Development Level

Tbio 51 | 10,625
Tchem 8 | 1,890
Tdark 3 | 7,003
Tclin 2 | 602

IMPC Term

preweaning lethality, complete... 4 | 633
increased circulating sodium l... 3 | 71
preweaning lethality, incomple... 3 | 260
abnormal behavior 2 | 226
abnormal bone mineralization 2 | 55
decreased body weight 2 | 174
decreased grip strength 2 | 123
male infertility 2 | 62
abnormal behavioral response t... 1 | 52
abnormal coat/ hair morphology 1 | 18
abnormal craniofacial morpholo... 1 | 12
abnormal gait 1 | 51
abnormal posture 1 | 5
abnormal retinal inner nuclear... 1 | 5
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal spleen morphology 1 | 36
abnormal tail movements 1 | 12
abnormal vocalization 1 | 21
cardiovascular system phenotyp... 1 | 35
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating choleste... 1 | 85
decreased circulating glucose ... 1 | 121
decreased circulating total pr... 1 | 41
decreased heart rate variabili... 1 | 11
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased lymphocyte cell numb... 1 | 9
decreased mean corpuscular hem... 1 | 34
decreased startle reflex 1 | 48
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
embryonic lethality prior to t... 1 | 187
female infertility 1 | 34
hypoactivity 1 | 89
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased bone mineral density 1 | 52
increased circulating chloride... 1 | 43
increased circulating total pr... 1 | 20
increased circulating triglyce... 1 | 24
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased heart rate 1 | 17
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased neutrophil cell numb... 1 | 15
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
increased total body fat amoun... 1 | 57
shortened RR interval 1 | 19
shortened ST segment 1 | 9
small testis 1 | 37
straub tail 1 | 26
thin tail 1 | 1
thrombocytopenia 1 | 46

