Development Level

Tbio 64 | 11,651
Tchem 15 | 1,388
Tclin 3 | 612
Tdark 1 | 6,593

Collection

GPCR: IDG Consortium (Targets) 1 | 126
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 10 | 979
embryonic lethality prior to t... 7 | 278
enlarged heart 5 | 210
decreased vertical activity 4 | 208
preweaning lethality, incomple... 4 | 499
abnormal heart morphology 3 | 162
decreased startle reflex 3 | 75
embryonic lethality prior to o... 3 | 239
increased startle reflex 3 | 112
abnormal eye morphology 2 | 68
abnormal kidney morphology 2 | 65
abnormal retina morphology 2 | 71
decreased body weight 2 | 161
decreased circulating serum al... 2 | 82
decreased lymphocyte cell numb... 2 | 83
edema 2 | 59
hydrometra 2 | 53
impaired glucose tolerance 2 | 75
increased circulating alkaline... 2 | 122
increased neutrophil cell numb... 2 | 46
increased total body fat amoun... 2 | 134
limb grasping 2 | 41
short tibia 2 | 97
small superior vagus ganglion 2 | 74
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal brain morphology 1 | 13
abnormal coat appearance 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal eye size 1 | 7
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal hindbrain morphology 1 | 10
abnormal iris morphology 1 | 13
abnormal limb morphology 1 | 13
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal response to new envir... 1 | 10
abnormal response to tactile s... 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
abnormal tail morphology 1 | 25
cataract 1 | 92
corneal opacity 1 | 32
cyanosis 1 | 7
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased basophil cell number 1 | 16
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
enlarged kidney 1 | 14
hemorrhage 1 | 23
hydroencephaly 1 | 14
hydrops fetalis 1 | 1
increased B cell number 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating glucose ... 1 | 24
increased circulating insulin ... 1 | 3
increased circulating triglyce... 1 | 42
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased spleen weight 1 | 10
increased vertical activity 1 | 24
mammalian phenotype 1 | 17
microphthalmia 1 | 26
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
respiratory system phenotype 1 | 2
small spleen 1 | 19
syndactyly 1 | 23

