Development Level

Tbio 85 | 11,445
Tdark 17 | 6,588
Tchem 11 | 1,598

IMPC Phenotype

preweaning lethality, incomple... 8 | 499
preweaning lethality, complete... 6 | 979
abnormal embryo size 3 | 220
decreased total body fat amoun... 3 | 207
embryonic lethality prior to t... 3 | 278
abnormal bone structure 2 | 187
abnormal coat appearance 2 | 31
abnormal retina morphology 2 | 71
abnormal vibrissa morphology 2 | 25
decreased circulating glucose ... 2 | 126
decreased circulating insulin ... 2 | 76
decreased fasted circulating g... 2 | 65
embryonic growth retardation 2 | 106
increased lean body mass 2 | 172
prenatal lethality prior to he... 2 | 87
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal placenta size 1 | 20
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
brachydactyly 1 | 19
cataract 1 | 92
convulsive seizures 1 | 13
corneal opacity 1 | 32
corneal vascularization 1 | 6
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating free fat... 1 | 31
decreased circulating triglyce... 1 | 79
decreased coping response 1 | 8
decreased lean body mass 1 | 135
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased total body fat amoun... 1 | 134
increased total retina thickne... 1 | 4
male infertility 1 | 123
narrow eye opening 1 | 12
pale liver 1 | 6
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
small kidney 1 | 16

Disease

psoriasis 80 | 6,694
Carcinoma 77 | 11,493
ovarian cancer 33 | 8,520
esophageal adenocarcinoma 32 | 737
cystic fibrosis 30 | 1,696
non-small cell lung cancer 30 | 2,890
lung cancer 29 | 4,740
osteosarcoma 28 | 7,950
Breast cancer 27 | 3,578
Cancer 25 | 2,499
spina bifida 25 | 1,074
Atopic dermatitis 24 | 952
Palmoplantar keratosis 20 | 74
interstitial cystitis 20 | 2,312
malignant mesothelioma 20 | 3,232
nasopharyngeal carcinoma 19 | 1,058
pancreatic cancer 19 | 2,398
medulloblastoma, large-cell 17 | 6,241
Kidney cancer 16 | 2,613
Hypotrichosis 15 | 47
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
lung adenocarcinoma 15 | 2,716
ductal carcinoma in situ 14 | 1,745
Dystrophia unguium 13 | 53
breast carcinoma 13 | 1,638
diabetes mellitus 13 | 1,728
Autosomal recessive predisposition 12 | 1,442
Congenital ichthyosiform erythroderma 12 | 28
adult high grade glioma 12 | 3,801
atypical teratoid / rhabdoid tumor 12 | 5,112
cutaneous lupus erythematosus 12 | 1,057
Alopecia 11 | 115
Epidermolytic hyperkeratosis 11 | 14
Monilethrix 11 | 18
Abnormal blistering of the skin 10 | 54
Blister of skin 10 | 54
Dermatitis 10 | 157
Erythema 10 | 58
Flushing 10 | 60
Ichthyoses 10 | 41
Keratosis 10 | 37
Nail Diseases 10 | 24
Nail abnormality 10 | 22
Netherton syndrome 10 | 15
Pachyonychia congenita 10 | 10
Skin bulla 10 | 54
glioblastoma 10 | 5,792
invasive ductal carcinoma 10 | 2,951
lung carcinoma 10 | 2,843
Hyperhidrosis disorder 9 | 81
Ichthyosis 9 | 56
Increased sweating 9 | 81
Melanoma 9 | 711
Skin cancer 9 | 469
Sweating 9 | 81
colon cancer 9 | 1,478
ependymoma 9 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
periodontitis 9 | 293
ulcerative colitis 9 | 1,819
Squamous cell carcinoma 8 | 129
pituitary cancer 8 | 1,972
Arrhythmogenic right ventricular cardiomyopathy 7 | 30
Carcinoma, Squamous Cell 7 | 110
Eczema 7 | 45
Epidermolysis bullosa simplex 7 | 9
Hereditary mucosal leukokeratosis 7 | 7
Ichthyosis vulgaris 7 | 11
Leukokeratosis 7 | 19
Leukoplakia, Oral 7 | 20
Nail dysplasia 7 | 52
Peeling skin syndrome 7 | 17
Prostatic Neoplasms 7 | 495
group 3 medulloblastoma 7 | 4,104
primitive neuroectodermal tumor 7 | 3,035
Abnormality of metabolism/homeostasis 6 | 134
Astrocytoma, Pilocytic 6 | 3,081
Brittle hair 6 | 25
Cardiomyopathy 6 | 116
Fractured hair 6 | 25
Fragile hair 6 | 25
Onychogryposis 6 | 13
Papilloma 6 | 44
Pemphigus 6 | 23
Reduced tensile strength of hair 6 | 25
Skin disease 6 | 66
Wooly hair 6 | 17
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
oligodendroglioma 6 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
subependymal giant cell astrocytoma 6 | 2,287
Contact Dermatitis 5 | 81
Dermatitis, Contact 5 | 71
Dilated cardiomyopathy 5 | 56
Highly variable severity 5 | 157
Liver cancer 5 | 604
Variable expressivity 5 | 157
astrocytic glioma 5 | 2,597
cystic fibrosis and chronic rhinosinusitis 5 | 214
primary pancreatic ductal adenocarcinoma 5 | 1,109

Tissue

Female tissues 105 | 17,400
Skin and soft tissues 103 | 17,230
Digestive Tract 100 | 17,369
Endocrine System 96 | 18,159
Blood and immune system 93 | 16,909
Male tissues 72 | 17,142
Liver and Pancreas 68 | 16,750
Nervous System 64 | 16,725
Urinary Tract 64 | 16,678
Respiratory system 63 | 16,393
Cardiovascular System 52 | 15,192

Target Family

Non-IDG 95 | 12,091
Enzyme 18 | 4,145

GO Process

cornification 113 | 113
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Suppressor of tumorigenicity 14 protein ST14 Tchem Non-IDG -2.50215 338.3 309
Kallikrein-12 KLK12 Tbio Enzyme -0.99694 11.0 111
Plakophilin-2 PKP2 Tbio Non-IDG -2.10355 135.3 243
Keratin, type II cytoskeletal 73 KRT73 Tdark Non-IDG 0.20 0.40 87
Small proline-rich protein 2F SPRR2F Tbio Non-IDG 0.44 0.31 12
Keratin, type II cytoskeletal 2 oral KRT76 Tdark Non-IDG -0.28255 1.97 156
Plakophilin-3 PKP3 Tbio Non-IDG -1.37372 26.0 200
Keratin, type I cytoskeletal 18 KRT18 Tbio Non-IDG -3.05211 1057.8 1953
Keratin, type II cytoskeletal 8 KRT8 Tbio Non-IDG -2.87670 710.7 1827
Late cornified envelope protein 3D LCE3D Tdark Non-IDG -0.13175 1.11 0