Development Level

Tbio 233 | 10,625
Tchem 87 | 1,890
Tclin 27 | 602
Tdark 11 | 7,003

Collection

Eligible Kinase Proteins 3 | 134
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 22 | 633
embryonic lethality prior to t... 6 | 187
preweaning lethality, incomple... 6 | 260
abnormal behavior 5 | 226
abnormal embryo size 5 | 112
abnormal bone structure 4 | 131
abnormal retina morphology 4 | 100
decreased body weight 4 | 174
embryonic lethality prior to o... 4 | 148
hyperactivity 4 | 108
increased or absent threshold ... 4 | 128
abnormal pericardium morpholog... 3 | 11
abnormal retinal pigmentation 3 | 61
abnormal spleen morphology 3 | 36
decreased body length 3 | 108
decreased grip strength 3 | 123
enlarged heart 3 | 111
increased circulating alkaline... 3 | 119
increased lean body mass 3 | 107
increased mean corpuscular vol... 3 | 91
increased vertical activity 3 | 18
tremors 3 | 34
abnormal behavioral response t... 2 | 52
abnormal cornea morphology 2 | 24
abnormal femur morphology 2 | 14
abnormal heart morphology 2 | 51
abnormal hindbrain development 2 | 24
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal placenta size 2 | 10
abnormal skin morphology 2 | 23
abnormal sleep behavior 2 | 63
decreased CD4-positive, CD25-p... 2 | 24
decreased NK T cell number 2 | 28
decreased bone mineral content 2 | 157
decreased bone mineral density 2 | 126
decreased circulating choleste... 2 | 85
decreased circulating insulin ... 2 | 75
decreased heart rate 2 | 10
decreased hemoglobin content 2 | 53
decreased leukocyte cell numbe... 2 | 54
decreased neutrophil cell numb... 2 | 37
decreased total body fat amoun... 2 | 186
female infertility 2 | 34
impaired glucose tolerance 2 | 52
improved glucose tolerance 2 | 56
increased circulating chloride... 2 | 43
increased monocyte cell number 2 | 27
pale yolk sac 2 | 12
prenatal lethality prior to he... 2 | 64
prolonged RR interval 2 | 2
small kidney 2 | 10
small superior vagus ganglion 2 | 20
abnormal allantois morphology 1 | 3
abnormal cranium morphology 1 | 32
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal forebrain development 1 | 18
abnormal heart looping 1 | 2
abnormal limb bud morphology 1 | 15
abnormal neural tube morpholog... 1 | 8
abnormal spinal cord morpholog... 1 | 8
abnormal tail bud morphology 1 | 6
abnormal testis morphology 1 | 30
abnormal tooth morphology 1 | 24
absent vibrissae 1 | 14
cataract 1 | 26
craniofacial phenotype 1 | 9
decreased basophil cell number 1 | 11
decreased circulating chloride... 1 | 32
decreased circulating phosphat... 1 | 15
decreased circulating triglyce... 1 | 83
decreased hematocrit 1 | 25
decreased mature B cell number 1 | 25
decreased mean corpuscular hem... 1 | 34
decreased monocyte cell number 1 | 28
edema 1 | 11
embryonic growth retardation 1 | 28
enlarged spleen 1 | 26
hemorrhage 1 | 12
hydrops fetalis 1 | 22
increased B cell number 1 | 23
increased CD4-positive, alpha ... 1 | 15
increased Ly6C high monocyte n... 1 | 12
increased NK cell number 1 | 19
increased circulating HDL chol... 1 | 63
increased circulating choleste... 1 | 53
increased circulating magnesiu... 1 | 10
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased rib number 1 | 41
increased startle reflex 1 | 38
irregularly shaped pupil 1 | 7
long tibia 1 | 13
pallor 1 | 13
persistence of hyaloid vascula... 1 | 22
polydactyly 1 | 22
prenatal lethality 1 | 16
small spleen 1 | 11
thrombocytopenia 1 | 46

