Development Level

Tbio 96 | 11,445
Tchem 56 | 1,598
Tclin 44 | 613
Tdark 23 | 6,588

Collection

RFA-RM-18-021 24 | 328
Ion Channel: IDG Consortium (T... 17 | 99
GPCR: IDG Consortium (Targets) 9 | 126
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

decreased total body fat amoun... 8 | 207
preweaning lethality, complete... 8 | 979
preweaning lethality, incomple... 7 | 499
abnormal behavior 6 | 298
abnormal embryo size 5 | 220
decreased grip strength 5 | 116
increased circulating chloride... 5 | 41
increased circulating sodium l... 5 | 71
decreased bone mineral content 4 | 151
decreased circulating HDL chol... 4 | 68
decreased fasted circulating g... 4 | 65
enlarged heart 4 | 210
hyperactivity 4 | 148
hypoactivity 4 | 132
impaired glucose tolerance 4 | 75
increased lean body mass 4 | 172
increased total body fat amoun... 4 | 134
abnormal heart morphology 3 | 162
decreased body weight 3 | 161
decreased circulating choleste... 3 | 93
decreased lean body mass 3 | 135
decreased vertical activity 3 | 208
impaired pupillary reflex 3 | 26
increased circulating triglyce... 3 | 42
increased startle reflex 3 | 112
tremors 3 | 39
abnormal bone structure 2 | 187
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal head morphology 2 | 10
abnormal pericardium morpholog... 2 | 26
abnormal testis morphology 2 | 43
decreased circulating LDL chol... 2 | 38
decreased circulating alkaline... 2 | 46
decreased exploration in new e... 2 | 11
decreased neutrophil cell numb... 2 | 42
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
improved glucose tolerance 2 | 79
increased bone mineral content 2 | 108
increased circulating iron lev... 2 | 30
increased mean corpuscular vol... 2 | 92
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
small testis 2 | 58
abnormal behavioral response t... 1 | 66
abnormal coat-hair pigmentatio... 1 | 64
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal kidney morphology 1 | 65
abnormal liver morphology 1 | 17
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
abnormal tail length 1 | 3
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased anxiety-related resp... 1 | 12
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating creatine... 1 | 4
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased heart left ventricle... 1 | 28
decreased pulmonary respirator... 1 | 5
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
edema 1 | 59
embryonic lethality prior to o... 1 | 239
enlarged stomach 1 | 2
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating creatine... 1 | 5
increased circulating fructosa... 1 | 13
increased circulating serum al... 1 | 22
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
limb grasping 1 | 41
microphthalmia 1 | 26
pale yolk sac 1 | 25
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small thymus 1 | 16
thin ventricular wall 1 | 24

