001 12.5 0
Estradiol 17-beta-dehydrogenase 8 HSD17B8 Tbio Enzyme -1.52642 45.1 97
Aromatase CYP19A1 Tclin Enzyme -3.36046 2296.5 412
17-beta-hydroxysteroid dehydrogenase 14 HSD17B14 Tchem Enzyme -0.74683 5.28 68