Development Level

Tbio 18 | 11,445
Tchem 18 | 1,598
Tclin 4 | 613

IMPC Phenotype

preweaning lethality, complete... 10 | 979
abnormal embryo size 4 | 220
abnormal behavior 2 | 298
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
microphthalmia 2 | 26
abnormal body wall morphology 1 | 9
abnormal coat- hair morphology 1 | 19
abnormal embryo turning 1 | 31
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
cataract 1 | 92
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased mean platelet volume 1 | 25
decreased vertical activity 1 | 208
enlarged seminal vesicle 1 | 10
enlarged spleen 1 | 41
enlarged testis 1 | 6
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
increased body length 1 | 32
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased total body fat amoun... 1 | 134
small epididymis 1 | 3
small seminal vesicle 1 | 10
small testis 1 | 58

Disease

Carcinoma 24 | 11,493
ovarian cancer 24 | 8,520
psoriasis 20 | 6,694
osteosarcoma 19 | 7,950
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
malignant mesothelioma 13 | 3,232
medulloblastoma, large-cell 13 | 6,241
Breast cancer 12 | 3,578
lung cancer 11 | 4,740
ductal carcinoma in situ 9 | 1,745
glioblastoma 9 | 5,792
Obesity 8 | 678
Pick disease 8 | 1,894
active Crohn's disease 8 | 922
oligodendroglioma 8 | 2,850
pancreatic cancer 8 | 2,398
Autosomal recessive predisposition 7 | 1,442
Cognitive delay 7 | 608
Global developmental delay 7 | 608
Mental and motor retardation 7 | 608
atypical teratoid / rhabdoid tumor 7 | 5,112
ependymoma 7 | 4,679
Cancer 6 | 2,499
Cataract 6 | 297
Epilepsy 6 | 792
adult high grade glioma 6 | 3,801
astrocytic glioma 6 | 2,597
group 3 medulloblastoma 6 | 4,104
invasive ductal carcinoma 6 | 2,951
lung carcinoma 6 | 2,843
Antley-Bixler syndrome 5 | 16
Atherosclerosis 5 | 291
Carcinoma, Hepatocellular 5 | 228
Coronary artery disease 5 | 268
Dull intelligence 5 | 645
Failure to gain weight 5 | 365
Hydrolethalus syndrome 5 | 128
Intellectual disability 5 | 1,016
Lipid metabolism disorder 5 | 114
Liver carcinoma 5 | 240
Low intelligence 5 | 645
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Pediatric failure to thrive 5 | 365
Poor school performance 5 | 645
Seizures 5 | 596
Smith-Lemli-Opitz syndrome 5 | 9
Waldenstrons macroglobulinemia 5 | 765
active ulcerative colitis 5 | 764
chronic rhinosinusitis 5 | 512
diabetes mellitus 5 | 1,728
group 4 medulloblastoma 5 | 1,855
interstitial cystitis 5 | 2,312
lung adenocarcinoma 5 | 2,716
subependymal giant cell astrocytoma 5 | 2,287
Cardiovascular system disease 4 | 246
Lens Opacities 4 | 231
Low set ears 4 | 181
Multiple myeloma 4 | 1,332
Muscle hypotonia 4 | 571
Nystagmus 4 | 317
Porokeratosis of Mibelli 4 | 4
Small head 4 | 374
Stippled epiphyses 4 | 28
Strabismus 4 | 270
astrocytoma 4 | 1,146
esophageal adenocarcinoma 4 | 737
non primary Sjogren syndrome sicca 4 | 891
non-small cell lung cancer 4 | 2,890
spina bifida 4 | 1,074
tuberculosis 4 | 2,010
Arthritis 3 | 290
Astrocytoma, Pilocytic 3 | 3,081
Atopic dermatitis 3 | 952
Cerebrovascular accident 3 | 63
Chagas disease 3 | 39
Chondrodysplasia punctata 3 | 41
Congenital Epicanthus 3 | 177
Hepatomegaly 3 | 285
Hydronephrosis 3 | 89
Hypercholesterolemia 3 | 44
Hypoplastic mandible condyle 3 | 275
Ichthyosis 3 | 56
Liver Cirrhosis, Experimental 3 | 769
Mandibular hypoplasia 3 | 275
Osteoporosis 3 | 363
Polyhydramnios 3 | 108
Posteriorly rotated ear 3 | 61
Pruritus 3 | 58
Short stature 3 | 531
Splenomegaly 3 | 190
breast carcinoma 3 | 1,638
gastric cancer 3 | 459
hepatocellular carcinoma 3 | 547
juvenile dermatomyositis 3 | 1,187
pituitary cancer 3 | 1,972
primitive neuroectodermal tumor 3 | 3,035

Tissue

Digestive Tract 40 | 17,369
Endocrine System 40 | 18,159
Skin and soft tissues 40 | 17,230
Female tissues 39 | 17,400
Liver and Pancreas 39 | 16,750
Male tissues 39 | 17,142
Urinary Tract 38 | 16,678
Blood and immune system 37 | 16,909
Nervous System 37 | 16,725
Respiratory system 37 | 16,393
Cardiovascular System 36 | 15,192

Target Family

Enzyme 27 | 4,145
Non-IDG 8 | 12,091
Kinase 3 | 634
Epigenetic 1 | 242
Ion Channel 1 | 344

GO Process

cholesterol biosynthetic proce... 40 | 40
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Hydroxymethylglutaryl-CoA synthase, mitochondrial HMGCS2 Tbio Enzyme -1.74279 54.0 126
Insulin-induced gene 2 protein INSIG2 Tbio Non-IDG -1.94599 88.7 78
Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 Tchem Enzyme -1.67608 43.7 137
ATP-citrate synthase ACLY Tchem Enzyme -2.82704 654.3 332
Niemann-Pick C1-like protein 1 NPC1L1 Tclin Non-IDG -2.33312 222.7 139
Delta(14)-sterol reductase TM7SF2 Tbio Enzyme -1.10571 12.4 88
Diphosphomevalonate decarboxylase MVD Tchem Enzyme -2.09917 118.7 136
Apolipoprotein A-V APOA5 Tbio Non-IDG -2.58826 425.0 481
Insulin-induced gene 1 protein INSIG1 Tbio Non-IDG -2.29727 186.9 147
7-dehydrocholesterol reductase DHCR7 Tchem Enzyme -2.44252 276.5 109