Disease

Carcinoma 67 | 11,493
Cancer 45 | 2,499
osteosarcoma 44 | 7,950
ovarian cancer 43 | 8,520
psoriasis 43 | 6,694
atypical teratoid / rhabdoid tumor 40 | 5,112
glioblastoma 34 | 5,792
medulloblastoma, large-cell 34 | 6,241
Breast cancer 29 | 3,578
ependymoma 27 | 4,679
interstitial cystitis 24 | 2,312
lung cancer 24 | 4,740
group 3 medulloblastoma 23 | 4,104
malignant mesothelioma 23 | 3,232
Kidney cancer 21 | 2,613
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
primitive neuroectodermal tumor 20 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
non-small cell lung cancer 19 | 2,890
oligodendroglioma 19 | 2,850
invasive ductal carcinoma 18 | 2,951
lung adenocarcinoma 18 | 2,716
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
Astrocytoma, Pilocytic 16 | 3,081
Schizophrenia 16 | 1,160
pancreatic cancer 16 | 2,398
adult high grade glioma 15 | 3,801
astrocytic glioma 15 | 2,597
breast carcinoma 15 | 1,638
ductal carcinoma in situ 15 | 1,745
colon cancer 14 | 1,478
tuberculosis 14 | 2,010
Autosomal recessive predisposition 13 | 1,442
Intellectual disability 13 | 1,016
Pick disease 13 | 1,894
Cleft Palate 12 | 271
lung carcinoma 12 | 2,843
Prostatic Neoplasms 11 | 495
Short stature 11 | 531
adrenocortical carcinoma 11 | 1,428
astrocytoma 11 | 1,146
subependymal giant cell astrocytoma 11 | 2,287
ulcerative colitis 11 | 1,819
Breast Neoplasms 10 | 445
Cognitive delay 10 | 608
Global developmental delay 10 | 608
Mental and motor retardation 10 | 608
cystic fibrosis 10 | 1,696
diabetes mellitus 10 | 1,728
Autistic Disorder 9 | 364
Bipolar Disorder 9 | 666
Carcinoma, Hepatocellular 9 | 228
Cryptorchidism 9 | 296
Liver carcinoma 9 | 240
Obesity 9 | 678
Osteoporosis 9 | 363
Parkinson's disease 9 | 392
Vascular disease 9 | 319
pediatric high grade glioma 9 | 1,064
pituitary cancer 9 | 1,972
spina bifida 9 | 1,074
Adenocarcinoma 8 | 122
Depressive disorder 8 | 409
Dull intelligence 8 | 645
Hypoplastic mandible condyle 8 | 275
Low intelligence 8 | 645
Lymphoid leukemia 8 | 160
Mammary Neoplasms 8 | 425
Mandibular hypoplasia 8 | 275
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Micrognathism 8 | 275
Poor school performance 8 | 645
acute quadriplegic myopathy 8 | 1,158
esophageal adenocarcinoma 8 | 737
fibroadenoma 8 | 559
group 4 medulloblastoma 8 | 1,855
hepatocellular carcinoma 8 | 547
medulloblastoma 8 | 720
nasopharyngeal carcinoma 8 | 1,058
Adenoma 7 | 167
Cleft Lip 7 | 141
Colonic Neoplasms 7 | 142
Colorectal Neoplasms 7 | 243
Endometrial cancer 7 | 311
Epilepsy 7 | 792
Immune system cancer 7 | 140
Liver cancer 7 | 604
Lung Neoplasms 7 | 232
Major Depressive Disorder 7 | 301
Muscle hypotonia 7 | 571
Orbital separation excessive 7 | 244
Rheumatoid arthritis 7 | 1,191
Seizures 7 | 596
acute myeloid leukemia 7 | 783
cutaneous lupus erythematosus 7 | 1,057
juvenile dermatomyositis 7 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
primary pancreatic ductal adenocarcinoma 7 | 1,109
Multiple myeloma 6 | 1,332

Tissue

Female tissues 79 | 17,400
Digestive Tract 78 | 17,369
Endocrine System 78 | 18,159
Blood and immune system 77 | 16,909
Nervous System 77 | 16,725
Skin and soft tissues 77 | 17,230
Male tissues 76 | 17,142
Urinary Tract 76 | 16,678
Liver and Pancreas 72 | 16,750
Respiratory system 72 | 16,393
Cardiovascular System 67 | 15,192

Target Family

Non-IDG 40 | 12,091
Transcription Factor 15 | 1,400
GPCR 9 | 408
Enzyme 8 | 4,145
Kinase 5 | 634
Epigenetic 3 | 242
Nuclear Receptor 2 | 48
Ion Channel 1 | 344

