Development Level

Tbio 72 | 11,445
Tchem 11 | 1,598
Tdark 10 | 6,588
Tclin 3 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 11 | 979
embryonic lethality prior to t... 4 | 278
male infertility 4 | 123
abnormal head morphology 3 | 10
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
decreased circulating choleste... 3 | 93
decreased circulating serum al... 3 | 82
decreased total body fat amoun... 3 | 207
preweaning lethality, incomple... 3 | 499
abnormal cranium morphology 2 | 36
abnormal embryo size 2 | 220
abnormal humerus morphology 2 | 11
decreased circulating calcium ... 2 | 36
decreased circulating total pr... 2 | 49
decreased lean body mass 2 | 135
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
hydrometra 2 | 53
small superior vagus ganglion 2 | 74
abnormal behavior 1 | 298
abnormal embryo turning 1 | 31
abnormal external female genit... 1 | 1
abnormal external male genital... 1 | 1
abnormal femur morphology 1 | 14
abnormal heart morphology 1 | 162
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal nail morphology 1 | 8
abnormal pericardium morpholog... 1 | 26
abnormal response to tactile s... 1 | 17
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal tail morphology 1 | 25
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 43
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 18
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
edema 1 | 59
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged uterus 1 | 11
hypoactivity 1 | 132
increased body weight 1 | 25
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating insulin ... 1 | 3
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small testis 1 | 58
vertebral fusion 1 | 23

Disease

Carcinoma 70 | 11,493
ovarian cancer 63 | 8,520
osteosarcoma 50 | 7,950
group 3 medulloblastoma 42 | 4,104
atypical teratoid / rhabdoid tumor 37 | 5,112
psoriasis 37 | 6,694
medulloblastoma, large-cell 36 | 6,241
ependymoma 35 | 4,679
lung cancer 33 | 4,740
glioblastoma 31 | 5,792
Intellectual disability 28 | 1,016
primitive neuroectodermal tumor 27 | 3,035
malignant mesothelioma 26 | 3,232
Kidney cancer 25 | 2,613
Breast cancer 24 | 3,578
Joubert syndrome 21 | 66
oligodendroglioma 21 | 2,850
Autosomal recessive predisposition 20 | 1,442
Cognitive delay 20 | 608
Global developmental delay 20 | 608
Mental and motor retardation 20 | 608
Nephronophthisis 20 | 80
adult high grade glioma 19 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
Dull intelligence 18 | 645
Low intelligence 18 | 645
Mental Retardation 18 | 645
Mental deficiency 18 | 645
Pick disease 18 | 1,894
Poor school performance 18 | 645
non-small cell lung cancer 17 | 2,890
Astrocytoma, Pilocytic 16 | 3,081
colon cancer 16 | 1,478
Meckel syndrome 15 | 46
Short stature 15 | 531
Small head 15 | 374
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
Microcephaly 14 | 166
Multiple myeloma 14 | 1,332
Polydactyly 14 | 107
astrocytic glioma 14 | 2,597
Muscle hypotonia 13 | 571
invasive ductal carcinoma 13 | 2,951
nasopharyngeal carcinoma 13 | 1,058
Senior-Loken syndrome 12 | 22
lung adenocarcinoma 12 | 2,716
Nystagmus 11 | 317
Cancer 10 | 2,499
Cataract 10 | 297
Cerebellar Ataxia 10 | 304
Ciliopathy 10 | 71
Lens Opacities 10 | 231
Retinal Degeneration 10 | 106
Schizophrenia 10 | 1,160
breast carcinoma 10 | 1,638
posterior fossa group B ependymoma 10 | 416
tuberculosis 10 | 2,010
Bardet-Biedl syndrome 9 | 51
Cystic kidney disease 9 | 26
Epilepsy 9 | 792
Hypoplastic mandible condyle 9 | 275
Mandibular hypoplasia 9 | 275
Meckel-Gruber syndrome 9 | 13
Micrognathism 9 | 275
Obesity 9 | 678
Orbital separation excessive 9 | 244
Seizures 9 | 596
Sloping forehead 9 | 46
diabetes mellitus 9 | 1,728
non primary Sjogren syndrome sicca 9 | 891
pancreatic cancer 9 | 2,398
Downward slant of palpebral fissure 8 | 158
Familial aplasia of the vermis 8 | 19
Hypertensive disease 8 | 292
Increase in blood pressure 8 | 119
Low Vision 8 | 174
Low set ears 8 | 181
Molar tooth sign on MRI 8 | 12
Orofaciodigital syndrome 8 | 21
Retinitis Pigmentosa 8 | 226
Visual Impairment 8 | 174
Waldenstrons macroglobulinemia 8 | 765
adrenocortical carcinoma 8 | 1,428
chronic rhinosinusitis 8 | 512
ductal carcinoma in situ 8 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
pediatric high grade glioma 8 | 1,064
ulcerative colitis 8 | 1,819
Cerebellar vermis hypoplasia 7 | 24
Cleft Palate 7 | 271
Electroretinogram abnormal 7 | 95
Fetal Growth Retardation 7 | 189
Infant, Small for Gestational Age 7 | 176
Intrauterine retardation 7 | 176
Multicystic Dysplastic Kidney 7 | 52
Retinal Dystrophies 7 | 33
Uranostaphyloschisis 7 | 167
juvenile dermatomyositis 7 | 1,187
subependymal giant cell astrocytoma 7 | 2,287

Tissue

Blood and immune system 96 | 16,909
Cardiovascular System 96 | 15,192
Digestive Tract 96 | 17,369
Endocrine System 96 | 18,159
Female tissues 96 | 17,400
Liver and Pancreas 96 | 16,750
Male tissues 96 | 17,142
Nervous System 96 | 16,725
Respiratory system 96 | 16,393
Skin and soft tissues 96 | 17,230
Urinary Tract 96 | 16,678

Target Family

Non-IDG 81 | 12,091
Kinase 9 | 634
Enzyme 6 | 4,145

GO Process

ciliary basal body-plasma memb... 96 | 96
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Centrosomal protein of 57 kDa CEP57 Tbio Non-IDG -0.98216 11.8 177
Nuclear distribution protein nudE homolog 1 NDE1 Tbio Non-IDG -2.01711 96.0 192
HAUS augmin-like complex subunit 2 HAUS2 Tbio Non-IDG 0.71 0.12 44
Tubulin beta-4A chain TUBB4A Tclin Non-IDG -2.98371 896.1 90
Centromere protein J CENPJ Tbio Non-IDG -1.79588 59.0 102
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Sodium channel and clathrin linker 1 SCLT1 Tdark Non-IDG -0.50820 2.61 97
Centrosomal protein of 290 kDa CEP290 Tbio Non-IDG -2.03755 107.9 152
Centrosomal protein of 131 kDa CEP131 Tbio Non-IDG -1.78486 61.9 82
B9 domain-containing protein 1 B9D1 Tdark Non-IDG -0.61316 3.72 43