Development Level

Tbio 59 | 10,625
Tchem 19 | 1,890
Tclin 3 | 602
Tdark 2 | 7,003

Collection

GPCR: IDG Consortium (Targets) 1 | 127

IMPC Phenotype

preweaning lethality, complete... 7 | 633
embryonic lethality prior to t... 4 | 187
preweaning lethality, incomple... 4 | 260
decreased startle reflex 3 | 48
abnormal bone mineralization 2 | 55
decreased body weight 2 | 174
enlarged heart 2 | 111
hydrops fetalis 2 | 22
impaired glucose tolerance 2 | 52
limb grasping 2 | 35
abnormal behavior 1 | 226
abnormal coat appearance 1 | 25
abnormal coat-hair pigmentatio... 1 | 54
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal iris morphology 1 | 12
abnormal limb bud morphology 1 | 15
abnormal limb morphology 1 | 7
abnormal response to new envir... 1 | 8
abnormal response to tactile s... 1 | 16
abnormal retinal pigmentation 1 | 61
abnormal sleep behavior 1 | 63
abnormal startle reflex 1 | 14
abnormal tail morphology 1 | 17
cataract 1 | 26
corneal opacity 1 | 25
cyanosis 1 | 6
decreased CD4-positive, alpha ... 1 | 19
decreased T cell number 1 | 31
decreased basophil cell number 1 | 11
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating fructosa... 1 | 31
decreased circulating insulin ... 1 | 75
decreased circulating triglyce... 1 | 83
decreased grip strength 1 | 123
decreased lean body mass 1 | 195
decreased total body fat amoun... 1 | 186
edema 1 | 11
hemorrhage 1 | 12
increased B cell number 1 | 23
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating alkaline... 1 | 119
increased circulating triglyce... 1 | 24
increased lean body mass 1 | 107
increased startle reflex 1 | 38
increased vertical activity 1 | 18
microphthalmia 1 | 15
persistence of hyaloid vascula... 1 | 22
prenatal lethality 1 | 16
prenatal lethality prior to he... 1 | 64
respiratory system phenotype 1 | 2
syndactyly 1 | 4

