Development Level

Tbio 51 | 11,445
Tchem 24 | 1,598
Tclin 9 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 10 | 979
abnormal behavior 5 | 298
embryonic lethality prior to t... 4 | 278
preweaning lethality, incomple... 4 | 499
abnormal bone structure 2 | 187
abnormal coat-hair pigmentatio... 2 | 64
abnormal heart morphology 2 | 162
abnormal retina morphology 2 | 71
abnormal seminal vesicle morph... 2 | 114
abnormal skin morphology 2 | 50
cataract 2 | 92
decreased circulating fructosa... 2 | 30
decreased circulating serum al... 2 | 82
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
edema 2 | 59
embryonic lethality prior to o... 2 | 239
enlarged heart 2 | 210
enlarged kidney 2 | 14
hydrometra 2 | 53
hyperactivity 2 | 148
hypoactivity 2 | 132
impaired righting response 2 | 26
increased blood urea nitrogen ... 2 | 48
increased circulating alkaline... 2 | 122
increased circulating triglyce... 2 | 42
increased neutrophil cell numb... 2 | 46
increased spleen weight 2 | 10
pallor 2 | 34
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal cecum morphology 1 | 7
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal hair texture 1 | 4
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal maxilla morphology 1 | 17
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal tail morphology 1 | 25
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
anophthalmia 1 | 33
cyanosis 1 | 7
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating aspartat... 1 | 34
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating total pr... 1 | 49
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
enlarged adrenal glands 1 | 3
enlarged cecum 1 | 5
enlarged epididymis 1 | 31
enlarged uterus 1 | 11
fusion of vertebral arches 1 | 7
hemorrhage 1 | 23
impaired pupillary reflex 1 | 26
increased circulating calcium ... 1 | 34
increased circulating free fat... 1 | 20
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
irregularly shaped pupil 1 | 7
pale yolk sac 1 | 25
polycystic kidney 1 | 15
prolonged PR interval 1 | 15
respiratory system phenotype 1 | 2
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56
unresponsive to tactile stimul... 1 | 8
vertebral fusion 1 | 23

