Development Level

Tbio 150 | 11,651
Tchem 16 | 1,388
Tclin 10 | 612
Tdark 5 | 6,593

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 9 | 979
decreased bone mineral content 6 | 151
embryonic lethality prior to t... 6 | 278
embryonic lethality prior to o... 5 | 239
abnormal bone structure 4 | 187
decreased mean corpuscular vol... 4 | 79
abnormal behavior 3 | 298
abnormal embryo size 3 | 220
increased lymphocyte cell numb... 3 | 32
increased neutrophil cell numb... 3 | 46
abnormal gait 2 | 69
abnormal neural tube closure 2 | 46
abnormal retina morphology 2 | 71
decreased bone mineral density 2 | 126
decreased lymphocyte cell numb... 2 | 83
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
increased circulating HDL chol... 2 | 80
increased lean body mass 2 | 172
increased red blood cell distr... 2 | 34
increased startle reflex 2 | 112
preweaning lethality, incomple... 2 | 499
abnormal coat- hair morphology 1 | 19
abnormal coat-hair pigmentatio... 1 | 64
abnormal esophagus morphology 1 | 5
abnormal hair growth 1 | 10
abnormal heart morphology 1 | 162
abnormal iris morphology 1 | 13
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal placenta size 1 | 20
abnormal seminal vesicle morph... 1 | 114
abnormal tooth morphology 1 | 24
decreased blood urea nitrogen ... 1 | 51
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased monocyte cell number 1 | 8
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
enlarged gallbladder 1 | 2
enlarged kidney 1 | 14
enlarged spleen 1 | 41
enlarged urinary bladder 1 | 8
female infertility 1 | 60
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased erythrocyte cell num... 1 | 39
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 36
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased total body fat amoun... 1 | 134
pale yolk sac 1 | 25
pallor 1 | 34
prolonged QRS complex duration 1 | 8
short tibia 1 | 97
small superior vagus ganglion 1 | 74
tremors 1 | 39

