Development Level

Tbio 80 | 10,625
Tchem 18 | 1,890
Tdark 10 | 7,003

Collection

Eligible Kinase Proteins 4 | 134

IMPC Term

preweaning lethality, complete... 4 | 633
decreased total body fat amoun... 3 | 186
increased or absent threshold ... 3 | 128
preweaning lethality, incomple... 3 | 260
abnormal bone structure 2 | 131
abnormal coat appearance 2 | 25
abnormal skin coloration 2 | 18
decreased bone mineral density 2 | 126
decreased circulating serum al... 2 | 79
increased circulating bilirubi... 2 | 16
increased circulating free fat... 2 | 17
increased exploration in new e... 2 | 56
increased mean corpuscular vol... 2 | 91
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal digit morphology 1 | 13
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal pelvic girdle bone mo... 1 | 11
abnormal placenta size 1 | 10
abnormal posture 1 | 5
abnormal respiratory quotient 1 | 9
abnormal retinal pigmentation 1 | 61
abnormal seminal vesicle morph... 1 | 47
abnormal tail morphology 1 | 17
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 14
convulsive seizures 1 | 11
craniofacial phenotype 1 | 9
decreased CD4-positive, CD25-p... 1 | 24
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating bilirubi... 1 | 14
decreased circulating glucose ... 1 | 121
decreased circulating magnesiu... 1 | 11
decreased circulating potassiu... 1 | 17
decreased circulating sodium l... 1 | 18
decreased erythrocyte cell num... 1 | 43
decreased gamma-delta T cell n... 1 | 18
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased thermal nociceptive ... 1 | 4
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
eye hemorrhage 1 | 1
female infertility 1 | 34
hypoactivity 1 | 89
immune system phenotype 1 | 17
impaired glucose tolerance 1 | 52
improved glucose tolerance 1 | 56
increased CD4-positive NK T ce... 1 | 3
increased NK T cell number 1 | 11
increased blood urea nitrogen ... 1 | 44
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased circulating triglyce... 1 | 24
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased mature B cell number 1 | 12
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased memory-marker CD4-po... 1 | 3
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82
small testis 1 | 37

Disease

osteosarcoma 62 | 7,933
ovarian cancer 50 | 8,484
psoriasis 50 | 6,685
glioblastoma 46 | 5,572
medulloblastoma, large-cell 43 | 6,234
atypical teratoid / rhabdoid tumor 38 | 4,369
intraductal papillary-mucinous adenoma (IPMA) 31 | 2,956
Breast cancer 28 | 3,094
lung cancer 28 | 4,466
malignant mesothelioma 27 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 26 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,289
non-small cell lung cancer 26 | 2,798
pediatric high grade glioma 26 | 2,712
lung carcinoma 25 | 2,844
pilocytic astrocytoma 25 | 3,086
primitive neuroectodermal tumor 25 | 3,031
Carcinoma 24 | 2,147
interstitial cystitis 24 | 2,299
invasive ductal carcinoma 24 | 2,950
breast carcinoma 23 | 1,614
pancreatic cancer 23 | 2,300
oligodendroglioma 21 | 2,849
subependymal giant cell astrocytoma 21 | 2,287
Cancer 20 | 2,346
group 4 medulloblastoma 20 | 1,875
lung adenocarcinoma 20 | 2,713
spina bifida 20 | 1,064
ependymoma 19 | 2,514
cystic fibrosis 17 | 1,665
ductal carcinoma in situ 17 | 1,745
Pick disease 16 | 1,893
adrenocortical carcinoma 16 | 1,427
adult high grade glioma 16 | 2,148
sonic hedgehog group medulloblastoma 16 | 1,482
ulcerative colitis 16 | 2,087
colon cancer 14 | 1,475
primary pancreatic ductal adenocarcinoma 14 | 1,271
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
pituitary cancer 13 | 1,972
posterior fossa group B ependymoma 13 | 1,530
tuberculosis 13 | 1,557
astrocytic glioma 12 | 2,241
esophageal adenocarcinoma 12 | 737
gastric carcinoma 12 | 832
medulloblastoma 12 | 1,524
nasopharyngeal carcinoma 12 | 1,056
astrocytoma 11 | 1,493
atypical teratoid/rhabdoid tumor 10 | 1,095
Atopic dermatitis 9 | 944
Down syndrome 9 | 548
acute myeloid leukemia 9 | 780
acute quadriplegic myopathy 9 | 1,157
group 3 medulloblastoma 9 | 2,254
juvenile dermatomyositis 9 | 1,189
posterior fossa group A ependymoma 9 | 1,511
Alzheimer's disease 8 | 644
diabetes mellitus 8 | 1,663
Rheumatoid Arthritis 7 | 1,160
cutaneous lupus erythematosus 7 | 1,056
fibroadenoma 7 | 557
tuberculosis and treatment for 6 months 7 | 686
Asthma 6 | 349
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 499
dermatomyositis 6 | 933
mucosa-associated lymphoid tissue lymphoma 6 | 480
progressive supranuclear palsy 6 | 674
Duchenne muscular dystrophy 5 | 602
Eosinophilia 5 | 65
HIV Infections 5 | 100
Hypersensitivity 5 | 63
Obesity 5 | 616
Schizophrenia 5 | 501
Squamous cell carcinoma of esophagus 5 | 82
Waldenstrons macroglobulinemia 5 | 765
active Crohn's disease 5 | 918
interstitial lung disease 5 | 291
pancreatic carcinoma 5 | 567
Aarskog-Scott syndrome 4 | 11
Atherosclerosis 4 | 275
Cardiovascular system disease 4 | 194
Cerebrovascular disease 4 | 231
Dermatitis 4 | 107
Glomerulonephritis 4 | 36
Hypertensive disease 4 | 193
Multiple myeloma 4 | 1,327
Neurodegenerative disease 4 | 383
Neuropathy 4 | 210
Pneumonia 4 | 133
Polycystic Ovary Syndrome 4 | 332
Stomach Neoplasms 4 | 282
Type 2 diabetes mellitus 4 | 189
gastric cancer 4 | 430
hepatocellular carcinoma 4 | 532
non primary Sjogren syndrome sicca 4 | 840
primary Sjogren syndrome 4 | 789
tuberculosis and treatment for 3 months 4 | 327
Endometriosis 3 | 535
nephrosclerosis 3 | 329
non diabetic and post-ischemic heart failure 3 | 200

Tissue

Cardiovascular System 107 | 17,958
Digestive Tract 106 | 18,473
Endocrine System 106 | 18,512
Female tissues 106 | 18,647
Liver and Pancreas 106 | 18,136
Male tissues 106 | 17,969
Nervous System 106 | 18,561
Urinary Tract 106 | 18,444
Blood and immune system 105 | 17,995
Respiratory system 105 | 17,484
Skin and soft tissues 105 | 18,115

Target Family

Non-IDG 76 | 11,971
Enzyme 15 | 4,146
Kinase 11 | 634
Epigenetic 4 | 242
Transcription Factor 2 | 1,400

GO Process

cytoskeleton organization 108 | 108
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788