Development Level

Tbio 10 | 11,445

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal allantois morphology 1 | 8
abnormal heart morphology 1 | 162
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
decreased circulating alkaline... 1 | 46
embryonic lethality prior to o... 1 | 239

Disease

Carcinoma 9 | 11,493
ovarian cancer 7 | 8,520
Congenital heart disease 5 | 93
Craniofacial Abnormalities 5 | 151
atypical teratoid / rhabdoid tumor 5 | 5,112
glioblastoma 5 | 5,792
medulloblastoma, large-cell 5 | 6,241
osteosarcoma 5 | 7,950
psoriasis 5 | 6,694
Astrocytoma, Pilocytic 4 | 3,081
Breast cancer 4 | 3,578
Cleft Palate 4 | 271
Intellectual disability 4 | 1,016
adult high grade glioma 4 | 3,801
group 3 medulloblastoma 4 | 4,104
malignant mesothelioma 4 | 3,232
Attention deficit hyperactivity disorder 3 | 278
Blepharoptosis 3 | 231
Delayed speech and language development 3 | 112
Dull intelligence 3 | 645
Epilepsy 3 | 792
Kidney cancer 3 | 2,613
Language Delay 3 | 112
Low intelligence 3 | 645
Low set ears 3 | 181
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Muscle hypotonia 3 | 571
Poor school performance 3 | 645
Seizures 3 | 596
Short stature 3 | 531
Speech Delay 3 | 112
Speech impairment 3 | 112
Ventricular Septal Defects 3 | 119
cystic fibrosis 3 | 1,696
ependymoma 3 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
invasive ductal carcinoma 3 | 2,951
lung cancer 3 | 4,740
lung carcinoma 3 | 2,843
nasopharyngeal carcinoma 3 | 1,058
primary Sjogren syndrome 3 | 735
Aggressive behavior 2 | 75
Aggressive reaction 2 | 75
Anteverted nostril 2 | 191
Autosomal recessive predisposition 2 | 1,442
Bilateral fifth finger clinodactyly 2 | 110
Bipolar Disorder 2 | 666
Broad forehead 2 | 59
Cardiovascular system disease 2 | 246
Cleft Lip 2 | 141
Cognitive delay 2 | 608
Concave bridge of nose 2 | 195
Conductive hearing loss 2 | 123
Congenital Heart Defects 2 | 58
Curvature of little finger 2 | 110
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Exophthalmos 2 | 112
Global developmental delay 2 | 608
Heart Defects, Congenital 2 | 37
Hernia, Inguinal 2 | 89
High forehead 2 | 102
High, narrow palate 2 | 32
Hypoplastic mandible condyle 2 | 275
Isolated cases 2 | 72
Long philtrum 2 | 137
Mandibular hypoplasia 2 | 275
Mental and motor retardation 2 | 608
Micrognathism 2 | 275
Multicystic Dysplastic Kidney 2 | 52
Orbital separation excessive 2 | 244
Patent ductus arteriosus 2 | 90
Physical aggression 2 | 76
Polycystic ovary syndrome 2 | 360
Prominent eyes 2 | 96
Prominent globes 2 | 96
Protruding eyes 2 | 96
Schizophrenia 2 | 1,160
Severe mental retardation (I.Q. 20-34) 2 | 99
Short neck 2 | 140
Short nose 2 | 132
Short philtrum 2 | 53
Small head 2 | 374
Small nose 2 | 132
Speech Disorders 2 | 58
Tall forehead 2 | 102
Upward slant of palpebral fissure 2 | 75
Uranostaphyloschisis 2 | 167
Waldenstrons macroglobulinemia 2 | 765
active Crohn's disease 2 | 922
active ulcerative colitis 2 | 764
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
lung adenocarcinoma 2 | 2,716
neural tube defect 2 | 9
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pituitary cancer 2 | 1,972
spina bifida 2 | 1,074

Tissue

Digestive Tract 10 | 17,369
Endocrine System 10 | 18,159
Female tissues 10 | 17,400
Urinary Tract 10 | 16,678
Blood and immune system 9 | 16,909
Cardiovascular System 9 | 15,192
Liver and Pancreas 9 | 16,750
Male tissues 9 | 17,142
Nervous System 9 | 16,725
Respiratory system 9 | 16,393
Skin and soft tissues 9 | 17,230

Target Family

Enzyme 5 | 4,145
Transcription Factor 4 | 1,400
Non-IDG 1 | 12,091

GO Process

embryonic viscerocranium morph... 10 | 10
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Forkhead box protein C2 FOXC2 Tbio Transcription Factor -2.23435 187.0 419
T-box transcription factor TBX1 TBX1 Tbio Transcription Factor -1.99519 95.5 207
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 NDST1 Tbio Enzyme -1.91878 84.7 146
Retinol dehydrogenase 10 RDH10 Tbio Enzyme -1.44544 31.3 110
Carbohydrate sulfotransferase 11 CHST11 Tbio Enzyme -1.44765 27.4 112
C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 Tbio Enzyme -1.97029 90.6 101
LIM/homeobox protein Lhx1 LHX1 Tbio Transcription Factor -1.69625 49.3 365
Nipped-B-like protein NIPBL Tbio Non-IDG -2.25874 186.3 134
Monofunctional C1-tetrahydrofolate synthase, mitochondrial MTHFD1L Tbio Enzyme -1.66972 40.2 102
Myocyte-specific enhancer factor 2C MEF2C Tbio Transcription Factor -2.30705 184.5 974