Disease

Carcinoma 105 | 11,493
ovarian cancer 97 | 8,520
psoriasis 90 | 6,694
osteosarcoma 80 | 7,950
glioblastoma 78 | 5,792
lung cancer 76 | 4,740
medulloblastoma, large-cell 68 | 6,241
cutaneous lupus erythematosus 57 | 1,057
Cancer 56 | 2,499
lung carcinoma 56 | 2,843
intraductal papillary-mucinous neoplasm (IPMN) 54 | 3,291
juvenile dermatomyositis 54 | 1,187
adult high grade glioma 53 | 3,801
Astrocytoma, Pilocytic 52 | 3,081
ependymoma 51 | 4,679
malignant mesothelioma 46 | 3,232
Multiple Sclerosis 45 | 540
Breast cancer 44 | 3,578
pancreatic cancer 44 | 2,398
Influenza 43 | 142
cystic fibrosis 42 | 1,696
atypical teratoid / rhabdoid tumor 39 | 5,112
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,989
primary Sjogren syndrome 38 | 735
tuberculosis 38 | 2,010
ulcerative colitis 38 | 1,819
active Crohn's disease 37 | 922
interstitial cystitis 37 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 37 | 2,955
subependymal giant cell astrocytoma 37 | 2,287
invasive ductal carcinoma 36 | 2,951
dermatomyositis 35 | 966
non-small cell lung cancer 32 | 2,890
group 4 medulloblastoma 30 | 1,855
Systemic lupus erythematosus 28 | 194
lung adenocarcinoma 28 | 2,716
Multiple myeloma 27 | 1,332
group 3 medulloblastoma 27 | 4,104
Influenza, Human 26 | 51
Microphthalmia with limb anomalies 26 | 40
Kidney cancer 25 | 2,613
Rheumatoid arthritis 24 | 1,191
diabetes mellitus 24 | 1,728
pituitary cancer 23 | 1,972
astrocytoma 22 | 1,146
Hepatitis C 21 | 94
Atopic dermatitis 20 | 952
Autosomal recessive predisposition 20 | 1,442
Liver Cirrhosis, Experimental 20 | 769
active ulcerative colitis 20 | 764
breast carcinoma 19 | 1,638
Asthma 18 | 385
primitive neuroectodermal tumor 18 | 3,035
Hepatitis B 17 | 108
Hypersensitivity reaction type II disease 17 | 253
acute quadriplegic myopathy 17 | 1,158
oligodendroglioma 17 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,962
Melanoma 16 | 711
hepatocellular carcinoma 16 | 547
nasopharyngeal carcinoma 16 | 1,058
primary pancreatic ductal adenocarcinoma 16 | 1,109
Hepatitis 15 | 67
Inflammatory bowel disease 15 | 151
Pick disease 15 | 1,894
esophageal adenocarcinoma 15 | 737
Arthritis 14 | 290
Dermatitis 14 | 157
Encephalitis 14 | 64
Lung disease 14 | 142
Schizophrenia 14 | 1,160
astrocytic glioma 14 | 2,597
colon cancer 14 | 1,478
ductal carcinoma in situ 14 | 1,745
non primary Sjogren syndrome sicca 14 | 891
Anemia 13 | 365
Waldenstrons macroglobulinemia 12 | 765
adrenocortical carcinoma 12 | 1,428
Breast Neoplasms 11 | 445
Duchenne muscular dystrophy 11 | 601
Vascular disease 11 | 319
head and neck cancer and chronic obstructive pulmonary disease 11 | 239
pediatric high grade glioma 11 | 1,064
sarcoidosis 11 | 370
Bipolar Disorder 10 | 666
Cognitive delay 10 | 608
Down syndrome 10 | 499
Global developmental delay 10 | 608
Human immunodeficiency virus infectious disease 10 | 138
Mammary Neoplasms 10 | 425
Mental and motor retardation 10 | 608
pancreatic carcinoma 10 | 562
Endometriosis 9 | 540
Prostatic Neoplasms 9 | 495
Seizures 9 | 596
acute myeloid leukemia 9 | 783
aldosterone-producing adenoma 9 | 665
gastric cancer 9 | 459
gastric carcinoma 9 | 807
progressive supranuclear palsy 9 | 676

Tissue

Blood and immune system 164 | 16,909
Endocrine System 163 | 18,159
Female tissues 160 | 17,400
Skin and soft tissues 160 | 17,230
Digestive Tract 159 | 17,369
Male tissues 159 | 17,142
Respiratory system 159 | 16,393
Urinary Tract 157 | 16,678
Liver and Pancreas 156 | 16,750
Nervous System 156 | 16,725
Cardiovascular System 152 | 15,192

Target Family

Non-IDG 111 | 12,091
Enzyme 47 | 4,145
Transcription Factor 10 | 1,400
Kinase 6 | 634
Epigenetic 2 | 242
GPCR 2 | 408
Transporter 2 | 473
Ion Channel 1 | 344

GO Process

defense response to virus 181 | 181
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
DNA-directed RNA polymerase III subunit RPC3 POLR3C Tbio Enzyme -0.84213 6.37 136
Protein FAM111A FAM111A Tbio Non-IDG -0.67981 5.64 27
Interferon gamma receptor 1 IFNGR1 Tbio Non-IDG -2.23009 172.7 518
Radical S-adenosyl methionine domain-containing protein 2 RSAD2 Tbio Non-IDG -1.99883 103.3 117
DNA-directed RNA polymerase III subunit RPC5 POLR3E Tbio Enzyme -2.17742 145.9 76
Stimulator of interferon genes protein TMEM173 Tbio Non-IDG -2.37722 230.3 450
Probable ATP-dependent RNA helicase DDX41 DDX41 Tbio Enzyme -3.62934 3930.0 230
Interferon epsilon IFNE Tbio Non-IDG -1.68928 47.2 109
E3 ubiquitin-protein ligase TRIM56 TRIM56 Tbio Enzyme -0.69719 6.78 109