Disease

osteosarcoma 45 | 7,933
psoriasis 44 | 6,685
ovarian cancer 43 | 8,491
Cancer 42 | 2,346
atypical teratoid / rhabdoid tumor 35 | 4,369
glioblastoma 34 | 5,572
medulloblastoma, large-cell 34 | 6,234
interstitial cystitis 24 | 2,299
lung cancer 24 | 4,473
Breast cancer 22 | 3,098
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,956
primitive neuroectodermal tumor 20 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,988
lung adenocarcinoma 19 | 2,714
malignant mesothelioma 19 | 3,163
oligodendroglioma 19 | 2,849
Carcinoma 18 | 2,147
invasive ductal carcinoma 18 | 2,950
ependymoma 17 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,289
non-small cell lung cancer 17 | 2,798
pediatric high grade glioma 17 | 2,712
astrocytoma 16 | 1,493
pilocytic astrocytoma 16 | 3,086
ductal carcinoma in situ 15 | 1,745
colon cancer 14 | 1,475
pancreatic cancer 14 | 2,300
sonic hedgehog group medulloblastoma 14 | 1,482
Pick disease 13 | 1,893
breast carcinoma 12 | 1,614
group 4 medulloblastoma 12 | 1,875
lung carcinoma 12 | 2,844
Cleft palate 11 | 125
adrenocortical carcinoma 11 | 1,427
posterior fossa group A ependymoma 11 | 1,511
subependymal giant cell astrocytoma 11 | 2,287
tuberculosis 11 | 1,563
ulcerative colitis 11 | 2,087
Intellectual disability 10 | 573
cystic fibrosis 10 | 1,670
group 3 medulloblastoma 10 | 2,254
Parkinson's disease 9 | 364
Prostatic Neoplasms 9 | 471
acute quadriplegic myopathy 9 | 1,157
astrocytic glioma 9 | 2,241
diabetes mellitus 9 | 1,663
pituitary cancer 9 | 1,972
primary pancreatic ductal adenocarcinoma 9 | 1,271
spina bifida 9 | 1,064
Mammary Neoplasms 8 | 410
Osteoporosis 8 | 259
esophageal adenocarcinoma 8 | 737
fibroadenoma 8 | 557
hepatocellular carcinoma 8 | 550
nasopharyngeal carcinoma 8 | 1,056
Colonic Neoplasms 7 | 126
Colorectal Neoplasms 7 | 217
Lung Neoplasms 7 | 171
Rheumatoid Arthritis 7 | 1,170
Robinow syndrome 7 | 12
acute myeloid leukemia 7 | 785
adult high grade glioma 7 | 2,148
cutaneous lupus erythematosus 7 | 1,056
gastric cancer 7 | 436
juvenile dermatomyositis 7 | 1,189
medulloblastoma 7 | 1,524
Adenocarcinoma 6 | 115
Adenoma 6 | 165
Autistic Disorder 6 | 320
Cleft Lip 6 | 91
Craniofacial Abnormalities 6 | 147
Liver carcinoma 6 | 217
Multiple myeloma 6 | 1,327
Obesity 6 | 616
Schizophrenia 6 | 503
Vascular disease 6 | 281
atypical teratoid/rhabdoid tumor 6 | 1,095
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 499
chronic rhinosinusitis 6 | 512
Dementia 5 | 129
Familial adenomatous polyposis 5 | 33
Juvenile arthritis 5 | 124
Neoplastic Cell Transformation 5 | 81
Pancreatic Neoplasm 5 | 79
Peripheral Neuropathy 5 | 303
aldosterone-producing adenoma 5 | 664
chronic lymphosyte leukemia 5 | 232
non primary Sjogren syndrome sicca 5 | 840
non-small cell lung carcinoma 5 | 413
pancreatic carcinoma 5 | 567
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
Alzheimer's disease 4 | 644
Atopic dermatitis 4 | 944
Crohn's disease 4 | 304
Down syndrome 4 | 548
Endometriosis 4 | 535
Kidney disease 4 | 397
chronic lymphocytic leukemia 4 | 244
gastric carcinoma 4 | 832
inflammatory breast cancer 4 | 404

Tissue

Digestive Tract 82 | 18,472
Endocrine System 82 | 18,511
Female tissues 82 | 18,646
Male tissues 82 | 17,968
Nervous System 82 | 18,560
Skin and soft tissues 82 | 18,114
Urinary Tract 82 | 18,443
Blood and immune system 81 | 17,994
Liver and Pancreas 81 | 18,135
Respiratory system 81 | 17,483
Cardiovascular System 79 | 17,957

Target Family

Non-IDG 40 | 11,969
Transcription Factor 15 | 1,400
GPCR 9 | 408
Enzyme 8 | 4,146
Kinase 5 | 634
Epigenetic 3 | 242
Nuclear Receptor 2 | 48
Ion Channel 1 | 341

