Development Level

Tbio 142 | 10,625
Tchem 45 | 1,890
Tdark 8 | 7,003
Tclin 6 | 602

Collection

Eligible Kinase Proteins 4 | 134

IMPC Term

preweaning lethality, complete... 13 | 633
preweaning lethality, incomple... 5 | 260
abnormal bone structure 3 | 131
abnormal gait 3 | 51
decreased bone mineral content 3 | 157
decreased lean body mass 3 | 195
decreased total body fat amoun... 3 | 186
embryonic lethality prior to t... 3 | 187
increased fasted circulating g... 3 | 68
abnormal behavior 2 | 226
abnormal behavioral response t... 2 | 52
abnormal bone mineralization 2 | 55
decreased basophil cell number 2 | 11
decreased body length 2 | 108
decreased body weight 2 | 174
decreased bone mineral density 2 | 126
decreased circulating glucose ... 2 | 121
decreased circulating insulin ... 2 | 75
decreased circulating triglyce... 2 | 83
decreased erythrocyte cell num... 2 | 43
decreased grip strength 2 | 123
decreased rib number 2 | 59
enlarged heart 2 | 111
hydrops fetalis 2 | 22
hyperactivity 2 | 108
increased blood urea nitrogen ... 2 | 44
increased bone mineral content 2 | 92
increased circulating glucose ... 2 | 16
increased exploration in new e... 2 | 56
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
narrow eye opening 2 | 15
short tibia 2 | 82
small testis 2 | 37
abnormal coat appearance 1 | 25
abnormal coat/ hair morphology 1 | 18
abnormal coat/hair pigmentatio... 1 | 54
abnormal embryo size 1 | 112
abnormal epididymis morphology 1 | 31
abnormal heart morphology 1 | 51
abnormal iris morphology 1 | 12
abnormal joint morphology 1 | 14
abnormal limb bud morphology 1 | 15
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 100
abnormal retinal inner nuclear... 1 | 5
abnormal sleep behavior 1 | 63
abnormal snout morphology 1 | 18
abnormal spleen morphology 1 | 36
abnormal tail morphology 1 | 17
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
convulsive seizures 1 | 11
craniofacial phenotype 1 | 9
cyanosis 1 | 6
decreased CD4-positive, CD25-p... 1 | 24
decreased circulating HDL chol... 1 | 77
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating iron lev... 1 | 25
decreased eosinophil cell numb... 1 | 41
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased mean platelet volume 1 | 12
decreased neutrophil cell numb... 1 | 37
decreased startle reflex 1 | 48
decreased total retina thickne... 1 | 20
edema 1 | 11
embryonic lethality prior to o... 1 | 148
enlarged spleen 1 | 26
hemorrhage 1 | 12
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
improved glucose tolerance 1 | 56
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating aspartat... 1 | 17
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased circulating iron lev... 1 | 25
increased circulating serum al... 1 | 25
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 20
increased circulating triglyce... 1 | 24
increased granulocyte number 1 | 8
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased lymphocyte cell numb... 1 | 9
increased mean corpuscular hem... 1 | 25
increased or absent threshold ... 1 | 128
increased vertical activity 1 | 18
irregularly shaped pupil 1 | 7
limb grasping 1 | 35
persistence of hyaloid vascula... 1 | 22
polydactyly 1 | 22
respiratory system phenotype 1 | 2
tremors 1 | 34

