Development Level

Tbio 104 | 10,625
Tchem 37 | 1,890
Tclin 18 | 602
Tdark 9 | 7,003

Collection

Eligible Kinase Proteins 4 | 134
Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

preweaning lethality, complete... 9 | 633
abnormal embryo size 6 | 112
decreased lean body mass 5 | 195
enlarged heart 4 | 111
increased mean corpuscular hem... 4 | 93
increased or absent threshold ... 4 | 128
preweaning lethality, incomple... 4 | 260
abnormal hindbrain development 3 | 24
abnormal midbrain development 3 | 22
abnormal neural tube closure 3 | 37
decreased body length 3 | 108
decreased bone mineral density 3 | 126
decreased lumbar vertebrae num... 3 | 62
embryonic lethality prior to t... 3 | 187
increased circulating alkaline... 3 | 119
abnormal bone structure 2 | 131
abnormal placenta size 2 | 10
abnormal retina morphology 2 | 100
abnormal retinal pigmentation 2 | 61
decreased bone mineral content 2 | 157
decreased circulating choleste... 2 | 85
decreased circulating serum al... 2 | 79
decreased fasted circulating g... 2 | 49
decreased total body fat amoun... 2 | 186
hypoactivity 2 | 89
impaired glucose tolerance 2 | 52
improved glucose tolerance 2 | 56
increased blood urea nitrogen ... 2 | 44
increased circulating triglyce... 2 | 24
increased exploration in new e... 2 | 56
increased grip strength 2 | 83
increased hemoglobin content 2 | 45
increased lean body mass 2 | 107
increased mean corpuscular vol... 2 | 91
increased sacral vertebrae num... 2 | 62
pale yolk sac 2 | 12
abnormal coat appearance 1 | 25
abnormal coat/hair pigmentatio... 1 | 54
abnormal digit morphology 1 | 13
abnormal eye morphology 1 | 38
abnormal forebrain development 1 | 18
abnormal heart morphology 1 | 51
abnormal lens morphology 1 | 73
abnormal limb bud morphology 1 | 15
abnormal liver morphology 1 | 5
abnormal lung morphology 1 | 15
abnormal pericardium morpholog... 1 | 11
abnormal response to new envir... 1 | 8
abnormal skin coloration 1 | 18
abnormal sleep behavior 1 | 63
abnormal spinal cord morpholog... 1 | 8
abnormal spleen morphology 1 | 36
abnormal tail morphology 1 | 17
abnormal vertebrae morphology 1 | 14
abnormal vocalization 1 | 21
absent heartbeat 1 | 6
anophthalmia 1 | 20
corneal opacity 1 | 25
craniofacial phenotype 1 | 9
decreased CD4-positive, CD25-p... 1 | 24
decreased NK T cell number 1 | 28
decreased caudal vertebrae num... 1 | 49
decreased circulating HDL chol... 1 | 77
decreased circulating calcium ... 1 | 33
decreased circulating creatini... 1 | 31
decreased circulating free fat... 1 | 39
decreased circulating iron lev... 1 | 25
decreased grip strength 1 | 123
decreased heart weight 1 | 44
decreased mature B cell number 1 | 25
decreased mean corpuscular vol... 1 | 50
decreased startle reflex 1 | 48
decreased vertical activity 1 | 22
edema 1 | 11
embryonic lethality prior to o... 1 | 148
herniated abdominal wall 1 | 4
hyperactivity 1 | 108
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating LDL chol... 1 | 15
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased coping response 1 | 3
increased effector memory CD4-... 1 | 15
increased leukocyte cell numbe... 1 | 37
increased respiratory quotient 1 | 12
mydriasis 1 | 9
pale liver 1 | 5
pallor 1 | 13
polydactyly 1 | 22
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
shortened PQ interval 1 | 6
shortened PR interval 1 | 5
shortened ST segment 1 | 9
thrombocytosis 1 | 23
vertebral fusion 1 | 23