GO Process

canonical Wnt signaling pathwa... 83 | 83
transcription, DNA-templated 1,779 | 1,779
regulation of transcription, D... 1,170 | 1,170
signal transduction 969 | 969
positive regulation of transcr... 845 | 845
G-protein coupled receptor sig... 666 | 666
negative regulation of transcr... 620 | 620
apoptotic process 506 | 506
positive regulation of transcr... 504 | 504
negative regulation of transcr... 483 | 483
multicellular organism develop... 456 | 456
positive regulation of cell pr... 451 | 451
cell differentiation 442 | 442
negative regulation of apoptot... 440 | 440
innate immune response 410 | 410
cell adhesion 409 | 409
immune response 398 | 398
negative regulation of cell pr... 379 | 379
inflammatory response 371 | 371
viral process 367 | 367
spermatogenesis 365 | 365
cell proliferation 358 | 358
protein transport 356 | 356
intracellular signal transduct... 355 | 355
cell division 330 | 330
regulation of transcription fr... 324 | 324
protein phosphorylation 320 | 320
response to drug 297 | 297
positive regulation of apoptot... 292 | 292
nervous system development 275 | 275
transcription from RNA polymer... 272 | 272
cell surface receptor signalin... 267 | 267
protein ubiquitination 260 | 260
transport 257 | 257
cell-cell signaling 249 | 249
regulation of immune response 247 | 247
positive regulation of gene ex... 242 | 242
mitotic nuclear division 241 | 241
chemical synaptic transmission 238 | 238
MAPK cascade 237 | 237
mRNA splicing, via spliceosome 219 | 219
angiogenesis 218 | 218
small GTPase mediated signal t... 215 | 215
translation 215 | 215
rRNA processing 209 | 209
intracellular protein transpor... 205 | 205
cellular response to DNA damag... 201 | 201
cell cycle 200 | 200
proteasome-mediated ubiquitin-... 199 | 199
proteolysis 199 | 199
visual perception 198 | 198
DNA repair 196 | 196
extracellular matrix organizat... 193 | 193
regulation of apoptotic proces... 190 | 190
brain development 183 | 183
positive regulation of cell mi... 181 | 181
protein polyubiquitination 180 | 180
in utero embryonic development 178 | 178
Fc-epsilon receptor signaling ... 175 | 175
Wnt signaling pathway 175 | 175
ion transmembrane transport 174 | 174
protein homooligomerization 173 | 173
heart development 170 | 170
positive regulation of ERK1 an... 170 | 170
blood coagulation 169 | 169
cell migration 168 | 168
regulation of cell proliferati... 167 | 167
protein autophosphorylation 166 | 166
response to hypoxia 164 | 164
mRNA processing 162 | 162
protein folding 162 | 162
negative regulation of canonic... 161 | 161
response to lipopolysaccharide 161 | 161
T cell receptor signaling path... 160 | 160
defense response to virus 160 | 160
RNA splicing 158 | 158
aging 158 | 158
positive regulation of I-kappa... 158 | 158
axon guidance 157 | 157
homophilic cell adhesion via p... 155 | 155
sensory perception of smell 155 | 155
ER to Golgi vesicle-mediated t... 151 | 151
interferon-gamma-mediated sign... 150 | 150
protein ubiquitination involve... 150 | 150
transcription initiation from ... 150 | 150
ubiquitin-dependent protein ca... 149 | 149
DNA replication 144 | 144
adaptive immune response 139 | 139
cell cycle arrest 139 | 139
receptor-mediated endocytosis 139 | 139
skeletal system development 136 | 136
regulation of cell shape 135 | 135
regulation of small GTPase med... 134 | 134
G2-M transition of mitotic cel... 133 | 133
oxidation-reduction process 133 | 133
positive regulation of cytosol... 133 | 133
protein stabilization 133 | 133
sensory perception of sound 132 | 132
positive regulation of NF-kapp... 131 | 131
type I interferon signaling pa... 130 | 130
endocytosis 129 | 129

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.73870 492.7 294
Frizzled-1 FZD1 Tbio GPCR -2.04125 74.3 233
Pro-epidermal growth factor EGF Tbio Non-IDG -3.74596 4837.7 851
Myc proto-oncogene protein MYC Tbio Transcription Factor -4.09050 11730.8 2241
Zinc finger protein SNAI2 SNAI2 Tbio Transcription Factor -3.22534 1564.7 495
Ubiquitin-conjugating enzyme E2 B UBE2B Tbio Non-IDG -1.56365 38.8 140
Frizzled-4 FZD4 Tbio GPCR -2.00958 92.5 273
Frizzled-10 FZD10 Tbio GPCR -1.33529 23.5 156
E3 ubiquitin-protein ligase ZNRF3 ZNRF3 Tbio Enzyme -1.07894 14.6 38
Norrin NDP Tbio Non-IDG -1.87903 218.2 87