Development Level

Tbio 33 | 10,625
Tchem 10 | 1,890
Tdark 2 | 7,003

IMPC Term

preweaning lethality, complete... 3 | 633
decreased total body fat amoun... 2 | 186
embryonic lethality prior to t... 2 | 187
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal coat appearance 1 | 25
abnormal embryo size 1 | 112
abnormal gait 1 | 51
abnormal sleep behavior 1 | 63
absent vibrissae 1 | 14
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating glucose ... 1 | 121
decreased circulating iron lev... 1 | 25
decreased circulating triglyce... 1 | 83
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased lean body mass 1 | 195
decreased leukocyte cell numbe... 1 | 54
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
decreased memory-marker CD4-po... 1 | 4
embryonic growth retardation 1 | 28
embryonic lethality prior to o... 1 | 148
enlarged heart 1 | 111
hydrometra 1 | 13
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased total body fat amoun... 1 | 57
long tibia 1 | 13
short tibia 1 | 82

Disease

ovarian cancer 24 | 8,484
Anemia 22 | 252
osteosarcoma 22 | 7,933
psoriasis 21 | 6,685
medulloblastoma, large-cell 20 | 6,234
Cancer 15 | 2,346
Hemochromatosis 15 | 55
glioblastoma 15 | 5,572
non-small cell lung cancer 13 | 2,798
atypical teratoid / rhabdoid tumor 12 | 4,369
lung cancer 12 | 4,466
lung carcinoma 12 | 2,844
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
pancreatic cancer 11 | 2,300
Aceruloplasminemia 10 | 17
invasive ductal carcinoma 10 | 2,950
lung adenocarcinoma 10 | 2,713
primitive neuroectodermal tumor 10 | 3,031
Breast cancer 9 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,956
malignant mesothelioma 9 | 3,162
pediatric high grade glioma 9 | 2,712
pituitary cancer 9 | 1,972
Atransferrinemia 8 | 8
acute quadriplegic myopathy 8 | 1,157
adrenocortical carcinoma 8 | 1,427
breast carcinoma 8 | 1,614
ductal carcinoma in situ 8 | 1,745
group 3 medulloblastoma 8 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,289
pilocytic astrocytoma 8 | 3,086
subependymal giant cell astrocytoma 8 | 2,287
ulcerative colitis 8 | 2,087
Neoplasm Invasiveness 7 | 127
Neurodegenerative disease 7 | 383
Obesity 7 | 616
Parkinson's disease 7 | 364
Rheumatoid Arthritis 7 | 1,160
Thalassemia 7 | 46
Vascular disease 7 | 281
diabetes mellitus 7 | 1,663
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,988
oligodendroglioma 7 | 2,849
tuberculosis 7 | 1,557
Alzheimer's disease 6 | 644
Iron deficiency anemia 6 | 6
Liver disease 6 | 219
adult high grade glioma 6 | 2,148
group 4 medulloblastoma 6 | 1,875
Carcinoma 5 | 2,147
Drug-Induced Liver Injury 5 | 118
Friedreich ataxia 5 | 23
Inflammation 5 | 109
Iron Overload 5 | 5
Kidney disease 5 | 396
Malaria 5 | 140
Multiple myeloma 5 | 1,327
Parkinson Disease 5 | 102
Pick disease 5 | 1,893
Siderosis 5 | 9
aldosterone-producing adenoma 5 | 664
astrocytoma 5 | 1,493
cystic fibrosis 5 | 1,665
ependymoma 5 | 2,514
interstitial cystitis 5 | 2,299
nasopharyngeal carcinoma 5 | 1,056
posterior fossa group A ependymoma 5 | 1,511
primary pancreatic ductal adenocarcinoma 5 | 1,271
Asthma 4 | 349
Atopic dermatitis 4 | 944
Beta thalassemia 4 | 19
Colorectal Neoplasms 4 | 217
Contact Dermatitis 4 | 80
Duchenne muscular dystrophy 4 | 602
Hereditary hemochromatosis 4 | 4
Hypertensive disease 4 | 193
Iron Metabolism Disorders 4 | 5
Iron metabolism disease 4 | 17
Liver neoplasms 4 | 109
Mammary Neoplasms 4 | 410
Neoplastic Cell Transformation 4 | 81
Peripheral vascular disease 4 | 90
Porphyria cutanea tarda 4 | 12
Sideroblastic anemia 4 | 18
active Crohn's disease 4 | 918
astrocytic glioma 4 | 2,241
cutaneous lupus erythematosus 4 | 1,056
gastric carcinoma 4 | 832
inflammatory breast cancer 4 | 404
medulloblastoma 4 | 1,524
mucosa-associated lymphoid tissue lymphoma 4 | 480
non diabetic and post-ischemic heart failure 4 | 200
pancreatic carcinoma 4 | 567
Endometriosis 3 | 535
Waldenstrons macroglobulinemia 3 | 765
colon cancer 3 | 1,475
dermatomyositis 3 | 933
esophageal adenocarcinoma 3 | 737
hepatocellular carcinoma 3 | 532
sonic hedgehog group medulloblastoma 3 | 1,482

Tissue

Blood and immune system 43 | 17,995
Cardiovascular System 43 | 17,958
Digestive Tract 43 | 18,473
Endocrine System 43 | 18,512
Female tissues 43 | 18,647
Liver and Pancreas 43 | 18,136
Male tissues 43 | 17,969
Nervous System 43 | 18,561
Skin and soft tissues 43 | 18,115
Urinary Tract 43 | 18,444
Respiratory system 42 | 17,484

Target Family

Non-IDG 24 | 11,971
Enzyme 9 | 4,146
Transporter 9 | 473
Transcription Factor 3 | 1,400

GO Process

cellular iron ion homeostasis 45 | 45
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transmembrane protease serine 6 TMPRSS6 Tchem Enzyme -1.99222 118.1 102
Ferritin heavy chain FTH1 Tbio Non-IDG -2.95630 924.5 435
Hemopexin HPX Tbio Non-IDG -2.83364 677.6 363
Serotransferrin TF Tchem Non-IDG -4.13136 13124.3 952
Transferrin receptor protein 1 TFRC Tbio Non-IDG -3.39868 2437.0 1167
Ferritin light chain FTL Tbio Non-IDG -2.37909 242.0 430
Bone morphogenetic protein 6 BMP6 Tbio Non-IDG -2.48343 339.1 259
Hemojuvelin HFE2 Tbio Non-IDG -2.13078 140.4 244
Humanin MT-RNR2 Tdark Non-IDG 0.00000 0
Iron-responsive element-binding protein 2 IREB2 Tbio Non-IDG -2.27333 195.8 216