Development Level

Tbio 23 | 11,651
Tdark 11 | 6,593
Tchem 4 | 1,388
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal liver morphology 1 | 17
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased total retina thickne... 1 | 17
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
increased circulating fructosa... 1 | 13
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased startle reflex 1 | 112
prenatal lethality prior to he... 1 | 87

Disease

osteosarcoma 16 | 7,950
Carcinoma 15 | 11,493
lung cancer 13 | 4,740
ovarian cancer 13 | 8,520
psoriasis 13 | 6,694
Breast cancer 12 | 3,578
Cancer 11 | 2,499
medulloblastoma, large-cell 9 | 6,241
glioblastoma 8 | 5,792
invasive ductal carcinoma 8 | 2,951
lung adenocarcinoma 8 | 2,716
atypical teratoid / rhabdoid tumor 7 | 5,112
breast carcinoma 7 | 1,638
malignant mesothelioma 7 | 3,232
diabetes mellitus 6 | 1,728
group 3 medulloblastoma 6 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
subependymal giant cell astrocytoma 6 | 2,287
Multiple myeloma 5 | 1,332
ductal carcinoma in situ 5 | 1,745
group 4 medulloblastoma 5 | 1,855
non-small cell lung carcinoma 5 | 317
Breast Neoplasms 4 | 445
Intellectual disability 4 | 1,016
Kidney cancer 4 | 2,613
Mammary Neoplasms 4 | 425
Schizophrenia 4 | 1,160
adrenocortical carcinoma 4 | 1,428
ependymoma 4 | 4,679
non-small cell lung cancer 4 | 2,890
primitive neuroectodermal tumor 4 | 3,035
Cleft Palate 3 | 271
Liver cancer 3 | 604
Male infertility 3 | 206
Obesity 3 | 678
Waldenstrons macroglobulinemia 3 | 765
adult high grade glioma 3 | 3,801
astrocytic glioma 3 | 2,597
cutaneous lupus erythematosus 3 | 1,057
gastric cancer 3 | 459
hepatocellular carcinoma 3 | 547
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
non primary Sjogren syndrome sicca 3 | 891
pancreatic cancer 3 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pituitary cancer 3 | 1,972
Acquired scoliosis 2 | 281
Blepharoptosis 2 | 231
Byzanthine arch palate 2 | 194
Cerebral atrophy 2 | 178
Cocaine-Related Disorders 2 | 92
Cognitive delay 2 | 608
Congenital deafness 2 | 185
Connective tissue disease 2 | 62
Curvature of spine 2 | 282
Deafness 2 | 198
Depressive disorder 2 | 409
Dilated ventricles (finding) 2 | 121
Dull intelligence 2 | 645
Endometriosis 2 | 540
Epilepsy 2 | 792
Failure to gain weight 2 | 365
Feeding difficulties in infancy 2 | 175
Global developmental delay 2 | 608
Hearing Loss, Partial 2 | 185
Huntington's disease 2 | 76
Large auricle 2 | 87
Large dysplastic ears 2 | 87
Large pinnae 2 | 87
Large prominent ears 2 | 87
Large protruding ears 2 | 87
Large, floppy ears 2 | 87
Low intelligence 2 | 645
Lupus erythematosus 2 | 57
Macrotia 2 | 87
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Mood Disorders 2 | 184
Muscle hypotonia 2 | 571
Neurodevelopmental Disorders 2 | 70
Parkinson's disease 2 | 392
Pediatric failure to thrive 2 | 365
Pick disease 2 | 1,894
Poor school performance 2 | 645
Psychotic Disorders 2 | 151
Rheumatoid arthritis 2 | 1,191
Seizures 2 | 596
Short stature 2 | 531
Small head 2 | 374
acute myeloid leukemia 2 | 783
astrocytoma 2 | 1,146
colon cancer 2 | 1,478
hearing impairment 2 | 199
oligodendroglioma 2 | 2,850
pancreatic carcinoma 2 | 562
pediatric high grade glioma 2 | 1,064
primary pancreatic ductal adenocarcinoma 2 | 1,109
spina bifida 2 | 1,074

Tissue

Endocrine System 36 | 18,159
Skin and soft tissues 36 | 17,230
Blood and immune system 35 | 16,909
Digestive Tract 35 | 17,369
Female tissues 35 | 17,400
Cardiovascular System 33 | 15,192
Liver and Pancreas 33 | 16,750
Male tissues 33 | 17,142
Nervous System 33 | 16,725
Respiratory system 32 | 16,393
Urinary Tract 32 | 16,678

Target Family

Non-IDG 28 | 12,091
Epigenetic 8 | 242
Enzyme 2 | 4,145
Transcription Factor 1 | 1,400

GO Process

chromatin silencing 39 | 39
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial SIRT4 Tbio Epigenetic -2.14139 133.9 254
E3 ubiquitin-protein ligase UBR2 UBR2 Tbio Enzyme -1.32729 22.3 158
NAD-dependent protein deacylase sirtuin-5, mitochondrial SIRT5 Tbio Epigenetic -2.36015 219.3 427
Histone H2A type 1-A HIST1H2AA Tbio Non-IDG -0.84480 8.19 69
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.19942 147.5 520
Methyl-CpG-binding protein 2 MECP2 Tchem Transcription Factor -3.26513 1878.2 658
Histone H2A.Z H2AFZ Tbio Non-IDG -2.53312 344.8 285
NAD-dependent protein deacetylase sirtuin-2 SIRT2 Tchem Epigenetic -2.83863 706.1 386
NAD-dependent protein deacetylase sirtuin-1 SIRT1 Tchem Epigenetic -3.50639 3413.7 733
Mortality factor 4-like protein 2 MORF4L2 Tbio Non-IDG -0.87952 8.10 128