Development Level

Tbio 93 | 10,625
Tchem 18 | 1,890
Tdark 17 | 7,003
Tclin 1 | 602

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 4 | 633
decreased grip strength 3 | 123
embryonic lethality prior to t... 3 | 187
increased mean corpuscular hem... 3 | 93
preweaning lethality, incomple... 3 | 260
abnormal behavior 2 | 226
abnormal coat/ hair morphology 2 | 18
decreased body weight 2 | 174
decreased lean body mass 2 | 195
decreased rib number 2 | 59
hypoactivity 2 | 89
abnormal QRS complex 1 | 25
abnormal coat appearance 1 | 25
abnormal coping response 1 | 12
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal eyelid aperture 1 | 3
abnormal forebrain development 1 | 18
abnormal hair growth 1 | 8
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal liver morphology 1 | 5
abnormal midbrain development 1 | 22
abnormal nail morphology 1 | 7
abnormal neural tube closure 1 | 37
abnormal posture 1 | 5
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal sleep behavior 1 | 63
abnormal spinal cord morpholog... 1 | 8
absent heartbeat 1 | 6
cardiovascular system phenotyp... 1 | 35
decreased bone mineral content 1 | 157
decreased circulating alanine ... 1 | 53
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased circulating glucose ... 1 | 121
decreased circulating triglyce... 1 | 83
decreased eosinophil cell numb... 1 | 41
decreased heart rate variabili... 1 | 11
decreased lymphocyte cell numb... 1 | 9
decreased mean corpuscular vol... 1 | 50
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
hyperactivity 1 | 108
impaired glucose tolerance 1 | 52
increased NK cell number 1 | 19
increased blood urea nitrogen ... 1 | 44
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 43
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased eosinophil cell numb... 1 | 9
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased hematocrit 1 | 36
increased mean corpuscular vol... 1 | 91
increased neutrophil cell numb... 1 | 15
increased or absent threshold ... 1 | 128
increased startle reflex 1 | 38
limb grasping 1 | 35
persistence of hyaloid vascula... 1 | 22
premature death 1 | 5
thrombocytosis 1 | 23

