Development Level

Tchem 15 | 1,598
Tbio 14 | 11,445

Collection

Kinase: IDG Consortium (Comple... 5 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal embryo size 2 | 220
embryonic lethality prior to t... 2 | 278
preweaning lethality, incomple... 2 | 499
abnormal QT variability 1 | 10
abnormal bone structure 1 | 187
abnormal retina morphology 1 | 71
absent startle reflex 1 | 24
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating alkaline... 1 | 46
decreased circulating free fat... 1 | 31
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased neutrophil cell numb... 1 | 42
embryonic lethality prior to o... 1 | 239
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating aspartat... 1 | 15
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
limb grasping 1 | 41
male infertility 1 | 123

Disease

Carcinoma 27 | 11,493
ovarian cancer 16 | 8,520
medulloblastoma, large-cell 15 | 6,241
atypical teratoid / rhabdoid tumor 14 | 5,112
osteosarcoma 14 | 7,950
Breast cancer 13 | 3,578
glioblastoma 13 | 5,792
Kidney cancer 12 | 2,613
ependymoma 12 | 4,679
non-small cell lung cancer 12 | 2,890
Cancer 11 | 2,499
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
malignant mesothelioma 11 | 3,232
oligodendroglioma 10 | 2,850
psoriasis 10 | 6,694
adult high grade glioma 9 | 3,801
group 3 medulloblastoma 9 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
primitive neuroectodermal tumor 9 | 3,035
pancreatic cancer 8 | 2,398
spina bifida 8 | 1,074
Astrocytoma, Pilocytic 7 | 3,081
Pick disease 7 | 1,894
Schizophrenia 7 | 1,160
astrocytic glioma 7 | 2,597
interstitial cystitis 7 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
lung adenocarcinoma 7 | 2,716
lung cancer 7 | 4,740
breast carcinoma 6 | 1,638
invasive ductal carcinoma 6 | 2,951
pituitary cancer 6 | 1,972
subependymal giant cell astrocytoma 6 | 2,287
Alzheimer's disease 5 | 658
ductal carcinoma in situ 5 | 1,745
group 4 medulloblastoma 5 | 1,855
tuberculosis 5 | 2,010
Bipolar Disorder 4 | 666
Rheumatoid arthritis 4 | 1,191
colon cancer 4 | 1,478
lung carcinoma 4 | 2,843
pediatric high grade glioma 4 | 1,064
primary pancreatic ductal adenocarcinoma 4 | 1,109
Parkinson's disease 3 | 392
Short stature 3 | 531
Ulnar polydactyly of fingers 3 | 47
cystic fibrosis 3 | 1,696
diabetes mellitus 3 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
progressive supranuclear palsy 3 | 676
Asthma 2 | 385
Autosomal recessive predisposition 2 | 1,442
BILIARY TRACT ABNORMALITY 2 | 16
Biliary Tract Diseases 2 | 16
Breast Neoplasms 2 | 445
Carcinoma, Hepatocellular 2 | 228
Carcinoma, Squamous Cell 2 | 110
Chronic Lymphocytic Leukemia 2 | 262
Cognitive delay 2 | 608
Dull intelligence 2 | 645
Fetal Growth Retardation 2 | 189
Global developmental delay 2 | 608
Hypertensive disease 2 | 292
Hypoplastic feet 2 | 66
Infant, Small for Gestational Age 2 | 176
Intellectual disability 2 | 1,016
Intrauterine retardation 2 | 176
Kidney Failure 2 | 111
Left Ventricular Hypertrophy 2 | 47
Liver carcinoma 2 | 240
Low intelligence 2 | 645
Mammary Neoplasms 2 | 425
Mental Depression 2 | 333
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Microcephaly 2 | 166
Neoplasm Invasiveness 2 | 161
Obesity 2 | 678
Orofacial cleft 2 | 54
Osteoporosis 2 | 363
Polydactyly 2 | 107
Polydactyly of toes 2 | 12
Poor school performance 2 | 645
Psychotic Disorders 2 | 151
Renal Insufficiency 2 | 90
Renal failure in adulthood 2 | 76
Squamous cell carcinoma 2 | 129
Strabismus 2 | 270
Syndactyly of the toes 2 | 45
cutaneous lupus erythematosus 2 | 1,057
gastric carcinoma 2 | 807
juvenile dermatomyositis 2 | 1,187
nasopharyngeal carcinoma 2 | 1,058
non primary Sjogren syndrome sicca 2 | 891
ulcerative colitis 2 | 1,819
Abnormal finger flexion creases 1 | 3
Chronic phase chronic myeloid leukemia 1 | 45
Iron deficiency anemia 1 | 12
Narrow palate 1 | 20

Tissue

Digestive Tract 29 | 17,369
Endocrine System 29 | 18,159
Female tissues 29 | 17,400
Liver and Pancreas 29 | 16,750
Male tissues 29 | 17,142
Nervous System 29 | 16,725
Respiratory system 29 | 16,393
Skin and soft tissues 29 | 17,230
Urinary Tract 29 | 16,678
Blood and immune system 28 | 16,909
Cardiovascular System 27 | 15,192

Target Family

Non-IDG 15 | 12,091
Kinase 13 | 634
Enzyme 1 | 4,145

GO Process

establishment of cell polarity 29 | 29
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase MARK2 MARK2 Tchem Kinase -2.49873 272.3 322
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
Ephrin type-B receptor 1 EPHB1 Tchem Kinase -1.70013 52.0 389
Serine/threonine-protein kinase BRSK2 BRSK2 Tchem Kinase -1.92813 85.3 187
Rho guanine nucleotide exchange factor 11 ARHGEF11 Tbio Non-IDG -1.61227 42.0 183
Protein KIBRA WWC1 Tbio Non-IDG -1.96854 92.8 130
Serine/threonine-protein kinase Nek3 NEK3 Tchem Kinase -0.96532 8.63 190
Polycystin-1 PKD1 Tbio Non-IDG -2.60276 379.9 123
Focal adhesion kinase 1 PTK2 Tchem Kinase -3.06733 1038.3 2013
Serine/threonine-protein kinase BRSK1 BRSK1 Tchem Kinase -1.44039 28.9 301