Development Level

Tbio 7 | 11,445

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal allantois morphology 1 | 8
abnormal heart morphology 1 | 162
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal testis morphology 1 | 43
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
edema 1 | 59
embryonic lethality prior to o... 1 | 239
enlarged lymph nodes 1 | 37
impaired glucose tolerance 1 | 75
increased circulating chloride... 1 | 41
increased total body fat amoun... 1 | 134

Disease

Carcinoma 6 | 11,493
psoriasis 4 | 6,694
Breast cancer 3 | 3,578
Cleft Lip 3 | 141
Cleft Palate 3 | 271
neural tube defect 3 | 9
Aggressive behavior 2 | 75
Aggressive reaction 2 | 75
Arachnodactyly 2 | 49
Autistic Disorder 2 | 364
Byzanthine arch palate 2 | 194
Cognitive delay 2 | 608
Congenital Heart Defects 2 | 58
Congenital heart disease 2 | 93
Craniofacial Abnormalities 2 | 151
Dull intelligence 2 | 645
Gastrointestinal Stromal Tumors 2 | 48
Global developmental delay 2 | 608
Hernia, Inguinal 2 | 89
Intellectual disability 2 | 1,016
Kidney cancer 2 | 2,613
Leiomyoma 2 | 32
Low intelligence 2 | 645
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Muscle hypotonia 2 | 571
Orbital separation excessive 2 | 244
Osteoarthritis 2 | 184
Pectus excavatum 2 | 100
Physical aggression 2 | 76
Poor school performance 2 | 645
Range of joint movement increased 2 | 32
Schizophrenia 2 | 1,160
Sensorineural Hearing Loss (disorder) 2 | 284
Short stature 2 | 531
Uranostaphyloschisis 2 | 167
Uterine fibroid 2 | 28
atypical teratoid / rhabdoid tumor 2 | 5,112
ductal carcinoma in situ 2 | 1,745
glioblastoma 2 | 5,792
lung adenocarcinoma 2 | 2,716
medulloblastoma, large-cell 2 | 6,241
osteosarcoma 2 | 7,950
ovarian cancer 2 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
Abnormality of the iris 1 | 14
Agitation 1 | 16
Anteriorly placed anus 1 | 7
Aortic aneurysm, familial thoracic 3 1 | 13
Ascending aortic dissection 1 | 13
Asymmetry of the posterior cranium 1 | 20
Birthmark 1 | 35
Brainstem abnormalities 1 | 7
Broad hallux 1 | 29
Cardiomyopathy, right ventricular 1 | 7
Claw hand 1 | 26
Cleft uvula 1 | 27
Congenital pectus carinatum 1 | 52
Connective tissue cancer 1 | 10
Cutis marmorata 1 | 32
Cystic medial necrosis of aorta 1 | 13
Decreased muscle mass 1 | 28
Deep philtrum 1 | 21
Depressed philtrum 1 | 21
Descending aortic dissection 1 | 13
Dyspnea on exertion 1 | 24
Dyspnea, Paroxysmal 1 | 13
Familial thoracic aortic aneurysm and aortic dissection 1 | 13
Flattening of cranial vault 1 | 20
Flattening of head 1 | 20
Generalized hypotonia 1 | 37
Goldenhar syndrome 1 | 20
Hantavirus pulmonary syndrome 1 | 6
High pitched voice 1 | 23
Hypernasal voice 1 | 39
Hypoplasia of scrotum 1 | 24
Impaired left ventricular function 1 | 16
Left-Sided Heart Failure 1 | 16
Loeys-Dietz Aortic Aneurysm Syndrome 1 | 13
Loeys-Dietz syndrome 1 | 23
Loeys-Dietz syndrome 4 1 | 4
Long nose 1 | 15
Low frustration tolerance 1 | 2
Lujan Fryns syndrome 1 | 3
Macroorchidism 1 | 7
Marfanoid body habitus 1 | 11
Narrow nose 1 | 20
Narrow palate 1 | 20
Nasal voice 1 | 39
Pinched bridge of nose 1 | 14
Pinched nasal bridge 1 | 14
Plagiocephaly 1 | 20
Plagiocephaly, Nonsynostotic 1 | 20
Rhomboid shaped head 1 | 20
Single transverse palmar crease 1 | 29
Stricture of anus 1 | 13
Tracheal stenosis 1 | 23
Wrinkled face 1 | 2
X-linked intellectual disability with marfanoid habitus 1 | 3

Tissue

Blood and immune system 7 | 16,909
Digestive Tract 7 | 17,369
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Male tissues 7 | 17,142
Respiratory system 7 | 16,393
Skin and soft tissues 7 | 17,230
Urinary Tract 7 | 16,678
Cardiovascular System 6 | 15,192
Nervous System 6 | 16,725

Target Family

Enzyme 4 | 4,145
Transcription Factor 2 | 1,400
Non-IDG 1 | 12,091

GO Process

embryonic neurocranium morphog... 7 | 7
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 NDST1 Tbio Enzyme -1.91878 84.7 146
Mediator of RNA polymerase II transcription subunit 12 MED12 Tbio Enzyme -2.60835 402.9 124
C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 Tbio Enzyme -1.97029 90.6 101
Transforming growth factor beta-3 TGFB3 Tbio Non-IDG -3.02749 1062.5 308
Homeobox protein Hox-A1 HOXA1 Tbio Transcription Factor -2.03844 103.7 289
Monofunctional C1-tetrahydrofolate synthase, mitochondrial MTHFD1L Tbio Enzyme -1.66972 40.2 102
Tubby-related protein 3 TULP3 Tbio Transcription Factor -0.96345 9.12 157