Development Level

Tbio 261 | 11,651
Tchem 69 | 1,388
Tclin 29 | 612
Tdark 7 | 6,593

Collection

Kinase: IDG Consortium (Target... 4 | 125
RFA-RM-18-021 4 | 328
GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

preweaning lethality, complete... 25 | 979
preweaning lethality, incomple... 12 | 499
abnormal embryo size 9 | 220
abnormal behavior 7 | 298
embryonic lethality prior to t... 7 | 278
hyperactivity 6 | 148
abnormal bone structure 5 | 187
decreased body weight 5 | 161
decreased vertical activity 5 | 208
embryonic lethality prior to o... 5 | 239
increased startle reflex 5 | 112
abnormal spleen morphology 4 | 55
decreased body length 4 | 101
abnormal pericardium morpholog... 3 | 26
decreased circulating choleste... 3 | 93
decreased leukocyte cell numbe... 3 | 73
enlarged heart 3 | 210
female infertility 3 | 60
increased blood urea nitrogen ... 3 | 48
increased lean body mass 3 | 172
increased mean corpuscular vol... 3 | 92
long tibia 3 | 25
tremors 3 | 39
abnormal behavioral response t... 2 | 66
abnormal cornea morphology 2 | 31
abnormal embryo development 2 | 7
abnormal eye anterior chamber ... 2 | 9
abnormal eye morphology 2 | 68
abnormal femur morphology 2 | 14
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal neural tube closure 2 | 46
abnormal skin morphology 2 | 50
abnormal sleep behavior 2 | 70
abnormal vertebrae morphology 2 | 18
brachydactyly 2 | 19
cardiovascular system phenotyp... 2 | 36
decreased exploration in new e... 2 | 11
decreased heart rate 2 | 18
decreased lean body mass 2 | 135
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
increased circulating chloride... 2 | 41
increased circulating triglyce... 2 | 42
increased heart rate 2 | 23
increased total body fat amoun... 2 | 134
increased vertical activity 2 | 24
male infertility 2 | 123
microphthalmia 2 | 26
pale yolk sac 2 | 25
prenatal lethality prior to he... 2 | 87
prolonged QT interval 2 | 38
prolonged RR interval 2 | 8
prolonged ST segment 2 | 36
short tibia 2 | 97
small superior vagus ganglion 2 | 74
small testis 2 | 58
abnormal body wall morphology 1 | 9
abnormal craniofacial morpholo... 1 | 33
abnormal embryo turning 1 | 31
abnormal heart left ventricle ... 1 | 16
abnormal heart looping 1 | 5
abnormal lens morphology 1 | 81
abnormal motor capabilities-co... 1 | 5
abnormal neural tube morpholog... 1 | 12
abnormal retina morphology 1 | 71
abnormal spine curvature 1 | 9
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
absent spleen 1 | 3
absent vibrissae 1 | 12
decreased blood urea nitrogen ... 1 | 51
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased neutrophil cell numb... 1 | 42
edema 1 | 59
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
enlarged urinary bladder 1 | 8
impaired pupillary reflex 1 | 26
increased anti-nuclear antigen... 1 | 19
increased cardiac muscle contr... 1 | 8
increased circulating HDL chol... 1 | 80
increased circulating amylase ... 1 | 25
increased circulating creatini... 1 | 38
increased circulating magnesiu... 1 | 10
prenatal lethality 1 | 28
shortened RR interval 1 | 17
small kidney 1 | 16
syndactyly 1 | 23
vertebral fusion 1 | 23