Disease

ovarian cancer 127 | 8,484
osteosarcoma 117 | 7,933
medulloblastoma, large-cell 90 | 6,234
psoriasis 77 | 6,685
Cancer 76 | 2,346
lung cancer 75 | 4,466
glioblastoma 71 | 5,572
Breast cancer 59 | 3,094
atypical teratoid / rhabdoid tumor 59 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 53 | 3,289
malignant mesothelioma 52 | 3,162
group 3 medulloblastoma 42 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 42 | 2,988
primitive neuroectodermal tumor 42 | 3,031
Carcinoma 41 | 2,147
oligodendroglioma 40 | 2,849
invasive ductal carcinoma 39 | 2,950
non-small cell lung cancer 38 | 2,798
Pick disease 35 | 1,893
pediatric high grade glioma 35 | 2,712
astrocytic glioma 33 | 2,241
ulcerative colitis 31 | 2,087
ependymoma 30 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,956
pituitary cancer 30 | 1,972
pancreatic cancer 29 | 2,300
subependymal giant cell astrocytoma 29 | 2,287
adrenocortical carcinoma 27 | 1,427
lung adenocarcinoma 27 | 2,713
diabetes mellitus 26 | 1,663
pilocytic astrocytoma 26 | 3,086
group 4 medulloblastoma 25 | 1,875
juvenile dermatomyositis 25 | 1,189
ductal carcinoma in situ 24 | 1,745
acute quadriplegic myopathy 23 | 1,157
astrocytoma 23 | 1,493
colon cancer 23 | 1,475
lung carcinoma 23 | 2,844
Multiple myeloma 22 | 1,327
Rheumatoid Arthritis 22 | 1,160
interstitial cystitis 21 | 2,299
adult high grade glioma 20 | 2,148
breast carcinoma 20 | 1,614
tuberculosis 20 | 1,557
Mammary Neoplasms 19 | 410
nasopharyngeal carcinoma 19 | 1,056
primary pancreatic ductal adenocarcinoma 19 | 1,271
sonic hedgehog group medulloblastoma 19 | 1,482
dermatomyositis 18 | 933
Atopic dermatitis 17 | 944
IGA Glomerulonephritis 17 | 454
Prostatic Neoplasms 17 | 471
medulloblastoma 17 | 1,524
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,795
posterior fossa group A ependymoma 16 | 1,511
progressive supranuclear palsy 16 | 674
cystic fibrosis 15 | 1,665
tuberculosis and treatment for 6 months 15 | 686
Ataxia telangiectasia 14 | 31
Nijmegen breakage syndrome 14 | 23
Intellectual disability 13 | 573
Lung Neoplasms 13 | 171
posterior fossa group B ependymoma 13 | 1,530
Alzheimer's disease 12 | 644
Amyotrophic Lateral Sclerosis 12 | 431
Fanconi's anemia 12 | 50
Peripheral Neuropathy 12 | 303
acute myeloid leukemia 12 | 780
atypical teratoid/rhabdoid tumor 12 | 1,095
primary Sjogren syndrome 12 | 789
Neoplastic Syndromes, Hereditary 11 | 48
gastric cancer 11 | 430
Bloom syndrome 10 | 30
Chronic Lymphocytic Leukemia 10 | 242
Endometriosis 10 | 535
gastric carcinoma 10 | 832
spina bifida 10 | 1,064
Down syndrome 9 | 548
Neurodegenerative disease 9 | 383
Stomach Neoplasms 9 | 282
Waldenstrons macroglobulinemia 9 | 765
Adenocarcinoma 8 | 115
Adenoid Cystic Carcinoma 8 | 99
Adenoma 8 | 165
Asthma 8 | 349
Colorectal Neoplasms 8 | 217
Liver carcinoma 8 | 217
Melanoma 8 | 261
Obesity 8 | 616
Vascular disease 8 | 281
Werner syndrome 8 | 29
active Crohn's disease 8 | 918
cutaneous lupus erythematosus 8 | 1,056
Cockayne syndrome 7 | 54
Colonic Neoplasms 7 | 126
Kidney disease 7 | 396
Multiple Sclerosis 7 | 498
Pancreatic Neoplasm 7 | 79
hepatocellular carcinoma 7 | 532
pancreatic carcinoma 7 | 567

Tissue

Digestive Tract 199 | 18,473
Female tissues 199 | 18,647
Nervous System 199 | 18,561
Blood and immune system 198 | 17,995
Endocrine System 198 | 18,512
Liver and Pancreas 198 | 18,136
Male tissues 198 | 17,969
Cardiovascular System 197 | 17,958
Urinary Tract 197 | 18,444
Respiratory system 196 | 17,484
Skin and soft tissues 195 | 18,115

Target Family

Non-IDG 98 | 11,971
Enzyme 48 | 4,146
Kinase 25 | 634
Transcription Factor 19 | 1,400
Epigenetic 11 | 242

GO Process

cellular response to DNA damag... 201 | 201
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
Transcriptional repressor protein YY1 YY1 Tbio Transcription Factor -2.75991 594.0 437
Ubiquitin-conjugating enzyme E2 B UBE2B Tbio Non-IDG -1.56439 38.8 140
N-glycosylase/DNA lyase OGG1 Tbio Enzyme -3.23405 1747.3 234
40S ribosomal protein S3 RPS3 Tbio Non-IDG -2.16121 152.6 207
DNA topoisomerase 2-alpha TOP2A Tclin Enzyme -2.81595 662.3 551
Double-strand break repair protein MRE11A MRE11 Tbio Non-IDG -1.95631 90.0 412
CST complex subunit CTC1 CTC1 Tbio Non-IDG -1.61677 49.3 42
SprT-like domain-containing protein Spartan SPRTN Tbio Non-IDG -2.15267 150.6 58
Syntaxin-binding protein 4 STXBP4 Tbio Non-IDG -0.73535 7.61 58