Disease

ovarian cancer 101 | 8,484
osteosarcoma 93 | 7,933
glioblastoma 87 | 5,572
psoriasis 78 | 6,685
medulloblastoma, large-cell 75 | 6,234
Cancer 73 | 2,346
atypical teratoid / rhabdoid tumor 57 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 54 | 3,289
lung cancer 53 | 4,466
pilocytic astrocytoma 52 | 3,086
Breast cancer 51 | 3,094
lung adenocarcinoma 51 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 48 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 48 | 2,988
non-small cell lung cancer 48 | 2,798
interstitial cystitis 47 | 2,299
Carcinoma 46 | 2,147
pancreatic cancer 46 | 2,300
invasive ductal carcinoma 45 | 2,950
malignant mesothelioma 45 | 3,162
pediatric high grade glioma 43 | 2,712
primitive neuroectodermal tumor 38 | 3,031
cystic fibrosis 35 | 1,665
lung carcinoma 33 | 2,844
primary pancreatic ductal adenocarcinoma 33 | 1,271
pituitary cancer 31 | 1,972
ependymoma 30 | 2,514
ulcerative colitis 30 | 2,087
group 3 medulloblastoma 29 | 2,254
oligodendroglioma 29 | 2,849
group 4 medulloblastoma 28 | 1,875
ductal carcinoma in situ 26 | 1,745
subependymal giant cell astrocytoma 26 | 2,287
breast carcinoma 25 | 1,614
adrenocortical carcinoma 24 | 1,427
adult high grade glioma 24 | 2,148
astrocytoma 24 | 1,493
juvenile dermatomyositis 23 | 1,189
sonic hedgehog group medulloblastoma 23 | 1,482
tuberculosis 23 | 1,557
colon cancer 21 | 1,475
gastric carcinoma 21 | 832
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,795
spina bifida 20 | 1,064
astrocytic glioma 19 | 2,241
posterior fossa group A ependymoma 19 | 1,511
posterior fossa group B ependymoma 19 | 1,530
diabetes mellitus 18 | 1,663
acute quadriplegic myopathy 17 | 1,157
esophageal adenocarcinoma 17 | 737
medulloblastoma 16 | 1,524
Atopic dermatitis 15 | 944
Pick disease 15 | 1,893
Prostatic Neoplasms 15 | 471
Rheumatoid Arthritis 15 | 1,160
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 499
dermatomyositis 15 | 933
nasopharyngeal carcinoma 14 | 1,056
Multiple Sclerosis 13 | 498
cutaneous lupus erythematosus 13 | 1,056
Schizophrenia 12 | 501
Blastic phase chronic myeloid leukemia 11 | 58
Chronic Myelocytic Leukemia Accelerated Phase 11 | 59
Chronic phase chronic myeloid leukemia 11 | 45
Duchenne muscular dystrophy 11 | 602
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 11 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 11 | 47
acute myeloid leukemia 11 | 780
fibroadenoma 11 | 557
non-small cell lung carcinoma 11 | 413
primary Sjogren syndrome 11 | 789
Kidney disease 10 | 396
active Crohn's disease 10 | 918
atypical teratoid/rhabdoid tumor 10 | 1,095
Alzheimer's disease 9 | 644
Down syndrome 9 | 548
Hypertension 9 | 287
Obesity 9 | 616
Waldenstrons macroglobulinemia 9 | 765
mucosa-associated lymphoid tissue lymphoma 9 | 480
urothelial carcinoma 9 | 318
Mammary Neoplasms 8 | 410
Multiple myeloma 8 | 1,327
Vascular disease 8 | 281
chronic rhinosinusitis 8 | 512
non primary Sjogren syndrome sicca 8 | 840
Amyotrophic Lateral Sclerosis 7 | 431
Arthritis 7 | 248
Endometriosis 7 | 535
Glaucoma 7 | 134
IGA Glomerulonephritis 7 | 454
Lung Neoplasms 7 | 171
aldosterone-producing adenoma 7 | 664
Heart failure 6 | 80
Intellectual disability 6 | 573
Melanoma 6 | 261
Neoplasm Metastasis 6 | 138
Stomach Neoplasms 6 | 282
inflammatory breast cancer 6 | 404
nephrosclerosis 6 | 329

Tissue

Digestive Tract 166 | 18,473
Endocrine System 166 | 18,512
Female tissues 166 | 18,647
Nervous System 166 | 18,561
Skin and soft tissues 166 | 18,115
Urinary Tract 166 | 18,444
Cardiovascular System 165 | 17,958
Liver and Pancreas 165 | 18,136
Male tissues 165 | 17,969
Blood and immune system 164 | 17,995
Respiratory system 164 | 17,484

Target Family

Non-IDG 88 | 11,971
Kinase 38 | 634
Enzyme 27 | 4,146
Transcription Factor 9 | 1,400
GPCR 5 | 406
Transporter 1 | 473

GO Process

cell migration 168 | 168
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ubiquitin carboxyl-terminal hydrolase 24 USP24 Tbio Enzyme -1.53939 36.4 61
Angiogenin ANG Tbio Enzyme -2.89794 796.0 203
Tenascin-N TNN Tbio Non-IDG -1.77329 68.8 63
Late secretory pathway protein AVL9 homolog AVL9 Tdark Non-IDG -0.62267 4.03 45
Nardilysin NRDC Tbio Enzyme -1.64244 49.9 83
Protein-tyrosine kinase 6 PTK6 Tchem Kinase -2.14303 167.1 320
Protein KIBRA WWC1 Tbio Non-IDG -1.88892 84.4 96
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 KCTD13 Tbio Non-IDG -0.85155 7.65 69
Glutamyl aminopeptidase ENPEP Tchem Enzyme -2.81004 644.6 267
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767