Disease

Carcinoma 240 | 11,493
ovarian cancer 212 | 8,520
psoriasis 175 | 6,694
osteosarcoma 173 | 7,950
Cancer 168 | 2,499
glioblastoma 155 | 5,792
medulloblastoma, large-cell 155 | 6,241
lung cancer 152 | 4,740
atypical teratoid / rhabdoid tumor 133 | 5,112
Breast cancer 116 | 3,578
ependymoma 107 | 4,679
malignant mesothelioma 106 | 3,232
group 3 medulloblastoma 104 | 4,104
non-small cell lung cancer 98 | 2,890
lung adenocarcinoma 94 | 2,716
adult high grade glioma 93 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 89 | 3,291
invasive ductal carcinoma 85 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 79 | 2,989
Astrocytoma, Pilocytic 75 | 3,081
pancreatic cancer 73 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 69 | 2,955
primitive neuroectodermal tumor 69 | 3,035
lung carcinoma 67 | 2,843
interstitial cystitis 66 | 2,312
oligodendroglioma 63 | 2,850
Kidney cancer 55 | 2,613
breast carcinoma 54 | 1,638
colon cancer 54 | 1,478
astrocytic glioma 52 | 2,597
diabetes mellitus 52 | 1,728
pituitary cancer 52 | 1,972
ulcerative colitis 51 | 1,819
ductal carcinoma in situ 48 | 1,745
subependymal giant cell astrocytoma 48 | 2,287
tuberculosis 45 | 2,010
Autosomal recessive predisposition 44 | 1,442
group 4 medulloblastoma 44 | 1,855
adrenocortical carcinoma 43 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 42 | 1,962
Endometriosis 41 | 540
Atopic dermatitis 40 | 952
Rheumatoid arthritis 40 | 1,191
Schizophrenia 40 | 1,160
cystic fibrosis 39 | 1,696
Multiple myeloma 38 | 1,332
astrocytoma 37 | 1,146
Pick disease 36 | 1,894
acute quadriplegic myopathy 36 | 1,158
juvenile dermatomyositis 36 | 1,187
spina bifida 34 | 1,074
cutaneous lupus erythematosus 33 | 1,057
active Crohn's disease 32 | 922
nasopharyngeal carcinoma 32 | 1,058
Breast Neoplasms 31 | 445
primary pancreatic ductal adenocarcinoma 31 | 1,109
Mammary Neoplasms 30 | 425
dermatomyositis 29 | 966
pediatric high grade glioma 29 | 1,064
Intellectual disability 28 | 1,016
gastric carcinoma 28 | 807
Melanoma 27 | 711
Prostatic Neoplasms 27 | 495
Waldenstrons macroglobulinemia 27 | 765
Alzheimer's disease 26 | 658
Cognitive delay 24 | 608
Epilepsy 24 | 792
Global developmental delay 24 | 608
Mental and motor retardation 24 | 608
Stomach Neoplasms 24 | 300
Asthma 23 | 385
Duchenne muscular dystrophy 23 | 601
Dull intelligence 23 | 645
Kidney disease 23 | 430
Liver Cirrhosis, Experimental 23 | 769
Low intelligence 23 | 645
Mental Retardation 23 | 645
Mental deficiency 23 | 645
Poor school performance 23 | 645
Short stature 23 | 531
esophageal adenocarcinoma 23 | 737
Obesity 22 | 678
Depressive disorder 21 | 409
Hypoplastic mandible condyle 21 | 275
Mandibular hypoplasia 21 | 275
Micrognathism 21 | 275
Seizures 21 | 596
Skin cancer 21 | 469
active ulcerative colitis 21 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 21 | 510
primary Sjogren syndrome 21 | 735
Heart disease 20 | 306
Multiple Sclerosis 20 | 540
Small head 20 | 374
non primary Sjogren syndrome sicca 19 | 891
non-small cell lung carcinoma 19 | 317
Carcinoma, Hepatocellular 18 | 228
Down syndrome 18 | 499
Liver cancer 18 | 604
Liver carcinoma 18 | 240

Tissue

Endocrine System 361 | 18,159
Skin and soft tissues 356 | 17,230
Female tissues 354 | 17,400
Digestive Tract 353 | 17,369
Male tissues 351 | 17,142
Liver and Pancreas 350 | 16,750
Nervous System 349 | 16,725
Urinary Tract 348 | 16,678
Blood and immune system 346 | 16,909
Respiratory system 345 | 16,393
Cardiovascular System 322 | 15,192

Target Family

Non-IDG 212 | 12,091
Enzyme 55 | 4,145
Kinase 42 | 634
Transcription Factor 30 | 1,400
GPCR 11 | 408
Epigenetic 10 | 242
Nuclear Receptor 4 | 48
TF/Epigenetic 1 | 38
Transporter 1 | 473

GO Process

cell proliferation 366 | 366
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Sphingosine kinase 2 SPHK2 Tchem Kinase -2.21878 154.9 314
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
CD160 antigen CD160 Tbio Non-IDG -1.70035 55.1 428
CCR4-NOT transcription complex subunit 11 CNOT11 Tbio Non-IDG -1.18963 14.4 52
F-box/LRR-repeat protein 7 FBXL7 Tbio Non-IDG -0.80631 6.84 53
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 ALKBH3 Tchem Enzyme -1.51372 33.2 194
Protein ecdysoneless homolog ECD Tbio Non-IDG -0.72245 9.93 113
Endothelial lipase LIPG Tchem Enzyme -2.28530 192.2 712