Development Level

Tbio 22 | 11,445
Tchem 5 | 1,598
Tclin 2 | 613

IMPC Phenotype

preweaning lethality, complete... 8 | 979
embryonic lethality prior to t... 3 | 278
increased startle reflex 3 | 112
abnormal behavior 2 | 298
decreased body weight 2 | 161
decreased circulating fructosa... 2 | 30
decreased circulating serum al... 2 | 82
decreased lean body mass 2 | 135
enlarged heart 2 | 210
increased total body fat amoun... 2 | 134
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal facial morphology 1 | 17
abnormal forebrain development 1 | 20
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal incisor morphology 1 | 4
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal placenta size 1 | 20
abnormal startle reflex 1 | 15
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal vertebral arch morpho... 1 | 9
cleft palate 1 | 8
corneal opacity 1 | 32
cyanosis 1 | 7
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
decreased grip strength 1 | 116
decreased lumbar vertebrae num... 1 | 2
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged uterus 1 | 11
fusion of vertebral arches 1 | 7
hydrometra 1 | 53
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased bone mineral density 1 | 72
increased heart weight 1 | 62
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
irregularly shaped pupil 1 | 7
limb grasping 1 | 41
mammalian phenotype 1 | 17
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality 1 | 28
small superior vagus ganglion 1 | 74
small testis 1 | 58
vertebral transformation 1 | 12

Disease

Carcinoma 22 | 11,493
lung cancer 17 | 4,740
Cancer 15 | 2,499
psoriasis 15 | 6,694
Cleft Palate 14 | 271
ovarian cancer 14 | 8,520
Breast cancer 12 | 3,578
osteosarcoma 11 | 7,950
Cleft Lip 10 | 141
atypical teratoid / rhabdoid tumor 10 | 5,112
medulloblastoma, large-cell 10 | 6,241
Kidney cancer 9 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,955
invasive ductal carcinoma 9 | 2,951
malignant mesothelioma 9 | 3,232
non-small cell lung cancer 9 | 2,890
pancreatic cancer 9 | 2,398
Abnormally small eyeball 8 | 97
Craniofacial Abnormalities 8 | 151
Cryptorchidism 8 | 296
Decreased size of eyeball 8 | 97
Intellectual disability 8 | 1,016
Microphthalmos 8 | 100
Polydactyly 8 | 107
Uranostaphyloschisis 8 | 167
ductal carcinoma in situ 8 | 1,745
glioblastoma 8 | 5,792
interstitial cystitis 8 | 2,312
pituitary cancer 8 | 1,972
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Strabismus 7 | 270
breast carcinoma 7 | 1,638
group 3 medulloblastoma 7 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
lung adenocarcinoma 7 | 2,716
Autosomal recessive predisposition 6 | 1,442
Blepharoptosis 6 | 231
Brachydactyly 6 | 156
Breast Neoplasms 6 | 445
Broad flat nasal bridge 6 | 236
Dull intelligence 6 | 645
Low intelligence 6 | 645
Mammary Neoplasms 6 | 425
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Nasal bridge wide 6 | 236
Poor school performance 6 | 645
Short stature 6 | 531
Syndactyly of the toes 6 | 45
Tooth agenesis 6 | 44
Ulnar polydactyly of fingers 6 | 47
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
primitive neuroectodermal tumor 6 | 3,035
Carcinoma, Hepatocellular 5 | 228
Cataract 5 | 297
Choanal Atresia 5 | 42
Congenital deafness 5 | 185
Congenital hypoplasia of penis 5 | 176
Deafness 5 | 198
Decreased projection of maxilla 5 | 66
Deficiency of upper jaw bones 5 | 66
Hearing Loss, Partial 5 | 185
Hydronephrosis 5 | 89
Hypoplasia of the maxilla 5 | 66
Hypotrophic malar bone 5 | 129
Hypotrophic maxilla 5 | 66
Lens Opacities 5 | 231
Liver carcinoma 5 | 240
Malar flattening 5 | 129
Maxillary retrognathia 5 | 66
Muscle hypotonia 5 | 571
Orbital separation excessive 5 | 244
Retrusion of upper jaw bones 5 | 66
Stomach Neoplasms 5 | 300
Syndactyly of fingers 5 | 48
Synostosis 5 | 15
ependymoma 5 | 4,679
hearing impairment 5 | 199
lung carcinoma 5 | 2,843
Alzheimer's disease 4 | 658
Atopic dermatitis 4 | 952
Bilateral fifth finger clinodactyly 4 | 110
Cognitive delay 4 | 608
Concave bridge of nose 4 | 195
Congenital Epicanthus 4 | 177
Corneal diameter decreased 4 | 47
Craniosynostosis 4 | 74
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Global developmental delay 4 | 608
Mental and motor retardation 4 | 608
Small head 4 | 374
Ventricular Septal Defects 4 | 119
adrenocortical carcinoma 4 | 1,428
adult high grade glioma 4 | 3,801
cystic fibrosis 4 | 1,696
sonic hedgehog group medulloblastoma 4 | 467
spina bifida 4 | 1,074

Tissue

Endocrine System 27 | 18,159
Digestive Tract 26 | 17,369
Female tissues 26 | 17,400
Liver and Pancreas 26 | 16,750
Male tissues 26 | 17,142
Skin and soft tissues 26 | 17,230
Urinary Tract 25 | 16,678
Nervous System 24 | 16,725
Blood and immune system 23 | 16,909
Respiratory system 23 | 16,393
Cardiovascular System 22 | 15,192

Target Family

Transcription Factor 13 | 1,400
Non-IDG 12 | 12,091
Nuclear Receptor 2 | 48
Enzyme 1 | 4,145
Epigenetic 1 | 242

GO Process

embryonic hindlimb morphogenes... 29 | 29
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
T-box transcription factor TBX3 TBX3 Tbio Transcription Factor -2.42253 255.6 328
AF4/FMR2 family member 3 AFF3 Tbio Transcription Factor -1.37981 25.3 50
Homeobox protein aristaless-like 4 ALX4 Tbio Transcription Factor -1.77762 62.7 213
Chromodomain-helicase-DNA-binding protein 7 CHD7 Tbio Epigenetic -2.91077 788.8 102
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas GNAS Tbio Non-IDG -2.63356 1389.7 509
Zinc finger and BTB domain-containing protein 16 ZBTB16 Tbio Transcription Factor -2.31797 210.0 275
Fibroblast growth factor 4 FGF4 Tbio Non-IDG -2.60388 394.1 327
Protein odd-skipped-related 1 OSR1 Tbio Transcription Factor -1.09901 15.0 343
Protein odd-skipped-related 2 OSR2 Tbio Transcription Factor -1.44425 27.8 101