Development Level

Tbio 44 | 10,625
Tchem 30 | 1,890
Tclin 9 | 602
Tdark 1 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 4 | 633
abnormal behavior 3 | 226
decreased circulating fructosa... 3 | 31
abnormal bone structure 2 | 131
abnormal coat/hair pigmentatio... 2 | 54
decreased bone mineral content 2 | 157
decreased circulating serum al... 2 | 79
decreased lumbar vertebrae num... 2 | 62
decreased total body fat amoun... 2 | 186
impaired righting response 2 | 19
increased circulating alkaline... 2 | 119
increased lean body mass 2 | 107
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
increased sacral vertebrae num... 2 | 62
preweaning lethality, incomple... 2 | 260
abnormal behavioral response t... 1 | 52
abnormal epididymis morphology 1 | 31
abnormal femur morphology 1 | 14
abnormal hair texture 1 | 4
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal retina morphology 1 | 100
abnormal rib morphology 1 | 28
abnormal seminal vesicle morph... 1 | 47
abnormal skin morphology 1 | 23
abnormal spleen morphology 1 | 36
abnormal vocalization 1 | 21
absent pinna reflex 1 | 21
corneal opacity 1 | 25
decreased body weight 1 | 174
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating alanine ... 1 | 53
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased circulating total pr... 1 | 41
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
embryonic lethality prior to t... 1 | 187
enlarged adrenal glands 1 | 3
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged kidney 1 | 7
enlarged uterus 1 | 3
female infertility 1 | 34
fusion of vertebral arches 1 | 7
hydrometra 1 | 13
hydrops fetalis 1 | 22
hyperactivity 1 | 108
hypoactivity 1 | 89
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 68
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased red blood cell distr... 1 | 21
increased startle reflex 1 | 38
irregularly shaped pupil 1 | 7
male infertility 1 | 62
polycystic kidney 1 | 9
short tibia 1 | 82
thrombocytopenia 1 | 46
vertebral fusion 1 | 23

