Development Level

Tbio 114 | 11,651
Tchem 36 | 1,388
Tclin 19 | 612
Tdark 12 | 6,593

Collection

RFA-RM-18-021 10 | 328
Kinase: IDG Consortium (Target... 9 | 125
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 12 | 979
abnormal embryo size 10 | 220
preweaning lethality, incomple... 10 | 499
decreased vertical activity 6 | 208
embryonic growth retardation 5 | 106
enlarged heart 5 | 210
abnormal seminal vesicle morph... 4 | 114
decreased lean body mass 4 | 135
embryonic lethality prior to t... 4 | 278
increased circulating alkaline... 4 | 122
increased mean corpuscular hem... 4 | 96
abnormal behavior 3 | 298
abnormal bone structure 3 | 187
abnormal eye morphology 3 | 68
decreased total body fat amoun... 3 | 207
abnormal heart morphology 2 | 162
abnormal liver morphology 2 | 17
abnormal placenta size 2 | 20
abnormal sleep behavior 2 | 70
abnormal tail morphology 2 | 25
decreased body length 2 | 101
decreased body weight 2 | 161
decreased circulating serum al... 2 | 82
decreased fasted circulating g... 2 | 65
embryonic lethality prior to o... 2 | 239
enlarged lymph nodes 2 | 37
hyperactivity 2 | 148
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
improved glucose tolerance 2 | 79
increased circulating triglyce... 2 | 42
increased hemoglobin content 2 | 45
increased lean body mass 2 | 172
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
pale yolk sac 2 | 25
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
small testis 2 | 58
abnormal bone mineralization 1 | 38
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal digit morphology 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal iris morphology 1 | 13
abnormal limb bud morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal skin coloration 1 | 25
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal urinary bladder morph... 1 | 11
abnormal vertebrae morphology 1 | 18
abnormal vocalization 1 | 21
absent urinary bladder 1 | 1
cataract 1 | 92
corneal opacity 1 | 32
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating creatini... 1 | 39
decreased circulating glycerol... 1 | 16
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
hemorrhage 1 | 23
impaired pupillary reflex 1 | 26
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased caudal vertebrae num... 1 | 7
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased coping response 1 | 4
increased exploration in new e... 1 | 8
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased vertical activity 1 | 24
pale liver 1 | 6
pallor 1 | 34
prenatal lethality 1 | 28
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Carcinoma 131 | 11,493
ovarian cancer 101 | 8,520
osteosarcoma 99 | 7,950
glioblastoma 91 | 5,792
Cancer 83 | 2,499
psoriasis 81 | 6,694
medulloblastoma, large-cell 79 | 6,241
atypical teratoid / rhabdoid tumor 71 | 5,112
ependymoma 64 | 4,679
lung cancer 60 | 4,740
Breast cancer 57 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 56 | 3,291
Astrocytoma, Pilocytic 53 | 3,081
malignant mesothelioma 53 | 3,232
non-small cell lung cancer 52 | 2,890
interstitial cystitis 51 | 2,312
lung adenocarcinoma 51 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 50 | 2,955
pancreatic cancer 50 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 49 | 2,989
adult high grade glioma 48 | 3,801
invasive ductal carcinoma 48 | 2,951
Kidney cancer 46 | 2,613
group 3 medulloblastoma 46 | 4,104
primitive neuroectodermal tumor 42 | 3,035
lung carcinoma 38 | 2,843
cystic fibrosis 35 | 1,696
primary pancreatic ductal adenocarcinoma 34 | 1,109
group 4 medulloblastoma 33 | 1,855
pituitary cancer 33 | 1,972
ulcerative colitis 30 | 1,819
oligodendroglioma 29 | 2,850
astrocytic glioma 28 | 2,597
ductal carcinoma in situ 28 | 1,745
breast carcinoma 26 | 1,638
juvenile dermatomyositis 26 | 1,187
subependymal giant cell astrocytoma 26 | 2,287
adrenocortical carcinoma 25 | 1,428
tuberculosis 24 | 2,010
Schizophrenia 23 | 1,160
gastric carcinoma 22 | 807
pediatric high grade glioma 22 | 1,064
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,962
spina bifida 21 | 1,074
colon cancer 20 | 1,478
diabetes mellitus 19 | 1,728
acute quadriplegic myopathy 18 | 1,158
astrocytoma 18 | 1,146
Atopic dermatitis 17 | 952
Rheumatoid arthritis 17 | 1,191
esophageal adenocarcinoma 17 | 737
Liver Cirrhosis, Experimental 16 | 769
cutaneous lupus erythematosus 16 | 1,057
dermatomyositis 16 | 966
Autosomal recessive predisposition 15 | 1,442
Multiple Sclerosis 15 | 540
Pick disease 15 | 1,894
autosomal dominant Emery-Dreifuss muscular dystrophy 15 | 510
Prostatic Neoplasms 14 | 495
nasopharyngeal carcinoma 13 | 1,058
primary Sjogren syndrome 13 | 735
Bipolar Disorder 12 | 666
Blastic phase chronic myeloid leukemia 12 | 58
Chronic Myelocytic Leukemia Accelerated Phase 12 | 59
Chronic phase chronic myeloid leukemia 12 | 45
Hypertension 12 | 396
Liver cancer 12 | 604
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 12 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 12 | 47
acute myeloid leukemia 12 | 783
Duchenne muscular dystrophy 11 | 601
Epilepsy 11 | 792
Intellectual disability 11 | 1,016
Waldenstrons macroglobulinemia 11 | 765
fibroadenoma 11 | 559
Kidney disease 10 | 430
Melanoma 10 | 711
Seizures 10 | 596
active Crohn's disease 10 | 922
sonic hedgehog group medulloblastoma 10 | 467
urothelial carcinoma 10 | 318
Breast Neoplasms 9 | 445
Multiple myeloma 9 | 1,332
Obesity 9 | 678
Skin cancer 9 | 469
mucosa-associated lymphoid tissue lymphoma 9 | 484
Alzheimer's disease 8 | 658
Depressive disorder 8 | 409
Down syndrome 8 | 499
Dull intelligence 8 | 645
Low intelligence 8 | 645
Lung Neoplasms 8 | 232
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Poor school performance 8 | 645
Vascular disease 8 | 319
active ulcerative colitis 8 | 764
aldosterone-producing adenoma 8 | 665
chronic rhinosinusitis 8 | 512
posterior fossa group B ependymoma 8 | 416

