Development Level

Tbio 142 | 10,625
Tchem 33 | 1,890
Tdark 23 | 7,003
Tclin 2 | 602

Collection

Eligible Kinase Proteins 3 | 134

IMPC Term

preweaning lethality, complete... 12 | 633
embryonic lethality prior to o... 7 | 148
embryonic lethality prior to t... 7 | 187
preweaning lethality, incomple... 7 | 260
abnormal behavior 5 | 226
decreased lean body mass 4 | 195
abnormal retina morphology 3 | 100
decreased bone mineral content 3 | 157
decreased circulating glucose ... 3 | 121
abnormal bone structure 2 | 131
abnormal coat/hair pigmentatio... 2 | 54
abnormal heart left ventricle ... 2 | 20
abnormal lens morphology 2 | 73
decreased circulating free fat... 2 | 39
decreased startle reflex 2 | 48
decreased total body fat amoun... 2 | 186
hyperactivity 2 | 108
improved glucose tolerance 2 | 56
increased bone mineral content 2 | 92
increased fasted circulating g... 2 | 68
increased lean body mass 2 | 107
increased rib number 2 | 41
increased total body fat amoun... 2 | 57
abnormal behavioral response t... 1 | 52
abnormal coat appearance 1 | 25
abnormal coat/ hair morphology 1 | 18
abnormal embryo size 1 | 112
abnormal femur morphology 1 | 14
abnormal gait 1 | 51
abnormal liver size 1 | 4
abnormal lumbar vertebrae morp... 1 | 6
abnormal optic disc morphology 1 | 10
abnormal pericardium morpholog... 1 | 11
abnormal retinal pigmentation 1 | 61
abnormal spleen morphology 1 | 36
abnormal thoracic vertebrae mo... 1 | 16
cataract 1 | 26
decreased CD8-positive, alpha-... 1 | 26
decreased T cell number 1 | 31
decreased basophil cell number 1 | 11
decreased body length 1 | 108
decreased brain size 1 | 4
decreased caudal vertebrae num... 1 | 49
decreased cervical vertebrae n... 1 | 12
decreased circulating LDL chol... 1 | 37
decreased circulating alkaline... 1 | 41
decreased circulating insulin ... 1 | 75
decreased circulating serum al... 1 | 79
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart rate 1 | 10
decreased hematocrit 1 | 25
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular vol... 1 | 50
decreased red blood cell distr... 1 | 11
decreased respiratory quotient 1 | 12
decreased rib number 1 | 59
decreased spleen weight 1 | 13
decreased threshold for audito... 1 | 32
decreased vertical activity 1 | 22
female infertility 1 | 34
hydrops fetalis 1 | 22
hypoactivity 1 | 89
immune system phenotype 1 | 17
increased CD4-positive NK T ce... 1 | 3
increased CD8-positive, naive ... 1 | 3
increased NK T cell number 1 | 11
increased blood urea nitrogen ... 1 | 44
increased blood uric acid leve... 1 | 5
increased circulating alkaline... 1 | 119
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 32
increased circulating chloride... 1 | 43
increased circulating glucose ... 1 | 16
increased circulating phosphat... 1 | 24
increased circulating serum al... 1 | 25
increased circulating triglyce... 1 | 24
increased granulocyte number 1 | 8
increased grip strength 1 | 83
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased memory-marker CD4-po... 1 | 3
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
male infertility 1 | 62
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
prolonged RR interval 1 | 2
small heart 1 | 8
small liver 1 | 8
small lung 1 | 5
small spleen 1 | 11
small superior vagus ganglion 1 | 20
thrombocytopenia 1 | 46
tremors 1 | 34

