Development Level

Tbio 47 | 11,445
Tchem 8 | 1,598
Tdark 3 | 6,588
Tclin 2 | 613

IMPC Phenotype

embryonic lethality prior to t... 4 | 278
preweaning lethality, complete... 4 | 979
preweaning lethality, incomple... 4 | 499
decreased bone mineral density 3 | 126
embryonic lethality prior to o... 3 | 239
male infertility 3 | 123
abnormal bone mineralization 2 | 38
decreased lean body mass 2 | 135
increased mean corpuscular vol... 2 | 92
increased total body fat amoun... 2 | 134
shortened RR interval 2 | 17
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal locomotor behavior 1 | 24
abnormal retinal inner nuclear... 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal tail morphology 1 | 25
abnormal vocalization 1 | 21
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased fluid intake 1 | 3
decreased heart rate variabili... 1 | 13
decreased lumbar vertebrae num... 1 | 2
decreased lymphocyte cell numb... 1 | 83
decreased red blood cell distr... 1 | 41
decreased sacral vertebrae num... 1 | 1
decreased startle reflex 1 | 75
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
female infertility 1 | 60
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased heart rate 1 | 23
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lumbar vertebrae num... 1 | 1
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
increased prepulse inhibition 1 | 32
increased sacral vertebrae num... 1 | 1
shortened ST segment 1 | 10
small testis 1 | 58
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 47 | 11,493
osteosarcoma 37 | 7,950
ovarian cancer 36 | 8,520
medulloblastoma, large-cell 32 | 6,241
glioblastoma 29 | 5,792
Cancer 26 | 2,499
lung cancer 26 | 4,740
group 3 medulloblastoma 25 | 4,104
Breast cancer 23 | 3,578
psoriasis 22 | 6,694
atypical teratoid / rhabdoid tumor 21 | 5,112
malignant mesothelioma 18 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
primitive neuroectodermal tumor 16 | 3,035
Kidney cancer 15 | 2,613
non-small cell lung cancer 14 | 2,890
Ataxia telangiectasia 12 | 34
invasive ductal carcinoma 12 | 2,951
lung adenocarcinoma 12 | 2,716
adult high grade glioma 11 | 3,801
ependymoma 11 | 4,679
Intellectual disability 10 | 1,016
Multiple myeloma 10 | 1,332
Nijmegen breakage syndrome 10 | 24
breast carcinoma 10 | 1,638
Autosomal recessive predisposition 9 | 1,442
Short stature 9 | 531
colon cancer 9 | 1,478
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
Fanconi anemia 8 | 56
Small head 8 | 374
ductal carcinoma in situ 8 | 1,745
subependymal giant cell astrocytoma 8 | 2,287
Chromosome Breakage 7 | 36
Dull intelligence 7 | 645
Hereditary Breast and Ovarian Cancer Syndrome 7 | 14
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
Prostatic Neoplasms 7 | 495
Xeroderma pigmentosum 7 | 43
astrocytic glioma 7 | 2,597
nasopharyngeal carcinoma 7 | 1,058
Breast Neoplasms 6 | 445
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Malignant neoplasm of breast 6 | 15
Mammary Neoplasms 6 | 425
Mental and motor retardation 6 | 608
Microcephaly 6 | 166
Neurodegenerative disease 6 | 414
Werner syndrome 6 | 29
adrenocortical carcinoma 6 | 1,428
group 4 medulloblastoma 6 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
non primary Sjogren syndrome sicca 6 | 891
Atopic dermatitis 5 | 952
Attention deficit hyperactivity disorder 5 | 278
Bloom syndrome 5 | 29
Endometriosis 5 | 540
Increased chromosomal breakage 5 | 27
Lymphoma 5 | 81
Ovarian Neoplasms 5 | 102
Prostate cancer 5 | 175
Waldenstrons macroglobulinemia 5 | 765
active Crohn's disease 5 | 922
astrocytoma 5 | 1,146
diabetes mellitus 5 | 1,728
juvenile dermatomyositis 5 | 1,187
oligodendroglioma 5 | 2,850
ovarian neoplasm 5 | 99
pituitary cancer 5 | 1,972
tuberculosis 5 | 2,010
Anemia 4 | 365
Choreatic disease 4 | 52
Colorectal Neoplasms 4 | 243
Concave bridge of nose 4 | 195
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Dysarthria 4 | 192
Fetal Growth Retardation 4 | 189
Glioma 4 | 74
Hypoplastic mandible condyle 4 | 275
Infant, Small for Gestational Age 4 | 176
Intrauterine retardation 4 | 176
Liver cancer 4 | 604
Low anterior hairline 4 | 30
Mandibular hypoplasia 4 | 275
Micrognathism 4 | 275
Multiple Sclerosis 4 | 540
Neuropathy 4 | 261
Rheumatoid arthritis 4 | 1,191
Schizophrenia 4 | 1,160
Severe combined immunodeficiency 4 | 51
lung carcinoma 4 | 2,843
pancreatic cancer 4 | 2,398
posterior fossa group A ependymoma 4 | 468
progressive supranuclear palsy 4 | 676
sonic hedgehog group medulloblastoma 4 | 467

Tissue

Blood and immune system 60 | 16,909
Endocrine System 60 | 18,159
Male tissues 60 | 17,142
Digestive Tract 59 | 17,369
Female tissues 59 | 17,400
Nervous System 59 | 16,725
Respiratory system 59 | 16,393
Skin and soft tissues 59 | 17,230
Urinary Tract 59 | 16,678
Liver and Pancreas 58 | 16,750
Cardiovascular System 57 | 15,192

Target Family

Non-IDG 31 | 12,091
Enzyme 25 | 4,145
Kinase 2 | 634
Epigenetic 1 | 242
Transcription Factor 1 | 1,400

GO Process

double-strand break repair 60 | 60
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meiosis regulator and mRNA stability factor 1 MARF1 Tdark Non-IDG -0.82344 7.58 23
Calcium and integrin-binding protein 1 CIB1 Tbio Non-IDG -2.08897 121.1 264
Tyrosyl-DNA phosphodiesterase 1 TDP1 Tchem Enzyme -2.09041 139.4 210
Gametogenetin GGN Tbio Non-IDG -2.15183 135.1 57
Fanconi anemia group J protein BRIP1 Tbio Non-IDG -1.81875 78.3 223
E3 ubiquitin-protein ligase RNF8 RNF8 Tbio Enzyme -1.80196 70.0 250
Breast cancer type 2 susceptibility protein BRCA2 Tbio Non-IDG -3.46139 2647.6 209
DNA ligase 4 LIG4 Tbio Enzyme -2.14909 140.9 204
Poly [ADP-ribose] polymerase 9 PARP9 Tbio Enzyme -1.31595 19.3 72
Double-strand-break repair protein rad21-like protein 1 RAD21L1 Tdark Non-IDG -0.98602 12.1 6