Development Level

Tbio 18 | 11,178
Tchem 2 | 1,885
Tclin 2 | 612

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal embryo turning 1 | 31
abnormal eye anterior chamber ... 1 | 9
abnormal heart left ventricle ... 1 | 16
abnormal retina morphology 1 | 71
abnormal tooth morphology 1 | 24
decreased bone mineral content 1 | 151
decreased lean body mass 1 | 135
decreased total body fat amoun... 1 | 207
dilated heart left ventricle 1 | 11
hypoactivity 1 | 132
increased anti-nuclear antigen... 1 | 19
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating potassiu... 1 | 29
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26

Disease

Carcinoma 17 | 11,192
ovarian cancer 16 | 8,297
osteosarcoma 15 | 7,766
group 3 medulloblastoma 11 | 4,002
atypical teratoid / rhabdoid tumor 9 | 4,971
lung cancer 9 | 4,607
psoriasis 9 | 6,514
Cancer 8 | 2,388
Breast cancer 7 | 3,469
Kidney cancer 7 | 2,548
medulloblastoma, large-cell 7 | 6,086
glioblastoma 6 | 5,635
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,902
Autosomal recessive predisposition 5 | 1,407
Short stature 5 | 514
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,872
malignant mesothelioma 5 | 3,135
primitive neuroectodermal tumor 5 | 2,957
spina bifida 5 | 1,053
subependymal giant cell astrocytoma 5 | 2,230
Abnormally small eyeball 4 | 94
Cataract 4 | 290
Cockayne syndrome 4 | 59
Cognitive delay 4 | 596
Craniofacial Abnormalities 4 | 141
Cryptorchidism 4 | 287
Decreased size of eyeball 4 | 94
Dull intelligence 4 | 634
Epilepsy 4 | 775
Global developmental delay 4 | 596
Hydrocephalus 4 | 148
Intellectual disability 4 | 998
Lens Opacities 4 | 227
Low intelligence 4 | 634
Melanoma 4 | 689
Mental Retardation 4 | 634
Mental and motor retardation 4 | 596
Mental deficiency 4 | 634
Microphthalmos 4 | 95
Photosensitive trichothiodystrophy 4 | 30
Poor school performance 4 | 634
Seizures 4 | 584
Strabismus 4 | 265
Xeroderma pigmentosum 4 | 42
adult high grade glioma 4 | 3,701
ependymoma 4 | 4,559
non primary Sjogren syndrome sicca 4 | 861
oligodendroglioma 4 | 2,768
Astrocytoma, Pilocytic 3 | 3,006
Brachydactyly 3 | 154
Broad flat nasal bridge 3 | 232
Broad forehead 3 | 58
Congenital anomaly of face 3 | 54
Congenital deafness 3 | 180
Deafness 3 | 193
Dilated ventricles (finding) 3 | 119
Electroencephalogram abnormal 3 | 100
Endometrial cancer 3 | 301
Failure to gain weight 3 | 359
Feeding difficulties in infancy 3 | 174
Fetal Growth Retardation 3 | 186
Flexion contracture of proximal interphalangeal joint 3 | 74
Hearing Loss, Partial 3 | 180
Highly variable severity 3 | 149
Hypogonadism 3 | 169
Hypoplastic mandible condyle 3 | 273
Infant, Small for Gestational Age 3 | 174
Intrauterine retardation 3 | 174
Liver cancer 3 | 589
Low Vision 3 | 167
Mandibular hypoplasia 3 | 273
Micrognathism 3 | 273
Muscle hypotonia 3 | 562
Nasal bridge wide 3 | 232
Optic Atrophy 3 | 239
Pediatric failure to thrive 3 | 359
Pick disease 3 | 1,856
Prostatic Neoplasms 3 | 472
Retinal Diseases 3 | 54
Schizophrenia 3 | 1,136
Sensorineural Hearing Loss (disorder) 3 | 281
Short neck 3 | 139
Small head 3 | 366
Stomach Neoplasms 3 | 287
Variable expressivity 3 | 149
Vertical Talus 3 | 25
Visual Impairment 3 | 167
adrenocortical carcinoma 3 | 1,385
breast carcinoma 3 | 1,589
colon cancer 3 | 1,428
hearing impairment 3 | 194
interstitial cystitis 3 | 2,237
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,204
invasive ductal carcinoma 3 | 2,867
lung adenocarcinoma 3 | 2,627
lung carcinoma 3 | 2,755
non-small cell lung cancer 3 | 2,799
pancreatic cancer 3 | 2,322
pediatric high grade glioma 3 | 1,035
posterior fossa group A ependymoma 3 | 456

Tissue

Blood and immune system 22 | 16,909
Digestive Tract 22 | 17,369
Endocrine System 22 | 18,159
Female tissues 22 | 17,400
Liver and Pancreas 22 | 16,750
Male tissues 22 | 17,142
Nervous System 22 | 16,725
Respiratory system 22 | 16,393
Skin and soft tissues 22 | 17,230
Urinary Tract 22 | 16,678
Cardiovascular System 21 | 15,192

Target Family

Non-IDG 8 | 12,091
Transcription Factor 8 | 1,400
Enzyme 4 | 4,145
Kinase 2 | 634

GO Process

embryonic organ development 22 | 22
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
TFIIH basal transcription factor complex helicase XPD subunit ERCC2 Tbio Enzyme -2.58326 365.8 191
Protein Wnt-7b WNT7B Tbio Non-IDG -1.76807 52.2 46
Methyl-CpG-binding domain protein 2 MBD2 Tchem Transcription Factor -1.74971 47.7 297
AT-rich interactive domain-containing protein 2 ARID2 Tbio Transcription Factor -1.32490 22.0 71
Zinc finger protein ZFPM2 ZFPM2 Tbio Transcription Factor -1.78912 62.9 93
Methyl-CpG-binding domain protein 3 MBD3 Tbio Transcription Factor -0.85800 7.92 309
Bone morphogenetic protein receptor type-1A BMPR1A Tchem Kinase -2.34984 211.0 622
E3 ubiquitin-protein ligase RBBP6 RBBP6 Tbio Enzyme -1.36066 29.2 241
Pre-mRNA-splicing factor SYF2 SYF2 Tbio Non-IDG -1.04825 13.2 124
Epsin-1 EPN1 Tbio Non-IDG -1.52389 32.5 163