Development Level

Tbio 65 | 11,651
Tchem 29 | 1,388
Tclin 12 | 612

IMPC Phenotype

preweaning lethality, incomple... 7 | 499
preweaning lethality, complete... 5 | 979
increased mean corpuscular hem... 4 | 96
increased mean corpuscular vol... 4 | 92
abnormal behavior 3 | 298
decreased bone mineral density 3 | 126
decreased erythrocyte cell num... 3 | 62
decreased vertical activity 3 | 208
hypoactivity 3 | 132
increased circulating HDL chol... 3 | 80
increased circulating total pr... 3 | 28
abnormal gait 2 | 69
abnormal retina morphology 2 | 71
abnormal sleep behavior 2 | 70
decreased blood urea nitrogen ... 2 | 51
decreased grip strength 2 | 116
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased blood urea nitrogen ... 2 | 48
increased circulating alkaline... 2 | 122
increased circulating calcium ... 2 | 34
increased circulating creatini... 2 | 38
increased circulating serum al... 2 | 22
increased monocyte cell number 2 | 63
increased or absent threshold ... 2 | 101
small superior vagus ganglion 2 | 74
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal iris morphology 1 | 13
abnormal lens morphology 1 | 81
abnormal pancreas morphology 1 | 13
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal testis morphology 1 | 43
cataract 1 | 92
decreased body length 1 | 101
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating chloride... 1 | 30
decreased circulating potassiu... 1 | 20
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
enlarged uterus 1 | 11
hydrometra 1 | 53
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating magnesiu... 1 | 10
increased circulating potassiu... 1 | 29
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased kidney weight 1 | 6
increased mean corpuscular hem... 1 | 36
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
prenatal lethality prior to he... 1 | 87
small testis 1 | 58
thrombocytopenia 1 | 56
tremors 1 | 39
urinary bladder obstruction 1 | 4

Disease

Carcinoma 70 | 11,493
ovarian cancer 68 | 8,520
Cancer 61 | 2,499
osteosarcoma 60 | 7,950
psoriasis 57 | 6,694
glioblastoma 53 | 5,792
lung cancer 51 | 4,740
medulloblastoma, large-cell 51 | 6,241
atypical teratoid / rhabdoid tumor 48 | 5,112
Breast cancer 43 | 3,578
malignant mesothelioma 39 | 3,232
group 3 medulloblastoma 37 | 4,104
non-small cell lung cancer 37 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 33 | 3,291
invasive ductal carcinoma 33 | 2,951
lung adenocarcinoma 33 | 2,716
primitive neuroectodermal tumor 31 | 3,035
ependymoma 29 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,989
adult high grade glioma 28 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,955
pancreatic cancer 28 | 2,398
diabetes mellitus 27 | 1,728
ulcerative colitis 26 | 1,819
astrocytic glioma 24 | 2,597
breast carcinoma 24 | 1,638
cystic fibrosis 24 | 1,696
ductal carcinoma in situ 24 | 1,745
pituitary cancer 24 | 1,972
Astrocytoma, Pilocytic 23 | 3,081
adrenocortical carcinoma 23 | 1,428
colon cancer 23 | 1,478
lung carcinoma 22 | 2,843
acute quadriplegic myopathy 21 | 1,158
Mammary Neoplasms 20 | 425
Prostatic Neoplasms 20 | 495
oligodendroglioma 20 | 2,850
Breast Neoplasms 19 | 445
Obesity 19 | 678
Schizophrenia 19 | 1,160
Hypertension 18 | 396
Kidney disease 18 | 430
interstitial cystitis 18 | 2,312
subependymal giant cell astrocytoma 17 | 2,287
tuberculosis 17 | 2,010
Asthma 16 | 385
Kidney cancer 16 | 2,613
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
Alzheimer's disease 15 | 658
Bipolar Disorder 15 | 666
Vascular disease 15 | 319
Diabetes Mellitus, Experimental 14 | 108
Hyperglycemia 14 | 137
nasopharyngeal carcinoma 14 | 1,058
Amyotrophic lateral sclerosis 13 | 451
Endometriosis 13 | 540
Heart disease 13 | 306
Intellectual disability 13 | 1,016
Renal Cell Carcinoma 13 | 214
group 4 medulloblastoma 13 | 1,855
pediatric high grade glioma 13 | 1,064
primary pancreatic ductal adenocarcinoma 13 | 1,109
Depressive disorder 12 | 409
Hypertensive disease 12 | 292
Liver Cirrhosis, Experimental 12 | 769
Melanoma 12 | 711
Pick disease 12 | 1,894
Adenoma 11 | 167
Carcinoma, Hepatocellular 11 | 228
Heart failure 11 | 162
Liver carcinoma 11 | 240
Major Depressive Disorder 11 | 301
Multiple myeloma 11 | 1,332
Parkinson's disease 11 | 392
Seizures 11 | 596
Stomach Neoplasms 11 | 300
gastric carcinoma 11 | 807
Atopic dermatitis 10 | 952
Autosomal recessive predisposition 10 | 1,442
Epilepsy 10 | 792
Lung Neoplasms 10 | 232
Neurodegenerative disease 10 | 414
Unipolar Depression 10 | 250
cutaneous lupus erythematosus 10 | 1,057
dermatomyositis 10 | 966
esophageal adenocarcinoma 10 | 737
juvenile dermatomyositis 10 | 1,187
non primary Sjogren syndrome sicca 10 | 891
non-small cell lung carcinoma 10 | 317
Anemia 9 | 365
Carcinoma, Non-Small-Cell Lung 9 | 107
Colonic Neoplasms 9 | 142
Diabetes Mellitus, Non-Insulin-Dependent 9 | 145
Lymphoid leukemia 9 | 160
Myocardial Infarction 9 | 151
Osteoporosis 9 | 363
Pancreatic Neoplasm 9 | 85
Skin Neoplasms 9 | 69
spina bifida 9 | 1,074
Mental Depression 8 | 333