Disease

ovarian cancer 80 | 8,484
osteosarcoma 71 | 7,933
medulloblastoma, large-cell 59 | 6,234
glioblastoma 57 | 5,572
psoriasis 48 | 6,685
atypical teratoid / rhabdoid tumor 44 | 4,369
lung cancer 38 | 4,466
pediatric high grade glioma 34 | 2,712
lung carcinoma 32 | 2,844
oligodendroglioma 31 | 2,849
subependymal giant cell astrocytoma 31 | 2,287
pilocytic astrocytoma 30 | 3,086
invasive ductal carcinoma 29 | 2,950
Carcinoma 28 | 2,147
ependymoma 27 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,956
Pick disease 25 | 1,893
malignant mesothelioma 25 | 3,162
Breast cancer 23 | 3,094
primitive neuroectodermal tumor 23 | 3,031
interstitial cystitis 22 | 2,299
non-small cell lung cancer 22 | 2,798
group 4 medulloblastoma 21 | 1,875
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,289
astrocytic glioma 20 | 2,241
astrocytoma 18 | 1,493
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,988
tuberculosis 18 | 1,557
Alzheimer's disease 17 | 644
lung adenocarcinoma 17 | 2,713
Cancer 16 | 2,346
gastric carcinoma 16 | 832
group 3 medulloblastoma 16 | 2,254
pancreatic cancer 16 | 2,300
diabetes mellitus 15 | 1,663
juvenile dermatomyositis 15 | 1,189
cystic fibrosis 14 | 1,665
sonic hedgehog group medulloblastoma 14 | 1,482
acute quadriplegic myopathy 13 | 1,157
ductal carcinoma in situ 13 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
posterior fossa group A ependymoma 13 | 1,511
primary pancreatic ductal adenocarcinoma 12 | 1,271
adult high grade glioma 11 | 2,148
Multiple myeloma 10 | 1,327
atypical teratoid/rhabdoid tumor 10 | 1,095
medulloblastoma 10 | 1,524
pituitary cancer 10 | 1,972
posterior fossa group B ependymoma 10 | 1,530
ulcerative colitis 10 | 2,087
adrenocortical carcinoma 9 | 1,427
dermatomyositis 9 | 933
Down syndrome 8 | 548
Neurodegenerative disease 8 | 383
Schizophrenia 8 | 501
breast carcinoma 8 | 1,614
colon cancer 8 | 1,475
cutaneous lupus erythematosus 8 | 1,056
primary Sjogren syndrome 8 | 789
tuberculosis and treatment for 6 months 8 | 686
Atopic dermatitis 7 | 944
aldosterone-producing adenoma 7 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 7 | 499
esophageal adenocarcinoma 7 | 737
mucosa-associated lymphoid tissue lymphoma 7 | 480
progressive supranuclear palsy 7 | 674
spina bifida 7 | 1,064
Amyotrophic Lateral Sclerosis 6 | 431
Dementia 6 | 129
Duchenne muscular dystrophy 6 | 602
Myocardial Ischemia 6 | 169
Parkinson's disease 6 | 364
Polycystic Ovary Syndrome 6 | 332
Rheumatoid Arthritis 6 | 1,160
Vascular disease 6 | 281
Waldenstrons macroglobulinemia 6 | 765
fibroadenoma 6 | 557
non primary Sjogren syndrome sicca 6 | 840
Autistic Disorder 5 | 320
Cardiovascular system disease 5 | 194
Epilepsy 5 | 346
Obesity 5 | 616
acute myeloid leukemia 5 | 780
non-small cell lung carcinoma 5 | 413
pancreatic carcinoma 5 | 567
sarcoidosis 5 | 358
Gaucher disease type 1 4 | 171
Intellectual disability 4 | 573
Nerve Degeneration 4 | 73
Renal Cell Carcinoma 4 | 199
Wiskott-Aldrich syndrome 4 | 27
active Crohn's disease 4 | 918
active ulcerative colitis 4 | 477
glioblastoma multiforme 4 | 347
inflammatory breast cancer 4 | 404
Becker muscular dystrophy 3 | 187
Endometriosis 3 | 535
Prostatic Neoplasms 3 | 471
hepatocellular carcinoma 3 | 532
non diabetic and post-ischemic heart failure 3 | 200

Tissue

Blood and immune system 129 | 17,995
Cardiovascular System 129 | 17,958
Digestive Tract 129 | 18,473
Endocrine System 129 | 18,512
Female tissues 129 | 18,647
Liver and Pancreas 129 | 18,136
Male tissues 129 | 17,969
Nervous System 129 | 18,561
Respiratory system 128 | 17,484
Skin and soft tissues 128 | 18,115
Urinary Tract 128 | 18,444

Target Family

Non-IDG 94 | 11,971
Enzyme 21 | 4,146
Kinase 11 | 634
Transporter 2 | 473
Ion Channel 1 | 341

GO Process

endocytosis 129 | 129
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable phospholipid-transporting ATPase IIB ATP9B Tdark Transporter -0.57248 3.74 5
Sialoadhesin SIGLEC1 Tbio Non-IDG -2.22508 195.6 309
Ras and Rab interactor 2 RIN2 Tbio Non-IDG -1.36829 24.1 51
GTPase-activating protein and VPS9 domain-containing protein 1 GAPVD1 Tbio Enzyme -0.50735 3.46 71
Ras-related protein Rab-7a RAB7A Tbio Enzyme -2.60609 403.7 216
Amphiphysin AMPH Tbio Non-IDG -2.64544 426.2 341
Low-density lipoprotein receptor-related protein 5 LRP5 Tbio Non-IDG -3.06756 1202.0 278
Casein kinase I isoform epsilon CSNK1E Tchem Kinase -1.76876 60.7 272
Metalloreductase STEAP2 STEAP2 Tbio Enzyme -1.70084 48.5 131
Delta and Notch-like epidermal growth factor-related receptor DNER Tbio Non-IDG -1.59708 45.6 159