Disease

osteosarcoma 42 | 7,933
ovarian cancer 38 | 8,484
medulloblastoma, large-cell 34 | 6,234
Cancer 27 | 2,346
glioblastoma 27 | 5,572
lung cancer 27 | 4,466
Breast cancer 25 | 3,094
psoriasis 24 | 6,685
group 3 medulloblastoma 19 | 2,254
malignant mesothelioma 19 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,289
primitive neuroectodermal tumor 18 | 3,031
atypical teratoid / rhabdoid tumor 15 | 4,369
non-small cell lung cancer 15 | 2,798
Carcinoma 14 | 2,147
invasive ductal carcinoma 14 | 2,950
lung adenocarcinoma 14 | 2,713
pediatric high grade glioma 13 | 2,712
sonic hedgehog group medulloblastoma 12 | 1,482
Ataxia telangiectasia 11 | 31
Multiple myeloma 11 | 1,327
colon cancer 10 | 1,475
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
Neoplastic Syndromes, Hereditary 9 | 48
Nijmegen breakage syndrome 9 | 23
Fanconi's anemia 8 | 50
breast carcinoma 8 | 1,614
ductal carcinoma in situ 8 | 1,745
nasopharyngeal carcinoma 8 | 1,056
subependymal giant cell astrocytoma 8 | 2,287
Hereditary Breast and Ovarian Cancer Syndrome 7 | 14
Malignant neoplasm of breast 7 | 63
Prostatic Neoplasms 7 | 471
astrocytic glioma 7 | 2,241
atypical teratoid/rhabdoid tumor 7 | 1,095
non primary Sjogren syndrome sicca 7 | 840
posterior fossa group A ependymoma 7 | 1,511
Mammary Neoplasms 6 | 410
Microcephaly 6 | 149
Neurodegenerative disease 6 | 383
Peripheral Neuropathy 6 | 303
Waldenstrons macroglobulinemia 6 | 765
Werner syndrome 6 | 29
active Crohn's disease 6 | 918
adrenocortical carcinoma 6 | 1,427
astrocytoma 6 | 1,493
group 4 medulloblastoma 6 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,956
Atopic dermatitis 5 | 944
Endometriosis 5 | 535
Prostate cancer 5 | 172
diabetes mellitus 5 | 1,663
ependymoma 5 | 2,514
juvenile dermatomyositis 5 | 1,189
lung carcinoma 5 | 2,844
oligodendroglioma 5 | 2,849
ovarian neoplasm 5 | 97
pancreatic cancer 5 | 2,300
pituitary cancer 5 | 1,972
Anemia 4 | 252
Bloom syndrome 4 | 30
Breast Cancer, Familial 4 | 12
Cockayne syndrome 4 | 54
Intellectual disability 4 | 573
Malignant neoplasm of ovary 4 | 13
Prostate cancer, familial 4 | 13
Rheumatoid Arthritis 4 | 1,160
Xeroderma pigmentosum 4 | 41
inflammatory breast cancer 4 | 404
medulloblastoma 4 | 1,524
posterior fossa group B ependymoma 4 | 1,530
progressive supranuclear palsy 4 | 674
tuberculosis 4 | 1,557
ulcerative colitis 4 | 2,087
Alzheimer's disease 3 | 644
Amyotrophic Lateral Sclerosis 3 | 431
Baller-Gerold syndrome 3 | 14
Choreatic disease 3 | 27
Colorectal Neoplasms 3 | 217
Li-Fraumeni Syndrome 3 | 13
Lynch syndrome 3 | 33
Malignant neoplasm of lung 3 | 16
Melanoma 3 | 261
Multiple Sclerosis 3 | 498
Neuropathy 3 | 210
Photosensitive trichothiodystrophy 3 | 24
Pick disease 3 | 1,893
Roberts syndrome 3 | 16
Rothmund-Thomson syndrome 3 | 22
Seckel syndrome 3 | 34
Williams-Beuren syndrome 3 | 45
acute myeloid leukemia 3 | 780
acute quadriplegic myopathy 3 | 1,157
adult high grade glioma 3 | 2,148
dermatomyositis 3 | 933
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
pilocytic astrocytoma 3 | 3,086
primary Sjogren syndrome 3 | 789
tuberculosis and treatment for 6 months 3 | 686
hepatocellular carcinoma 2 | 532

Tissue

Blood and immune system 64 | 17,995
Digestive Tract 64 | 18,473
Endocrine System 64 | 18,512
Liver and Pancreas 64 | 18,136
Male tissues 64 | 17,969
Nervous System 64 | 18,561
Respiratory system 64 | 17,484
Urinary Tract 64 | 18,444
Cardiovascular System 63 | 17,958
Female tissues 63 | 18,647
Skin and soft tissues 63 | 18,115

Target Family

Non-IDG 33 | 11,971
Enzyme 25 | 4,146
Epigenetic 2 | 242
Kinase 2 | 634
Transcription Factor 2 | 1,400

GO Process

double-strand break repair 64 | 64
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable crossover junction endonuclease EME2 EME2 Tbio Enzyme -1.53403 32.3 56
Double-strand break repair protein MRE11A MRE11 Tbio Non-IDG -1.95631 90.0 412
DNA ligase 4 LIG4 Tbio Enzyme -2.11773 136.0 194
DNA ligase 3 LIG3 Tbio Enzyme -2.71696 505.0 223
E3 ubiquitin-protein ligase RNF168 RNF168 Tbio Enzyme -1.46566 28.7 150
E3 ubiquitin-protein ligase RNF8 RNF8 Tbio Enzyme -1.74520 64.0 226
Poly [ADP-ribose] polymerase 3 PARP3 Tclin Enzyme -1.59573 37.3 182
BRCA1-A complex subunit BRE BRE Tbio Non-IDG -2.26989 193.7 145
Breast cancer type 2 susceptibility protein BRCA2 Tbio Non-IDG -3.42019 2495.6 219
Aprataxin and PNK-like factor APLF Tbio Non-IDG -1.62842 45.0 169