Development Level

Tbio 17 | 11,651
Tchem 2 | 1,388
Tclin 1 | 612

IMPC Phenotype

abnormal behavioral response t... 1 | 66
abnormal coat appearance 1 | 31
abnormal locomotor activation 1 | 16
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
decreased IgE level 1 | 6
decreased blood urea nitrogen ... 1 | 51
decreased circulating alkaline... 1 | 46
decreased circulating triglyce... 1 | 79
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
hypoactivity 1 | 132
increased circulating calcium ... 1 | 34
increased circulating glucose ... 1 | 24
increased lean body mass 1 | 172
mammalian phenotype 1 | 17
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 15 | 11,493
psoriasis 14 | 6,694
Breast cancer 11 | 3,578
ovarian cancer 9 | 8,520
pancreatic cancer 9 | 2,398
Cancer 8 | 2,499
interstitial cystitis 8 | 2,312
non-small cell lung cancer 8 | 2,890
ductal carcinoma in situ 7 | 1,745
lung cancer 7 | 4,740
osteosarcoma 7 | 7,950
Atopic dermatitis 6 | 952
Ichthyoses 6 | 41
Kidney cancer 6 | 2,613
adult high grade glioma 6 | 3,801
esophageal adenocarcinoma 6 | 737
invasive ductal carcinoma 6 | 2,951
Congenital ichthyosiform erythroderma 5 | 28
Ichthyosis 5 | 56
Palmoplantar keratosis 5 | 74
atypical teratoid / rhabdoid tumor 5 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
medulloblastoma, large-cell 5 | 6,241
spina bifida 5 | 1,074
Alopecia 4 | 115
Carcinoma, Squamous Cell 4 | 110
Dry skin 4 | 75
Eczema 4 | 45
Hypotrichosis 4 | 47
Melanoma 4 | 711
Schizophrenia 4 | 1,160
Skin cancer 4 | 469
Squamous cell carcinoma 4 | 129
Xerosis 4 | 75
breast carcinoma 4 | 1,638
cystic fibrosis 4 | 1,696
ependymoma 4 | 4,679
glioblastoma 4 | 5,792
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
lung adenocarcinoma 4 | 2,716
lung carcinoma 4 | 2,843
malignant mesothelioma 4 | 3,232
periodontitis 4 | 293
pituitary cancer 4 | 1,972
Anhidrosis 3 | 23
Astrocytoma, Pilocytic 3 | 3,081
Autosomal recessive predisposition 3 | 1,442
Breast Neoplasms 3 | 445
Congenital Nonbullous Ichthyosiform Erythroderma 3 | 16
Congenital deafness 3 | 185
Congenital non-bullous ichthyosiform erythroderma 3 | 7
Corneal erosion 3 | 16
DOID:2627 3 | 94
Deafness 3 | 198
Dystrophia unguium 3 | 53
Endometrial cancer 3 | 311
Epidermolytic hyperkeratosis 3 | 14
Exfoliative dermatitis 3 | 24
Hearing Loss, Partial 3 | 185
Hyperkeratosis 3 | 50
Hypohidrosis 3 | 34
Ichthyosis, Lamellar 3 | 4
Keratitis 3 | 62
Large intestine cancer 3 | 126
Mammary Neoplasms 3 | 425
Nail Diseases 3 | 24
Nail abnormality 3 | 22
Sparse hair 3 | 59
Thin, sparse hair 3 | 59
astrocytic glioma 3 | 2,597
hearing impairment 3 | 199
nasopharyngeal carcinoma 3 | 1,058
oligodendroglioma 3 | 2,850
ulcerative colitis 3 | 1,819
Abnormal blistering of the skin 2 | 54
Absence of eyebrows 2 | 31
Adenocarcinoma of lung 2 | 142
Aplasia/Hypoplasia of the eyebrow 2 | 31
Autosomal recessive congenital ichthyosis 2 | 11
Blister of skin 2 | 54
Colorectal Neoplasms 2 | 243
Dental caries 2 | 164
Esophageal Neoplasms 2 | 69
Hair shaft abnormalities 2 | 30
Hyperhidrosis disorder 2 | 81
Hypodontia 2 | 81
Ichthyosis vulgaris 2 | 11
Increased sweating 2 | 81
Liver cancer 2 | 604
Lung Neoplasms 2 | 232
Neoplasm Metastasis 2 | 168
Ovarian Neoplasms 2 | 102
Pruritus 2 | 58
Skin bulla 2 | 54
Sparse or absent eyebrows 2 | 31
Sparse/absent eyebrows 2 | 31
Sweating 2 | 81
hair abnormalities (non-specific) 2 | 30
non-small cell lung carcinoma 2 | 317
ovarian neoplasm 2 | 99

Tissue

Digestive Tract 20 | 17,369
Endocrine System 20 | 18,159
Female tissues 20 | 17,400
Skin and soft tissues 20 | 17,230
Blood and immune system 19 | 16,909
Male tissues 18 | 17,142
Nervous System 18 | 16,725
Urinary Tract 18 | 16,678
Liver and Pancreas 17 | 16,750
Cardiovascular System 14 | 15,192
Respiratory system 14 | 16,393

Target Family

Non-IDG 12 | 12,091
Enzyme 3 | 4,145
Transcription Factor 3 | 1,400
Kinase 1 | 634
Transporter 1 | 473

GO Process

establishment of skin barrier 20 | 20
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Filaggrin FLG Tbio Non-IDG -3.03594 1055.2 253
14-3-3 protein sigma SFN Tbio Non-IDG -2.56638 391.2 550
Stathmin STMN1 Tbio Non-IDG -2.90296 824.2 1052
Transmembrane protein 79 TMEM79 Tbio Non-IDG -2.00064 98.9 62
Hydroperoxide isomerase ALOXE3 ALOXE3 Tbio Enzyme -1.51120 32.2 118
Tumor protein 63 TP63 Tbio Transcription Factor -3.07398 1154.1 448
Hepatocyte growth factor receptor MET Tclin Kinase -3.32232 2013.7 1982
Arachidonate 12-lipoxygenase, 12R-type ALOX12B Tbio Enzyme -1.33994 24.1 71
Claudin-4 CLDN4 Tbio Non-IDG -2.57691 369.5 428
Keratinocyte differentiation factor 1 KDF1 Tbio Non-IDG -0.26977 2.27 78