Disease

ovarian cancer 56 | 8,484
osteosarcoma 43 | 7,933
glioblastoma 42 | 5,572
medulloblastoma, large-cell 41 | 6,234
psoriasis 40 | 6,685
atypical teratoid / rhabdoid tumor 35 | 4,369
Cancer 33 | 2,346
oligodendroglioma 32 | 2,849
pilocytic astrocytoma 29 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,289
lung cancer 27 | 4,466
Breast cancer 26 | 3,094
Carcinoma 25 | 2,147
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,956
pediatric high grade glioma 24 | 2,712
astrocytic glioma 23 | 2,241
malignant mesothelioma 23 | 3,162
pancreatic cancer 23 | 2,300
primitive neuroectodermal tumor 23 | 3,031
ependymoma 22 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,988
lung carcinoma 20 | 2,844
Pick disease 18 | 1,893
astrocytoma 17 | 1,493
cystic fibrosis 17 | 1,665
pituitary cancer 16 | 1,972
subependymal giant cell astrocytoma 16 | 2,287
Blastic phase chronic myeloid leukemia 15 | 58
Chronic Myelocytic Leukemia Accelerated Phase 15 | 59
invasive ductal carcinoma 15 | 2,950
lung adenocarcinoma 15 | 2,713
medulloblastoma 15 | 1,524
non-small cell lung cancer 15 | 2,798
primary pancreatic ductal adenocarcinoma 15 | 1,271
Chronic phase chronic myeloid leukemia 14 | 45
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 14 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 14 | 47
cutaneous lupus erythematosus 14 | 1,056
Alzheimer's disease 13 | 644
group 4 medulloblastoma 13 | 1,875
adult high grade glioma 12 | 2,148
diabetes mellitus 12 | 1,663
Multiple myeloma 11 | 1,327
Waldenstrons macroglobulinemia 11 | 765
ductal carcinoma in situ 11 | 1,745
breast carcinoma 10 | 1,614
esophageal adenocarcinoma 10 | 737
interstitial cystitis 10 | 2,299
juvenile dermatomyositis 10 | 1,189
primary Sjogren syndrome 10 | 789
spina bifida 10 | 1,064
ulcerative colitis 10 | 2,087
Down syndrome 9 | 548
Intellectual disability 9 | 573
colon cancer 9 | 1,475
non primary Sjogren syndrome sicca 9 | 840
posterior fossa group A ependymoma 9 | 1,511
tuberculosis 9 | 1,557
Mammary Neoplasms 8 | 410
Rheumatoid Arthritis 8 | 1,160
adrenocortical carcinoma 8 | 1,427
dermatomyositis 8 | 933
group 3 medulloblastoma 8 | 2,254
sonic hedgehog group medulloblastoma 8 | 1,482
Craniofrontonasal syndrome 7 | 13
Duchenne muscular dystrophy 7 | 602
IGA Glomerulonephritis 7 | 454
Neoplasm Invasiveness 7 | 127
posterior fossa group B ependymoma 7 | 1,530
Heart disease 6 | 279
Kidney disease 6 | 396
Liver carcinoma 6 | 217
Mammary Neoplasms, Experimental 6 | 150
Schizophrenia 6 | 501
aldosterone-producing adenoma 6 | 664
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,795
progressive supranuclear palsy 6 | 674
Amyotrophic Lateral Sclerosis 5 | 431
Animal Mammary Neoplasms 5 | 136
Atopic dermatitis 5 | 944
Hypertension 5 | 287
Noonan Syndrome 5 | 33
Parkinson's disease 5 | 364
Proteinuria 5 | 63
acute quadriplegic myopathy 5 | 1,157
mucosa-associated lymphoid tissue lymphoma 5 | 480
Acquired metabolic disease 4 | 267
Neoplastic Cell Transformation 4 | 81
Vascular disease 4 | 281
Wiskott-Aldrich syndrome 4 | 27
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 499
glioblastoma multiforme 4 | 347
head and neck cancer and chronic obstructive pulmonary disease 4 | 237
hereditary spastic paraplegia 4 | 313
interstitial lung disease 4 | 291
nasopharyngeal carcinoma 4 | 1,056
tuberculosis and treatment for 6 months 4 | 686
Endometriosis 3 | 535
nephrosclerosis 3 | 329
pancreatic carcinoma 3 | 567

Tissue

Blood and immune system 84 | 17,995
Cardiovascular System 84 | 17,958
Digestive Tract 84 | 18,473
Endocrine System 84 | 18,512
Female tissues 84 | 18,647
Liver and Pancreas 84 | 18,136
Male tissues 84 | 17,969
Nervous System 84 | 18,561
Respiratory system 84 | 17,484
Skin and soft tissues 84 | 18,115
Urinary Tract 84 | 18,444

Target Family

Non-IDG 42 | 11,971
Kinase 25 | 634
Enzyme 15 | 4,146
Ion Channel 2 | 341

GO Process

ephrin receptor signaling path... 84 | 84
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Actin-related protein 2 ACTR2 Tchem Non-IDG -1.84526 72.5 184
Actin-related protein 3 ACTR3 Tbio Non-IDG -1.25542 16.8 169
Matrix metalloproteinase-9 MMP9 Tchem Enzyme -3.90528 8199.7 1129
Presenilin-2 PSEN2 Tchem Enzyme -2.77295 585.2 282
Transforming protein RhoA RHOA Tbio Enzyme -3.48838 3096.5 467
Tyrosine-protein phosphatase non-receptor type 11 PTPN11 Tchem Enzyme -3.06784 1308.8 971
Actin-related protein 2/3 complex subunit 5 ARPC5 Tbio Non-IDG -1.07398 11.5 63
Rho-associated protein kinase 2 ROCK2 Tclin Kinase -2.39656 248.3 472
Ephrin-A2 EFNA2 Tchem Non-IDG -1.82361 66.5 220
Gamma-secretase subunit PEN-2 PSENEN Tchem Enzyme -2.84502 678.2 177