Disease

Carcinoma 163 | 11,493
glioblastoma 115 | 5,792
medulloblastoma, large-cell 113 | 6,241
ependymoma 109 | 4,679
atypical teratoid / rhabdoid tumor 103 | 5,112
oligodendroglioma 98 | 2,850
Schizophrenia 92 | 1,160
adult high grade glioma 92 | 3,801
psoriasis 92 | 6,694
astrocytic glioma 82 | 2,597
group 3 medulloblastoma 80 | 4,104
primitive neuroectodermal tumor 80 | 3,035
Astrocytoma, Pilocytic 76 | 3,081
ovarian cancer 70 | 8,520
Kidney cancer 67 | 2,613
osteosarcoma 65 | 7,950
Bipolar Disorder 61 | 666
lung carcinoma 56 | 2,843
Epilepsy 53 | 792
subependymal giant cell astrocytoma 52 | 2,287
lung cancer 51 | 4,740
Depressive disorder 49 | 409
Pick disease 49 | 1,894
Alcoholic Intoxication, Chronic 47 | 289
Mental Depression 44 | 333
Breast cancer 40 | 3,578
malignant mesothelioma 38 | 3,232
Mood Disorders 37 | 184
Major Depressive Disorder 36 | 301
Parkinson's disease 33 | 392
pituitary cancer 33 | 1,972
Seizures 32 | 596
Alzheimer's disease 30 | 658
group 4 medulloblastoma 28 | 1,855
invasive ductal carcinoma 27 | 2,951
Autistic Disorder 26 | 364
Intellectual disability 26 | 1,016
Unipolar Depression 26 | 250
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,955
Cancer 24 | 2,499
Alcohol dependence 23 | 107
Liver cancer 23 | 604
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,989
Obesity 21 | 678
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
Attention deficit hyperactivity disorder 20 | 278
Toxic encephalopathy 20 | 141
astrocytoma 20 | 1,146
colon cancer 20 | 1,478
Cocaine-Related Disorders 19 | 92
Cognitive delay 19 | 608
Global developmental delay 19 | 608
Mental and motor retardation 19 | 608
Pain agnosia 19 | 104
Substance Withdrawal Syndrome 19 | 55
interstitial cystitis 19 | 2,312
Neurodegenerative disease 18 | 414
adrenocortical carcinoma 18 | 1,428
Melanoma 17 | 711
Migraine 17 | 83
pediatric high grade glioma 17 | 1,064
Autosomal recessive predisposition 16 | 1,442
Muscle hypotonia 16 | 571
diabetes mellitus 16 | 1,728
Dementia 15 | 175
General anesthesia 15 | 53
medulloblastoma 15 | 720
non primary Sjogren syndrome sicca 15 | 891
Down syndrome 14 | 499
Dull intelligence 14 | 645
Huntington's disease 14 | 76
Hyperalgesia 14 | 83
Low intelligence 14 | 645
Mental Retardation 14 | 645
Mental deficiency 14 | 645
Pain 14 | 103
Poor school performance 14 | 645
ductal carcinoma in situ 14 | 1,745
Amyotrophic lateral sclerosis 13 | 451
Cerebellar Ataxia 13 | 304
Cocaine Dependence 13 | 51
Irritable bowel syndrome 13 | 60
Opiate dependence 13 | 29
Skin cancer 13 | 469
lung adenocarcinoma 13 | 2,716
Hypertension 12 | 396
Psychotic Disorders 12 | 151
Substance abuse 12 | 59
tuberculosis 12 | 2,010
Alcoholism 11 | 45
Gastroesophageal reflux disease 11 | 110
Infantile onset 11 | 238
Multiple Sclerosis 11 | 540
Neuropathy 11 | 261
Status Epilepticus 11 | 98
non-small cell lung cancer 11 | 2,890
obsessive-compulsive disorder 11 | 61
pancreatic cancer 11 | 2,398
Atopic dermatitis 10 | 952
cystic fibrosis 10 | 1,696

Tissue

Endocrine System 208 | 18,159
Nervous System 204 | 16,725
Female tissues 195 | 17,400
Digestive Tract 193 | 17,369
Skin and soft tissues 192 | 17,230
Male tissues 183 | 17,142
Blood and immune system 180 | 16,909
Liver and Pancreas 179 | 16,750
Urinary Tract 172 | 16,678
Respiratory system 168 | 16,393
Cardiovascular System 146 | 15,192

Target Family

Non-IDG 90 | 12,091
GPCR 52 | 408
Ion Channel 48 | 344
Enzyme 13 | 4,145
Transporter 12 | 473
Kinase 4 | 634

GO Process

chemical synaptic transmission 219 | 219
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Metabotropic glutamate receptor 5 GRM5 Tchem GPCR -3.12353 1370.3 396
Protocadherin beta-14 PCDHB14 Tdark Non-IDG 0.78 0.14 90
Protocadherin beta-12 PCDHB12 Tdark Non-IDG 0.00000 88
Protocadherin beta-13 PCDHB13 Tdark Non-IDG 0.00000 101
Protocadherin beta-9 PCDHB9 Tdark Non-IDG -0.10307 2.55 1
Protocadherin beta-6 PCDHB6 Tdark Non-IDG 1.04 0.08 32
5-hydroxytryptamine receptor 1F HTR1F Tchem GPCR -2.39159 244.1 131
Metabotropic glutamate receptor 3 GRM3 Tchem GPCR -2.30964 186.9 274
Metabotropic glutamate receptor 7 GRM7 Tchem GPCR -2.25415 190.8 304
Metabotropic glutamate receptor 4 GRM4 Tchem GPCR -2.34335 217.2 150