Development Level

Tbio 29 | 11,445
Tchem 14 | 1,598
Tclin 8 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal sleep behavior 2 | 70
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased grip strength 2 | 116
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
hypoactivity 2 | 132
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
abnormal brain morphology 1 | 13
abnormal head morphology 1 | 10
abnormal retina morphology 1 | 71
absent testes 1 | 6
cataract 1 | 92
decreased body weight 1 | 161
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased threshold for audito... 1 | 26
decreased urine creatinine lev... 1 | 3
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
hydroencephaly 1 | 14
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased circulating alkaline... 1 | 122
increased circulating fructosa... 1 | 13
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased lean body mass 1 | 172
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
premature death 1 | 5
prolonged QRS complex duration 1 | 8
small heart 1 | 10
small kidney 1 | 16
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 19

Disease

Carcinoma 36 | 11,493
glioblastoma 26 | 5,792
psoriasis 26 | 6,694
osteosarcoma 25 | 7,950
ovarian cancer 25 | 8,520
medulloblastoma, large-cell 23 | 6,241
atypical teratoid / rhabdoid tumor 21 | 5,112
ependymoma 21 | 4,679
lung cancer 21 | 4,740
group 3 medulloblastoma 20 | 4,104
adult high grade glioma 19 | 3,801
Breast cancer 18 | 3,578
Astrocytoma, Pilocytic 17 | 3,081
Cancer 17 | 2,499
invasive ductal carcinoma 17 | 2,951
cystic fibrosis 14 | 1,696
non-small cell lung cancer 14 | 2,890
oligodendroglioma 14 | 2,850
pancreatic cancer 14 | 2,398
ulcerative colitis 14 | 1,819
astrocytic glioma 13 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
lung adenocarcinoma 13 | 2,716
Autosomal recessive predisposition 12 | 1,442
Kidney cancer 12 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
lung carcinoma 12 | 2,843
primitive neuroectodermal tumor 11 | 3,035
tuberculosis 11 | 2,010
Kidney disease 10 | 430
colon cancer 10 | 1,478
malignant mesothelioma 10 | 3,232
pituitary cancer 10 | 1,972
Liver Cirrhosis, Experimental 9 | 769
adrenocortical carcinoma 9 | 1,428
diabetes mellitus 9 | 1,728
ductal carcinoma in situ 9 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Obesity 8 | 678
Pick disease 8 | 1,894
Depressive disorder 7 | 409
Mental Depression 7 | 333
Prostatic Neoplasms 7 | 495
Seizures 7 | 596
breast carcinoma 7 | 1,638
interstitial cystitis 7 | 2,312
Amyotrophic lateral sclerosis 6 | 451
Atopic dermatitis 6 | 952
Intellectual disability 6 | 1,016
Polycystic ovary syndrome 6 | 360
Short stature 6 | 531
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 510
juvenile dermatomyositis 6 | 1,187
primary pancreatic ductal adenocarcinoma 6 | 1,109
Atrial Fibrillation 5 | 124
Cognitive delay 5 | 608
Down syndrome 5 | 499
Duchenne muscular dystrophy 5 | 601
Dull intelligence 5 | 645
Epilepsy 5 | 792
Failure to gain weight 5 | 365
Global developmental delay 5 | 608
Heart disease 5 | 306
Low intelligence 5 | 645
Melanoma 5 | 711
Mental Retardation 5 | 645
Mental and motor retardation 5 | 608
Mental deficiency 5 | 645
Parkinson's disease 5 | 392
Pediatric failure to thrive 5 | 365
Poor school performance 5 | 645
acute quadriplegic myopathy 5 | 1,158
aldosterone-producing adenoma 5 | 665
mucosa-associated lymphoid tissue lymphoma 5 | 484
nephrosclerosis 5 | 333
non primary Sjogren syndrome sicca 5 | 891
pancreatic carcinoma 5 | 562
Alcoholic Intoxication, Chronic 4 | 289
Bipolar Disorder 4 | 666
Breast Neoplasms 4 | 445
Carcinoma, Hepatocellular 4 | 228
Cerebrovascular disease 4 | 238
Diarrhea 4 | 253
Heart conduction disease 4 | 83
Heart failure 4 | 162
Hypertension 4 | 396
Liver carcinoma 4 | 240
Mammary Neoplasms 4 | 425
Multiple myeloma 4 | 1,332
Muscle hypotonia 4 | 571
Polyhydramnios 4 | 108
active ulcerative colitis 4 | 764
astrocytoma 4 | 1,146
cutaneous lupus erythematosus 4 | 1,057
esophageal adenocarcinoma 4 | 737
fibroadenoma 4 | 559
gastric carcinoma 4 | 807
subependymal giant cell astrocytoma 4 | 2,287
dermatomyositis 3 | 966

Tissue

Endocrine System 50 | 18,159
Digestive Tract 49 | 17,369
Male tissues 49 | 17,142
Nervous System 49 | 16,725
Skin and soft tissues 49 | 17,230
Blood and immune system 48 | 16,909
Female tissues 48 | 17,400
Liver and Pancreas 48 | 16,750
Urinary Tract 48 | 16,678
Respiratory system 47 | 16,393
Cardiovascular System 46 | 15,192

Target Family

Non-IDG 19 | 12,091
Enzyme 13 | 4,145
Ion Channel 9 | 344
Transporter 4 | 473
Kinase 3 | 634
Epigenetic 1 | 242
GPCR 1 | 408
Transcription Factor 1 | 1,400

GO Process

cellular response to cAMP 51 | 51
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 HCN2 Tclin Ion Channel -1.16715 13.3 162
Aquaporin-1 AQP1 Tbio Non-IDG -3.08125 1107.4 374
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 HCN4 Tclin Ion Channel -2.48671 270.6 121
Rap guanine nucleotide exchange factor 2 RAPGEF2 Tbio Non-IDG -1.41107 29.0 79
Polycystin-2 PKD2 Tchem Ion Channel -2.63806 461.3 231
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114
Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 Tclin Ion Channel -2.90675 800.2 365
Rap guanine nucleotide exchange factor 1 RAPGEF1 Tbio Non-IDG -2.41980 281.2 167
Aquaporin-9 AQP9 Tbio Non-IDG -2.13315 155.0 84
Aquaporin-8 AQP8 Tbio Non-IDG -2.06724 116.3 124