GO Process

canonical Wnt signaling pathwa... 83 | 83
transcription, DNA-templated 1,742 | 1,742
regulation of transcription, D... 1,135 | 1,135
G-protein coupled receptor sig... 1,053 | 1,053
signal transduction 1,005 | 1,005
positive regulation of transcr... 932 | 932
negative regulation of transcr... 683 | 683
positive regulation of transcr... 529 | 529
apoptotic process 511 | 511
cell differentiation 511 | 511
negative regulation of transcr... 492 | 492
neutrophil degranulation 484 | 484
negative regulation of apoptot... 479 | 479
positive regulation of cell pr... 470 | 470
innate immune response 469 | 469
multicellular organism develop... 460 | 460
cell adhesion 458 | 458
immune response 426 | 426
viral process 405 | 405
negative regulation of cell pr... 398 | 398
spermatogenesis 389 | 389
intracellular signal transduct... 376 | 376
inflammatory response 373 | 373
cell proliferation 366 | 366
post-translational protein mod... 356 | 356
protein transport 348 | 348
protein ubiquitination 347 | 347
cell division 345 | 345
regulation of transcription fr... 345 | 345
protein phosphorylation 334 | 334
nervous system development 321 | 321
positive regulation of apoptot... 320 | 320
response to drug 303 | 303
cell-cell signaling 300 | 300
positive regulation of gene ex... 297 | 297
transcription from RNA polymer... 286 | 286
protein deubiquitination 271 | 271
cell cycle 268 | 268
regulation of immune response 259 | 259
transport 255 | 255
regulation of apoptotic proces... 250 | 250
MAPK cascade 242 | 242
cell surface receptor signalin... 239 | 239
mRNA splicing, via spliceosome 236 | 236
protein polyubiquitination 222 | 222
angiogenesis 220 | 220
chemical synaptic transmission 219 | 219
cellular response to DNA damag... 217 | 217
proteolysis 217 | 217
proteasome-mediated ubiquitin-... 210 | 210
adaptive immune response 209 | 209
intracellular protein transpor... 209 | 209
DNA repair 206 | 206
leukocyte migration 206 | 206
protein homooligomerization 206 | 206
rRNA processing 204 | 204
extracellular matrix organizat... 198 | 198
visual perception 198 | 198
positive regulation of ERK1 an... 194 | 194
cellular protein metabolic pro... 192 | 192
brain development 188 | 188
axon guidance 186 | 186
Fc-epsilon receptor signaling ... 182 | 182
keratinization 182 | 182
cell migration 181 | 181
defense response to virus 181 | 181
positive regulation of cell mi... 179 | 179
regulation of cell proliferati... 177 | 177
in utero embryonic development 176 | 176
Wnt signaling pathway 175 | 175
cilium assembly 175 | 175
blood coagulation 170 | 170
RNA splicing 169 | 169
translation 169 | 169
mRNA processing 168 | 168
protein autophosphorylation 168 | 168
aging 167 | 167
response to hypoxia 166 | 166
T cell receptor signaling path... 164 | 164
heart development 164 | 164
negative regulation of canonic... 164 | 164
positive regulation of I-kappa... 164 | 164
ubiquitin-dependent protein ca... 164 | 164
ER to Golgi vesicle-mediated t... 162 | 162
protein stabilization 160 | 160
response to lipopolysaccharide 160 | 160
transcription initiation from ... 160 | 160
defense response to bacterium 159 | 159
protein folding 159 | 159
sensory perception of smell 157 | 157
homophilic cell adhesion via p... 156 | 156
transmembrane transport 154 | 154
negative regulation of gene ex... 151 | 151
interferon-gamma-mediated sign... 150 | 150
receptor-mediated endocytosis 150 | 150
ion transmembrane transport 148 | 148
peptidyl-serine phosphorylatio... 148 | 148
positive regulation of protein... 148 | 148
antigen processing and present... 143 | 143
DNA replication 142 | 142
cell cycle arrest 142 | 142

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pygopus homolog 2 PYGO2 Tbio Epigenetic -1.26911 24.4 92
Chromodomain-helicase-DNA-binding protein 8 CHD8 Tbio Epigenetic -1.64766 47.4 81
B-cell CLL/lymphoma 9-like protein BCL9L Tbio Non-IDG -1.02513 10.8 100
Pro-epidermal growth factor EGF Tbio Non-IDG -3.75933 4903.2 978
Frizzled-4 FZD4 Tbio GPCR -2.05508 106.8 313
Norrin NDP Tbio Non-IDG -1.91603 84.4 96
Ubiquitin-conjugating enzyme E2 B UBE2B Tbio Non-IDG -1.56328 38.9 167
E3 ubiquitin-protein ligase ZNRF3 ZNRF3 Tbio Enzyme -1.17415 16.1 57
Proto-oncogene Wnt-1 WNT1 Tbio Non-IDG -2.76391 516.8 355
Lymphoid enhancer-binding factor 1 LEF1 Tchem Transcription Factor -2.60971 375.2 591