Development Level

Tbio 202 | 11,651
Tchem 35 | 1,388
Tdark 28 | 6,593
Tclin 3 | 612

Collection

Kinase: IDG Consortium (Target... 5 | 125
RFA-RM-18-021 5 | 328
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 23 | 979
preweaning lethality, incomple... 15 | 499
embryonic lethality prior to o... 9 | 239
abnormal behavior 8 | 298
embryonic lethality prior to t... 7 | 278
abnormal bone structure 4 | 187
decreased body length 4 | 101
decreased body weight 4 | 161
increased mean corpuscular vol... 4 | 92
male infertility 4 | 123
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased mean corpuscular vol... 3 | 79
decreased red blood cell distr... 3 | 41
decreased startle reflex 3 | 75
hyperactivity 3 | 148
hypoactivity 3 | 132
increased fasted circulating g... 3 | 76
increased startle reflex 3 | 112
abnormal coat-hair pigmentatio... 2 | 64
abnormal embryo size 2 | 220
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal retina morphology 2 | 71
abnormal snout morphology 2 | 23
decreased blood urea nitrogen ... 2 | 51
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased lean body mass 2 | 135
decreased total body fat amoun... 2 | 207
enlarged heart 2 | 210
female infertility 2 | 60
increased blood urea nitrogen ... 2 | 48
increased circulating alkaline... 2 | 122
increased circulating calcium ... 2 | 34
increased leukocyte cell numbe... 2 | 47
increased total body fat amoun... 2 | 134
prenatal lethality 2 | 28
prenatal lethality prior to he... 2 | 87
small testis 2 | 58
abnormal behavioral response t... 1 | 66
abnormal brain morphology 1 | 13
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal epididymis morphology 1 | 42
abnormal heart left ventricle ... 1 | 16
abnormal optic disc morphology 1 | 10
abnormal pancreas morphology 1 | 13
abnormal pelvic girdle bone mo... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal posture 1 | 2
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
corneal opacity 1 | 32
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased circulating creatini... 1 | 39
decreased circulating insulin ... 1 | 76
decreased circulating phosphat... 1 | 27
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart rate 1 | 18
decreased mean platelet volume 1 | 25
decreased threshold for audito... 1 | 26
edema 1 | 59
enlarged epididymis 1 | 31
hydroencephaly 1 | 14
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased blood uric acid leve... 1 | 5
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating amylase ... 1 | 25
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating lipase l... 1 | 3
increased heart rate 1 | 23
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
prolonged RR interval 1 | 8
small spleen 1 | 19
small superior vagus ganglion 1 | 74
thrombocytosis 1 | 27
tremors 1 | 39
urinary bladder obstruction 1 | 4
vertebral fusion 1 | 23