Tissue

Digestive Tract 105 | 17,369
Endocrine System 105 | 18,159
Female tissues 104 | 17,400
Urinary Tract 104 | 16,678
Blood and immune system 103 | 16,909
Liver and Pancreas 103 | 16,750
Male tissues 103 | 17,142
Nervous System 103 | 16,725
Skin and soft tissues 103 | 17,230
Respiratory system 101 | 16,393
Cardiovascular System 96 | 15,192

Target Family

Non-IDG 51 | 12,091
Enzyme 15 | 4,145
Kinase 10 | 634
Transcription Factor 9 | 1,400
Epigenetic 6 | 242
Ion Channel 6 | 344
Transporter 5 | 473
GPCR 2 | 408
Nuclear Receptor 2 | 48

GO Process

cellular response to hypoxia 106 | 106
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-1 EDN1 Tbio Non-IDG -4.07520 12851.9 607
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial SIRT4 Tbio Epigenetic -2.14139 133.9 254
DNA (cytosine-5)-methyltransferase 3A DNMT3A Tclin Epigenetic -2.91291 722.8 693
Endothelial PAS domain-containing protein 1 EPAS1 Tchem Non-IDG -2.29071 180.5 477
Equilibrative nucleoside transporter 1 SLC29A1 Tclin Transporter -2.61544 427.2 413
Vasorin VASN Tbio Non-IDG -1.23949 17.5 130
Hypoxia up-regulated protein 1 HYOU1 Tbio Non-IDG -1.99998 112.6 246
Guanine nucleotide-binding protein G(T) subunit gamma-T1 GNGT1 Tbio Non-IDG -1.43842 22.5 61
Serine/threonine-protein kinase PINK1, mitochondrial PINK1 Tbio Kinase -2.81574 706.5 546
Potassium voltage-gated channel subfamily D member 2 KCND2 Tclin Ion Channel -2.39309 245.7 317