Development Level

Tbio 60 | 11,445
Tdark 8 | 6,588
Tchem 7 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 9 | 979
embryonic lethality prior to t... 4 | 278
embryonic lethality prior to o... 3 | 239
preweaning lethality, incomple... 3 | 499
decreased lean body mass 2 | 135
hypoactivity 2 | 132
increased total body fat amoun... 2 | 134
male infertility 2 | 123
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal limb morphology 1 | 13
abnormal placement of pupils 1 | 6
abnormal retinal inner nuclear... 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
anophthalmia 1 | 33
corneal opacity 1 | 32
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating glucose ... 1 | 126
decreased eosinophil cell numb... 1 | 24
decreased fluid intake 1 | 3
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased total retina thickne... 1 | 17
edema 1 | 59
female infertility 1 | 60
increased aggression 1 | 4
increased body length 1 | 32
increased bone mineral density 1 | 72
increased grip strength 1 | 41
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
shortened RR interval 1 | 17
tremors 1 | 39

Disease

Carcinoma 48 | 11,493
ovarian cancer 47 | 8,520
osteosarcoma 45 | 7,950
medulloblastoma, large-cell 33 | 6,241
group 3 medulloblastoma 28 | 4,104
Breast cancer 27 | 3,578
lung cancer 27 | 4,740
malignant mesothelioma 26 | 3,232
psoriasis 26 | 6,694
glioblastoma 23 | 5,792
Cancer 21 | 2,499
atypical teratoid / rhabdoid tumor 21 | 5,112
Fanconi anemia 18 | 56
primitive neuroectodermal tumor 17 | 3,035
Autosomal recessive predisposition 14 | 1,442
Kidney cancer 14 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
Intellectual disability 13 | 1,016
adult high grade glioma 13 | 3,801
ependymoma 13 | 4,679
non-small cell lung cancer 13 | 2,890
Breast Neoplasms 12 | 445
Mammary Neoplasms 12 | 425
Short stature 12 | 531
Bloom syndrome 11 | 29
Waldenstrons macroglobulinemia 11 | 765
Dull intelligence 10 | 645
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
Xeroderma pigmentosum 10 | 43
colon cancer 10 | 1,478
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
lung adenocarcinoma 10 | 2,716
Chromosome Breakage 9 | 36
Hereditary Breast and Ovarian Cancer Syndrome 9 | 14
Nijmegen breakage syndrome 9 | 24
Small head 9 | 374
diabetes mellitus 9 | 1,728
invasive ductal carcinoma 9 | 2,951
nasopharyngeal carcinoma 9 | 1,058
Increased chromosomal breakage 8 | 27
Multiple myeloma 8 | 1,332
Ataxia telangiectasia 7 | 34
Malignant neoplasm of breast 7 | 15
Pick disease 7 | 1,894
Prostatic Neoplasms 7 | 495
Werner syndrome 7 | 29
astrocytic glioma 7 | 2,597
breast carcinoma 7 | 1,638
Acquired scoliosis 6 | 281
Anemia 6 | 365
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3 6 | 9
Curvature of spine 6 | 282
Decreased platelet count 6 | 111
Radial aplasia/hypoplasia 6 | 29
Rheumatoid arthritis 6 | 1,191
Schizophrenia 6 | 1,160
Thrombocytopenia 6 | 197
adrenocortical carcinoma 6 | 1,428
non primary Sjogren syndrome sicca 6 | 891
oligodendroglioma 6 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
subependymal giant cell astrocytoma 6 | 2,287
Almond-shaped eyes 5 | 23
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 5 | 13
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 2 5 | 8
Breast Cancer, Familial 5 | 8
Cockayne syndrome 5 | 60
Cognitive delay 5 | 608
Esophageal atresia with or without tracheoesophageal fistula 5 | 21
Global developmental delay 5 | 608
Irregular hyperpigmentation 5 | 33
Leukopenia 5 | 72
Liver cancer 5 | 604
Melanoma 5 | 711
Mental and motor retardation 5 | 608
Neurodegenerative disease 5 | 414
Prostate cancer 5 | 175
Pyridoxine-responsive sideroblastic anemia 5 | 17
Rothmund-Thomson syndrome 5 | 19
Short palpebral fissure 5 | 38
Xeroderma pigmentosum group F 5 | 22
ductal carcinoma in situ 5 | 1,745
esophageal atresia/tracheoesophageal fistula 5 | 22
group 4 medulloblastoma 5 | 1,855
hypopigmented skin patch 5 | 59
juvenile dermatomyositis 5 | 1,187
pancreatic cancer 5 | 2,398
pituitary cancer 5 | 1,972
primary Sjogren syndrome 5 | 735
ulcerative colitis 5 | 1,819
Astrocytoma, Pilocytic 4 | 3,081
Intrauterine retardation 4 | 176
acute myeloid leukemia 4 | 783
acute quadriplegic myopathy 4 | 1,158
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
lung carcinoma 4 | 2,843
progressive supranuclear palsy 4 | 676

Tissue

Blood and immune system 75 | 16,909
Endocrine System 75 | 18,159
Male tissues 75 | 17,142
Digestive Tract 74 | 17,369
Female tissues 74 | 17,400
Liver and Pancreas 74 | 16,750
Skin and soft tissues 74 | 17,230
Cardiovascular System 73 | 15,192
Nervous System 73 | 16,725
Respiratory system 73 | 16,393
Urinary Tract 73 | 16,678

Target Family

Non-IDG 43 | 12,091
Enzyme 27 | 4,145
Transcription Factor 3 | 1,400
Epigenetic 2 | 242
Kinase 1 | 634

GO Process

double-strand break repair via... 76 | 76
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Swi5-dependent recombination DNA repair protein 1 homolog SFR1 Tbio Non-IDG -1.28087 18.4 68
DNA repair and recombination protein RAD54B RAD54B Tbio Non-IDG -1.41173 28.9 153
ATP-dependent DNA helicase Q4 RECQL4 Tbio Enzyme 0.00000 0
ATP-dependent DNA helicase Q5 RECQL5 Tbio Enzyme -1.67373 56.2 148
AP-5 complex subunit sigma-1 AP5S1 Tdark Non-IDG 0.00000 4
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
Oral cancer-overexpressed protein 1 ORAOV1 Tbio Non-IDG -1.06859 14.3 41
Fanconi-associated nuclease 1 FAN1 Tbio Enzyme -2.06970 115.9 85
E3 ubiquitin-protein ligase RNF138 RNF138 Tbio Transcription Factor -1.08996 12.5 148
DNA repair protein XRCC3 XRCC3 Tbio Non-IDG -2.50791 314.0 414