Development Level

Tbio 133 | 10,625
Tchem 57 | 1,890
Tclin 41 | 602
Tdark 36 | 7,003

Collection

GPCR: IDG Consortium (Targets) 26 | 127
GPCR: IDG Consortium (Complete/Control) 10 | 26
Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 8 | 633
decreased bone mineral content 7 | 157
decreased bone mineral density 4 | 126
decreased lean body mass 4 | 195
decreased leukocyte cell numbe... 4 | 54
abnormal behavior 3 | 226
decreased body length 3 | 108
decreased circulating glucose ... 3 | 121
decreased hemoglobin content 3 | 53
decreased mean corpuscular vol... 3 | 50
increased circulating calcium ... 3 | 32
increased circulating serum al... 3 | 25
increased grip strength 3 | 83
increased or absent threshold ... 3 | 128
preweaning lethality, incomple... 3 | 260
abnormal bone structure 2 | 131
abnormal embryo size 2 | 112
abnormal retina morphology 2 | 100
abnormal sleep behavior 2 | 63
decreased NK T cell number 2 | 28
decreased circulating HDL chol... 2 | 77
decreased circulating choleste... 2 | 85
decreased mean corpuscular hem... 2 | 34
decreased startle reflex 2 | 48
decreased vertical activity 2 | 22
enlarged heart 2 | 111
improved glucose tolerance 2 | 56
increased circulating creatini... 2 | 29
increased circulating iron lev... 2 | 25
increased circulating total pr... 2 | 20
increased fasted circulating g... 2 | 68
increased gamma-delta T cell n... 2 | 16
increased hemoglobin content 2 | 45
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
increased startle reflex 2 | 38
increased total body fat amoun... 2 | 57
thrombocytopenia 2 | 46
tremors 2 | 34
abnormal behavioral response t... 1 | 52
abnormal brain morphology 1 | 6
abnormal gait 1 | 51
abnormal heart morphology 1 | 51
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal retinal pigmentation 1 | 61
abnormal vocalization 1 | 21
decreased CD8-positive, alpha-... 1 | 26
decreased Ly6C high monocyte n... 1 | 18
decreased Ly6C low monocyte nu... 1 | 23
decreased T cell number 1 | 31
decreased alpha-beta T cell nu... 1 | 12
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating glycerol... 1 | 19
decreased circulating iron lev... 1 | 25
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased hematocrit 1 | 25
decreased lumbar vertebrae num... 1 | 62
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 19
decreased monocyte cell number 1 | 28
decreased rib number 1 | 59
decreased spleen weight 1 | 13
embryonic lethality prior to t... 1 | 187
female infertility 1 | 34
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased CD4-positive, alpha ... 1 | 15
increased NK cell number 1 | 19
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased body weight 1 | 42
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating alkaline... 1 | 119
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased circulating glucose ... 1 | 16
increased circulating potassiu... 1 | 31
increased effector memory T-he... 1 | 5
increased hematocrit 1 | 36
increased red blood cell distr... 1 | 21
increased sacral vertebrae num... 1 | 62
irregularly shaped pupil 1 | 7
lethargy 1 | 5
persistence of hyaloid vascula... 1 | 22
polydactyly 1 | 22
short tibia 1 | 82
shortened PQ interval 1 | 6
small seminal vesicle 1 | 6
small superior vagus ganglion 1 | 20

