Development Level

Tbio 16 | 11,445
Tchem 9 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 3 | 499
decreased circulating glucose ... 2 | 126
increased circulating sodium l... 2 | 71
male infertility 2 | 123
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased circulating alanine ... 1 | 47
decreased circulating glycerol... 1 | 16
decreased fasted circulating g... 1 | 65
decreased mean corpuscular hem... 1 | 50
decreased total body fat amoun... 1 | 207
decreased urine creatinine lev... 1 | 3
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating magnesiu... 1 | 10
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased lean body mass 1 | 172
increased mean platelet volume 1 | 45
preweaning lethality, complete... 1 | 979
thrombocytopenia 1 | 56
tremors 1 | 39

Disease

Carcinoma 16 | 11,493
medulloblastoma, large-cell 13 | 6,241
ovarian cancer 12 | 8,520
psoriasis 11 | 6,694
glioblastoma 10 | 5,792
osteosarcoma 9 | 7,950
Astrocytoma, Pilocytic 8 | 3,081
atypical teratoid / rhabdoid tumor 8 | 5,112
invasive ductal carcinoma 7 | 2,951
tuberculosis 7 | 2,010
Autosomal recessive predisposition 6 | 1,442
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
malignant mesothelioma 6 | 3,232
non-small cell lung cancer 6 | 2,890
Neurodegenerative disease 5 | 414
ependymoma 5 | 4,679
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
lung adenocarcinoma 5 | 2,716
Breast cancer 4 | 3,578
Congenital Nonbullous Ichthyosiform Erythroderma 4 | 16
Dull intelligence 4 | 645
Epilepsy 4 | 792
Intellectual disability 4 | 1,016
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Multiple myeloma 4 | 1,332
Neuronal ceroid lipofuscinosis 9 4 | 5
Poor school performance 4 | 645
active ulcerative colitis 4 | 764
adult high grade glioma 4 | 3,801
cutaneous lupus erythematosus 4 | 1,057
ductal carcinoma in situ 4 | 1,745
interstitial cystitis 4 | 2,312
lung cancer 4 | 4,740
pancreatic cancer 4 | 2,398
Anhidrosis 3 | 23
Autosomal recessive congenital ichthyosis 3 | 11
Cancer 3 | 2,499
Congenital ichthyosiform erythroderma 3 | 28
Congenital non-bullous ichthyosiform erythroderma 3 | 7
Failure to gain weight 3 | 365
Ichthyosis 3 | 56
Pediatric failure to thrive 3 | 365
active Crohn's disease 3 | 922
breast carcinoma 3 | 1,638
cystic fibrosis 3 | 1,696
facioscapulohumeral dystrophy 3 | 288
group 3 medulloblastoma 3 | 4,104
lung carcinoma 3 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pituitary cancer 3 | 1,972
primary pancreatic ductal adenocarcinoma 3 | 1,109
Bipolar Disorder 2 | 666
Cerebral atrophy 2 | 178
Congenital deafness 2 | 185
Congenital pes cavus 2 | 88
Deafness 2 | 198
Decreased tendon reflex 2 | 122
Degenerative brain disorder 2 | 100
Dementia 2 | 175
Depressive disorder 2 | 409
Distal limb muscle weakness due to peripheral neuropathy 2 | 62
Distal muscle weakness 2 | 62
Distal sensory impairment 2 | 52
Distal sensory impairment of all modalities 2 | 7
Dyspnea 2 | 76
Ecchymosis 2 | 66
Epistaxis 2 | 43
Hearing Loss, Partial 2 | 185
Hepatomegaly 2 | 285
Hereditary Sensory Autonomic Neuropathy, Type 1 2 | 4
Highly variable clinical phenotype 2 | 150
Highly variable phenotype and severity 2 | 150
Highly variable phenotype, even within families 2 | 150
Increased tendency to bruise 2 | 66
Lipid storage disease 2 | 8
Multiple Sclerosis 2 | 540
Muscle Spasticity 2 | 195
Myoclonic Epilepsies, Progressive 2 | 44
Myoclonus 2 | 74
Neuropathy 2 | 261
Phenotypic variability 2 | 150
Pick disease 2 | 1,894
Prostatic Neoplasms 2 | 495
Recurrent respiratory infections 2 | 141
Rheumatoid arthritis 2 | 1,191
Seizures 2 | 596
Supratentorial atrophy 2 | 94
Vascular disease 2 | 319
aldosterone-producing adenoma 2 | 665
diabetes mellitus 2 | 1,728
hearing impairment 2 | 199
hepatocellular carcinoma 2 | 547
juvenile dermatomyositis 2 | 1,187
nasopharyngeal carcinoma 2 | 1,058
posterior fossa group A ependymoma 2 | 468
ulcerative colitis 2 | 1,819

Tissue

Blood and immune system 25 | 16,909
Digestive Tract 25 | 17,369
Endocrine System 25 | 18,159
Female tissues 25 | 17,400
Male tissues 25 | 17,142
Nervous System 25 | 16,725
Skin and soft tissues 25 | 17,230
Urinary Tract 24 | 16,678
Liver and Pancreas 23 | 16,750
Respiratory system 22 | 16,393
Cardiovascular System 21 | 15,192

Target Family

Enzyme 17 | 4,145
Transcription Factor 5 | 1,400
Ion Channel 2 | 344
Non-IDG 2 | 12,091

GO Process

ceramide biosynthetic process 26 | 26
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
Protein FAM57B FAM57B Tdark Non-IDG 0.48 0.62 20
Ceramide synthase 6 CERS6 Tbio Transcription Factor -1.48442 32.4 167
Ceramide synthase 1 CERS1 Tbio Enzyme -1.58899 36.9 179
Phosphatidylcholine:ceramide cholinephosphotransferase 1 SGMS1 Tchem Enzyme -1.61164 41.6 0
Ceramide synthase 3 CERS3 Tbio Transcription Factor -1.06194 11.5 105
Phosphatidylcholine:ceramide cholinephosphotransferase 2 SGMS2 Tchem Enzyme -1.45924 31.1 204
Protein CLN8 CLN8 Tbio Non-IDG -1.61744 37.6 96
Serine palmitoyltransferase 1 SPTLC1 Tchem Enzyme -2.16711 143.2 285
Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 DEGS2 Tbio Enzyme -1.71761 46.1 74