Development Level

Tbio 36 | 11,445
Tchem 1 | 1,598

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal behavior 3 | 298
embryonic lethality prior to t... 3 | 278
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating aspartat... 2 | 34
decreased circulating glucose ... 2 | 126
decreased mean corpuscular hem... 2 | 50
embryonic lethality prior to o... 2 | 239
hyperactivity 2 | 148
increased circulating alkaline... 2 | 122
abnormal craniofacial morpholo... 1 | 33
abnormal eye morphology 1 | 68
abnormal hindbrain morphology 1 | 10
abnormal lung morphology 1 | 26
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal thoracic cage shape 1 | 3
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating lactate ... 1 | 3
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic growth retardation 1 | 106
increased body length 1 | 32
increased circulating amylase ... 1 | 25
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
prenatal lethality prior to he... 1 | 87
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97

Disease

ovarian cancer 21 | 8,520
Carcinoma 17 | 11,493
osteosarcoma 16 | 7,950
medulloblastoma, large-cell 14 | 6,241
glioblastoma 10 | 5,792
lung cancer 10 | 4,740
psoriasis 10 | 6,694
atypical teratoid / rhabdoid tumor 8 | 5,112
invasive ductal carcinoma 7 | 2,951
Breast cancer 6 | 3,578
Kidney cancer 6 | 2,613
Pick disease 6 | 1,894
astrocytic glioma 6 | 2,597
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
primitive neuroectodermal tumor 6 | 3,035
spina bifida 6 | 1,074
adult high grade glioma 5 | 3,801
lung carcinoma 5 | 2,843
malignant mesothelioma 5 | 3,232
non-small cell lung cancer 5 | 2,890
subependymal giant cell astrocytoma 5 | 2,287
Amyotrophic lateral sclerosis 4 | 451
Astrocytoma, Pilocytic 4 | 3,081
Autosomal recessive predisposition 4 | 1,442
Cancer 4 | 2,499
Neurodegenerative disease 4 | 414
Schizophrenia 4 | 1,160
colon cancer 4 | 1,478
ependymoma 4 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
Aggressive behavior 3 | 75
Aggressive reaction 3 | 75
Anxiety 3 | 136
Anxiety disease 3 | 113
Bipolar Disorder 3 | 666
Cognitive delay 3 | 608
Dull intelligence 3 | 645
Failure to gain weight 3 | 365
Fatigue 3 | 182
Global developmental delay 3 | 608
Intellectual disability 3 | 1,016
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental and motor retardation 3 | 608
Mental deficiency 3 | 645
Muscle hypotonia 3 | 571
Paraplegia 3 | 74
Pediatric failure to thrive 3 | 365
Physical aggression 3 | 76
Poor school performance 3 | 645
acute myeloid leukemia 3 | 783
breast carcinoma 3 | 1,638
diabetes mellitus 3 | 1,728
ductal carcinoma in situ 3 | 1,745
group 4 medulloblastoma 3 | 1,855
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
oligodendroglioma 3 | 2,850
pancreatic cancer 3 | 2,398
progressive supranuclear palsy 3 | 676
Acquired metabolic disease 2 | 336
Alzheimer's disease 2 | 658
Cerebral atrophy 2 | 178
Cortical white matter abnormalities seen on MRI 2 | 18
Decreased tendon reflex 2 | 122
Depressive disorder 2 | 409
Dysarthria 2 | 192
Epilepsy 2 | 792
Frequent fractures 2 | 53
Frontotemporal dementia 2 | 51
Generalized muscle weakness 2 | 57
Hyperreflexia 2 | 209
Increased fracture rate 2 | 53
Leukoaraiosis 2 | 18
Loss of speech 2 | 16
Mood swings 2 | 77
Muscle Spasticity 2 | 195
Nerve Degeneration 2 | 121
Neurogenic Muscular Atrophy 2 | 139
Neurogenic muscle atrophy, especially in the lower limbs 2 | 139
Parkinson's disease 2 | 392
Personality change 2 | 23
Polycystic ovary syndrome 2 | 360
Respiratory Failure 2 | 104
Seizures 2 | 596
Skeletal muscle atrophy 2 | 139
Tremor 2 | 113
Varying degree of multiple fractures 2 | 53
acute quadriplegic myopathy 2 | 1,158
aldosterone-producing adenoma 2 | 665
esophageal adenocarcinoma 2 | 737
hepatocellular carcinoma 2 | 547
lung adenocarcinoma 2 | 2,716
medulloblastoma 2 | 720
muscle degeneration 2 | 139
pediatric high grade glioma 2 | 1,064
tuberculosis 2 | 2,010
tuberculosis and treatment for 3 months 2 | 179

Tissue

Blood and immune system 36 | 16,909
Cardiovascular System 36 | 15,192
Digestive Tract 36 | 17,369
Endocrine System 36 | 18,159
Female tissues 36 | 17,400
Liver and Pancreas 36 | 16,750
Male tissues 36 | 17,142
Nervous System 36 | 16,725
Respiratory system 36 | 16,393
Skin and soft tissues 36 | 17,230
Urinary Tract 36 | 16,678

Target Family

Non-IDG 31 | 12,091
Enzyme 4 | 4,145
Kinase 2 | 634

GO Process

endosome organization 37 | 37
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Sorting nexin-10 SNX10 Tbio Non-IDG -1.13183 16.8 72
Lysosomal-associated transmembrane protein 4B LAPTM4B Tbio Non-IDG -1.90763 86.1 91
Sorting nexin-33 SNX33 Tbio Non-IDG -0.49386 3.94 99
Protein Hook homolog 1 HOOK1 Tbio Non-IDG -1.16190 13.1 187
Pleckstrin homology domain-containing family F member 1 PLEKHF1 Tbio Non-IDG -1.81298 66.0 108
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 ARFGEF2 Tbio Non-IDG -1.15371 14.4 81
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.71624 54.4 193
DnaJ homolog subfamily C member 13 DNAJC13 Tbio Non-IDG -1.12451 16.4 28
Transmembrane protein 127 TMEM127 Tbio Non-IDG -1.31365 19.5 26