Development Level

Tbio 62 | 11,445
Tchem 17 | 1,598
Tclin 3 | 613
Tdark 1 | 6,588

Collection

GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 10 | 979
embryonic lethality prior to t... 7 | 278
enlarged heart 5 | 210
decreased vertical activity 4 | 208
preweaning lethality, incomple... 4 | 499
abnormal heart morphology 3 | 162
decreased startle reflex 3 | 75
embryonic lethality prior to o... 3 | 239
increased startle reflex 3 | 112
abnormal eye morphology 2 | 68
abnormal kidney morphology 2 | 65
abnormal retina morphology 2 | 71
decreased body weight 2 | 161
decreased circulating serum al... 2 | 82
decreased lymphocyte cell numb... 2 | 83
edema 2 | 59
hydrometra 2 | 53
impaired glucose tolerance 2 | 75
increased circulating alkaline... 2 | 122
increased neutrophil cell numb... 2 | 46
increased total body fat amoun... 2 | 134
limb grasping 2 | 41
short tibia 2 | 97
small superior vagus ganglion 2 | 74
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal brain morphology 1 | 13
abnormal coat appearance 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal eye size 1 | 7
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal iris morphology 1 | 13
abnormal limb morphology 1 | 13
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal response to new envir... 1 | 10
abnormal response to tactile s... 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
abnormal tail morphology 1 | 25
cataract 1 | 92
corneal opacity 1 | 32
cyanosis 1 | 7
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased basophil cell number 1 | 16
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
enlarged kidney 1 | 14
hemorrhage 1 | 23
hydroencephaly 1 | 14
hydrops fetalis 1 | 1
increased B cell number 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating glucose ... 1 | 24
increased circulating insulin ... 1 | 3
increased circulating triglyce... 1 | 42
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased spleen weight 1 | 10
increased vertical activity 1 | 24
mammalian phenotype 1 | 17
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
respiratory system phenotype 1 | 2
small spleen 1 | 19
syndactyly 1 | 23

Disease

Carcinoma 67 | 11,493
Cancer 45 | 2,499
osteosarcoma 44 | 7,950
ovarian cancer 43 | 8,520
psoriasis 43 | 6,694
atypical teratoid / rhabdoid tumor 40 | 5,112
glioblastoma 34 | 5,792
medulloblastoma, large-cell 34 | 6,241
Breast cancer 29 | 3,578
ependymoma 27 | 4,679
interstitial cystitis 24 | 2,312
lung cancer 24 | 4,740
group 3 medulloblastoma 23 | 4,104
malignant mesothelioma 23 | 3,232
Kidney cancer 21 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
primitive neuroectodermal tumor 20 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
non-small cell lung cancer 19 | 2,890
oligodendroglioma 19 | 2,850
invasive ductal carcinoma 18 | 2,951
lung adenocarcinoma 18 | 2,716
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
Astrocytoma, Pilocytic 16 | 3,081
Schizophrenia 16 | 1,160
pancreatic cancer 16 | 2,398
adult high grade glioma 15 | 3,801
astrocytic glioma 15 | 2,597
breast carcinoma 15 | 1,638
ductal carcinoma in situ 15 | 1,745
colon cancer 14 | 1,478
tuberculosis 14 | 2,010
Autosomal recessive predisposition 13 | 1,442
Intellectual disability 13 | 1,016
Pick disease 13 | 1,894
Cleft Palate 12 | 271
lung carcinoma 12 | 2,843
Prostatic Neoplasms 11 | 495
Short stature 11 | 531
adrenocortical carcinoma 11 | 1,428
astrocytoma 11 | 1,146
subependymal giant cell astrocytoma 11 | 2,287
ulcerative colitis 11 | 1,819
Breast Neoplasms 10 | 445
Cognitive delay 10 | 608
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
cystic fibrosis 10 | 1,696
diabetes mellitus 10 | 1,728
Autistic Disorder 9 | 364
Bipolar Disorder 9 | 666
Carcinoma, Hepatocellular 9 | 228
Cryptorchidism 9 | 296
Liver carcinoma 9 | 240
Obesity 9 | 678
Osteoporosis 9 | 363
Parkinson's disease 9 | 392
Vascular disease 9 | 319
pediatric high grade glioma 9 | 1,064
pituitary cancer 9 | 1,972
spina bifida 9 | 1,074
Adenocarcinoma 8 | 122
Depressive disorder 8 | 409
Dull intelligence 8 | 645
Hypoplastic mandible condyle 8 | 275
Low intelligence 8 | 645
Lymphoid leukemia 8 | 160
Mammary Neoplasms 8 | 425
Mandibular hypoplasia 8 | 275
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Micrognathism 8 | 275
Poor school performance 8 | 645
acute quadriplegic myopathy 8 | 1,158
esophageal adenocarcinoma 8 | 737
fibroadenoma 8 | 559
group 4 medulloblastoma 8 | 1,855
hepatocellular carcinoma 8 | 547
medulloblastoma 8 | 720
nasopharyngeal carcinoma 8 | 1,058
Adenoma 7 | 167
Cleft Lip 7 | 141
Colonic Neoplasms 7 | 142
Colorectal Neoplasms 7 | 243
Endometrial cancer 7 | 311
Epilepsy 7 | 792
Immune system cancer 7 | 140
Liver cancer 7 | 604
Lung Neoplasms 7 | 232
Major Depressive Disorder 7 | 301
Muscle hypotonia 7 | 571
Orbital separation excessive 7 | 244
Rheumatoid arthritis 7 | 1,191
Seizures 7 | 596
acute myeloid leukemia 7 | 783
cutaneous lupus erythematosus 7 | 1,057
juvenile dermatomyositis 7 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
primary pancreatic ductal adenocarcinoma 7 | 1,109
Multiple myeloma 6 | 1,332

Tissue

Female tissues 79 | 17,400
Digestive Tract 78 | 17,369
Endocrine System 78 | 18,159
Blood and immune system 77 | 16,909
Nervous System 77 | 16,725
Skin and soft tissues 77 | 17,230
Male tissues 76 | 17,142
Urinary Tract 76 | 16,678
Liver and Pancreas 72 | 16,750
Respiratory system 72 | 16,393
Cardiovascular System 67 | 15,192

Target Family

Non-IDG 40 | 12,091
Transcription Factor 15 | 1,400
GPCR 9 | 408
Enzyme 8 | 4,145
Kinase 5 | 634
Epigenetic 3 | 242
Nuclear Receptor 2 | 48
Ion Channel 1 | 344

GO Process

canonical Wnt signaling pathwa... 83 | 83
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Putative segment polarity protein dishevelled homolog DVL1P1 DVL1P1 Tdark Non-IDG -2.11561 188.4 0
Krueppel-like factor 4 KLF4 Tbio Transcription Factor -2.89447 774.1 686
Brachyury protein TBXT Tbio Transcription Factor -2.24737 158.4 337
Lysine-specific demethylase 6A KDM6A Tchem Epigenetic -2.27999 176.8 119
Frizzled-7 FZD7 Tbio GPCR -1.81873 66.4 345
Low-density lipoprotein receptor-related protein 5 LRP5 Tbio Non-IDG -3.10429 1247.5 302
Zinc finger protein SNAI2 SNAI2 Tbio Transcription Factor -3.25853 1689.4 685
Cell division control protein 42 homolog CDC42 Tchem Enzyme -3.37283 2188.5 380
Protein Wnt-7b WNT7B Tbio Non-IDG -1.76807 52.2 46
Nuclear receptor subfamily 4 group A member 2 NR4A2 Tchem Nuclear Receptor -2.59490 415.4 307