Development Level

Tbio 5 | 11,445
Tchem 1 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 3 | 979
abnormal embryo size 2 | 220
embryonic growth retardation 2 | 106
abnormal embryo turning 1 | 31
abnormal heart morphology 1 | 162
abnormal neural tube closure 1 | 46
abnormal tail bud morphology 1 | 8
decreased circulating lipase l... 1 | 3
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278

Disease

Congenital disorder of glycosylation 4 | 54
ovarian cancer 4 | 8,520
Breast cancer 3 | 3,578
Carcinoma 3 | 11,493
Autosomal recessive predisposition 2 | 1,442
Cataract 2 | 297
Epilepsy 2 | 792
Intellectual disability 2 | 1,016
Seizures 2 | 596
ductal carcinoma in situ 2 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
invasive ductal carcinoma 2 | 2,951
osteosarcoma 2 | 7,950
tuberculosis 2 | 2,010
Abnormal isoelectric focusing of serum transferrin 1 | 3
Acquired scoliosis 1 | 281
Autosomal recessive non-syndromic intellectual disability 1 | 7
Batten disease 1 | 13
Bilateral fifth finger clinodactyly 1 | 110
Blood Coagulation Disorders 1 | 42
Botulism 1 | 24
Bullous pemphigoid 1 | 18
Cardiomyopathy, Dilated 1 | 83
Cenani-Lenz syndactyly syndrome 1 | 4
Cerebral atrophy 1 | 178
Citrullinemia 1 | 14
Coagulation abnormalities 1 | 27
Coloboma 1 | 51
Colorectal Neoplasms 1 | 243
Congenital Disorder Of Glycosylation, Type Im 1 | 1
Congenital myasthenic syndrome 1 | 25
Creutzfeldt-Jakob Syndrome 1 | 10
Creutzfeldt-Jakob disease 1 | 21
Curvature of little finger 1 | 110
Curvature of spine 1 | 282
DK1-CDG 1 | 1
Death in early childhood 1 | 82
Death in infancy 1 | 82
Dementia 1 | 175
Disease Progression 1 | 136
Disseminated superficial actinic porokeratosis 1 | 4
Dry skin 1 | 75
Endometriosis 1 | 540
Exotropia 1 | 35
Failure to gain weight 1 | 365
Familial isolated dilated cardiomyopathy 1 | 41
Fukuyama congenital muscular dystrophy 1 | 8
Glaucoma 1 | 239
Hemorrhagic Disorders 1 | 30
Hepatomegaly 1 | 285
Highly variable severity 1 | 157
Hyperreflexia 1 | 209
Hypersensitivity reaction type II disease 1 | 253
Hypoketotic hypoglycemia 1 | 11
Hypsarrhythmia 1 | 25
Ichthyoses 1 | 41
Impaired cognition 1 | 96
Isoelectric focusing of serum transferrin consistent with CDG type I 1 | 10
LEFT VENTRICULAR NONCOMPACTION 10 1 | 40
LEFT VENTRICULAR NONCOMPACTION 8 1 | 40
Lipoatrophy 1 | 19
Melanoma 1 | 711
Mental impairment 1 | 95
Mitral valve insufficiency 1 | 49
Motor delay 1 | 147
Myalgia 1 | 54
Myasthenic Syndromes, Congenital 1 | 16
Myopathy 1 | 185
Neurodegenerative disease 1 | 414
Neuropathy 1 | 261
Nipples absent or rudimentary 1 | 3
No development of motor milestones 1 | 147
Otitis Media 1 | 52
POROKERATOSIS 7, MULTIPLE TYPES 1 | 1
Pediatric failure to thrive 1 | 365
Porokeratosis of Mibelli 1 | 4
Porokeratosis, Disseminated Superficial Actinic 1 | 4
Postnatal microcephaly 1 | 24
Prenatal onset 1 | 139
Proximal muscle weakness 1 | 47
Proximal neurogenic muscle weakness 1 | 47
Ptosis 1 | 48
Retinitis pigmentosa 59 1 | 11
Single transverse palmar crease 1 | 29
Slow progression 1 | 89
Sparse eyebrow 1 | 42
Sparse eyelashes 1 | 31
Stomach Neoplasms 1 | 300
Variable expressivity 1 | 157
Waterhouse-Friderichsen syndrome 1 | 11
Xerosis 1 | 75
active Crohn's disease 1 | 922
active ulcerative colitis 1 | 764
breast carcinoma 1 | 1,638
chronic rhinosinusitis 1 | 512
lung adenocarcinoma 1 | 2,716
nasopharyngeal carcinoma 1 | 1,058
pancreatic cancer 1 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,962

Tissue

Blood and immune system 7 | 16,909
Cardiovascular System 7 | 15,192
Digestive Tract 7 | 17,369
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Male tissues 7 | 17,142
Nervous System 7 | 16,725
Respiratory system 7 | 16,393
Skin and soft tissues 7 | 17,230
Urinary Tract 7 | 16,678

Target Family

Enzyme 7 | 4,145

GO Process

dolichyl diphosphate biosynthe... 7 | 7
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dolichol kinase DOLK Tbio Enzyme -1.89047 77.2 58
Diphosphomevalonate decarboxylase MVD Tchem Enzyme -2.09917 118.7 136
Polyprenol reductase SRD5A3 Tbio Enzyme -1.38816 25.5 72
Dolichyldiphosphatase 1 DOLPP1 Tdark Enzyme 0.30 0.50 60
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase DPAGT1 Tbio Enzyme -2.76697 571.2 136
Dehydrodolichyl diphosphate synthase complex subunit DHDDS DHDDS Tbio Enzyme -2.87826 731.1 74
Dehydrodolichyl diphosphate synthase complex subunit NUS1 NUS1 Tbio Enzyme -1.37569 28.5 55