Development Level

Tbio 270 | 11,651
Tchem 44 | 1,388
Tdark 27 | 6,593
Tclin 4 | 612

Collection

Kinase: IDG Consortium (Comple... 5 | 37
Kinase: IDG Consortium (Target... 4 | 125
RFA-RM-18-021 4 | 328

IMPC Phenotype

preweaning lethality, complete... 45 | 979
preweaning lethality, incomple... 17 | 499
embryonic lethality prior to o... 12 | 239
embryonic lethality prior to t... 12 | 278
abnormal embryo size 10 | 220
increased fasted circulating g... 7 | 76
male infertility 7 | 123
embryonic growth retardation 6 | 106
abnormal seminal vesicle morph... 5 | 114
decreased body weight 5 | 161
abnormal behavior 4 | 298
abnormal coat-hair pigmentatio... 4 | 64
cataract 4 | 92
decreased body length 4 | 101
decreased total body fat amoun... 4 | 207
impaired glucose tolerance 4 | 75
increased circulating alkaline... 4 | 122
increased leukocyte cell numbe... 4 | 47
increased mean corpuscular vol... 4 | 92
abnormal bone structure 3 | 187
abnormal heart morphology 3 | 162
abnormal kidney morphology 3 | 65
abnormal lens morphology 3 | 81
abnormal placenta size 3 | 20
abnormal skin morphology 3 | 50
abnormal tail morphology 3 | 25
decreased bone mineral content 3 | 151
decreased caudal vertebrae num... 3 | 53
decreased circulating choleste... 3 | 93
decreased circulating serum al... 3 | 82
decreased lean body mass 3 | 135
decreased mean corpuscular hem... 3 | 50
decreased mean corpuscular vol... 3 | 79
edema 3 | 59
female infertility 3 | 60
hypoactivity 3 | 132
increased circulating HDL chol... 3 | 80
increased mean corpuscular hem... 3 | 96
microphthalmia 3 | 26
small testis 3 | 58
abnormal behavioral response t... 2 | 66
abnormal craniofacial morpholo... 2 | 33
abnormal cranium morphology 2 | 36
abnormal joint morphology 2 | 23
abnormal placenta morphology 2 | 5
abnormal skin coloration 2 | 25
abnormal snout morphology 2 | 23
abnormal testis morphology 2 | 43
abnormal vertebrae morphology 2 | 18
anophthalmia 2 | 33
decreased circulating HDL chol... 2 | 68
decreased circulating glucose ... 2 | 126
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
hyperactivity 2 | 148
improved glucose tolerance 2 | 79
increased body length 2 | 32
increased circulating chloride... 2 | 41
increased circulating creatini... 2 | 38
increased mean platelet volume 2 | 45
increased startle reflex 2 | 112
prenatal lethality 2 | 28
prenatal lethality prior to he... 2 | 87
small spleen 2 | 19
syndactyly 2 | 23
thrombocytopenia 2 | 56
thrombocytosis 2 | 27
vertebral fusion 2 | 23
abnormal body wall morphology 1 | 9
abnormal cornea morphology 1 | 31
abnormal embryo turning 1 | 31
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal retinal inner nuclear... 1 | 8
abnormal spleen morphology 1 | 55
abnormal tail movements 1 | 12
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
brachydactyly 1 | 19
decreased IgG1 level 1 | 8
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating magnesiu... 1 | 13
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fluid intake 1 | 3
decreased red blood cell distr... 1 | 41
enlarged spleen 1 | 41
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased heart weight 1 | 62
long tibia 1 | 25
small kidney 1 | 16
small superior vagus ganglion 1 | 74
tremors 1 | 39