Disease

osteosarcoma 106 | 7,933
ovarian cancer 104 | 8,484
medulloblastoma, large-cell 79 | 6,234
psoriasis 70 | 6,685
glioblastoma 67 | 5,572
Cancer 57 | 2,346
atypical teratoid / rhabdoid tumor 54 | 4,369
lung cancer 54 | 4,466
Breast cancer 50 | 3,094
malignant mesothelioma 47 | 3,162
primitive neuroectodermal tumor 44 | 3,031
non-small cell lung cancer 41 | 2,798
group 3 medulloblastoma 37 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 36 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,988
invasive ductal carcinoma 34 | 2,950
lung adenocarcinoma 33 | 2,713
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,956
oligodendroglioma 28 | 2,849
pediatric high grade glioma 28 | 2,712
Multiple myeloma 27 | 1,327
Pick disease 27 | 1,893
lung carcinoma 26 | 2,844
colon cancer 25 | 1,475
ependymoma 25 | 2,514
pancreatic cancer 25 | 2,300
pilocytic astrocytoma 25 | 3,086
breast carcinoma 24 | 1,614
interstitial cystitis 23 | 2,299
juvenile dermatomyositis 23 | 1,189
subependymal giant cell astrocytoma 23 | 2,287
group 4 medulloblastoma 22 | 1,875
adult high grade glioma 21 | 2,148
ductal carcinoma in situ 21 | 1,745
astrocytoma 20 | 1,493
Rheumatoid Arthritis 19 | 1,160
adrenocortical carcinoma 19 | 1,427
tuberculosis 19 | 1,557
Carcinoma 18 | 2,147
astrocytic glioma 18 | 2,241
medulloblastoma 18 | 1,524
ulcerative colitis 18 | 2,087
atypical teratoid/rhabdoid tumor 16 | 1,095
dermatomyositis 16 | 933
primary pancreatic ductal adenocarcinoma 16 | 1,271
sonic hedgehog group medulloblastoma 16 | 1,482
acute myeloid leukemia 15 | 780
acute quadriplegic myopathy 15 | 1,157
posterior fossa group B ependymoma 15 | 1,530
diabetes mellitus 13 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
posterior fossa group A ependymoma 13 | 1,511
Mammary Neoplasms 12 | 410
Waldenstrons macroglobulinemia 12 | 765
cutaneous lupus erythematosus 12 | 1,056
cystic fibrosis 12 | 1,665
nasopharyngeal carcinoma 12 | 1,056
non primary Sjogren syndrome sicca 12 | 840
pituitary cancer 12 | 1,972
IGA Glomerulonephritis 11 | 454
spina bifida 11 | 1,064
tuberculosis and treatment for 6 months 11 | 686
gastric carcinoma 10 | 832
progressive supranuclear palsy 10 | 674
Atopic dermatitis 9 | 944
active Crohn's disease 9 | 918
Down syndrome 8 | 548
Intellectual disability 8 | 573
esophageal adenocarcinoma 8 | 737
interstitial lung disease 8 | 291
primary Sjogren syndrome 8 | 789
Parkinson's disease 7 | 364
fibroadenoma 7 | 557
hepatocellular carcinoma 7 | 532
Alzheimer's disease 6 | 644
Duchenne muscular dystrophy 6 | 602
Endometriosis 6 | 535
Multiple Sclerosis 6 | 498
Prostatic Neoplasms 6 | 471
Stomach Neoplasms 6 | 282
aldosterone-producing adenoma 6 | 664
pancreatic carcinoma 6 | 567
Amyotrophic Lateral Sclerosis 5 | 431
Crohn's disease 5 | 304
Lung Neoplasms 5 | 171
Neoplasm Invasiveness 5 | 127
Peripheral vascular disease 5 | 90
Vascular disease 5 | 281
hereditary spastic paraplegia 5 | 313
mucosa-associated lymphoid tissue lymphoma 5 | 480
Arthritis 4 | 248
Hyperalgesia 4 | 71
Liver carcinoma 4 | 217
Liver neoplasms 4 | 109
Microcephaly 4 | 149
Neoplasm Metastasis 4 | 138
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 499
chronic rhinosinusitis 4 | 512
gastric cancer 4 | 430
ovarian neoplasm 4 | 97

Tissue

Liver and Pancreas 199 | 18,136
Blood and immune system 198 | 17,995
Cardiovascular System 198 | 17,958
Digestive Tract 198 | 18,473
Female tissues 198 | 18,647
Male tissues 198 | 17,969
Nervous System 198 | 18,561
Urinary Tract 197 | 18,444
Endocrine System 196 | 18,512
Respiratory system 196 | 17,484
Skin and soft tissues 196 | 18,115

Target Family

Non-IDG 117 | 11,971
Enzyme 32 | 4,146
Kinase 27 | 634
Transcription Factor 16 | 1,400
Epigenetic 7 | 242
GPCR 1 | 406

GO Process

cell cycle 200 | 200
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 368 | 368
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
MAPK cascade 238 | 238
chemical synaptic transmission 238 | 238
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
proteasome-mediated ubiquitin-... 200 | 200
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 181 | 181
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 176 | 176
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
negative regulation of canonic... 162 | 162
protein folding 162 | 162
T cell receptor signaling path... 161 | 161
response to lipopolysaccharide 161 | 161
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2/M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
antigen processing and present... 130 | 130
type I interferon signaling pa... 130 | 130

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199
Multicilin MCIDAS Tbio Non-IDG -2.00076 101.0 59
Host cell factor 1 HCFC1 Tbio Non-IDG -2.50024 341.6 160
Nuclear autoantigenic sperm protein NASP Tbio Non-IDG -1.72078 58.3 103
Septin-1 SEPT1 Tdark Non-IDG -1.92957 87.4 0
RCC1 and BTB domain-containing protein 1 RCBTB1 Tbio Non-IDG -1.74139 45.5 174
Annexin A11 ANXA11 Tbio Non-IDG -1.63325 49.7 192
Protein lin-9 homolog LIN9 Tbio Non-IDG -1.88736 79.3 89
Cyclin-dependent kinase 20 CDK20 Tbio Kinase -1.77301 61.5 206