Disease

ovarian cancer 206 | 8,484
psoriasis 171 | 6,685
osteosarcoma 168 | 7,933
Cancer 155 | 2,346
medulloblastoma, large-cell 155 | 6,234
glioblastoma 146 | 5,572
lung cancer 144 | 4,466
atypical teratoid / rhabdoid tumor 110 | 4,369
Breast cancer 105 | 3,094
malignant mesothelioma 95 | 3,162
non-small cell lung cancer 95 | 2,798
lung adenocarcinoma 93 | 2,713
intraductal papillary-mucinous neoplasm (IPMN) 88 | 3,289
invasive ductal carcinoma 84 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 78 | 2,988
pediatric high grade glioma 77 | 2,712
pilocytic astrocytoma 75 | 3,086
pancreatic cancer 72 | 2,300
primitive neuroectodermal tumor 69 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 68 | 2,956
interstitial cystitis 65 | 2,299
group 3 medulloblastoma 64 | 2,254
oligodendroglioma 64 | 2,849
lung carcinoma 63 | 2,844
ulcerative colitis 55 | 2,087
astrocytoma 53 | 1,493
colon cancer 53 | 1,475
breast carcinoma 51 | 1,614
pituitary cancer 51 | 1,972
Carcinoma 50 | 2,147
ependymoma 50 | 2,514
diabetes mellitus 48 | 1,663
ductal carcinoma in situ 48 | 1,745
posterior fossa group A ependymoma 47 | 1,511
adult high grade glioma 45 | 2,148
subependymal giant cell astrocytoma 45 | 2,287
adrenocortical carcinoma 44 | 1,427
group 4 medulloblastoma 44 | 1,875
Endometriosis 42 | 535
Atopic dermatitis 41 | 944
Rheumatoid Arthritis 38 | 1,160
cystic fibrosis 38 | 1,665
Multiple myeloma 37 | 1,327
juvenile dermatomyositis 37 | 1,189
Pick disease 36 | 1,893
acute quadriplegic myopathy 36 | 1,157
medulloblastoma 36 | 1,524
primary pancreatic ductal adenocarcinoma 36 | 1,271
tuberculosis 36 | 1,557
astrocytic glioma 34 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 34 | 1,795
Mammary Neoplasms 32 | 410
cutaneous lupus erythematosus 32 | 1,056
spina bifida 32 | 1,064
active Crohn's disease 31 | 918
nasopharyngeal carcinoma 31 | 1,056
atypical teratoid/rhabdoid tumor 29 | 1,095
dermatomyositis 29 | 933
Waldenstrons macroglobulinemia 28 | 765
Prostatic Neoplasms 27 | 471
gastric carcinoma 27 | 832
posterior fossa group B ependymoma 27 | 1,530
sonic hedgehog group medulloblastoma 27 | 1,482
non-small cell lung carcinoma 25 | 413
Alzheimer's disease 24 | 644
Duchenne muscular dystrophy 24 | 602
Schizophrenia 23 | 501
primary Sjogren syndrome 23 | 789
esophageal adenocarcinoma 22 | 737
Asthma 21 | 349
Down syndrome 21 | 548
Kidney disease 21 | 396
Stomach Neoplasms 21 | 282
autosomal dominant Emery-Dreifuss muscular dystrophy 21 | 499
IGA Glomerulonephritis 20 | 454
non primary Sjogren syndrome sicca 18 | 840
Heart disease 17 | 279
Liver carcinoma 17 | 217
Obesity 17 | 616
aldosterone-producing adenoma 17 | 664
pancreatic carcinoma 16 | 567
Adenoma 15 | 165
Multiple Sclerosis 15 | 498
Peripheral Neuropathy 15 | 303
Polycystic Ovary Syndrome 15 | 332
Vascular disease 15 | 281
active ulcerative colitis 15 | 477
chronic rhinosinusitis 15 | 512
Colorectal Neoplasms 14 | 217
Adenocarcinoma 13 | 115
Colonic Neoplasms 13 | 126
Intellectual disability 13 | 573
Melanoma 13 | 261
Neoplasm Invasiveness 13 | 127
Parkinson's disease 13 | 364
acute myeloid leukemia 13 | 780
mucosa-associated lymphoid tissue lymphoma 13 | 480
Neoplasm Metastasis 12 | 138
progressive supranuclear palsy 12 | 674
tuberculosis and treatment for 6 months 12 | 686

Tissue

Female tissues 355 | 18,647
Nervous System 355 | 18,561
Digestive Tract 354 | 18,473
Endocrine System 354 | 18,512
Cardiovascular System 352 | 17,958
Urinary Tract 352 | 18,444
Male tissues 351 | 17,969
Blood and immune system 349 | 17,995
Liver and Pancreas 348 | 18,136
Skin and soft tissues 346 | 18,115
Respiratory system 339 | 17,484

Target Family

Non-IDG 205 | 11,971
Enzyme 56 | 4,146
Kinase 41 | 634
Transcription Factor 29 | 1,400
Epigenetic 11 | 242
GPCR 11 | 406
Nuclear Receptor 3 | 48
TF/Epigenetic 1 | 38
Transporter 1 | 473

GO Process

cell proliferation 358 | 358
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Epidermal growth factor receptor kinase substrate 8 EPS8 Tbio Enzyme -1.80380 77.2 248
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
Nuclear autoantigenic sperm protein NASP Tbio Non-IDG -1.72078 58.3 103
Pro-neuropeptide Y NPY Tbio Non-IDG -3.81741 7285.3 401
Nardilysin NRDC Tbio Enzyme -1.64244 49.9 83
Centromere protein F CENPF Tbio Non-IDG -1.98596 103.0 180
Transcription factor E4F1 E4F1 Tbio Transcription Factor -1.47845 33.6 74
Cullin-5 CUL5 Tbio Non-IDG -1.93258 89.1 172
Bystin BYSL Tbio Non-IDG -1.20821 15.6 54