Disease

Carcinoma 61 | 11,493
ovarian cancer 56 | 8,520
glioblastoma 44 | 5,792
osteosarcoma 44 | 7,950
medulloblastoma, large-cell 40 | 6,241
psoriasis 40 | 6,694
Cancer 36 | 2,499
atypical teratoid / rhabdoid tumor 36 | 5,112
ependymoma 34 | 4,679
oligodendroglioma 32 | 2,850
Breast cancer 30 | 3,578
Kidney cancer 29 | 2,613
lung cancer 29 | 4,740
Astrocytoma, Pilocytic 28 | 3,081
astrocytic glioma 28 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,291
adult high grade glioma 24 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
malignant mesothelioma 23 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,989
pancreatic cancer 22 | 2,398
primitive neuroectodermal tumor 22 | 3,035
group 4 medulloblastoma 21 | 1,855
lung carcinoma 20 | 2,843
cystic fibrosis 18 | 1,696
group 3 medulloblastoma 18 | 4,104
Pick disease 17 | 1,894
subependymal giant cell astrocytoma 17 | 2,287
pituitary cancer 16 | 1,972
Blastic phase chronic myeloid leukemia 15 | 58
Chronic Myelocytic Leukemia Accelerated Phase 15 | 59
lung adenocarcinoma 15 | 2,716
non-small cell lung cancer 15 | 2,890
Chronic phase chronic myeloid leukemia 14 | 45
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 14 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 14 | 47
cutaneous lupus erythematosus 14 | 1,057
invasive ductal carcinoma 14 | 2,951
Alzheimer's disease 13 | 658
Schizophrenia 13 | 1,160
tuberculosis 13 | 2,010
astrocytoma 12 | 1,146
diabetes mellitus 12 | 1,728
primary pancreatic ductal adenocarcinoma 12 | 1,109
Intellectual disability 11 | 1,016
Waldenstrons macroglobulinemia 11 | 765
ductal carcinoma in situ 11 | 1,745
pediatric high grade glioma 11 | 1,064
Multiple myeloma 10 | 1,332
breast carcinoma 10 | 1,638
esophageal adenocarcinoma 10 | 737
interstitial cystitis 10 | 2,312
juvenile dermatomyositis 10 | 1,187
primary Sjogren syndrome 10 | 735
spina bifida 10 | 1,074
ulcerative colitis 10 | 1,819
Down syndrome 9 | 499
colon cancer 9 | 1,478
non primary Sjogren syndrome sicca 9 | 891
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Rheumatoid arthritis 8 | 1,191
Amyotrophic lateral sclerosis 7 | 451
Breast Neoplasms 7 | 445
Craniofrontonasal syndrome 7 | 13
Dull intelligence 7 | 645
Epilepsy 7 | 792
Heart disease 7 | 306
Hypertension 7 | 396
Low intelligence 7 | 645
Mammary Neoplasms 7 | 425
Mammary Neoplasms, Experimental 7 | 154
Melanoma 7 | 711
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Neoplasm Invasiveness 7 | 161
Poor school performance 7 | 645
adrenocortical carcinoma 7 | 1,428
aldosterone-producing adenoma 7 | 665
dermatomyositis 7 | 966
Alcoholic Intoxication, Chronic 6 | 289
Bipolar Disorder 6 | 666
Carcinoma, Hepatocellular 6 | 228
Carcinoma, Squamous Cell 6 | 110
Cell Transformation, Neoplastic 6 | 97
Duchenne muscular dystrophy 6 | 601
Kidney disease 6 | 430
Liver cancer 6 | 604
Liver carcinoma 6 | 240
Muscle hypotonia 6 | 571
Seizures 6 | 596
Short stature 6 | 531
Skin cancer 6 | 469
progressive supranuclear palsy 6 | 676
Animal Mammary Neoplasms 5 | 136
Atopic dermatitis 5 | 952
Mammary Neoplasms, Animal 5 | 136
Orbital separation excessive 5 | 244
Parkinson's disease 5 | 392
Proteinuria 5 | 144
mucosa-associated lymphoid tissue lymphoma 5 | 484

Tissue

Digestive Tract 84 | 17,369
Endocrine System 84 | 18,159
Liver and Pancreas 83 | 16,750
Nervous System 83 | 16,725
Skin and soft tissues 83 | 17,230
Blood and immune system 82 | 16,909
Female tissues 82 | 17,400
Male tissues 81 | 17,142
Respiratory system 80 | 16,393
Urinary Tract 80 | 16,678
Cardiovascular System 79 | 15,192

Target Family

Non-IDG 42 | 12,091
Kinase 25 | 634
Enzyme 15 | 4,145
Ion Channel 2 | 344

GO Process

ephrin receptor signaling path... 84 | 84
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Signal-induced proliferation-associated 1-like protein 1 SIPA1L1 Tbio Non-IDG -0.56258 5.05 40
ARF GTPase-activating protein GIT1 GIT1 Tbio Enzyme -1.84352 75.7 358
Ephrin type-B receptor 3 EPHB3 Tchem Kinase -1.68968 47.7 409
Ephrin type-A receptor 5 EPHA5 Tchem Kinase -2.28294 191.7 407
Ephrin type-B receptor 4 EPHB4 Tchem Kinase -2.26622 206.3 514
Ephrin type-B receptor 1 EPHB1 Tchem Kinase -1.70013 52.0 389
Ephrin-A2 EFNA2 Tbio Non-IDG -1.78296 60.7 253
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
Rho-associated protein kinase 1 ROCK1 Tclin Kinase -2.64622 378.2 461
Ephrin-A3 EFNA3 Tbio Non-IDG -1.53049 26.8 219