Development Level

Tbio 56 | 10,625
Tchem 20 | 1,890
Tdark 11 | 7,003
Tclin 6 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 7 | 633
decreased grip strength 5 | 123
decreased bone mineral density 4 | 126
hyperactivity 4 | 108
abnormal behavior 3 | 226
abnormal bone mineralization 3 | 55
decreased body weight 3 | 174
decreased circulating triglyce... 3 | 83
decreased lean body mass 3 | 195
embryonic lethality prior to o... 3 | 148
increased circulating alkaline... 3 | 119
abnormal kidney morphology 2 | 30
abnormal respiratory quotient 2 | 9
abnormal vocalization 2 | 21
decreased body length 2 | 108
decreased circulating choleste... 2 | 85
decreased circulating glucose ... 2 | 121
decreased heart weight 2 | 44
decreased leukocyte cell numbe... 2 | 54
decreased prepulse inhibition 2 | 52
hypoactivity 2 | 89
increased fasted circulating g... 2 | 68
male infertility 2 | 62
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal body size 1 | 1
abnormal bone structure 1 | 131
abnormal cranium morphology 1 | 32
abnormal defecation 1 | 1
abnormal esophagus morphology 1 | 4
abnormal femur morphology 1 | 14
abnormal glucose homeostasis 1 | 5
abnormal heart morphology 1 | 51
abnormal joint morphology 1 | 14
abnormal locomotor activation 1 | 26
abnormal pancreas morphology 1 | 6
abnormal radius morphology 1 | 8
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal skin coloration 1 | 18
abnormal sleep behavior 1 | 63
abnormal startle reflex 1 | 14
abnormal tail morphology 1 | 17
abnormal testis morphology 1 | 30
abnormal thyroid gland morphol... 1 | 3
abnormal tibia morphology 1 | 14
abnormal trachea morphology 1 | 3
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 14
abnormal vertebral arch morpho... 1 | 9
absent lymph nodes 1 | 3
absent vibrissae 1 | 14
anophthalmia 1 | 20
cardiovascular system phenotyp... 1 | 35
decreased B cell number 1 | 30
decreased CD103-positive CD11b... 1 | 2
decreased KLRG1-positive NK ce... 1 | 9
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating calcium ... 1 | 33
decreased circulating glycerol... 1 | 19
decreased circulating insulin ... 1 | 75
decreased circulating phosphat... 1 | 15
decreased eosinophil cell numb... 1 | 41
decreased hematocrit 1 | 25
decreased mature B cell number 1 | 25
decreased mean platelet volume 1 | 12
decreased respiratory quotient 1 | 12
decreased startle reflex 1 | 48
decreased total body fat amoun... 1 | 186
decreased vertical activity 1 | 22
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
enlarged liver 1 | 3
enlarged spleen 1 | 26
female infertility 1 | 34
impaired glucose tolerance 1 | 52
increased bone mineral content 1 | 92
increased circulating LDL chol... 1 | 15
increased circulating choleste... 1 | 53
increased circulating free fat... 1 | 17
increased circulating glycerol... 1 | 11
increased circulating potassiu... 1 | 31
increased effector memory CD4-... 1 | 15
increased eosinophil cell numb... 1 | 9
increased grip strength 1 | 83
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased or absent threshold ... 1 | 128
increased startle reflex 1 | 38
preweaning lethality, incomple... 1 | 260
short tail 1 | 4
small testis 1 | 37
thick tail 1 | 1
thrombocytopenia 1 | 46
thrombocytosis 1 | 23