Disease

Carcinoma 170 | 11,493
ovarian cancer 149 | 8,520
osteosarcoma 141 | 7,950
medulloblastoma, large-cell 112 | 6,241
glioblastoma 100 | 5,792
psoriasis 97 | 6,694
atypical teratoid / rhabdoid tumor 91 | 5,112
group 3 medulloblastoma 85 | 4,104
Breast cancer 80 | 3,578
Cancer 73 | 2,499
lung cancer 73 | 4,740
adult high grade glioma 66 | 3,801
primitive neuroectodermal tumor 66 | 3,035
ependymoma 63 | 4,679
malignant mesothelioma 63 | 3,232
invasive ductal carcinoma 52 | 2,951
non-small cell lung cancer 52 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 50 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 50 | 3,291
lung adenocarcinoma 44 | 2,716
Astrocytoma, Pilocytic 38 | 3,081
Multiple myeloma 38 | 1,332
Kidney cancer 36 | 2,613
adrenocortical carcinoma 35 | 1,428
breast carcinoma 34 | 1,638
oligodendroglioma 34 | 2,850
pancreatic cancer 34 | 2,398
ductal carcinoma in situ 33 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,955
lung carcinoma 33 | 2,843
Pick disease 32 | 1,894
Rheumatoid arthritis 29 | 1,191
colon cancer 29 | 1,478
subependymal giant cell astrocytoma 29 | 2,287
tuberculosis 29 | 2,010
astrocytic glioma 28 | 2,597
group 4 medulloblastoma 26 | 1,855
interstitial cystitis 25 | 2,312
juvenile dermatomyositis 24 | 1,187
diabetes mellitus 22 | 1,728
astrocytoma 21 | 1,146
ulcerative colitis 21 | 1,819
dermatomyositis 20 | 966
acute quadriplegic myopathy 19 | 1,158
primary pancreatic ductal adenocarcinoma 19 | 1,109
cystic fibrosis 18 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,962
pituitary cancer 18 | 1,972
Intellectual disability 17 | 1,016
Atopic dermatitis 16 | 952
acute myeloid leukemia 16 | 783
nasopharyngeal carcinoma 16 | 1,058
non primary Sjogren syndrome sicca 16 | 891
Breast Neoplasms 15 | 445
Schizophrenia 15 | 1,160
Waldenstrons macroglobulinemia 15 | 765
progressive supranuclear palsy 14 | 676
Endometriosis 13 | 540
Liver Cirrhosis, Experimental 13 | 769
Mammary Neoplasms 13 | 425
active Crohn's disease 13 | 922
gastric carcinoma 13 | 807
medulloblastoma 13 | 720
cutaneous lupus erythematosus 12 | 1,057
esophageal adenocarcinoma 12 | 737
spina bifida 12 | 1,074
Autosomal recessive predisposition 11 | 1,442
Dull intelligence 11 | 645
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
posterior fossa group A ependymoma 11 | 468
tuberculosis and treatment for 6 months 11 | 409
Cognitive delay 10 | 608
Down syndrome 10 | 499
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
Short stature 10 | 531
atypical teratoid/rhabdoid tumor 10 | 357
Alzheimer's disease 9 | 658
Amyotrophic lateral sclerosis 9 | 451
Duchenne muscular dystrophy 9 | 601
Prostatic Neoplasms 9 | 495
interstitial lung disease 9 | 298
pediatric high grade glioma 9 | 1,064
sonic hedgehog group medulloblastoma 9 | 467
Cleft Palate 8 | 271
Crohn's disease 8 | 321
Epilepsy 8 | 792
Multiple Sclerosis 8 | 540
Muscle hypotonia 8 | 571
Obesity 8 | 678
Small head 8 | 374
Stomach Neoplasms 8 | 300
aldosterone-producing adenoma 8 | 665
pancreatic carcinoma 8 | 562
primary Sjogren syndrome 8 | 735
Hypoplastic mandible condyle 7 | 275
Mandibular hypoplasia 7 | 275

Tissue

Endocrine System 264 | 18,159
Male tissues 261 | 17,142
Digestive Tract 260 | 17,369
Female tissues 259 | 17,400
Skin and soft tissues 259 | 17,230
Liver and Pancreas 258 | 16,750
Blood and immune system 257 | 16,909
Nervous System 256 | 16,725
Respiratory system 256 | 16,393
Urinary Tract 255 | 16,678
Cardiovascular System 249 | 15,192

Target Family

Non-IDG 159 | 12,091
Enzyme 49 | 4,145
Kinase 34 | 634
Transcription Factor 16 | 1,400
Epigenetic 8 | 242
GPCR 1 | 408
Nuclear Receptor 1 | 48

GO Process

cell cycle 268 | 268
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Inactive serine/threonine-protein kinase PLK5 PLK5 Tbio Kinase -0.60609 4.07 119
Chromatin assembly factor 1 subunit A CHAF1A Tbio Non-IDG -1.60312 40.7 157
Chromatin assembly factor 1 subunit B CHAF1B Tbio Non-IDG -1.02167 9.99 181
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
Fidgetin FIGN Tbio Enzyme -1.34015 21.2 103
Insulinoma-associated protein 1 INSM1 Tbio Transcription Factor -2.56531 362.4 56
Nuclear-interacting partner of ALK ZC3HC1 Tbio Non-IDG -2.13812 136.0 171
BRISC and BRCA1-A complex member 1 BABAM1 Tbio Non-IDG -1.20557 16.7 162
BRISC and BRCA1-A complex member 2 BABAM2 Tbio Non-IDG -1.84649 70.2 156
Malignant T-cell-amplified sequence 1 MCTS1 Tbio Non-IDG -0.79616 5.89 149