Disease

psoriasis 121 | 6,685
osteosarcoma 114 | 7,933
ovarian cancer 111 | 8,491
glioblastoma 90 | 5,572
lung cancer 86 | 4,473
lung carcinoma 84 | 2,844
medulloblastoma, large-cell 84 | 6,234
Cancer 76 | 2,346
interstitial cystitis 70 | 2,299
lung adenocarcinoma 64 | 2,714
ulcerative colitis 63 | 2,087
intraductal papillary-mucinous neoplasm (IPMN) 62 | 3,289
atypical teratoid / rhabdoid tumor 61 | 4,369
non-small cell lung cancer 59 | 2,798
pilocytic astrocytoma 57 | 3,086
cutaneous lupus erythematosus 55 | 1,056
intraductal papillary-mucinous adenoma (IPMA) 54 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 53 | 2,988
invasive ductal carcinoma 53 | 2,950
tuberculosis 50 | 1,563
Breast cancer 49 | 3,098
malignant mesothelioma 47 | 3,163
pancreatic cancer 47 | 2,300
adult high grade glioma 43 | 2,148
diabetes mellitus 42 | 1,663
ductal carcinoma in situ 40 | 1,745
breast carcinoma 39 | 1,614
pituitary cancer 39 | 1,972
colon cancer 38 | 1,475
pediatric high grade glioma 38 | 2,712
subependymal giant cell astrocytoma 38 | 2,287
oligodendroglioma 37 | 2,849
Rheumatoid Arthritis 36 | 1,170
Carcinoma 35 | 2,147
pancreatic ductal adenocarcinoma liver metastasis 35 | 1,795
ependymoma 33 | 2,514
primitive neuroectodermal tumor 32 | 3,031
group 4 medulloblastoma 30 | 1,875
cystic fibrosis 29 | 1,670
posterior fossa group A ependymoma 27 | 1,511
astrocytoma 26 | 1,493
Asthma 25 | 349
group 3 medulloblastoma 24 | 2,254
juvenile dermatomyositis 24 | 1,189
mucosa-associated lymphoid tissue lymphoma 23 | 480
primary Sjogren syndrome 23 | 788
Multiple Sclerosis 22 | 498
posterior fossa group B ependymoma 22 | 1,530
Hypersensitivity reaction type II disease 21 | 235
adrenocortical carcinoma 21 | 1,427
gastric carcinoma 21 | 832
non-small cell lung carcinoma 21 | 413
dermatomyositis 20 | 966
esophageal adenocarcinoma 20 | 737
medulloblastoma 20 | 1,524
sonic hedgehog group medulloblastoma 20 | 1,482
spina bifida 20 | 1,064
Hypertension 19 | 293
Obesity 19 | 616
astrocytic glioma 19 | 2,241
nasopharyngeal carcinoma 19 | 1,056
Kidney disease 18 | 397
primary pancreatic ductal adenocarcinoma 18 | 1,271
Multiple myeloma 17 | 1,327
Pick disease 17 | 1,893
atypical teratoid/rhabdoid tumor 17 | 1,095
Atopic dermatitis 16 | 944
Lung disease 16 | 136
active Crohn's disease 16 | 918
Heart disease 15 | 279
Hypertensive disease 15 | 193
Inflammation 15 | 109
Schizophrenia 15 | 503
Anemia 14 | 252
Down syndrome 14 | 548
IGA Glomerulonephritis 14 | 454
Inflammatory bowel disease 14 | 142
acute quadriplegic myopathy 14 | 1,157
fibroadenoma 14 | 557
head and neck cancer and chronic obstructive pulmonary disease 14 | 237
Arthritis 13 | 248
Duchenne muscular dystrophy 13 | 602
Endometriosis 13 | 535
Human immunodeficiency virus infectious disease 13 | 129
Mammary Neoplasms 13 | 410
Vascular disease 12 | 281
head and neck cancer 12 | 270
hepatocellular carcinoma 12 | 550
sarcoidosis 12 | 368
Atherosclerosis 11 | 275
Common variable immunodeficiency 11 | 98
Liver disease 11 | 219
Pneumonia 11 | 133
Prostatic Neoplasms 11 | 471
pancreatic carcinoma 11 | 567
Cerebrovascular disease 10 | 231
Neoplasm Metastasis 10 | 138
acute myeloid leukemia 10 | 785
Waldenstrons macroglobulinemia 9 | 764
aldosterone-producing adenoma 9 | 664

Tissue

Urinary Tract 260 | 18,443
Female tissues 259 | 18,646
Nervous System 257 | 18,560
Endocrine System 256 | 18,511
Digestive Tract 255 | 18,472
Blood and immune system 253 | 17,994
Liver and Pancreas 251 | 18,135
Skin and soft tissues 250 | 18,114
Cardiovascular System 249 | 17,957
Respiratory system 246 | 17,483
Male tissues 243 | 17,968

Target Family

Non-IDG 138 | 11,969
GPCR 82 | 408
Enzyme 14 | 4,146
Kinase 14 | 634
oGPCR 13 | 421
Ion Channel 3 | 341
Epigenetic 2 | 242
Transcription Factor 1 | 1,400

GO Process

cell surface receptor signalin... 267 | 267
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 367 | 367
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
chemical synaptic transmission 238 | 238
MAPK cascade 237 | 237
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 199 | 199
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 180 | 180
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 175 | 175
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
protein folding 162 | 162
negative regulation of canonic... 161 | 161
response to lipopolysaccharide 161 | 161
T cell receptor signaling path... 160 | 160
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2-M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
type I interferon signaling pa... 130 | 130
endocytosis 129 | 129

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Somatostatin receptor type 1 SSTR1 Tclin GPCR -2.13194 126.3 290
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.04868 9.00 130
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
Protein arginine N-methyltransferase 1 PRMT1 Tchem Epigenetic -2.30739 200.5 309
Angiotensinogen AGT Tchem Non-IDG -3.23867 1673.4 609
Complement C5 C5 Tclin Non-IDG -2.22372 154.9 317
C-X-C chemokine receptor type 1 CXCR1 Tchem GPCR -2.45436 257.8 324
Olfactory receptor 11H12 OR11H12 Tdark oGPCR 0.00000 18
Lymphocyte antigen 96 LY96 Tbio Non-IDG -2.73333 490.7 314
Interleukin-7 receptor subunit alpha IL7R Tbio Non-IDG -2.76199 528.6 688