Tissue

Female tissues 177 | 17,400
Male tissues 177 | 17,142
Skin and soft tissues 177 | 17,230
Endocrine System 176 | 18,159
Liver and Pancreas 175 | 16,750
Respiratory system 175 | 16,393
Digestive Tract 174 | 17,369
Blood and immune system 173 | 16,909
Nervous System 173 | 16,725
Urinary Tract 172 | 16,678
Cardiovascular System 166 | 15,192

Target Family

Non-IDG 93 | 12,091
Kinase 47 | 634
Enzyme 25 | 4,145
Transcription Factor 10 | 1,400
GPCR 5 | 408
Transporter 1 | 473

GO Process

cell migration 181 | 181
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.77409 55.5 444
Thrombospondin-1 THBS1 Tbio Non-IDG -3.06622 1281.6 504
Syndecan-4 SDC4 Tbio Non-IDG -2.39649 274.8 297
Probable inactive serine protease 37 PRSS37 Tdark Enzyme -0.32034 2.85 18
EMILIN-1 EMILIN1 Tbio Non-IDG -1.54226 36.3 0
Tyrosine-protein kinase JAK3 JAK3 Tclin Kinase -2.64385 453.7 292
NADPH oxidase 1 NOX1 Tchem Enzyme -2.59188 397.6 233
Sperm flagellar protein 1 SPEF1 Tdark Non-IDG -0.39794 2.39 16
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222