Disease

Carcinoma 220 | 11,493
ovarian cancer 216 | 8,520
osteosarcoma 180 | 7,950
medulloblastoma, large-cell 178 | 6,241
glioblastoma 168 | 5,792
group 3 medulloblastoma 156 | 4,104
atypical teratoid / rhabdoid tumor 150 | 5,112
psoriasis 150 | 6,694
lung cancer 133 | 4,740
primitive neuroectodermal tumor 133 | 3,035
Breast cancer 130 | 3,578
adult high grade glioma 111 | 3,801
ependymoma 109 | 4,679
non-small cell lung cancer 104 | 2,890
malignant mesothelioma 103 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 99 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 97 | 3,291
invasive ductal carcinoma 90 | 2,951
Cancer 89 | 2,499
adrenocortical carcinoma 88 | 1,428
lung adenocarcinoma 80 | 2,716
ductal carcinoma in situ 65 | 1,745
pancreatic cancer 61 | 2,398
Astrocytoma, Pilocytic 60 | 3,081
oligodendroglioma 60 | 2,850
breast carcinoma 58 | 1,638
colon cancer 57 | 1,478
Kidney cancer 56 | 2,613
Atopic dermatitis 52 | 952
nasopharyngeal carcinoma 52 | 1,058
Endometriosis 48 | 540
Multiple myeloma 46 | 1,332
Pick disease 44 | 1,894
astrocytic glioma 42 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 39 | 2,955
tuberculosis 37 | 2,010
astrocytoma 36 | 1,146
ulcerative colitis 35 | 1,819
Intellectual disability 33 | 1,016
Waldenstrons macroglobulinemia 33 | 765
pituitary cancer 32 | 1,972
Rheumatoid arthritis 31 | 1,191
interstitial cystitis 31 | 2,312
subependymal giant cell astrocytoma 31 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 30 | 1,962
lung carcinoma 29 | 2,843
dermatomyositis 28 | 966
group 4 medulloblastoma 28 | 1,855
Cognitive delay 27 | 608
Global developmental delay 27 | 608
Mental and motor retardation 27 | 608
pediatric high grade glioma 27 | 1,064
Autosomal recessive predisposition 24 | 1,442
Small head 24 | 374
acute quadriplegic myopathy 23 | 1,158
juvenile dermatomyositis 23 | 1,187
Short stature 22 | 531
Dull intelligence 21 | 645
Low intelligence 21 | 645
Mental Retardation 21 | 645
Mental deficiency 21 | 645
Poor school performance 21 | 645
diabetes mellitus 21 | 1,728
progressive supranuclear palsy 21 | 676
Hypoplastic mandible condyle 20 | 275
Mandibular hypoplasia 20 | 275
Micrognathism 20 | 275
primary pancreatic ductal adenocarcinoma 19 | 1,109
Microcephaly 18 | 166
acute myeloid leukemia 17 | 783
primary Sjogren syndrome 17 | 735
medulloblastoma 16 | 720
non primary Sjogren syndrome sicca 16 | 891
posterior fossa group A ependymoma 16 | 468
active Crohn's disease 15 | 922
esophageal adenocarcinoma 15 | 737
cystic fibrosis 14 | 1,696
gastric carcinoma 14 | 807
spina bifida 14 | 1,074
Fetal Growth Retardation 13 | 189
Infant, Small for Gestational Age 13 | 176
Intrauterine retardation 13 | 176
Duchenne muscular dystrophy 12 | 601
Liver Cirrhosis, Experimental 12 | 769
Liver cancer 12 | 604
Schizophrenia 12 | 1,160
Acquired metabolic disease 11 | 336
Amyotrophic lateral sclerosis 11 | 451
Breast Neoplasms 11 | 445
Concave bridge of nose 11 | 195
Depressed nasal bridge 11 | 195
Depressed nasal root/bridge 11 | 195
Melanoma 11 | 711
Type 2 diabetes mellitus 11 | 272
pancreatic carcinoma 11 | 562
Alzheimer's disease 10 | 658
Bipolar Disorder 10 | 666
Cerebellar Hypoplasia 10 | 61
Congenital Epicanthus 10 | 177
Orbital separation excessive 10 | 244

Tissue

Endocrine System 343 | 18,159
Male tissues 339 | 17,142
Skin and soft tissues 339 | 17,230
Digestive Tract 338 | 17,369
Female tissues 338 | 17,400
Respiratory system 338 | 16,393
Nervous System 337 | 16,725
Blood and immune system 336 | 16,909
Liver and Pancreas 336 | 16,750
Urinary Tract 335 | 16,678
Cardiovascular System 325 | 15,192

Target Family

Non-IDG 247 | 12,091
Enzyme 57 | 4,145
Kinase 32 | 634
Transcription Factor 4 | 1,400
Epigenetic 3 | 242
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

GO Process

cell division 345 | 345
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Inactive serine/threonine-protein kinase PLK5 PLK5 Tbio Kinase -0.60609 4.07 119
Fidgetin FIGN Tbio Enzyme -1.34015 21.2 103
Ankyrin repeat and LEM domain-containing protein 2 ANKLE2 Tbio Non-IDG -1.07238 11.8 76
Securin PTTG1 Tbio Non-IDG -2.42127 261.4 311
Nuclear-interacting partner of ALK ZC3HC1 Tbio Non-IDG -2.13812 136.0 171
F-box/LRR-repeat protein 7 FBXL7 Tbio Non-IDG -0.80631 6.84 53
BRISC and BRCA1-A complex member 1 BABAM1 Tbio Non-IDG -1.20557 16.7 162
BRISC and BRCA1-A complex member 2 BABAM2 Tbio Non-IDG -1.84649 70.2 156
Cytoplasmic dynein 1 light intermediate chain 1 DYNC1LI1 Tbio Non-IDG -1.67860 45.9 100
Serine/threonine-protein kinase VRK1 VRK1 Tbio Kinase -2.05267 119.8 168