Development Level

Tbio 17 | 11,445
Tchem 3 | 1,598
Tclin 1 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal embryo size 2 | 220
abnormal limb bud morphology 2 | 17
abnormal neural tube closure 2 | 46
decreased circulating HDL chol... 2 | 68
decreased circulating choleste... 2 | 93
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
abnormal behavior 1 | 298
abnormal body wall morphology 1 | 9
abnormal cranium morphology 1 | 36
abnormal eye morphology 1 | 68
abnormal facial morphology 1 | 17
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal incisor morphology 1 | 4
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal liver size 1 | 5
abnormal midbrain development 1 | 20
abnormal placenta size 1 | 20
abnormal radius morphology 1 | 8
abnormal response to new envir... 1 | 10
abnormal snout morphology 1 | 23
abnormal stomach morphology 1 | 10
abnormal tail morphology 1 | 25
abnormal tooth morphology 1 | 24
abnormal ulna morphology 1 | 8
cataract 1 | 92
cleft palate 1 | 8
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased lymphocyte cell numb... 1 | 83
embryonic lethality prior to o... 1 | 239
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
increased blood urea nitrogen ... 1 | 48
increased circulating triglyce... 1 | 42
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 17 | 11,493
osteosarcoma 12 | 7,950
ovarian cancer 10 | 8,520
Breast cancer 9 | 3,578
atypical teratoid / rhabdoid tumor 9 | 5,112
medulloblastoma, large-cell 9 | 6,241
psoriasis 9 | 6,694
glioblastoma 8 | 5,792
malignant mesothelioma 8 | 3,232
Kidney cancer 7 | 2,613
lung cancer 7 | 4,740
Cancer 6 | 2,499
invasive ductal carcinoma 6 | 2,951
lung adenocarcinoma 6 | 2,716
Muscle hypotonia 5 | 571
adult high grade glioma 5 | 3,801
lung carcinoma 5 | 2,843
Brachydactyly 4 | 156
Orbital separation excessive 4 | 244
Polydactyly 4 | 107
Rheumatoid arthritis 4 | 1,191
colon cancer 4 | 1,478
cystic fibrosis 4 | 1,696
ductal carcinoma in situ 4 | 1,745
ependymoma 4 | 4,679
group 4 medulloblastoma 4 | 1,855
pituitary cancer 4 | 1,972
primary pancreatic ductal adenocarcinoma 4 | 1,109
primitive neuroectodermal tumor 4 | 3,035
Acquired metabolic disease 3 | 336
Autosomal recessive predisposition 3 | 1,442
Blepharoptosis 3 | 231
Breast Neoplasms 3 | 445
Broad flat nasal bridge 3 | 236
Cardiovascular system disease 3 | 246
Cleft Palate 3 | 271
Congenital Epicanthus 3 | 177
Congenital clubfoot 3 | 109
Cryptorchidism 3 | 296
Mammary Neoplasms 3 | 425
Motor delay 3 | 147
Nasal bridge wide 3 | 236
No development of motor milestones 3 | 147
Syndactyly of the toes 3 | 45
group 3 medulloblastoma 3 | 4,104
interstitial lung disease 3 | 298
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
non-small cell lung cancer 3 | 2,890
spina bifida 3 | 1,074
Abnormally small eyeball 2 | 97
Accessory nipple 2 | 11
Acquired scoliosis 2 | 281
Anteverted nostril 2 | 191
Arthritis, Rheumatoid 2 | 174
Astrocytoma, Pilocytic 2 | 3,081
Atopic dermatitis 2 | 952
Bell Palsy 2 | 58
Big calvaria 2 | 147
Broad thumbs 2 | 28
Class III malocclusion 2 | 78
Coarse facial features 2 | 108
Concave bridge of nose 2 | 195
Craniosynostosis 2 | 74
Curvature of spine 2 | 282
Death in early childhood 2 | 82
Death in infancy 2 | 82
Decreased size of eyeball 2 | 97
Depressed nasal bridge 2 | 195
Depressed nasal root/bridge 2 | 195
Downward slant of palpebral fissure 2 | 158
Dull intelligence 2 | 645
Facial Paresis 2 | 59
Facial muscle weakness of muscles innervated by CN VII 2 | 58
Gastrointestinal Stromal Tumors 2 | 48
Hypertrophy of lower jaw 2 | 78
Increased head circumference 2 | 147
Increased size of cranium 2 | 147
Increased size of mandible 2 | 78
Increased size of skull 2 | 147
Mandibular hyperplasia 2 | 78
Pectus excavatum 2 | 100
Polyhydramnios 2 | 108
Strabismus 2 | 270
Thickened facial skin with coarse facial features 2 | 108
Ventricular Septal Defects 2 | 119
astrocytoma 2 | 1,146
breast carcinoma 2 | 1,638
cutaneous lupus erythematosus 2 | 1,057
gastric carcinoma 2 | 807
interstitial cystitis 2 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
mandibular excess (physical finding) 2 | 78
nasopharyngeal carcinoma 2 | 1,058
oligodendroglioma 2 | 2,850
pancreatic cancer 2 | 2,398
pancreatic carcinoma 2 | 562
pediatric high grade glioma 2 | 1,064
posterior fossa group B ependymoma 2 | 416
ulcerative colitis 2 | 1,819

Tissue

Blood and immune system 22 | 16,909
Cardiovascular System 22 | 15,192
Digestive Tract 22 | 17,369
Endocrine System 22 | 18,159
Female tissues 22 | 17,400
Liver and Pancreas 22 | 16,750
Male tissues 22 | 17,142
Respiratory system 22 | 16,393
Skin and soft tissues 22 | 17,230
Urinary Tract 22 | 16,678
Nervous System 21 | 16,725

Target Family

Non-IDG 14 | 12,091
Enzyme 3 | 4,145
Kinase 2 | 634
Transcription Factor 2 | 1,400
TF/Epigenetic 1 | 38

GO Process

coronary vasculature developme... 22 | 22
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Latent-transforming growth factor beta-binding protein 1 LTBP1 Tbio Non-IDG -1.97590 101.5 128
Plexin-D1 PLXND1 Tbio Non-IDG -1.64721 46.3 171
Cytoplasmic dynein 2 heavy chain 1 DYNC2H1 Tbio Non-IDG -1.60757 39.5 23
Mothers against decapentaplegic homolog 6 SMAD6 Tbio Transcription Factor -2.07569 106.7 450
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 NDST1 Tbio Enzyme -1.91878 84.7 146
Zinc finger and BTB domain-containing protein 14 ZBTB14 Tbio Transcription Factor -1.36289 24.1 47
Protein JBTS17 C5orf42 Tbio Non-IDG -2.19760 152.8 9
Proprotein convertase subtilisin/kexin type 5 PCSK5 Tchem Enzyme -2.88342 751.2 143
Multiple epidermal growth factor-like domains protein 8 MEGF8 Tbio Non-IDG -0.21967 1.88 58
Sorting nexin-17 SNX17 Tbio Non-IDG -1.19414 18.3 101