Disease

ovarian cancer 59 | 8,484
osteosarcoma 50 | 7,933
psoriasis 37 | 6,685
glioblastoma 31 | 5,572
lung cancer 29 | 4,466
medulloblastoma, large-cell 28 | 6,234
atypical teratoid / rhabdoid tumor 27 | 4,369
Breast cancer 22 | 3,094
Cancer 19 | 2,346
non-small cell lung cancer 18 | 2,798
pediatric high grade glioma 18 | 2,712
astrocytic glioma 17 | 2,241
invasive ductal carcinoma 17 | 2,950
pancreatic cancer 17 | 2,300
Multiple myeloma 16 | 1,327
malignant mesothelioma 16 | 3,162
oligodendroglioma 16 | 2,849
pilocytic astrocytoma 15 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
lung carcinoma 14 | 2,844
ependymoma 13 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
primitive neuroectodermal tumor 13 | 3,031
Carcinoma 11 | 2,147
group 3 medulloblastoma 11 | 2,254
juvenile dermatomyositis 11 | 1,189
lung adenocarcinoma 11 | 2,713
primary pancreatic ductal adenocarcinoma 11 | 1,271
diabetes mellitus 10 | 1,663
group 4 medulloblastoma 10 | 1,875
Pick disease 9 | 1,893
astrocytoma 9 | 1,493
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
ulcerative colitis 9 | 2,087
dermatomyositis 8 | 933
esophageal adenocarcinoma 8 | 737
interstitial cystitis 8 | 2,299
medulloblastoma 8 | 1,524
pituitary cancer 8 | 1,972
sonic hedgehog group medulloblastoma 8 | 1,482
tuberculosis 8 | 1,557
acute quadriplegic myopathy 7 | 1,157
cystic fibrosis 7 | 1,665
posterior fossa group A ependymoma 7 | 1,511
subependymal giant cell astrocytoma 7 | 2,287
tuberculosis and treatment for 6 months 7 | 686
IGA Glomerulonephritis 6 | 454
adult high grade glioma 6 | 2,148
atypical teratoid/rhabdoid tumor 6 | 1,095
posterior fossa group B ependymoma 6 | 1,530
Mammary Neoplasms 5 | 410
Parkinson's disease 5 | 364
Waldenstrons macroglobulinemia 5 | 765
active Crohn's disease 5 | 918
adrenocortical carcinoma 5 | 1,427
breast carcinoma 5 | 1,614
chronic rhinosinusitis 5 | 512
gastric carcinoma 5 | 832
nasopharyngeal carcinoma 5 | 1,056
pancreatic carcinoma 5 | 567
progressive supranuclear palsy 5 | 674
Amyotrophic Lateral Sclerosis 4 | 431
Down syndrome 4 | 548
Duchenne muscular dystrophy 4 | 602
Hepatitis B 4 | 103
Multiple Sclerosis 4 | 498
Obesity 4 | 616
Prostatic Neoplasms 4 | 471
Schizophrenia 4 | 501
inflammatory breast cancer 4 | 404
non primary Sjogren syndrome sicca 4 | 840
Asthma 3 | 349
Atopic dermatitis 3 | 944
Blastic phase chronic myeloid leukemia 3 | 58
Chronic Myelocytic Leukemia Accelerated Phase 3 | 59
Chronic phase chronic myeloid leukemia 3 | 45
Diarrhea 3 | 155
Drug-Induced Liver Injury 3 | 118
Epilepsy 3 | 346
Gastroenteritis 3 | 46
Heart disease 3 | 279
Liver neoplasms 3 | 109
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 3 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 3 | 47
Polycystic Ovary Syndrome 3 | 332
Rheumatoid Arthritis 3 | 1,160
Skin disease 3 | 65
gastric cancer 3 | 430
glioblastoma multiforme 3 | 347
hepatocellular carcinoma 3 | 532
sarcoidosis 3 | 358
spina bifida 3 | 1,064
Atherosclerosis 2 | 275
Brain Ischemia 2 | 87
Chronic obstructive pulmonary disease 2 | 146
Dermatitis, Allergic Contact 2 | 66
Hypertension 2 | 287
Kidney disease 2 | 396
Peripheral vascular disease 2 | 90

Tissue

Cardiovascular System 92 | 17,958
Digestive Tract 92 | 18,473
Endocrine System 92 | 18,512
Female tissues 92 | 18,647
Liver and Pancreas 92 | 18,136
Male tissues 92 | 17,969
Nervous System 92 | 18,561
Respiratory system 92 | 17,484
Skin and soft tissues 92 | 18,115
Urinary Tract 92 | 18,444
Blood and immune system 91 | 17,995

Target Family

Enzyme 51 | 4,146
Non-IDG 27 | 11,971
Kinase 12 | 634
GPCR 2 | 406
Transporter 1 | 473

GO Process

cellular protein modification ... 93 | 93
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin-conjugating enzyme E2 R1 CDC34 Tbio Non-IDG -2.08055 124.6 194
Ubiquitin-conjugating enzyme E2 variant 3 UEVLD Tdark Non-IDG 0.18 0.85 86
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase ST8SIA4 Tbio Enzyme -2.16905 134.5 95
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Selenide, water dikinase 1 SEPHS1 Tbio Enzyme -1.70455 49.1 115
Phosphorylase b kinase regulatory subunit alpha, liver isoform PHKA2 Tbio Kinase -2.16150 149.4 57
Tubulin--tyrosine ligase TTL Tchem Enzyme -1.29724 15.2 55
Inactive polyglycylase TTLL10 TTLL10 Tdark Enzyme -0.44270 3.73 26
Muscarinic acetylcholine receptor M1 CHRM1 Tclin GPCR -2.13645 135.9 210
Tyrosine-protein kinase ABL1 ABL1 Tclin Kinase -3.47805 3222.2 1533